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1. Full Text MicroRNA-21 in Scleroderma Fibrosis and its Function in TGF-β- Regulated Fibrosis-Related Genes Expression
by Zhu, Honglin and Luo, Hui and Li, Yisha and Zhou, Yaou and Jiang, Ying and Chai, Jin and Xiao, Xianzhong and You, Yunhui and Zuo, Xiaoxia
Journal of Clinical Immunology, ISSN 0271-9142, 8/2013, Volume 33, Issue 6, pp. 1100 - 1109
Uncontrolled fibrosis in multiple organs is the main cause of death in systemic sclerosis (SSc), and transforming growth factor-β (TGF-β) activation plays a... 
Medical Microbiology | Biomedicine | Immunology | Infectious Diseases | Internal Medicine | TGF-β | miR-21 | Scleroderma | Smad7 | MULTIPLE-MYELOMA | LUNG | PROTEASOME INHIBITION | PREVENTS FIBROSIS | IMMUNOLOGY | SYSTEMIC-SCLEROSIS | CANCER | RENAL FIBROSIS | TGF-beta | GROWTH-FACTOR-BETA | CARDIAC FIBROSIS | RNA, Small Interfering - genetics | Humans | MicroRNAs - metabolism | Molecular Targeted Therapy | Scleroderma, Diffuse - genetics | Bleomycin - metabolism | Scleroderma, Diffuse - pathology | Female | Mice, Inbred DBA | Smad7 Protein - genetics | Skin - pathology | Fibroblasts - metabolism | Bortezomib | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Fibroblasts - pathology | Animals | Fibroblasts - drug effects | Fibrosis | Scleroderma, Diffuse - drug therapy | Mice | Pyrazines - pharmacology | Transforming Growth Factor beta - metabolism | Boronic Acids - pharmacology | Index Medicus | Bleomycin
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2. Full Text Assessment of Myocardial Fibrosis Using Multimodality Imaging in Severe Aortic Stenosis: Comparison With Histologic Fibrosis
by Park, Sung-Ji and Cho, Sung Woo and Kim, Sung Mok and Kim, Sung Mok and Ahn, Joonghyun and Carriere, Keumhee and Carriere, Keumhee and Jeong, Dong Seop and Jeong, Dong Seop and Lee, Sang-Chol and Lee, Sang-Chol and Park, Seung Woo and Choe, Yeon Hyeon and Choe, Yeon Hyeon and Park, Pyo Won and Park, Pyo Won and Oh, Jae K and Oh, Jae K
JACC: Cardiovascular Imaging, ISSN 1936-878X, 01/2019, Volume 12, Issue 1, pp. 109 - 119
Objectives: This study assessed diffuse myocardial fibrosis (MF) by cardiac magnetic resonance (CMR) imaging and speckle-tracking echocardiography (STE) in... 
global longitudinal strain | severe aortic stenosis | extracellular volume | myocardial fibrosis | CARDIAC & CARDIOVASCULAR SYSTEMS | QUANTIFICATION | PROGNOSTIC VALUE | DEFORMATION | RECOMMENDATIONS | MAGNETIC-RESONANCE | SPECKLE-TRACKING ECHOCARDIOGRAPHY | ASYMPTOMATIC PATIENTS | EXTRACELLULAR VOLUME FRACTION | ASSOCIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Care and treatment | Usage | Echocardiography | Magnetic resonance imaging | Comparative analysis | Aortic valve stenosis
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3. Full Text Relationship of Myocardial Fibrosis to Left Ventricular and Mitochondrial Function in Nonischemic Dilated Cardiomyopathy—A Comparison of Focal and Interstitial Fibrosis
by Yamada, Takashi, MD and Hirashiki, Akihiro, MD, PhD and Cheng, Xian Wu, MD, PhD and Okumura, Takahiro, MD, PhD and Shimazu, Shuzo, MD and Okamoto, Rie, MD and Shinoda, Norihiro, MD and Isobe, Satoshi, MD, PhD and Takeshita, Kyosuke, MD, PhD and Naganawa, Shinji, MD, PhD and Kondo, Takahisa, MD, PhD and Murohara, Toyoaki, MD, PhD
Journal of Cardiac Failure, ISSN 1071-9164, 2013, Volume 19, Issue 8, pp. 557 - 564
Abstract Background Mitochondrial damage is associated with histologic myocardial fibrosis. Late gadolinium enhancement (LGE) on cardiac magnetic resonance... 
