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1. Cardiac glycosides 1785-1985
: biochemistry, pharmacology, clinical relevance
by Achenbach, C. (Christopher) and Erdmann, Erland and Greeff, K and Skou, J. C
1986, Boehringer Mannheim international symposia, ISBN 0387912754, xvii, 552
Cardiac glycosides
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2. Full Text Novel therapeutic applications of cardiac glycosides
by Prassas, Ioannis and Diamandis, Eleftherios P
Nature Reviews Drug Discovery, ISSN 1474-1776, 11/2008, Volume 7, Issue 11, pp. 926 - 935
Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit Na+/K+-ATPase. Members of this family have been in clinical use... 
BREAST-CANCER | BUFALIN-INDUCED APOPTOSIS | DIGITALIS-LIKE COMPOUNDS | HUMAN LEUKEMIA-CELLS | SODIUM-PUMP | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NA+/K+-ATPASE | BINDING-SITE | PHARMACOLOGY & PHARMACY | LUNG-CANCER CELLS | VASCULAR SMOOTH-MUSCLE | HUMAN TUMOR-CELLS | Cardiac Glycosides - pharmacology | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Apoptosis - drug effects | Humans | Neoplasms - enzymology | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Animals | Cardiac Glycosides - chemistry | Antineoplastic Agents - pharmacology | Cardiac Glycosides - therapeutic use | Cell Proliferation - drug effects | Heart Diseases - drug therapy | Molecular Structure | Tumor Cells, Cultured | Dosage and administration | Properties | Cardiotonic agents | Cardiac glycosides
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3. Full Text Cardiac Glycosides from the Seeds of Thevetia peruviana
by Tian, Dan-Mei and Cheng, Huo-Yun and Jiang, Miao-Miao and Shen, Wei-Zai and Tang, Jin-Shan and Yao, Xin-Sheng
Journal of Natural Products, ISSN 0163-3864, 01/2016, Volume 79, Issue 1, pp. 38 - 50
Investigation of the seeds of Thevetia peruviana resulted in the isolation of 15 new (2–16) and 18 known (1 and 17–33) cardiac glycosides. Eight... 
CARDENOLIDE GLYCOSIDES | CELLS | APOPTOSIS | CHEMISTRY, MEDICINAL | LEAVES | NERIIFOLIA | CANCER | 5-ALPHA-CARDENOLIDES | PLANT SCIENCES | CERBERA-ODOLLAM | PHARMACOLOGY & PHARMACY | ASCLEPIAS-CURASSAVICA | ANTIARIS-TOXICARIA | Cardiac Glycosides - pharmacology | Thevetia - chemistry | Humans | Drugs, Chinese Herbal - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Structure-Activity Relationship | Cardenolides - chemistry | Cardenolides - isolation & purification | Drugs, Chinese Herbal - chemistry | Cardiac Glycosides - chemistry | Inhibitory Concentration 50 | Nuclear Magnetic Resonance, Biomolecular | Molecular Structure | Seeds - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Cardiac Glycosides - isolation & purification | Drugs, Chinese Herbal - isolation & purification | Cardenolides - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor
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4. Full Text Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth
by Wilhelm Schoner and Georgios Scheiner-Bobis
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2007, Volume 293, Issue 2, pp. 509 - 536
Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in mammals. Among them are the hydrophilic cardenolide ouabain and the... 
