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Nature Neuroscience, ISSN 1097-6256, 11/2012, Volume 15, Issue 11, pp. 1488 - 1497
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.... 
NEURODEGENERATIVE DISEASE | GENE | AMYOTROPHIC-LATERAL-SCLEROSIS | FAMILY PROTEINS | FUS PATHOLOGY | MUTATIONS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING | NEUROSCIENCES | BRAIN | NASCENT TRANSCRIPTION | RNA, Small Interfering - genetics | Protein Binding - genetics | Oligonucleotide Array Sequence Analysis | Humans | tau Proteins - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - metabolism | Brain - metabolism | Frontotemporal Dementia - metabolism | RNA Splicing - genetics | Frontotemporal Dementia - genetics | RNA-Binding Protein FUS - deficiency | Amyotrophic Lateral Sclerosis - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | RNA-Binding Protein FUS - genetics | Mice, Knockout | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Shal Potassium Channels - metabolism | Brain - pathology | Mice | Neurofilament Proteins - metabolism | RNA, Small Interfering - metabolism | Immunoprecipitation | Spinal Cord - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | tau Proteins - genetics | Cell Cycle Proteins - genetics | Female | RNA Precursors - metabolism | Excitatory Amino Acid Transporter 2 - genetics | Membrane Proteins - metabolism | Frontotemporal Dementia - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA Precursors - genetics | Protein Structure, Tertiary - genetics | RNA-Binding Protein FUS - metabolism | DNA-Binding Proteins - genetics | Excitatory Amino Acid Transporter 2 - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neural Cell Adhesion Molecules - metabolism | Neural Stem Cells - metabolism | Cell Line, Transformed | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Messenger RNA | Health aspects | Index Medicus
Journal Article
by Fitzgerald, T.W and Gerety, S.S and Jones, W.D and Van Kogelenberg, M and King, D.A and McRae, J and Morley, K.I and Parthiban, V and Al-Turki, S and Ambridge, K and Barrett, D.M and Bayzetinova, T and Clayton, S and Coomber, E.L and Gribble, S and Jones, P and Krishnappa, N and Mason, L.E and Middleton, A and Miller, R and Prigmore, E and Rajan, D and Sifrim, A and Tivey, A.R and Ahmed, M and Akawi, N and Andrews, R and Anjum, U and Archer, H and Armstrong, R and Balasubramanian, M and Banerjee, R and Baralle, D and Batstone, P and Baty, D and Bennett, C and Berg, J and Bernhard, B and Bevan, A.P and Blair, E and Blyth, M and Bohanna, D and Bourdon, L and Bourn, D and Brady, A and Bragin, E and Brewer, C and Brueton, L and Brunstrom, K and Bumpstead, S.J and Bunyan, D.J and Burn, J and Burton, J and Canham, N and Castle, B and Chandler, K and Clasper, S and Clayton-Smith, J and Cole, T and Collins, A and Collinson, M.N and Connell, F and Cooper, N and Cox, H and Cresswell, L and Cross, G and Crow, Y and D'Alessandro, M and Dabir, T and Davidson, R and Davies, S and Dean, J and Deshpande, C and Devlin, G and Dixit, A and Dominiczak, A and Donnelly, C and Donnelly, D and Douglas, A and Duncan, A and Eason, J and Edkins, S and Ellard, S and Ellis, P and Elmslie, F and Evans, K and Everest, S and Fendick, T and Fisher, R and Flinter, F and Foulds, N and Fryer, A and Fu, B and Gardiner, C and Gaunt, L and Ghali, N and Gibbons, R and Gomes Pereira, S.L and Goodship, J and Goudie, D and ... and Deciphering Dev Disorders Study and Deciphering Developmental Disorders Study and The Deciphering Developmental Disorders Study
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7542, pp. 223 - 228
Despite three decades of successful, predominantly phenotype-driven discovery of the genetic causes of monogenic disorders(1), up to half of children with... 
INTELLECTUAL DISABILITY | HUMAN-DISEASE | DE-NOVO MUTATIONS | MULTIDISCIPLINARY SCIENCES | FRAMEWORK | MODEL | AUTISM SPECTRUM DISORDERS | COPY-NUMBER VARIATION | CHILDREN | Rare Diseases - genetics | Humans | Parents | Child, Preschool | Infant | Male | Developmental Disabilities - genetics | Dynamin I - genetics | Mutation, Missense - genetics | Polycomb Repressive Complex 1 - genetics | Gene Expression Regulation, Developmental | Transposases - genetics | Female | Nuclear Proteins - genetics | Child | Developmental Disabilities - diagnosis | Infant, Newborn | Guanine Nucleotide Exchange Factors - genetics | Protein Phosphatase 2 - genetics | Protein-Serine-Threonine Kinases - genetics | United Kingdom | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Genome, Human - genetics | Homeodomain Proteins - genetics | Zebrafish - genetics | Chromosomal Proteins, Non-Histone - genetics | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Animals | Adolescent | Chromosome Aberrations | Genes, Dominant - genetics | Usage | Genomics | Child development deviations | Genetic aspects | Research | Risk factors | Developmental disabilities | Studies | Hypotheses | Genes | Developmental psychology | Families & family life | Genomes | Mutation | Children & youth | Index Medicus
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 11/2013, Volume 18, Issue 11, pp. 1225 - 1234
Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer's... 