Cardiovascular | magnetic resonance imaging | diastolic function | Cardiomyopathy | mitochondria | CARDIAC & CARDIOVASCULAR SYSTEMS | FORCE-FREQUENCY | CARDIOVASCULAR MAGNETIC-RESONANCE | MECHANISMS | DIASTOLIC HEART-FAILURE | HYPERTROPHIC CARDIOMYOPATHY | FREQUENCY RELATIONS | MILDLY SYMPTOMATIC PATIENTS | DYSFUNCTION | UP-REGULATION | CONTRACTILE RESERVE | Prospective Studies | Humans | Middle Aged | Male | Myocardium - pathology | Cardiomyopathy, Dilated - physiopathology | Mitochondria, Heart - physiology | Fibrosis | Adult | Cardiomyopathy, Dilated - diagnosis | Female | Ventricular Function, Left - physiology | Aged | Comparative analysis | Collagen | Cardiomyopathy, Dilated | Index Medicus
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4. Full Text Nintedanib in patients with idiopathic pulmonary fibrosis: Combined evidence from the TOMORROW and INPULSIS® trials
by Richeldi, Luca and Cottin, Vincent and du Bois, Roland M and Selman, Moisés and Kimura, Toshio and Bailes, Zelie and Schlenker-Herceg, Rozsa and Stowasser, Susanne and Brown, Kevin K
Respiratory Medicine, ISSN 0954-6111, 2016, Volume 113, pp. 74 - 79
Abstract Background and purpose The Phase II TOMORROW trial and two Phase III INPULSIS® trials investigated the efficacy and safety of nintedanib versus... 
Pulmonary/Respiratory | Acute exacerbations | Forced vital capacity | Mortality | Disease progression | Quality of life | CARDIAC & CARDIOVASCULAR SYSTEMS | EFFICACY | RESPIRATORY SYSTEM | Drug Administration Schedule | Humans | Middle Aged | Enzyme Inhibitors - pharmacology | Male | Treatment Outcome | Diarrhea - chemically induced | Indoles - administration & dosage | Randomized Controlled Trials as Topic | Enzyme Inhibitors - administration & dosage | Vital Capacity - drug effects | Clinical Trials, Phase III as Topic | Female | Indoles - pharmacology | Aged | Idiopathic Pulmonary Fibrosis - physiopathology | Idiopathic Pulmonary Fibrosis - drug therapy | Clinical Trials, Phase II as Topic | Pulmonary fibrosis | Lung diseases | Data collection | Diarrhea | Pharmaceutical industry | Drug dosages | Growth factors | Index Medicus
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5. Full Text Association of Atrial Tissue Fibrosis Identified by Delayed Enhancement MRI and Atrial Fibrillation Catheter Ablation: The DECAAF Study
by Marrouche, Nassir F and Wilber, David and Hindricks, Gerhard and Jais, Pierre and Akoum, Nazem and Marchlinski, Francis and Kholmovski, Eugene and Burgon, Nathan and Hu, Nan and Mont, Lluis and Deneke, Thomas and Duytschaever, Mattias and Neumann, Thomas and Mansour, Moussa and Mahnkopf, Christian and Herweg, Bengt and Daoud, Emile and Wissner, Erik and Bansmann, Paul and Brachmann, Johannes
JAMA, ISSN 0098-7484, 02/2014, Volume 311, Issue 5, pp. 498 - 506
IMPORTANCE Left atrial fibrosis is prominent in patients with atrial fibrillation (AF). Extensive atrial tissue fibrosis identified by delayed enhancement... 
PULMONARY VEIN | MEDICINE, GENERAL & INTERNAL | CONTRACTILE | TASK-FORCE | RISK | MECHANISMS | EUROPEAN-SOCIETY | IRREVERSIBLE INJURY | BLOOD-PRESSURE | RADIOFREQUENCY ABLATION | ANTIARRHYTHMIC-DRUGS | Atrial Fibrillation - pathology | Recurrence | Heart Atria - pathology | Prospective Studies | Atrial Fibrillation - therapy | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Catheter Ablation | Male | Risk | Treatment Outcome | Incidence | Fibrosis | Female | Aged | Cardiac arrhythmia | Nuclear magnetic resonance--NMR | Patients | Medical procedures | Index Medicus | Abridged Index Medicus | Arrítmia | Aleteig auricular | Arrhythmia | Fibril·lació auricular | Atrial fibrillation | Atrial flutter
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6. Full Text Repeated Adeno-Associated Virus Serotype 2 Aerosol-Mediated Cystic Fibrosis Transmembrane Regulator Gene Transfer to the Lungs of Patients with Cystic Fibrosis: A Multicenter, Double-Blind, Placebo-Controlled Trial
by Moss, Richard B and Rodman, David and Spencer, L. Terry and Aitken, Moira L and Zeitlin, Pamela L and Waltz, David and Milla, Carlos and Brody, Alan S and Clancy, John P and Ramsey, Bonnie and Hamblett, Nicole and Heald, Alison E
Chest, ISSN 0012-3692, 2004, Volume 125, Issue 2, pp. 509 - 521
Study objectives: The primary objective was to determine the safety and tolerability of repeated doses of aerosolized adeno-associated serotype 2 vector... 
