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P L o S Genetics (Print), ISSN 1553-7390, 06/2009, Volume 5, Issue 6, pp. e1000504 - e1000504
Journal Article
Genome Biology, ISSN 1465-6906, 06/2016, Volume 17, Issue 1, p. 138
Background: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids... 
DNA methylation | Lipids | Mendelian randomization | Gene expression | SURVIVAL | SYSTEM | CHOLESTEROL | PATTERNS | TIME | PLASMA | CPT1A LOCUS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | EPIGENOME-WIDE ASSOCIATION | EXPOSURE | Nerve Tissue Proteins - blood | ATP Binding Cassette Transporter, Subfamily G, Member 1 - blood | Carnitine O-Palmitoyltransferase - genetics | Lipids - genetics | Epigenesis, Genetic | Humans | Middle Aged | Male | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | Lipids - blood | Oxidoreductases Acting on CH-CH Group Donors - blood | Aged, 80 and over | Adult | Cholesterol, LDL - blood | Female | Lipid Metabolism - genetics | Oxidoreductases Acting on CH-CH Group Donors - genetics | Carnitine O-Palmitoyltransferase - blood | Gene Expression Regulation - genetics | DNA Methylation - genetics | Cholesterol, HDL - genetics | Nerve Tissue Proteins - genetics | Cholesterol, LDL - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Sterol Regulatory Element Binding Protein 1 - blood | Adolescent | Triglycerides - blood | Cholesterol, HDL - blood | CpG Islands - genetics | Aged | Triglycerides - genetics | Genome, Human | Lipoproteins (low density) | Triglycerides | Genomes | Ribonucleic acid--RNA | Blood | Cholesterol | Studies | Consortia | Genotype & phenotype | Pleiotropy | External stimuli | Arteriosclerosis | Atherosclerosis | Quality control | Standard deviation | Lipid metabolism | Bioinformatics | Lipoproteins (high density) | Deoxyribonucleic acid--DNA | CpG islands
Journal Article
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 2016, Volume 25, Issue 20, pp. 4556 - 4565
Lipid traits (total, low-density and high-density lipoprotein cholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is... 
DENSITY-LIPOPROTEIN CHOLESTEROL | THIOREDOXIN INTERACTING PROTEIN | GENE PROMOTER | RISK-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | FAMILIAL COMBINED HYPERLIPIDEMIA | BODY-MASS INDEX | ASSOCIATION | CORONARY-ARTERY-DISEASE | LOWERING DRUGS | BLOOD | Carnitine O-Palmitoyltransferase - genetics | Cholesterol - blood | Epigenesis, Genetic | Humans | Amino Acid Transport System y+ - genetics | Male | Genetic Loci | ATP Binding Cassette Transporter, Subfamily G, Member 1 - metabolism | Cardiovascular Diseases - enzymology | Cardiovascular Diseases - genetics | Cholesterol - chemistry | ras GTPase-Activating Proteins - genetics | DNA Methylation | Amino Acid Transport System y+ - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | Carnitine O-Palmitoyltransferase - metabolism | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Genetic Predisposition to Disease | Phosphoric Monoester Hydrolases - genetics | ras GTPase-Activating Proteins - metabolism | Cardiovascular Diseases - metabolism | Genetic Association Studies | Ubiquitin-Protein Ligases - metabolism | Cholesterol - metabolism | Sequence Analysis, DNA | Triglycerides - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Sterol Regulatory Element Binding Protein 1 - genetics | Triglycerides - blood | CpG Islands | Triglycerides - genetics | Phosphoric Monoester Hydrolases - metabolism | Ubiquitin-Protein Ligases - genetics | Epigènesi | ADN
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2018, Volume 496, Issue 2, pp. 287 - 293
Recent studies have highlighted recruiting and activating brite adipocytes in WAT (so-called “browning”) would be an attractive anti-obesity strategy. Zinc... 
Obesity | Browning | Mitochondrial biogenesis | Zinc alpha2 glycoprotein | WHITE | ACTIVATION | LIPID-METABOLISM | BETA-ADRENERGIC-RECEPTORS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | BIOPHYSICS | FAT-LIKE PHENOTYPE | 3T3-L1 | ADIPOSE-TISSUE | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Carnitine O-Palmitoyltransferase - genetics | Adipocytes, Brown - metabolism | Glycoproteins - metabolism | Nuclear Respiratory Factor 1 - genetics | DNA-Binding Proteins - metabolism | Carbon-Carbon Ligases - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Isoquinolines - pharmacology | Carnitine O-Palmitoyltransferase - metabolism | Nuclear Respiratory Factor 1 - metabolism | Apoptosis Regulatory Proteins - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Lipid Metabolism - genetics | NF-E2-Related Factor 2 - genetics | Carbon-Carbon Ligases - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Glycoproteins - genetics | Uncoupling Protein 1 - genetics | Signal Transduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Gene Expression Regulation | Imidazoles - pharmacology | Lipase - metabolism | Transcription Factors - genetics | 3T3-L1 Cells | DNA-Binding Proteins - genetics | Sulfonamides - pharmacology | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | NF-E2-Related Factor 2 - metabolism | Mice | Pyridines - pharmacology | Adipocytes, Brown - cytology | Lipase - genetics | Lipids | Biosynthesis | Lipase | Body weight | Stem cells
Journal Article
Diabetologia, ISSN 0012-186X, 11/2005, Volume 48, Issue 11, pp. 2354 - 2364
AMP-activated protein kinase (AMPK) regulates metabolic adaptations in skeletal muscle. The aim of this study was to investigate whether AMPK modulates the... 