Cell proliferation | Arterial hypertension | Endogenous cardiotonic steroids | Rostafuroxin | Sodium/potassium-adenosinetriphosphatase | Cancer therapy | Ouabain | Marinobufagenin | Sodium pump | Oleandrin | Bufalin | Sodium metabolism | ouabain | PROTEIN-KINASE-C | PHYSIOLOGY | BOVINE ADRENOCORTICAL-CELLS | BUFALIN INDUCES APOPTOSIS | PLASMALEMMAL NA/K-ATPASE | cell proliferation | SIGNAL-TRANSDUCING FUNCTION | endogenous cardiotonic steroids | FACTOR-KAPPA-B | oleandrin | sodium/potassium-adenosinetriphosphatase | VASCULAR SMOOTH-MUSCLE | NA+-K+-ATPASE | CELL BIOLOGY | arterial hypertension | cancer therapy | OUABAIN-LIKE COMPOUND | sodium pump | DIGITALIS-LIKE COMPOUNDS | bufalin | rostafuroxin | sodium metabolism | marinobufagenin | Cardiac Glycosides - pharmacology | Neoplasms - metabolism | Antihypertensive Agents - pharmacology | Digoxin - metabolism | Calcium - metabolism | Humans | Myocardial Contraction - drug effects | Hypertension - drug therapy | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Antihypertensive Agents - metabolism | Ouabain - metabolism | Antineoplastic Agents - metabolism | Bufanolides - metabolism | Antineoplastic Agents - pharmacology | Blood Pressure - drug effects | Molecular Structure | Cell Death - drug effects | Sodium Chloride - metabolism | Ouabain - pharmacology | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Diabetes Mellitus - metabolism | Cardiovascular System - drug effects | Antihypertensive Agents - therapeutic use | Antineoplastic Agents - chemistry | Digoxin - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Neoplasms - drug therapy | Antihypertensive Agents - chemistry | Sodium-Potassium-Exchanging ATPase - metabolism | Animals | Myocytes, Cardiac - drug effects | Cardiovascular System - metabolism | Diabetes Mellitus - physiopathology | Cardiac Glycosides - chemistry | Myocytes, Cardiac - metabolism | Bufanolides - pharmacology | Cardiac Glycosides - metabolism | Cardiac Glycosides - therapeutic use | Cell Proliferation - drug effects | Neoplasms - pathology
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5. Full Text Regioselective Diversification of a Cardiac Glycoside, Lanatoside C, by Organocatalysis
by Ueda, Yoshihiro and Mishiro, Kenji and Yoshida, Keisuke and Furuta, Takumi and Kawabata, Takeo
The Journal of Organic Chemistry, ISSN 0022-3263, 09/2012, Volume 77, Issue 18, pp. 7850 - 7857
Acylation of lanatoside C in the presence of organocatalyst 5 gave the C(4′′′′)-O-acylate in up to 90% regioselectivity (catalyst-controlled regioselectivity).... 
ALCOHOLS | CRYSTAL-STRUCTURE ANALYSIS | ACYLATION | ACETYLATION | ESTERIFICATION | CHEMISTRY, ORGANIC | SUGARS | ANHYDRIDE | Lanatosides - chemical synthesis | Catalysis | Stereoisomerism | Cardiac Glycosides - chemistry | Acylation | Lanatosides - chemistry | Anhydrides | Glycosides | Glycosidic bonds | Chemical properties | Analysis
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6. Full Text Cardiac Glycosides as Novel Cancer Therapeutic Agents
by Robert A. Newman and Peiying Yang and Alison D. Pawlus and Keith I. Block
Molecular Interventions, ISSN 1534-0384, 02/2008, Volume 8, Issue 1, pp. 36 - 49
The class of steroid-like compounds designated cardiac glycosides includes well-known drugs such as digoxin, digitoxin, and ouabain. Their continued efficacy... 
HUMAN MONOCYTIC CELLS | CYTOTOXIC CARDENOLIDE GLYCOSIDE | BUFALIN INDUCES APOPTOSIS | TOPOISOMERASE-II | HUMAN LEUKEMIA-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NA+/K+-ATPASE | OLEANDRIN SUPPRESSES ACTIVATION | FACTOR-KAPPA-B | BETA-SUBUNIT | PLANT ANTICANCER AGENTS | Cardiac Glycosides - pharmacology | Receptors, Estrogen - metabolism | Sodium-Potassium-Exchanging ATPase - physiology | Signal Transduction | Species Specificity | Apoptosis - drug effects | Humans | Rats | Neoplasms - prevention & control | Antineoplastic Agents - therapeutic use | Growth Inhibitors - chemistry | Antineoplastic Agents - chemistry | Autophagy - drug effects | Growth Inhibitors - metabolism | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Animals | Cardiac Glycosides - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Cardiac Glycosides - metabolism | Cardiac Glycosides - therapeutic use | Mice | Growth Inhibitors - pharmacology
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7. Full Text Synthesis of Cardiac Glycoside Analogs by Catalyst-Controlled, Regioselective Glycosylation of Digitoxin
by Beale, Thomas M and Taylor, Mark S
Organic Letters, ISSN 1523-7060, 03/2013, Volume 15, Issue 6, pp. 1358 - 1361
The cardiac glycoside natural product digitoxin was selectively glycosylated at one of its five hydroxyl groups using a borinic acid derived catalyst. This... 