Brain | Tau | BIN1 | Alzheimer | Drosophila | COMMON VARIANTS | PHOSPHORYLATION | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | brain | ENDOCYTOSIS | NEUROSCIENCES | IDENTIFIES VARIANTS | DISEASE | AMPHIPHYSIN-II | GENOME-WIDE ASSOCIATION | Endophenotypes | Gene Expression - genetics | Humans | Transcription Factors - deficiency | Nerve Degeneration - genetics | tau Proteins - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Case-Control Studies | Alzheimer Disease - pathology | Brain - metabolism | Drosophila melanogaster - metabolism | Synaptosomes - pathology | Nuclear Proteins - biosynthesis | Tumor Suppressor Proteins - genetics | Nuclear Proteins - genetics | tau Proteins - antagonists & inhibitors | Genetic Predisposition to Disease - genetics | Plaque, Amyloid - pathology | Cells, Cultured | Transcription Factors - genetics | Nerve Degeneration - pathology | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Alzheimer Disease - metabolism | Drosophila Proteins - deficiency | Brain - pathology | Polymorphism, Single Nucleotide - genetics | Adaptor Proteins, Signal Transducing - biosynthesis | Mice | Drosophila Proteins - genetics | Alzheimer Disease - genetics | Tumor Suppressor Proteins - biosynthesis | Physiological aspects | Complications and side effects | Genetic aspects | Alzheimer's disease | Risk factors | Amyloid beta-protein | Index Medicus | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 31, pp. 12817 - 12821
MicroRNAs (miRNAs) are regulators of gene expression in plants and animals. The biogenesis of miRNAs is precisely controlled to secure normal development of... 
Proteins | MicroRNA | Double stranded RNA | RNA | Gels | DNA | Small interfering RNA | Antibodies | Gene expression regulation | RNA binding proteins | DNA METHYLATION | GENE | MECHANISM | THALIANA | MICRORNA BIOGENESIS | ELEGANS | MULTIDISCIPLINARY SCIENCES | PLANTS | SIRNAS | ABSCISIC-ACID | SERRATE | Calcium-Binding Proteins - metabolism | RNA-Binding Proteins - genetics | Arabidopsis Proteins - genetics | Ribonuclease III - genetics | Ribonuclease III - metabolism | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Intercellular Signaling Peptides and Proteins - genetics | MicroRNAs - metabolism | RNA Processing, Post-Transcriptional - physiology | RNA, Plant - genetics | RNA, Plant - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Carrier Proteins - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Carrier Proteins - metabolism | Serrate-Jagged Proteins | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | MicroRNAs - genetics | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | Arabidopsis | Plant genetics | Physiological aspects | Genetic aspects | Research | Genetic regulation | Binding proteins | Health aspects | Flowers & plants | Ribonucleic acid--RNA | Gene expression | Binding sites | Index Medicus | Biological Sciences
Journal Article
Journal Article
Science, ISSN 0036-8075, 1/2011, Volume 331, Issue 6013, pp. 76 - 79
Vernalization is an environmentally-induced epigenetic switch in which winter cold triggers epigenetic silencing of floral repressors and thus provides... 
Chromatin | Cold regions | RNA | Reverse transcriptase polymerase chain reaction | Vernalization | REPORTS | Epigenetics | Genetic loci | Promoter regions | Repression | Plants | ARABIDOPSIS-THALIANA | COMPLEX | X-CHROMOSOME | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GENES | REQUIRES | FLC | POLYCOMB | Chromatin - metabolism | Arabidopsis - physiology | RNA, Untranslated - metabolism | Arabidopsis - growth & development | Genes, Plant | Epigenesis, Genetic | Homeodomain Proteins - metabolism | RNA Polymerase II - metabolism | RNA, Plant - metabolism | RNA, Untranslated - genetics | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | RNA Interference | Plants, Genetically Modified | Gene Expression Regulation, Plant | Transcription, Genetic | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Arabidopsis Proteins - genetics | Cold Temperature | Response Elements | Introns | MADS Domain Proteins - genetics | Gene Silencing | Nuclear Proteins - metabolism | Polycomb-Group Proteins | RNA, Plant - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Flowers - growth & development | Arabidopsis - genetics | MADS Domain Proteins - metabolism | Transcription Factors - metabolism | Carrier Proteins - metabolism | RNA, Antisense - metabolism | Histones - metabolism | RNA, Antisense - genetics | Epigenetic inheritance | Genetic aspects | Research | Plant biology | Plant reproduction | Flowers & plants | Gene expression | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 08/2014, Volume 17, Issue 9, pp. 1156 - 1163
Journal Article
Journal Article