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Arteriosclerosis Thrombosis and Vascular Biology, ISSN 1079-5642, 02/2016, Volume 36, Issue 2, pp. 295 - 307
OBJECTIVE—Oxidative stress is considered a hallmark of atherosclerosis. In particular, the superoxide-generating type 1 NADPH oxidase (NOX1) has been shown to... 
atherosclerosis | endothelial cells | diabetes mellitus | NADPH oxidase | reactive oxygen species | OXIDATIVE STRESS | ACCELERATED ATHEROSCLEROSIS | CARDIOVASCULAR-SYSTEM | NECROSIS-FACTOR-ALPHA | COLLAGEN-SYNTHESIS | TRANSFORMING GROWTH-FACTOR-BETA-1 | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | DIABETES-ASSOCIATED ATHEROSCLEROSIS | PHARMACOLOGICAL INHIBITION | HEMATOLOGY | Inflammation - pathology | Vascular Remodeling | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Oxidative Stress | Atherosclerosis - genetics | Humans | NADPH Oxidases - metabolism | Male | Case-Control Studies | NADPH Oxidases - deficiency | Atherosclerosis - enzymology | Transfection | RNA Interference | Time Factors | Inflammation Mediators - metabolism | Superoxides - metabolism | Aortic Diseases - prevention & control | NADPH Oxidases - genetics | Aortic Diseases - enzymology | NADH, NADPH Oxidoreductases - metabolism | Aorta - enzymology | Aortic Diseases - pathology | Disease Models, Animal | Fibrillar Collagens - metabolism | Atherosclerosis - pathology | Cytokines - metabolism | Signal Transduction | Cells, Cultured | NADPH Oxidase 4 | Plaque, Atherosclerotic | NADPH Oxidase 2 | NADPH Oxidase 1 | Hydrogen Peroxide - metabolism | Mice, Knockout | Aorta - pathology | Aortic Diseases - genetics | Animals | Apolipoproteins E - genetics | Inflammation - genetics | Inflammation - prevention & control | Endothelial Cells - pathology | Endothelial Cells - enzymology | Inflammation - enzymology | Atherosclerosis - prevention & control | Index Medicus
Journal Article
Annals of Neurology, ISSN 0364-5134, 12/2013, Volume 74, Issue 6, pp. 914 - 919
Journal Article
Journal Article
Atherosclerosis, ISSN 0021-9150, 2017, Volume 262, pp. 113 - 122
Journal Article
Atherosclerosis, ISSN 0021-9150, 2006, Volume 191, Issue 2, pp. 391 - 396
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2016, Volume 37, Issue 2, pp. 328 - 340
OBJECTIVE—The calcium composition of atherosclerotic plaque is thought to be associated with increased risk for cardiovascular events, but whether plaque... 
atherosclerosis | coronary artery disease | macrophages | inflammation | biomarkers | C-REACTIVE PROTEIN | CORONARY-ARTERY CALCIUM | CARDIOVASCULAR EVENTS | VASCULAR CALCIFICATION | VULNERABLE PATIENT | RISK-ASSESSMENT STRATEGIES | COMPUTED-TOMOGRAPHY | IN-VIVO | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | NF-KAPPA-B | Up-Regulation | Prognosis | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Humans | Myocytes, Smooth Muscle - pathology | rac GTP-Binding Proteins - deficiency | rac GTP-Binding Proteins - metabolism | Male | Coronary Artery Disease - enzymology | Atherosclerosis - enzymology | Transfection | Interleukin-1beta - metabolism | rac GTP-Binding Proteins - genetics | Coronary Artery Disease - pathology | Inflammation Mediators - metabolism | Aortic Diseases - prevention & control | Vascular Calcification - mortality | Female | Vascular Calcification - enzymology | Aortic Diseases - enzymology | Interleukin 1 Receptor Antagonist Protein - pharmacology | Aorta - enzymology | Aortic Diseases - pathology | Atherosclerosis - pathology | Coronary Vessels - pathology | Genetic Predisposition to Disease | Coronary Vessels - enzymology | Macrophages - pathology | Signal Transduction | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Neuropeptides - metabolism | Coronary Artery Disease - mortality | Plaque, Atherosclerotic | Vascular Calcification - pathology | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Aortic Diseases - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Apolipoproteins E - genetics | Muscle, Smooth, Vascular - enzymology | Atherosclerosis - prevention & control | rac1 GTP-Binding Protein - metabolism | Index Medicus
Journal Article
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 08/2014, Volume 115, Issue 4, pp. 450 - 459
RATIONALE:Increased arginase activity contributes to endothelial dysfunction by competition for L-arginine substrate and reciprocal regulation of nitric oxide... 
