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Journal of the American College of Cardiology, ISSN 0735-1097, 2009, Volume 54, Issue 20, pp. 1891 - 1898
Journal Article
American journal of physiology. Regulatory, integrative and comparative physiology, ISSN 1522-1490, 2011, Volume 300, Issue 2, pp. R186 - R200
Diabetic cardiomyopathy is associated with increased risk of heart failure in type 1 diabetic patients. Mitochondrial dysfunction is suggested as an underlying... 
Mitochondria | Diabetes | CARDIOLIPIN | OXIDATIVE STRESS | PHYSIOLOGY | GENE DELIVERY | SUPEROXIDE-PRODUCTION | mitochondria | CARDIOMYOPATHY | RATS | MECHANISMS | SKELETAL-MUSCLE | TRANSPORT | diabetes | CARDIAC MITOCHONDRIA | Proteome - genetics | Diabetic Cardiomyopathies - metabolism | Mitochondria, Heart - metabolism | 3-Hydroxyacyl CoA Dehydrogenases - metabolism | Diabetes Mellitus, Type 1 - metabolism | Male | Protein Transport - physiology | Mitochondrial Proteins - genetics | Insulin - blood | Diabetic Cardiomyopathies - physiopathology | Recombinant Fusion Proteins - metabolism | Diabetes Mellitus, Experimental - blood | Racemases and Epimerases - metabolism | Mitochondrial Proteins - metabolism | Gene Expression - physiology | Myocardium - metabolism | Up-Regulation - physiology | Muscle Proteins - metabolism | Membrane Potential, Mitochondrial - physiology | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Experimental - physiopathology | Heart - physiopathology | Diabetes Mellitus, Type 1 - physiopathology | Enoyl-CoA Hydratase - metabolism | Mice, Inbred Strains | Carbon-Carbon Double Bond Isomerases - metabolism | Protein Processing, Post-Translational - physiology | HSP70 Heat-Shock Proteins - metabolism | Down-Regulation - physiology | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Acetyl-CoA C-Acyltransferase - metabolism | Diabetes Mellitus, Type 1 - blood | Electron Transport Chain Complex Proteins - metabolism | Proteomics | Citric Acid Cycle - physiology | Mice | Blood Glucose - metabolism | Proteome - metabolism | Physiological aspects | Research | Type 1 diabetes | Call for Papers
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7690, pp. 128 - 132
.... This in part reflects the need for mitochondria to generate one-carbon units and export them to the cytosol for anabolic metabolism(2,9... 
CHAIN | HYPERTROPHIC CARDIOMYOPATHY | SERINE HYDROXYMETHYLTRANSFERASE | METABOLISM | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | DEFECT | LACTIC-ACIDOSIS | MUTATIONS | IDENTIFICATION | ANTICODON WOBBLE NUCLEOTIDE | Mitochondria - enzymology | Electron Transport | Protein Biosynthesis | Humans | Ribosomes - metabolism | Sarcosine - metabolism | Multifunctional Enzymes - metabolism | Thymine Nucleotides - biosynthesis | Oxidative Phosphorylation - drug effects | Glycine Hydroxymethyltransferase - deficiency | HEK293 Cells | RNA, Transfer - genetics | Codon - genetics | RNA, Transfer - chemistry | Leucine - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Biocatalysis | RNA, Transfer - metabolism | HCT116 Cells | Mitochondria - metabolism | Mitochondria - drug effects | Glycine Hydroxymethyltransferase - metabolism | Guanosine - metabolism | Tetrahydrofolates - metabolism | Lysine - genetics | Carrier Proteins - metabolism | Methylation - drug effects | Folic Acid - metabolism | Aminohydrolases - metabolism | Folic Acid Antagonists - pharmacology | GTP-Binding Proteins - metabolism | Mitochondria | Physiological aspects | Genetic aspects | Methylation | Observations | Genetic translation | Folic acid | Transfer RNA | Phosphorylation | Inborn errors of metabolism | Peptides | Serine | Biosynthesis | Mitochondrial DNA | Thymidine | Catalytic activity | Leucine | Cytosol | Experiments | Anticancer properties | Proteins | Purines | Antitumor agents | Metabolites | Lymphocytes | Vitamin B | Catalysis | Enzymes | Translation | tRNA Ala | tRNA | Methionine | Metabolism | Carbon | Immunosuppression | Oxidative phosphorylation | Lysine | Proteomics | Electron transport | Respiration | Codons | Cancer
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 1522-1539, 2013, Volume 304, Issue 8, pp. H1060 - H1076
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 3, p. e0193967
Objectives A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla... 