Adeno-associated virus | Gene transfer | Pulmonary function | Aerosol | Cytokine | High-resolution CT | Cystic fibrosis | Inflammation | Gene therapy | Vector | cytokine | high-resolution CT | CARDIAC & CARDIOVASCULAR SYSTEMS | AAV-CFTR | gene transfer | CLINICAL-TRIAL | SAFETY | CONDUCTANCE REGULATOR | pulmonary function | gene therapy | adeno-associated virus | inflammation | RESPIRATORY SYSTEM | cystic fibrosis | MAXILLARY SINUS | vector | PHASE-I | EXPRESSION | RECOMBINANT ADENOVIRUS | aerosol | RECTIFYING CHLORIDE CHANNELS | Bronchoscopy | Cystic Fibrosis - therapy | Severity of Illness Index | Gene Transfer Techniques | Double-Blind Method | Drug Administration Schedule | Risk Assessment | Humans | Administration, Inhalation | Probability | Male | Treatment Outcome | Aerosols - administration & dosage | Dose-Response Relationship, Drug | Analysis of Variance | Adolescent | Statistics, Nonparametric | Cystic Fibrosis Transmembrane Conductance Regulator - administration & dosage | Adult | Cystic Fibrosis - diagnosis | Female | Respiratory Function Tests | Child | Genetic Therapy - methods | Index Medicus | Abridged Index Medicus
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7. Full Text Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin efficacy of recoupling nitric oxide synthase as a therapeutic strategy
by Moens, An L and Takimoto, Eiki and Tocchetti, Carlo G and Chakir, Khalid and Bedja, Djahida and Cormaci, Gianfranco and Ketner, Elizabeth A and Majmudar, Maulik and Gabrielson, Kathleen and Halushka, Marc K and Mitchell, James B and Biswal, Shyam and Channon, Keith M and Wolin, Michael S and Alp, Nicholas J and Paolocci, Nazareno and Champion, Hunter C and Kass, David A
Circulation, ISSN 0009-7322, 05/2008, Volume 117, Issue 20, pp. 2626 - 2636
Background-Sustained pressure overload induces pathological cardiac hypertrophy and dysfunction. Oxidative stress linked to nitric oxide synthase (NOS)... 
Antioxidants | Heart failure | Reactive oxygen species | Therapeutics | Nitric oxide synthase | Remodeling | Hypertrophy | heart failure | remodeling | therapeutics | SIGNALING PATHWAYS | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | antioxidants | hypertrophy | HEART-FAILURE | PRESERVED EJECTION FRACTION | ANGIOTENSIN-II | SUPPLEMENTATION | CYCLOHYDROLASE-I OVEREXPRESSION | reactive oxygen species | CARDIOVASCULAR-DISEASE | KINASE TYPE-I | PERIPHERAL VASCULAR DISEASE | MICE | nitric oxide synthase | HEMATOLOGY | Fibrosis - drug therapy | Biopterin - pharmacology | Mice, Inbred C57BL | Cardiomegaly - drug therapy | Male | Mice, Transgenic | Myocardium - pathology | Gene Expression Profiling | Spin Labels | Biopterin - analogs & derivatives | Cyclic N-Oxides - therapeutic use | Animals | Cyclic N-Oxides - pharmacology | Biopterin - therapeutic use | Hypertension - complications | Mice | Nitric Oxide Synthase Type III - metabolism | GTP Cyclohydrolase - genetics | Disease Models, Animal | Care and treatment | Phenylalanine | Heart enlargement | Nitric oxide | Fibrosis | Physiological aspects | Research | Index Medicus | Abridged Index Medicus
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8. Full Text Potential Therapeutic Targets for Cardiac Fibrosis: TGFβ, Angiotensin, Endothelin, CCN2, and PDGF, Partners in Fibroblast Activation
by Leask, Andrew
Circulation Research, ISSN 0009-7330, 06/2010, Volume 106, Issue 11, pp. 1675 - 1680
Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because of a persistent tissue repair program. During... 