atherosclerosis | nitric oxide synthase type III | oxidized low density lipoprotein | mitochondrial processing peptidase | mitochondria | arginase | CARDIAC & CARDIOVASCULAR SYSTEMS | NITRIC-OXIDE SYNTHASE | MACROPHAGES | LOW-DENSITY-LIPOPROTEIN | MEDIATED DILATION | INHIBITION | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | ISCHEMIA-REPERFUSION | CORONARY ARTERIOLES | HEMATOLOGY | EXPRESSION | Metalloendopeptidases - genetics | Mitochondria - enzymology | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Humans | Arginase - metabolism | Molecular Sequence Data | Male | Metalloendopeptidases - metabolism | rho-Associated Kinases - antagonists & inhibitors | Cytosol - enzymology | Atherosclerosis - enzymology | Transfection | RNA Interference | Time Factors | rho-Associated Kinases - metabolism | Aortic Diseases - prevention & control | Aortic Diseases - enzymology | Lipoproteins, LDL - metabolism | Aorta - physiopathology | Aorta - enzymology | Aortic Diseases - pathology | Disease Models, Animal | Metalloendopeptidases - antagonists & inhibitors | Amino Acid Sequence | Atherosclerosis - pathology | Scavenger Receptors, Class E - genetics | Signal Transduction | Atherosclerosis - physiopathology | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Arginase - genetics | Mitochondria - drug effects | Mice, Knockout | Protein Transport | Aorta - pathology | Aortic Diseases - genetics | Aortic Diseases - physiopathology | Animals | Apolipoproteins E - genetics | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Scavenger Receptors, Class E - deficiency | Endothelial Cells - enzymology | Atherosclerosis - prevention & control | Endothelial Cells - drug effects | Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 11/2017, Volume 113, Issue 13, pp. 1664 - 1676
Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and hypertension by a mechanism involving decreased nitric oxide (NO)... 
Obesity | Arginase | Diabetes | Vascular dysfunction | Fibrosis | CARDIAC & CARDIOVASCULAR SYSTEMS | NITRIC-OXIDE SYNTHASE | DIET-INDUCED OBESITY | AORTIC STIFFNESS | HYPERTENSIVE PATIENTS | INHIBITION | INFLAMMATION | CARDIOVASCULAR-DISEASE | SMOOTH-MUSCLE-CELLS | ARGININE BIOAVAILABILITY RATIOS | ADIPOSE-TISSUE | Blood Pressure | Vascular Diseases - prevention & control | Ornithine - blood | Obesity - drug therapy | Oxidative Stress | Diabetes Mellitus, Experimental - enzymology | Diabetes Mellitus, Type 2 - genetics | Arginase - metabolism | Diabetes Mellitus, Experimental - genetics | Endothelium, Vascular - drug effects | Male | Endothelium, Vascular - enzymology | Insulin - blood | Obesity - genetics | Vasodilation | Diabetes Mellitus, Experimental - prevention & control | Diet, High-Fat | Metabolic Syndrome - physiopathology | Arginase - antagonists & inhibitors | Dietary Sucrose | Diabetes Mellitus, Experimental - physiopathology | Metabolic Syndrome - enzymology | Genetic Predisposition to Disease | Signal Transduction | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - enzymology | Diabetes Mellitus, Type 2 - prevention & control | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Vascular Diseases - genetics | Obesity - physiopathology | Arginase - genetics | Vascular Diseases - physiopathology | Vascular Diseases - enzymology | Mice, Knockout | Phenotype | Animals | Diabetes Mellitus, Type 2 - physiopathology | Metabolic Syndrome - genetics | Arginine - blood | Vascular Stiffness - drug effects | Endothelium, Vascular - pathology | Metabolic Syndrome - prevention & control | Obesity - enzymology | Blood Glucose - metabolism | Nitric Oxide - metabolism | Index Medicus | Original
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2016, Volume 36, Issue 6, pp. 1085 - 1089
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2018, Volume 38, Issue 2, pp. 324 - 334
Journal Article