POWERFUL PREDICTOR | GENERAL-POPULATION | MENAQUINONE-7 SUPPLEMENTATION | ARTERIAL STIFFNESS | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | K-DEPENDENT PROTECTION | VITAMIN-K | PRESERVED EJECTION FRACTION | BONE MORPHOGENETIC PROTEIN-4 | FILLING PRESSURE | Multivariate Analysis | Myocardial Ischemia - metabolism | Cardiomyopathy, Dilated - pathology | Cardiomyopathy, Dilated - surgery | Humans | Middle Aged | Male | Young Adult | Netherlands | Myocardium - metabolism | Ventricular Dysfunction, Left - pathology | Aged, 80 and over | Electrocardiography | Myocardial Ischemia - diagnostic imaging | Adult | Female | Extracellular Matrix Proteins - metabolism | Calcium-Binding Proteins - metabolism | Ventricular Dysfunction, Left - epidemiology | Heart Transplantation | Myocardium - pathology | Cardiomyopathy, Dilated - metabolism | Switzerland | Ventricular Dysfunction, Left - diagnostic imaging | Heart - diagnostic imaging | Myocardial Ischemia - pathology | Ventricular Dysfunction, Left - metabolism | Cardiomyopathy, Dilated - diagnostic imaging | Aged | Myocardial Ischemia - surgery | Cohort Studies | Physiological aspects | Development and progression | Calcium-binding proteins | Heart enlargement | Health aspects | Heart muscle | Health care | Heart | Nephrology | Cardiomyopathy | Antibodies | Interstitial cells | Epidemiology | Proteins | Ischemia | Measurement methods | Population | Blood pressure | Capillaries | Cardiology | Heart diseases | Enzyme-linked immunosorbent assay | Vitamin K | Hypertension | Research & development--R&D | Hospitals | Dilated cardiomyopathy | Calcification | Myocardium | Microvasculature | Ventricle | Integrity | Research & development | R&D
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2014, Volume 79, pp. 275 - 283
Abstract Background Obesity leads to metabolic heart disease (MHD) that is associated with a pathologic increase in myocardial fatty acid (FA) uptake and... 
Cardiovascular | Obesity | Metabolic heart disease | Mitochondria | Lipid excess | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PROLIFERATOR-ACTIVATED RECEPTOR | KINASE-C | FATTY-ACIDS | CELL BIOLOGY | REDUCES DIABETIC CARDIOMYOPATHY | SKELETAL-MUSCLE | LIPOTOXIC CARDIOMYOPATHY | FAILING HEART | COACTIVATOR PGC-1 | TRANSCRIPTIONAL CONTROL | Mitochondria, Heart - ultrastructure | Phosphorylation | Mitochondria, Heart - metabolism | Carnitine - metabolism | RNA, Messenger - metabolism | Fatty Acid Transport Proteins - metabolism | Diglycerides - metabolism | Protein Kinase C - metabolism | Adenosine Triphosphate - metabolism | Myocardium - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Carnitine - analogs & derivatives | Proto-Oncogene Proteins c-akt - metabolism | Myocardium - ultrastructure | Ceramides - metabolism | Sphingomyelins - metabolism | RNA, Messenger - genetics | Gene Expression Regulation | Oxygen Consumption | Lipids - adverse effects | Myocardium - pathology | Organ Specificity | Hydrogen Peroxide - metabolism | Catalase - metabolism | Transcription Factors - metabolism | Animals | Electron Transport Complex II - metabolism | Models, Biological | Cyclic AMP Response Element-Binding Protein - metabolism | Myocytes, Cardiac - metabolism | Mice | PPAR alpha - metabolism | Fatty acids | Analysis | Mitochondrial DNA | Index Medicus | Metabolic Heart Disease | Lipid Excess
Journal Article
Cardiovascular diabetology, ISSN 1475-2840, 2012, Volume 11, Issue 1, pp. 73 - 73
Background: Alpha-lipoic acid (ALA), a naturally occurring compound, exerts powerful protective effects in various cardiovascular disease models. However, its... 
