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Nature Medicine, ISSN 1078-8956, 07/2012, Volume 18, Issue 7, pp. 1148 - 1153
Host remodeling is important for the success of medical implants, including vascular substitutes. Synthetic and tissue-engineered grafts have yet to show... 
ENGINEERED BLOOD-VESSELS | MEDICINE, RESEARCH & EXPERIMENTAL | SMALL-INTESTINAL SUBMUCOSA | VASCULAR GRAFTS | COLLAGEN | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAROTID-ARTERY | INJURY | CELL BIOLOGY | SMALL-DIAMETER | SAPHENOUS-VEIN | SURFACE | Humans | Myocytes, Smooth Muscle - pathology | Rats, Inbred Lew | Extracellular Matrix - metabolism | Endothelium, Vascular - drug effects | Male | Blood Vessel Prosthesis | Arteries - ultrastructure | Glycerol - pharmacology | Aorta - physiopathology | Porosity - drug effects | Glycerol - analogs & derivatives | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Microscopy, Electron, Scanning | Tissue Engineering - methods | Aorta - drug effects | Extracellular Matrix - drug effects | Rats | Arteries - drug effects | Decanoates - pharmacology | Arteries - pathology | Vascular Patency - drug effects | Platelet Adhesiveness - drug effects | Aorta - pathology | Animals | Cell-Free System | Arteries - physiopathology | Staining and Labeling | Polymers - pharmacology | Endothelium, Vascular - pathology | Elastomers - pharmacology | Blood Vessel Prosthesis Implantation | Physiological aspects | Vascular endothelium | Usage | Research | Tissue engineering | Arteries | Biodegradation | Skin & tissue grafts | Cells | Veins & arteries | Index Medicus
Journal Article
Aging Cell, ISSN 1474-9718, 08/2015, Volume 14, Issue 4, pp. 644 - 658
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous... 
dasatinib | plasminogen‐activated inhibitor | dependence receptors | quercetin | ephrins | 3K delta | p21 | Dasatinib | Dependence receptors | Ephrins | Plasminogen-activated inhibitor | Quercetin | PI3K delta | P21 | ENDOTHELIAL DYSFUNCTION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | EXPRESSION PROFILES | plasminogen-activated inhibitor | CELLULAR SENESCENCE | CANCER-THERAPY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | LUNG-CANCER | SET ENRICHMENT ANALYSIS | GENE-EXPRESSION | IONIZING-RADIATION | TUMOR-GROWTH | Carotid Arteries - drug effects | Endonucleases - genetics | Plasminogen Activator Inhibitor 2 - genetics | Transcriptome | Gene Expression Profiling | Adipocytes - drug effects | Aging - genetics | Osteoporosis - metabolism | Ephrins - metabolism | Plasminogen Activator Inhibitor 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Osteoporosis - genetics | Intervertebral Disc - pathology | Fibroblasts - metabolism | Endothelial Cells - metabolism | Intervertebral Disc - chemistry | Fibroblasts - pathology | Mesenchymal Stem Cells - pathology | Mice, Knockout | Dasatinib - pharmacology | Osteoporosis - pathology | Ephrins - genetics | Fibroblasts - drug effects | Mice | Endothelial Cells - pathology | bcl-X Protein - metabolism | Aging - metabolism | Aging - drug effects | bcl-X Protein - genetics | Cellular Senescence - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Mesenchymal Stem Cells - drug effects | Mesenchymal Stem Cells - metabolism | Heart - physiopathology | Cellular Senescence - genetics | Osteoporosis - prevention & control | DNA-Binding Proteins - genetics | Adipocytes - pathology | Aging - pathology | Phosphatidylinositol 3-Kinases - genetics | Animals | Quercetin - pharmacology | Adipocytes - metabolism | Heart - drug effects | Carotid Arteries - pathology | Intervertebral Disc - drug effects | Drug Combinations | Endothelial Cells - drug effects | Index Medicus | Original
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2016, Volume 374, Issue 13, pp. 1221 - 1231
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 06/2008, Volume 294, Issue 6, pp. 2721 - 2735
The dietary polyphenolic compound resveratrol, by activating the protein deacetylase enzyme silent information regulator 2/sirtuin 1 (SIRT1), prolongs life... 
Vascular aging | Polyphenol | Stroke | Tobacco | Sirtuin 1 | Inflammation | Apoptosis | sirtuin 1 | LIFE-SPAN | MITOCHONDRIAL SUPEROXIDE-PRODUCTION | ELECTRON-SPIN-RESONANCE | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | DNA-DAMAGE | apoptosis | NECROSIS-FACTOR-ALPHA | polyphenol | stroke | CORONARY-ARTERIES | NAD(P)H OXIDASE | ENDOTHELIUM-DEPENDENT DILATION | inflammation | vascular aging | CALORIC RESTRICTION | PERIPHERAL VASCULAR DISEASE | tobacco | NF-KAPPA-B | Carotid Arteries - drug effects | Smoking - adverse effects | Inflammation - pathology | Reactive Oxygen Species - metabolism | Rats, Wistar | Apoptosis - drug effects | Male | NF-kappa B - metabolism | Stilbenes - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Smoking - physiopathology | Inflammation Mediators - metabolism | Resveratrol | Carotid Arteries - enzymology | Models, Animal | Sirtuins - genetics | Cytoprotection | DNA Damage - drug effects | Coronary Vessels - drug effects | Coronary Vessels - enzymology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Smoke - adverse effects | Cells, Cultured | Rats | Arteries - drug effects | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Inflammation - etiology | Smoking - metabolism | Phenotype | Animals | Arteries - enzymology | Arteries - physiopathology | Smoking - pathology | Inflammation - prevention & control | Oxidative Stress - drug effects | Vasodilation - drug effects | Endothelial Cells - enzymology | Inflammation - enzymology | Sirtuins - metabolism | Endothelial Cells - drug effects | Inflammation - physiopathology | Studies | Genotype & phenotype | Cell culture | Tobacco smoke | Antibiotics | Rodents | Coronary vessels | Effects | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2007, Volume 356, Issue 16, pp. 1620 - 1630
Since torcetrapib, an inhibitor of cholesteryl ester transfer protein, markedly increases levels of high-density lipoprotein cholesterol and lowers levels of... 