Medicine | Fasting | Transcription | AMP-activated protein kinase | Metabolism | Skeletal muscle | OXIDATION | ENZYME-ACTIVITIES | transcription | GLYCOGEN-CONTENT | INCREASES | fasting | FATTY-ACIDS | PYRUVATE-DEHYDROGENASE COMPLEX | INSULIN | CARRIER PIGS | ENDOCRINOLOGY & METABOLISM | metabolism | UNCOUPLING PROTEIN-3 | MICE | skeletal muscle | Protein Kinases - metabolism | Protein Kinases - genetics | CD36 Antigens - genetics | Ion Channels | Multienzyme Complexes - metabolism | Mitochondrial Proteins | AMP-Activated Protein Kinases | Fatty Acids, Nonesterified - metabolism | Glycogen - metabolism | Lipid Metabolism - genetics | Protein-Serine-Threonine Kinases - metabolism | PPAR gamma - genetics | Isoenzymes - genetics | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Multienzyme Complexes - genetics | Muscle, Skeletal - physiology | Acetyl Coenzyme A - metabolism | Mice, Knockout | Triglycerides - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | L-Lactate Dehydrogenase - genetics | Glucose - metabolism | Mice | Mutation | Uncoupling Protein 3 | Genetically modified animals | RNA | Glycogen | Genes | Muscles | Animal genetic engineering | Lipoprotein lipase | Genetic transcription | Glucose | Fatty acids | Dextrose | Carnitine | Proteins | Synthesis | Analysis | Physiological aspects | Genetic research | Protein kinases | Fatty Acids; Nonesterified/metabolism | Mice; Transgenic | Acetyl Coenzyme A/metabolism | Triglycerides/metabolism | Mice; Knockout | Protein Kinases/genetics/metabolism | Antigens; CD36/genetics | L-Lactate Dehydrogenase/genetics | Isoenzymes/genetics | Multienzyme Complexes/genetics/metabolism | Protein-Serine-Threonine Kinases/genetics/metabolism | Muscle; Skeletal/physiology | Glucose/metabolism | Lipid Metabolism/genetics | Research Support; Non-U.S. Gov't | Glycogen/metabolism | Carrier Proteins/genetics/metabolism | PPAR gamma/genetics
Journal Article
Metabolism, ISSN 0026-0495, 2005, Volume 54, Issue 8, pp. 1048 - 1055
In skeletal muscle of humans, transcription of several metabolic genes is transiently induced during recovery from exercise when no food is consumed. To... 
INSULIN | ACTIVATION | LIPID-METABOLISM | RAT | MESSENGER-RNA EXPRESSION | STIMULATED GLUCOSE-TRANSPORT | GLYCOGEN-CONTENT | KINASE | ENDOCRINOLOGY & METABOLISM | GLUT-4 PROTEIN EXPRESSION | SHORT-TERM | Carnitine O-Palmitoyltransferase - genetics | Protein Kinases - genetics | CD36 Antigens - genetics | Ion Channels | Physical Exertion - physiology | Humans | Male | Gene Expression Regulation, Enzymologic - physiology | Mitochondrial Proteins | RNA, Messenger - metabolism | Heat-Shock Proteins - genetics | Glycogen - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Adult | Energy Metabolism - genetics | Hexokinase - genetics | Monosaccharide Transport Proteins - genetics | Glycogen Synthase - genetics | Muscle, Skeletal - enzymology | Recovery of Function - genetics | Glucose Transporter Type 4 | Lipoprotein Lipase - genetics | PPAR alpha - genetics | Muscle, Skeletal - physiology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Muscle Proteins - genetics | Carrier Proteins - genetics | Forkhead Box Protein O1 | Transcriptional Activation - physiology | Forkhead Transcription Factors | Uncoupling Protein 3 | Glycogen | Esterases | Lipoprotein lipase | Glucose | Blood lipoproteins | Fatty acids | Dextrose | Carnitine | Proteolipids | Lipoproteins | Exercise | Messenger RNA | Low carbohydrate foods | Nurses | Physiological aspects | Genetic research | Genetic aspects
Journal Article
Annual Review of Genetics, ISSN 0066-4197, 11/2017, Volume 51, Issue 1, pp. 241 - 263
Much progress has been made in the identification of specific human gene variants that contribute to enhanced susceptibility or resistance to viral diseases.... 
infection | GWAS | SNP | single nucleotide polymorphism | virus | genome-wide association study | Infection | Virus | Single nucleotide polymorphism | Genome-wide association study | HUMAN-PAPILLOMAVIRUS TYPE-16 | T-CELL LEUKEMIA/LYMPHOMA | CHRONIC HEPATITIS-C | INTERFERON-STIMULATED GENES | LINKED LYMPHOPROLIFERATIVE DISEASE | TROPICAL SPASTIC PARAPARESIS | CARNITINE PALMITOYLTRANSFERASE-II | GENETICS & HEREDITY | HERPES-SIMPLEX ENCEPHALITIS | RESPIRATORY SYNCYTIAL VIRUS | GENOME-WIDE ASSOCIATION | Adaptive Immunity | Human Genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Virus Diseases - immunology | Receptors, KIR - genetics | Signal Transduction | Gene Expression Regulation - immunology | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - immunology | Humans | Interferon Regulatory Factors - genetics | Virus Diseases - virology | Receptors, Virus - genetics | Immunity, Innate | Host-Pathogen Interactions - immunology | Interferon Regulatory Factors - immunology | Host-Pathogen Interactions - genetics | Virus Diseases - pathology | Receptors, Virus - immunology | Virus Diseases - genetics | Cytokines - genetics | Receptors, KIR - immunology | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics | Cytokines - immunology | Influenza viruses | Genomics | Genetic research | Disease susceptibility | Single nucleotide polymorphisms | Health aspects | Papillomavirus infections | Virus diseases | Genome-wide association studies | Usage | Genetic aspects | Research
Journal Article