TGF | Endothelin | Scarring | PDGF | Fibrosis | CARDIAC & CARDIOVASCULAR SYSTEMS | scarring | GENE-REGULATION | FIBROTIC PHENOTYPE | MATRIX CONTRACTION | endothelin | GROWTH-FACTOR-BETA | MYOCARDIAL FIBROSIS | IN-VIVO | PERIPHERAL VASCULAR DISEASE | fibrosis | SMOOTH-MUSCLE-CELLS | DERMAL FIBROBLASTS | TGF beta | MICE LACKING SMAD3 | HEMATOLOGY | MYOFIBROBLAST DIFFERENTIATION
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9. Full Text Prevention of cardiac dysfunction, kidney fibrosis and lipid metabolic alterations in l-NAME hypertensive rats by sinapic acid—Role of HMG-CoA reductase
by Silambarasan, Thangarasu and Manivannan, Jeganathan and Raja, Boobalan and Chatterjee, Suvro
European Journal of Pharmacology, ISSN 0014-2999, 04/2016, Volume 777, pp. 113 - 123
The present study was designed to evaluate the effect of sinapic acid, a bioactive phenolic acid on high blood pressure associated cardiac dysfunction, kidney... 
Sinapic acid | Oxidative stress | Kidney fibrosis | Cardiac dysfunction | Dyslipidemia | CHOLESTEROL | NITRIC-OXIDE SYNTHASE | NO INHIBITION | LOW-DENSITY-LIPOPROTEIN | MYOCARDIAL INFARCTED RATS | BLOOD-PRESSURE | HYPERTROPHY | PLASMA | CARDIOVASCULAR-DISEASE | PHARMACOLOGY & PHARMACY | Kidney - pathology | Rats, Wistar | Mitochondria, Liver - metabolism | Antioxidants - metabolism | Male | Lipid Peroxidation - drug effects | Lipoproteins - metabolism | Blood Pressure - drug effects | Acyl Coenzyme A - metabolism | Heart - physiopathology | NG-Nitroarginine Methyl Ester - pharmacology | Kidney - drug effects | Coumaric Acids - metabolism | Rats | Lipoproteins - blood | Mitochondria, Liver - enzymology | Hypertension - physiopathology | Acyl Coenzyme A - chemistry | Hypertension - metabolism | Mitochondria, Liver - drug effects | Organ Size - drug effects | Animals | Fibrosis | Heart - drug effects | Protein Conformation | Molecular Docking Simulation | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Coumaric Acids - pharmacology | Metabolites | Index Medicus
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10. Full Text Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis
by Khalil, Hadi and Kanisicak, Onur and Prasad, Vikram and Correll, Robert N and Fu, Xing and Schips, Tobias and Vagnozzi, Ronald J and Liu, Ruijie and Huynh, Thanh and Lee, Se-Jin and Karch, Jason and Molkentin, Jeffery D
Journal of Clinical Investigation, ISSN 0021-9738, 10/2017, Volume 127, Issue 10, pp. 3770 - 3783
The master cytokine TGF-beta mediates tissue fibrosis associated with inflammation and tissue injury. TGF-beta induces fibroblast activation and... 
GENETIC MANIPULATION | MEDICINE, RESEARCH & EXPERIMENTAL | HYPERTROPHY | GROWTH-FACTOR-BETA | HEART-DISEASE | TGF-BETA | SMAD3 | MYOCARDIAL-INFARCTION | IN-VIVO | MYOFIBROBLAST DIFFERENTIATION | PROTECTS | Receptors, Transforming Growth Factor beta - genetics | Heart Diseases - metabolism | Male | Smad3 Protein - metabolism | Myofibroblasts - metabolism | Smad3 Protein - genetics | Gene Deletion | Myocardium - metabolism | Smad2 Protein - genetics | Protein-Serine-Threonine Kinases - metabolism | Myofibroblasts - pathology | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Smad2 Protein - metabolism | Mice, Transgenic | Myocardium - pathology | Organ Specificity | Myocytes, Cardiac - pathology | Animals | Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - metabolism | Fibrosis | Myocytes, Cardiac - metabolism | Mice | Transforming Growth Factor beta - metabolism | Heart Diseases - genetics | Heart Diseases - pathology | Transcription factors | Phosphorylation | Heart attacks | Disease | Homeostasis | Smad3 protein | Gene deletion | Kinases | Proteins | Clonal deletion | Smad2 protein | Rodents | Fibroblasts | Extracellular matrix | Heart diseases | Growth factors | Heart failure | Cytokines | Cardiomyocytes | Gene expression | Pressure | Latency | Adenoviruses | Genetic engineering | Apoptosis | Index Medicus | Abridged Index Medicus
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11. Full Text Aging and cardiac fibrosis
by Biernacka, Anna and Frangogiannis, Nikolaos G
Aging and Disease, ISSN 2152-5250, 2011, Volume 2, Issue 2, pp. 158 - 173
The aging heart is characterized by morphological and structural changes that lead to its functional decline and are associated with diminished ability to meet... 