HYDROXY-GROUPS | BIOTRANSFORMATION | HEXOPYRANOSIDES | NATURAL-PRODUCTS | BUILDING-BLOCKS | CHEMISTRY, ORGANIC | CHEMICAL-SYNTHESIS | STEREOSELECTIVE-SYNTHESIS | GLYCOSYLTRANSFERASES | DERIVATIVES | CELL-CULTURES | Digitalis - chemistry | Digitoxin - analogs & derivatives | Cardiac Glycosides - chemical synthesis | Stereoisomerism | Borinic Acids - chemistry | Cardiac Glycosides - chemistry | Digitoxin - chemistry | Digitoxin - chemical synthesis | Glycosylation | Molecular Structure | Catalysis
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8. Full Text Enhancing the Anticancer Properties of Cardiac Glycosides by Neoglycorandomization
by Joseph M. Langenhan and Noël R. Peters and Ilia A. Guzei and F. Michael Hoffmann and Jon S. Thorson and Kyriacos C. Nicolaou
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2005, Volume 102, Issue 35, pp. 12305 - 12310
Glycosylated natural products are reliable platforms for the development of many front-line drugs, yet our understanding of the relationship between attached... 
Physical Sciences | Epithelial cells | Cell lines | Digitoxins | Cytotoxicity | Libraries | Kidney cells | Inhibitory concentration 50 | Sugars | Cardiac glycosides | Crystal structure | Natural product | Carbohydrate | Sugar | APOPTOSIS | STEROIDS | natural product | MULTIDISCIPLINARY SCIENCES | GLYCOPROTEINS | BREAST-CANCER-CELLS | GLYCORANDOMIZATION | GLYCOSYLATION | CHEMOSELECTIVE LIGATION | carbohydrate | DIGITOXIN | DIGOXIN | sugar | CYTOTOXICITY | Cardiac Glycosides - pharmacology | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Antineoplastic Agents - chemical synthesis | Drug Stability | Humans | Digitoxin - pharmacology | Enzyme Inhibitors - pharmacology | Glycosylation | Antineoplastic Agents - chemistry | Hydrolysis | Animals | Digitoxin - analogs & derivatives | Cardiac Glycosides - chemical synthesis | Cardiac Glycosides - chemistry | Enzyme Inhibitors - chemistry | Drug Design | Cell Line, Tumor | Digitoxin - chemistry | Antineoplastic Agents - pharmacology | Digitoxin - chemical synthesis | Mice | Molecular Structure | Drug Screening Assays, Antitumor | Carbohydrates | Care and treatment | Research | Health aspects | Cancer
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9. Full Text Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials
by Slingerland, M and Cerella, C and Guchelaar, H J and Diederich, M and Gelderblom, H
Investigational New Drugs, ISSN 0167-6997, 8/2013, Volume 31, Issue 4, pp. 1087 - 1094
Cardiac glycosides have a long history in the treatment of cardiac disease. However, several preclinical studies as well as two phase I studies have shown that... 
Cardenolide | Na + /K + -ATPase | Medicine & Public Health | Cell death | Cardiac glycoside | Oncology | Cytotoxicity | UNBS1450 | Pharmacology/Toxicology | ATPase | GROWTH-INHIBITION | Na+/K+-ATPase | APOPTOTIC VOLUME DECREASE | CELL-CYCLE ARREST | FACTOR-KAPPA-B | CARDIOTONIC STEROIDS | BREAST-CANCER | CALOTROPIS-PROCERA | IN-VITRO | ONCOLOGY | SODIUM-PUMP | PHARMACOLOGY & PHARMACY | INTRACELLULAR ACIDIFICATION | Cardiac Glycosides - pharmacology | Animals | Cardiac Glycosides - chemistry | Humans | Antineoplastic Agents - pharmacology | Antineoplastic Agents - therapeutic use | Cardiac Glycosides - therapeutic use | Clinical Trials as Topic | Cell Death - drug effects | Antineoplastic Agents - chemistry | Drug Screening Assays, Antitumor | Neoplasms - drug therapy | Complications and side effects | Glycosides | Dosage and administration | Research | Drug therapy | Heart diseases | Cancer | Drugs | Studies | Cardiovascular disease | Cancer therapies | Pharmaceutical sciences | Index Medicus
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10. Full Text Chemical Synthesis of the Cardiotonic Steroid Glycosides and Related Natural Products
by Heasley, Brian
Chemistry – A European Journal, ISSN 0947-6539, 03/2012, Volume 18, Issue 11, pp. 3092 - 3120
The active components from the extracts of Digitalis, cardiotonic steroid glycosides, have been ingested by humans for more than 200 years as a medicinal... 
