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Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, pp. 6692 - 6692
During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells... 
ACTIVATION | LIPID-METABOLISM | MEMORY | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | RESPIRATORY CAPACITY | CTLA-4 | CHRONIC VIRAL-INFECTION | TUMOR-GROWTH | EXPRESSION | DISEASE PROGRESSION | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 5592 - 5592
Periconceptional diet may persistently influence DNA methylation levels with phenotypic consequences. However, a comprehensive assessment of the... 
HUNGER WINTER FAMILIES | HUMAN GENOME | CPT1A LOCUS | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | GENE-EXPRESSION | CPG METHYLATION | EPIGENETIC EPIDEMIOLOGY | DEVELOPMENTAL ORIGINS | DUTCH FAMINE | MASS-SPECTROMETRY | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 08/2014, Volume 130, Issue 7, pp. 565 - 572
Journal Article
Genome Biology, ISSN 1465-6906, 06/2016, Volume 17, Issue 1, pp. 138 - 138
Background: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids... 
DNA methylation | Lipids | Mendelian randomization | Gene expression | SURVIVAL | SYSTEM | CHOLESTEROL | PATTERNS | TIME | PLASMA | CPT1A LOCUS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | EPIGENOME-WIDE ASSOCIATION | EXPOSURE | Nerve Tissue Proteins - blood | ATP Binding Cassette Transporter, Subfamily G, Member 1 - blood | Carnitine O-Palmitoyltransferase - genetics | Lipids - genetics | Epigenesis, Genetic | Humans | Middle Aged | Male | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | Lipids - blood | Oxidoreductases Acting on CH-CH Group Donors - blood | Aged, 80 and over | Adult | Cholesterol, LDL - blood | Female | Lipid Metabolism - genetics | Oxidoreductases Acting on CH-CH Group Donors - genetics | Carnitine O-Palmitoyltransferase - blood | Gene Expression Regulation - genetics | DNA Methylation - genetics | Cholesterol, HDL - genetics | Nerve Tissue Proteins - genetics | Cholesterol, LDL - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Sterol Regulatory Element Binding Protein 1 - blood | Adolescent | Triglycerides - blood | Cholesterol, HDL - blood | CpG Islands - genetics | Aged | Triglycerides - genetics | Genome, Human | Lipoproteins (low density) | Triglycerides | Genomes | Ribonucleic acid--RNA | Blood | Cholesterol | Studies | Consortia | Genotype & phenotype | Pleiotropy | External stimuli | Arteriosclerosis | Atherosclerosis | Quality control | Standard deviation | Lipid metabolism | Methylation | Bioinformatics | Lipoproteins (high density) | Deoxyribonucleic acid--DNA | CpG islands | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 05/2011, Volume 25, Issue 10, pp. 1041 - 1051
Journal Article
Obesity, ISSN 1930-7381, 07/2015, Volume 23, Issue 7, pp. 1493 - 1501
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7639, pp. 49 - 54
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 192 - 197
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CFT1A, a rate-limiting enzyme of... 
OXIDATION | DISTRIBUTIONS | GLYCOLYSIS | REDUCTIVE GLUTAMINE-METABOLISM | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | TUMOR | PROLIFERATION | GROWTH-FACTOR | CANCER | CULTURE | Carnitine O-Palmitoyltransferase - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Neovascularization, Pathologic - pathology | Nucleotides - chemistry | Carnitine O-Palmitoyltransferase - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Carnitine O-Palmitoyltransferase - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Nucleotides - biosynthesis | Nucleotides - pharmacology | Oxidation-Reduction - drug effects | DNA - biosynthesis | Carnitine O-Palmitoyltransferase - deficiency | Fatty Acids - metabolism | Disease Models, Animal | Carbon - metabolism | Fatty Acids - chemistry | Human Umbilical Vein Endothelial Cells - drug effects | Endothelial Cells - metabolism | Gene Silencing | Acetic Acid - pharmacology | Blood Vessels - cytology | Citric Acid Cycle | Animals | Retinopathy of Prematurity - drug therapy | Endothelial Cells - cytology | Neovascularization, Pathologic - drug therapy | Blood Vessels - drug effects | Cell Line, Tumor | Glucose - metabolism | Human Umbilical Vein Endothelial Cells - pathology | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Retinopathy of Prematurity - metabolism | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Retinopathy of Prematurity - pathology | Physiological aspects | Deoxyribonucleotides | Fatty acids | Carbon | Endothelium | Proteins | Angiogenesis | Protein synthesis | Glucose | Kinases | Deoxyribonucleic acid--DNA | Cells | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 57, Issue 1, pp. 141 - 149
Background & Aims Non-alcoholic steatohepatitis (NASH) is characterized by steatosis associated with liver inflammation. Steatosis causes recruitment of... 
Gastroenterology and Hepatology | Obesity | Inflammation | NASH | Lipidomic | Kupffer cells | ACTIVATION | MECHANISM | CHOLESTEROL | FATTY LIVER-DISEASE | SENSITIVITY | NONALCOHOLIC STEATOHEPATITIS | PATHOGENESIS | DIET | MICE | GASTROENTEROLOGY & HEPATOLOGY | T-CELLS | Dietary Fats - metabolism | Kupffer Cells - pathology | Carnitine O-Palmitoyltransferase - genetics | Fatty Liver - pathology | Obesity - immunology | Acetyltransferases - genetics | Lymphocytes - immunology | Gene Expression - physiology | Non-alcoholic Fatty Liver Disease | Kupffer Cells - metabolism | Nuclear Proteins - genetics | Fatty Acid Synthases - genetics | PPAR gamma - genetics | Fatty Liver - metabolism | Mice, Inbred C57BL | Transcription Factors - genetics | Fatty Acid-Binding Proteins - genetics | Stearoyl-CoA Desaturase - genetics | Obesity - metabolism | Phenotype | Animals | Diacylglycerol O-Acyltransferase - genetics | Fatty Liver - immunology | Mice, Obese | Mice | Dietary Fats - toxicity | Kupffer Cells - immunology | Thiols | Low density lipoproteins | Esters | Lipids | Phospholipids | Glucose | Biological response modifiers | Macrophages | Glucose tolerance tests | Proteins | Synthesis | Lymphocytes | Genetic aspects | Blood lipids | Protein binding | Enzymes | Triglycerides | Automated teller machines | Fatty acids | Cells | Dextrose | Cholesterol | Carnitine | Binding proteins | Mitogens | Interferon gamma | Index Medicus | Life Sciences | Agricultural sciences
Journal Article