Alpha-Lipoic acid | Mitochondrial oxidative stress | Cardiac fibrosis | Extracellular matrix remodeling | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | METALLOTHIONEIN | KINASE | RATS | FIBROBLASTS | HEART | PATHOGENESIS | OVEREXPRESSION | ATTENUATION | ENDOCRINOLOGY & METABOLISM | Diabetes Mellitus, Experimental - drug therapy | Phosphorylation | Diabetic Cardiomyopathies - metabolism | Mitochondria, Heart - metabolism | Diabetic Cardiomyopathies - etiology | Rats, Wistar | Actins - metabolism | Extracellular Matrix - metabolism | Male | Mitochondria, Heart - drug effects | Diabetic Cardiomyopathies - physiopathology | Collagen Type II - metabolism | Myofibroblasts - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Cardiac Catheterization | Myocardium - metabolism | Gelatinases - metabolism | Diabetic Cardiomyopathies - prevention & control | Diabetes Mellitus, Experimental - complications | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Experimental - physiopathology | Myofibroblasts - pathology | Collagen Type I - metabolism | Matrix Metalloproteinase 2 - metabolism | Extracellular Matrix - drug effects | Ventricular Function, Left - drug effects | Rats | Myocardium - pathology | Thioctic Acid - pharmacology | Cardiotonic Agents - pharmacology | Myofibroblasts - drug effects | Blotting, Western | Enzyme Precursors - metabolism | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Fibrosis | Diabetes Mellitus, Experimental - pathology | Diabetic Cardiomyopathies - pathology | Enzyme Activation | Oxidative Stress - drug effects | Spectrophotometry | Transforming Growth Factor beta - metabolism | Ventricular Remodeling - drug effects | Mitogen-Activated Protein Kinases - metabolism | Proteins | Medical research | Cardiovascular disease | Diabetes | Rodents | Metabolic disorders
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2009, Volume 297, Issue 6, pp. 2096 - 2108
Diabetic cardiomyopathy is an important contributor to diastolic and systolic heart failure. We examined the nature and mechanism of the cardiomyopathy in... 
Sarco(endo)plasmic reticulum calcium-ATPase 2a | Insulin | Fibrosis | Hypertrophy | OVERLOAD | PROTEIN-KINASE-C | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | insulin | MECHANISM | hypertrophy | HEART-FAILURE | CHRONIC ACTIVATION | sarco(endo)plasmic reticulum calcium-ATPase 2a | INSULIN-RESISTANCE | EJECTION FRACTION | PERIPHERAL VASCULAR DISEASE | fibrosis | MICE | EXPRESSION | Cardiomyopathies - diagnostic imaging | Mitochondria, Heart - metabolism | Age Factors | Diastole | Natriuretic Peptide, Brain - metabolism | Diabetes Mellitus, Type 1 - metabolism | Myocardial Contraction - drug effects | Male | Diabetes Mellitus, Type 1 - diagnostic imaging | Diabetes Mellitus, Type 1 - complications | Systole | Insulin - blood | Echocardiography, Doppler, Pulsed | Myosin Heavy Chains - metabolism | Cardiomyopathies - genetics | Cardiomyopathies - physiopathology | Diglycerides - metabolism | Ventricular Dysfunction, Left - genetics | Mice, Mutant Strains | Myocardium - metabolism | Lipid Metabolism - genetics | Insulin - genetics | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Cardiomyopathies - drug therapy | Insulin - pharmacology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Ceramides - metabolism | Acyl-CoA Dehydrogenase, Long-Chain - metabolism | Diabetes Mellitus, Type 1 - physiopathology | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - genetics | Disease Progression | Ventricular Dysfunction, Left - diagnostic imaging | Ventricular Dysfunction, Left - physiopathology | Diabetes Mellitus, Type 1 - drug therapy | Hypoglycemic Agents - pharmacology | Triglycerides - metabolism | Stroke Volume | Ventricular Dysfunction, Left - metabolism | Animals | Ventricular Dysfunction, Left - drug therapy | Cardiomyopathies - metabolism | Lipid Metabolism - drug effects | Mice | Ventricular Pressure | Blood Glucose - metabolism | Heart failure | Complications and side effects | Prognosis | Cardiomyopathy | Type 1 diabetes | Heart diseases | Risk factors
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2012, Volume 125, Issue 23, pp. 2844 - 2853
Journal Article
Cardiovascular Research, ISSN 0008-6363, 3/2010, Volume 85, Issue 4, pp. 773 - 784
Journal Article