Chemokine | Cardiac fibrosis | MCP-1 | angiotensin II | Aging | TGF-β | Cardiac remodeling | chemokine | TGF-beta | cardiac fibrosis | cardiac remodeling | GERIATRICS & GERONTOLOGY
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12. Full Text Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: Preliminary validation in humans
by Flett, Andrew S and Hayward, Martin P and Ashworth, Michael T and Hansen, Michael S and Taylor, Andrew M and Elliott, Perry M and McGregor, Christopher and Moon, James C
Circulation, ISSN 0009-7322, 07/2010, Volume 122, Issue 2, pp. 138 - 144
Background-Diffuse myocardial fibrosis is a final end point in most cardiac diseases. It is missed by the cardiovascular magnetic resonance (CMR) late... 
Endomyocardial fibrosis | Magnetic resonance imaging | Cardiomyopathy | Collagen | Imaging | SURVIVAL | magnetic resonance imaging | CARDIAC & CARDIOVASCULAR SYSTEMS | DIASTOLIC FUNCTION | collagen | CMR | imaging | FAILURE | endomyocardial fibrosis | FLOW | HEART | HYPERTROPHIC CARDIOMYOPATHY | SEVERE AORTIC-STENOSIS | RELAXATION-TIMES | PERIPHERAL VASCULAR DISEASE | cardiomyopathy | HEMATOLOGY | VALVE DISEASE | Aortic Valve Stenosis - pathology | Cardiomyopathy, Hypertrophic - surgery | Biopsy | Contrast Media - administration & dosage | Humans | Magnetic Resonance Imaging - methods | Female | Male | Aortic Valve Stenosis - surgery | Endomyocardial Fibrosis - pathology | Gadolinium DTPA - administration & dosage | Cardiomyopathy, Hypertrophic - pathology | Case studies | Usage | Diagnosis | Fibrosis | Index Medicus | Abridged Index Medicus
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13. Full Text Noninvasive Detection of Fibrosis Applying Contrast-Enhanced Cardiac Magnetic Resonance in Different Forms of Left Ventricular Hypertrophy. Relation to Remodeling
by Rudolph, Andre and Abdel-Aty, Hassan and Bohl, Steffen and Boyé, Philipp and Zagrosek, Anja and Dietz, Rainer and Schulz-Menger, Jeanette
Journal of the American College of Cardiology, ISSN 0735-1097, 01/2009, Volume 53, Issue 3, pp. 284 - 291
Objectives: We aimed to evaluate the incidence and patterns of late gadolinium enhancement (LGE) in different forms of left ventricular hypertrophy (LVH) and... 
late gadolinium enhancement | left ventricular hypertrophy | cardiomyopathy | cardiac magnetic resonance imaging | CARDIAC & CARDIOVASCULAR SYSTEMS | SUDDEN-DEATH | HEART-FAILURE | AORTIC-STENOSIS | RISK | DIASTOLIC DYSFUNCTION | SYSTOLIC DYSFUNCTION | HYPERTENSION | CORONARY-ARTERY-DISEASE | Follow-Up Studies | Humans | Middle Aged | Hypertrophy, Left Ventricular - diagnosis | Magnetic Resonance Imaging - methods | Gadolinium | Male | Case-Control Studies | Aortic Valve Stenosis - mortality | Sensitivity and Specificity | Adult | Female | Hypertension - mortality | Image Enhancement - methods | Hypertension - diagnosis | Heart Function Tests | Severity of Illness Index | Hypertrophy, Left Ventricular - mortality | Risk Assessment | Probability | Aortic Valve Stenosis - diagnosis | Ventricular Remodeling - physiology | Chi-Square Distribution | Cardiomyopathy, Hypertrophic - diagnosis | Cardiomyopathy, Hypertrophic - mortality | Aged | Fibrosis - pathology | Cohort Studies | Studies | Heart attacks | Cardiology | Coronary vessels | Index Medicus | Abridged Index Medicus
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