ouabain | semisynthesis | steroids | total synthesis | medicinal chemistry | digitoxin | DIELS-ALDER | ASYMMETRIC-SYNTHESIS | DEFENSIVE STEROIDS | ABC RING-SYSTEM | SEX-HORMONES | REDUCTIVE ALKYLATION | CARDIOACTIVE STEROIDS | CHEMISTRY, MULTIDISCIPLINARY | STEREOSELECTIVE SYNTHESIS | CONVERGENT SYNTHESIS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | Biological Products - chemical synthesis | Digitalis Glycosides - chemical synthesis | Biological Products - chemistry | Digitalis - chemistry | Cardiac Glycosides - chemical synthesis | Cardiac Glycosides - chemistry | Digitalis Glycosides - chemistry | Humans | Molecular Structure | Chemical synthesis | Ouabain | Heart | Therapy | Construction | Glycosides | Rhythm | Pharmacology | Failure | Steroids
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11. Full Text Forsythoneosides A–D, Neuroprotective Phenethanoid and Flavone Glycoside Heterodimers from the Fruits of Forsythia suspensa
by Zhang, Fan and Yang, Ya-Nan and Song, Xiu-Yun and Shao, Si-Yuan and Feng, Zi-Ming and Jiang, Jian-Shuang and Li, Li and Chen, Nai-Hong and Zhang, Pei-Cheng
Journal of Natural Products, ISSN 0163-3864, 10/2015, Volume 78, Issue 10, pp. 2390 - 2397
Forsythoneosides A–D (1–4), four unusual adducts of a flavonoid unit fused to a phenylethanoid glycoside through a pyran ring or carbon–carbon bond, and four... 
CELLS | CHEMISTRY, MEDICINAL | PHENYLPROPANOID GLYCOSIDES | VIRIDISSIMA | ANTIOXIDANT | PHENYLETHANOID GLYCOSIDES | INJURY | PHARMACOLOGY & PHARMACY | ACTEOSIDE | PLANT SCIENCES | Cardiac Glycosides | Neuroprotective Agents - chemistry | Fruit - chemistry | Lignans - chemistry | Drugs, Chinese Herbal - pharmacology | Forsythia - chemistry | Rats | Flavones - chemistry | Glycosides - pharmacology | PC12 Cells | Animals | Neuroprotective Agents - pharmacology | Neuroprotective Agents - isolation & purification | Drugs, Chinese Herbal - chemistry | Glycosides - isolation & purification | Molecular Structure | Flavones - isolation & purification | Circular Dichroism | Drugs, Chinese Herbal - isolation & purification | Glycosides - chemistry | Flavones - pharmacology
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12. Full Text Evaluating the cancer therapeutic potential of cardiac glycosides
by Calderón-Montaño, José Manuel and Burgos-Morón, Estefanía and Orta, Manuel Luis and Maldonado-Navas, Dolores and García-Domínguez, Irene and López-Lázaro, Miguel
BioMed Research International, ISSN 2314-6133, 2014, Volume 2014, pp. 794930 - 9
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring... 
MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | SODIUM-PUMP | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ANTICANCER AGENT | INHIBITS GROWTH | NA+/K+-ATPASE | CELL-CYCLE ARREST | CARDIOTONIC STEROIDS | ANTITUMOR-ACTIVITY | TUMOR-GROWTH | GLIOBLASTOMA CELLS | Animals | Cardiac Glycosides - chemistry | Humans | Antineoplastic Agents - therapeutic use | Cardiac Glycosides - therapeutic use | Drug Evaluation, Preclinical | Neoplasms - drug therapy | Physiological aspects | Research | Cardiotonic agents | Adenosine triphosphatase | Cardiac glycosides | Clinical trials | Cell growth |