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Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7341, pp. 57 - 65
Metabolomics studies hold promise for the discovery of pathways linked to disease processes. Cardiovascular disease (CVD) represents the leading cause of death... 
CHLAMYDIA-PNEUMONIAE | TRIMETHYLAMINE-N-OXIDE | DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | MURINE MACROPHAGES | MOUSE | GENE-EXPRESSION | ATHEROSCLEROSIS | MICE | CORONARY-HEART-DISEASE | MASS-SPECTROMETRY | Choline - metabolism | Dietary Fats - metabolism | Metabolomics | Liver - enzymology | Diet - adverse effects | Atherosclerosis - genetics | Betaine - metabolism | Humans | Phosphatidylcholines - administration & dosage | Phosphatidylcholines - metabolism | Choline - blood | Dietary Fats - pharmacology | Oxygenases - metabolism | Cardiovascular Diseases - blood | Female | Atherosclerosis - microbiology | Betaine - blood | Methylamines - pharmacology | Cardiovascular Diseases - diagnosis | Methylamines - metabolism | Receptors, Scavenger - metabolism | Biomarkers - metabolism | Phosphatidylcholines - blood | Cardiovascular Diseases - metabolism | Risk Assessment | Atherosclerosis - chemically induced | Mice, Inbred C57BL | Phosphatidylcholines - pharmacology | Gene Expression Regulation | Methylamines - blood | Gastrointestinal Tract - microbiology | Biomarkers - blood | Dietary Fats - blood | Atherosclerosis - metabolism | Gastrointestinal Tract - metabolism | Cardiovascular Diseases - microbiology | Macrophages - metabolism | Phenotype | Animals | Choline - administration & dosage | Choline - pharmacology | Germ-Free Life | Cholesterol, HDL - blood | Mice | Oxygenases - genetics | Lecithin | Microbiota (Symbiotic organisms) | Physiological aspects | Research | Cardiovascular diseases | Metabolism | Health aspects | Risk factors | Plasma | Nuclear magnetic resonance--NMR | Heart attacks | Pathogenesis | Lipids | Cardiovascular disease | Probiotics | Metabolites | Diet | Atherosclerosis | Bacteria | Insulin resistance | Mass spectrometry | Index Medicus | atherosclerosis | intestinal microbiota | choline | diet | phospholipid | metabolomics
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | Index Medicus | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
Diabetes, ISSN 0012-1797, 2014, Volume 63, Issue 6, pp. 1860 - 1869
Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of... 
C-REACTIVE PROTEIN | HEALTH ABC | METAANALYSIS | SHIFT WORK | GLUCOSE-METABOLISM | MALE JAPANESE WORKERS | DISEASE | ENDOCRINOLOGY & METABOLISM | NIGHT-EATING SYNDROME | RISK | WEIGHT-GAIN | Prospective Studies | Cardiovascular Diseases - prevention & control | Humans | Male | Chronobiology Disorders - complications | Diabetes Mellitus, Type 2 - metabolism | Inflammation - metabolism | Occupational Diseases - physiopathology | C-Reactive Protein - metabolism | Wakefulness | Adult | Diabetes Mellitus, Type 2 - etiology | Female | Prediabetic State | Biomarkers - metabolism | Occupational Diseases - metabolism | Cardiovascular Diseases - etiology | Cardiovascular Diseases - metabolism | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Chronobiology Disorders - physiopathology | Circadian Rhythm - physiology | Occupational Diseases - complications | Sleep Deprivation - metabolism | Sleep Deprivation - complications | Insulin - metabolism | Sleep | Chronobiology Disorders - metabolism | Complications and side effects | Circadian rhythm sleep disorders | Analysis | Insulin resistance | Inflammation | Diabetes | Risk factors | Circadian rhythm | Risk assessment | Sleep deprivation | Shift work | Index Medicus | Abridged Index Medicus | Metabolism | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 7519 - 12
In silico network-based methods have shown promising results in the field of drug development. Yet, most of networks used in the previous research have not... 