INTIMA-MEDIA THICKNESS | RANDOMIZED CONTROLLED-TRIALS | MEDICINE, GENERAL & INTERNAL | TRANSFER PROTEIN INHIBITOR | CHOLESTERYL ESTER TRANSFER | CARDIOVASCULAR-DISEASE | DOUBLE-BLIND | HDL CHOLESTEROL | CORONARY-DISEASE | SECONDARY PREVENTION | HIGH-DENSITY-LIPOPROTEIN | Carotid Arteries - drug effects | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Prospective Studies | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Male | Quinolines - pharmacology | Atherosclerosis - etiology | Carotid Artery Diseases - pathology | Adult | Cholesterol, LDL - blood | Female | Hyperlipoproteinemia Type II - drug therapy | Drug Therapy, Combination | Pyrroles - therapeutic use | Carotid Artery Diseases - drug therapy | Hyperlipoproteinemia Type II - complications | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Carotid Artery Diseases - etiology | Double-Blind Method | Hyperlipoproteinemia Type II - blood | Disease Progression | Atorvastatin Calcium | Anticholesteremic Agents - therapeutic use | Cholesterol, HDL - blood | Heterozygote | Carotid Arteries - pathology | Quinolines - therapeutic use | Anticholesteremic Agents - pharmacology | Hypercholesterolemia | High density lipoproteins | Atherosclerosis | Anticholesteremic agents | Dosage and administration | Research | Drug therapy | Cardiovascular disease | Diet | Apolipoproteins | Cholesterol | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2015, Volume 309, Issue 10, pp. H1679 - H1696
Normal pregnancy is associated with adaptive hemodynamic, hormonal, and vascular changes, and estrogen (E-2) may promote vasodilation during pregnancy;... 
Vascular smooth muscle | Calcium | Nitric oxide | Estrogen | Endothelium | endothelium | estrogen | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | vascular smooth muscle | calcium | CA2+ ENTRY MECHANISMS | EPICARDIAL CORONARY-ARTERIES | MESENTERIC MICROVESSELS | VASCULAR SMOOTH-MUSCLE | ENDOTHELIAL NITRIC-OXIDE | GENDER-SPECIFIC REDUCTION | IN-VITRO | FEMALE RAT | PULMONARY-ARTERY ENDOTHELIUM | PERIPHERAL VASCULAR DISEASE | SIGNAL-REGULATED KINASE | Carotid Arteries - drug effects | Carotid Arteries - metabolism | Immunohistochemistry | Mesenteric Arteries - physiology | Receptors, G-Protein-Coupled - metabolism | Calcium - metabolism | Endothelium, Vascular - drug effects | Estrogen Receptor beta - metabolism | Estrogen Receptor alpha - agonists | Potassium Channel Blockers - pharmacology | Muscle, Smooth, Vascular - drug effects | Phenols - pharmacology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Arteries - drug effects | Mesenteric Arteries - metabolism | Vasoconstriction - drug effects | Blotting, Western | Endothelium, Vascular - metabolism | Carotid Arteries - physiology | Vasodilation - drug effects | Adaptation, Physiological | Blood Pressure | Tetraethylammonium - pharmacology | Muscle, Smooth, Vascular - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Mesenteric Arteries - drug effects | Receptors, G-Protein-Coupled - agonists | Arteries - metabolism | Endothelium, Vascular - physiology | Vasoconstriction - physiology | Estrogen Receptor beta - agonists | Pregnancy - metabolism | Arteries - physiology | Aorta, Thoracic - physiology | Estrogen Receptor alpha - metabolism | Female | Renal Artery - metabolism | Aorta, Thoracic - drug effects | Vasodilation - physiology | Estrogens - metabolism | Muscle, Smooth, Vascular - physiology | Pregnancy - physiology | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Renal Artery - physiology | Animals | Renal Artery - drug effects | Pregnancy | Dilatation | Pregnant women | Vasodilators | Blood vessels | Phenols | G proteins | Membrane proteins | Research | Health aspects | Genomics | Protein expression | Physiology | Hormones | Index Medicus | Vascular Biology and Microcirculation
Journal Article
Circulation Research, ISSN 0009-7330, 06/2007, Volume 100, Issue 11, pp. 1579 - 1588
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2009, Volume 361, Issue 22, pp. 2113 - 2122
Journal Article