SYSTEM | DATABASE | RENIN | GENE | PATHWAY | MULTIDISCIPLINARY SCIENCES | TISSUE | KEGG | NEBIVOLOL | HYPERTENSION | BLOOD-PRESSURE | Hematologic Diseases - pathology | Liver - pathology | Metabolic Diseases - pathology | Respiratory Tract Diseases - metabolism | Kidney - pathology | Skin - metabolism | Hematologic Diseases - metabolism | Humans | Muscle, Skeletal - metabolism | Respiratory Tract Diseases - drug therapy | Respiratory Tract Diseases - genetics | Brain - metabolism | Musculoskeletal Diseases - pathology | Kidney - metabolism | Liver - drug effects | Muscle, Skeletal - drug effects | Myocardium - metabolism | Nervous System Diseases - metabolism | Nutrition Disorders - pathology | Computational Biology - methods | Kidney - drug effects | Liver - metabolism | Nervous System Diseases - drug therapy | Connective Tissue Diseases - metabolism | Neoplasms - drug therapy | Brain - drug effects | Connective Tissue Diseases - drug therapy | Connective Tissue Diseases - pathology | Lung - drug effects | Brain - pathology | Hematologic Diseases - genetics | Prescription Drugs - pharmacokinetics | Digestive System Diseases - pathology | Neoplasms - metabolism | Cardiovascular Diseases - drug therapy | Drugs, Investigational - pharmacokinetics | Respiratory Tract Diseases - pathology | Hematologic Diseases - drug therapy | Metabolic Diseases - drug therapy | Cardiovascular Diseases - pathology | Nervous System Diseases - genetics | Cardiovascular Diseases - genetics | Musculoskeletal Diseases - genetics | Neoplasms - genetics | Lung - metabolism | Skin - pathology | Nervous System Diseases - pathology | Lung - pathology | Musculoskeletal Diseases - drug therapy | Cardiovascular Diseases - metabolism | Musculoskeletal Diseases - metabolism | Nutrition Disorders - drug therapy | Nutrition Disorders - genetics | Myocardium - pathology | Organ Specificity | Digestive System Diseases - genetics | Algorithms | Digestive System Diseases - drug therapy | Nutrition Disorders - metabolism | Metabolic Diseases - metabolism | Digestive System Diseases - metabolism | Metabolic Diseases - genetics | Connective Tissue Diseases - genetics | Muscle, Skeletal - pathology | Neoplasms - pathology | Skin - drug effects | Drug development | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 05/2014, Volume 129, Issue 18, pp. 1821 - 1831
Journal Article
Scientific Reports, ISSN 2045-2322, 05/2014, Volume 4, Issue 1, pp. 4828 - 4828
Periodontitis has been implicated as a risk factor for metabolic disorders such as type 2 diabetes, atherosclerotic vascular diseases, and non-alcoholic fatty... 
C-REACTIVE PROTEIN | RHEUMATOID-ARTHRITIS | POLYMERASE-CHAIN-REACTION | PORPHYROMONAS-GINGIVALIS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | CORONARY-HEART-DISEASE | DIET-INDUCED OBESITY | PERIODONTAL-DISEASE | ADIPOSE-TISSUE | Glucose Intolerance - metabolism | Inflammation - pathology | Ileum - pathology | Metabolic Diseases - pathology | Diabetes Mellitus, Type 2 - microbiology | Periodontitis - microbiology | Glucose Intolerance - microbiology | Ileum - metabolism | Male | Glucose Intolerance - pathology | Diabetes Mellitus, Type 2 - metabolism | Endotoxemia - pathology | Periodontitis - metabolism | Dental Plaque - microbiology | Gingiva - metabolism | Inflammation - metabolism | Microbiota | Gingiva - pathology | Insulin Resistance - physiology | Tight Junction Proteins - metabolism | Disease Models, Animal | Endotoxemia - microbiology | Porphyromonas gingivalis | Inflammation - microbiology | Cytokines - metabolism | Mice, Inbred C57BL | Periodontitis - pathology | Insulin - metabolism | Animals | Metabolic Diseases - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Endotoxemia - metabolism | Gingiva - microbiology | Ileum - microbiology | Metabolic Diseases - microbiology | Liver diseases | Diabetes mellitus | Oral administration | Dental plaque | Inflammation | Gene expression | Insulin | Ileum | Glucose tolerance | Intolerance | Fatty liver | Vascular diseases | Periodontitis | Arteriosclerosis | Rodents | Gingiva | Endotoxemia | Metabolic disorders | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 02/2009, Volume 104, Issue 4, pp. 476 - 487
MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that negatively regulate gene expression. Functionally, an individual miRNA is... 
Vascular disease | Proliferation | Gene regulation | MicroRNAs | Vascular smooth muscle cells | microRNAs | CARDIAC & CARDIOVASCULAR SYSTEMS | proliferation | DOWN-REGULATION | CARDIOVASCULAR BIOLOGY | P27(KIP1) | BREAST-CANCER | INHIBITION | vascular disease | MESSENGER-RNA | gene regulation | RAT CAROTID-ARTERY | GROWTH | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | vascular smooth muscle cells | MICRORNA EXPRESSION | PROGRESSION | Carotid Artery Diseases - prevention & control | Cyclin-Dependent Kinase Inhibitor p57 - metabolism | Cell Proliferation | Muscle, Smooth, Vascular - metabolism | Hyperplasia | Myocytes, Smooth Muscle - pathology | Oligonucleotides, Antisense - metabolism | Male | MicroRNAs - metabolism | Angioplasty, Balloon - adverse effects | Gene Knockdown Techniques | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | RNA Interference | Time Factors | Carotid Artery Diseases - pathology | Carotid Artery Diseases - metabolism | Myocytes, Smooth Muscle - metabolism | Disease Models, Animal | Carotid Artery, Common - metabolism | Proto-Oncogene Proteins c-sis | Cells, Cultured | Rats | Rats, Sprague-Dawley | Tunica Intima - metabolism | Muscle, Smooth, Vascular - pathology | Platelet-Derived Growth Factor - metabolism | Animals | Tunica Intima - pathology | Carotid Artery Diseases - genetics | Carotid Artery, Common - pathology | RNA, Small Interfering - metabolism | Index Medicus
Journal Article