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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2013, Volume 110, Issue 5, pp. 1875 - 1880
Here we examined the involvement of Notch signaling in the endochondral ossification process, which is crucial for osteoarthritis (OA) development.... 
Cartilage | Knee joint | Articular cartilage | Chondrocytes | Ligands | Bones | Mice | Skeletal development | Gene expression regulation | Osteoarthritis | Cartilage degradation | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cartilage - pathology | Homeodomain Proteins - metabolism | Humans | Cartilage - drug effects | Collagen Type II - metabolism | Knee Joint - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Serrate-Jagged Proteins | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Jagged-1 Protein | SOX9 Transcription Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Osteoarthritis - metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Line, Tumor | HeLa Cells | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Receptor, Notch2 - antagonists & inhibitors | Receptor, Notch2 - genetics | Chondrocytes - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Membrane Proteins - metabolism | Chondrocytes - metabolism | Calcium-Binding Proteins - metabolism | Knee Joint - metabolism | Cell Line | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Osteoarthritis - prevention & control | Dipeptides - pharmacology | Knee Joint - drug effects | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Receptor, Notch1 - metabolism | Cartilage - metabolism | Collagen Type II - genetics | Homeodomain Proteins - genetics | Osteoarthritis - genetics | Animals | Fluorescent Antibody Technique | SOX9 Transcription Factor - genetics | Osteogenesis | Endochondral ossification | Physiological aspects | Development and progression | Cellular signal transduction | Health aspects | Membrane proteins | Index Medicus | cartilage degradation | Biological Sciences | skeletal development
Journal Article
Osteoarthritis and cartilage, ISSN 1063-4584, 01/2016, Volume 24, Issue 1, pp. 146 - 157
Summary Objective Mechanical signals control key cellular processes in articular cartilage. Previously we have shown that mechanical compression is an... 
Rheumatology | Mechanosensitivity | Cartilage | Signal transduction | TGF-beta | Smad2/3P signaling | Ageing | Life Sciences & Biomedicine | Orthopedics | Science & Technology | Receptors, Transforming Growth Factor beta - genetics | Transforming Growth Factor beta1 - metabolism | Gene Expression Profiling | Smad3 Protein - metabolism | Cartilage, Articular - physiology | Collagen Type II - metabolism | Smad3 Protein - genetics | Aging - genetics | Heparan Sulfate Proteoglycans - genetics | Plasminogen Activator Inhibitor 1 - metabolism | Cartilage, Articular - metabolism | Cattle | Bone Morphogenetic Protein 2 - metabolism | Smad2 Protein - genetics | Plasminogen Activator Inhibitor 1 - genetics | Protein-Serine-Threonine Kinases - metabolism | Bone Morphogenetic Protein 2 - genetics | Extracellular Matrix | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Smad2 Protein - metabolism | Osteoarthritis - metabolism | Transforming Growth Factor beta1 - genetics | Aggrecans - metabolism | Aggrecans - genetics | Pressure | Collagen Type II - genetics | Fibronectins - metabolism | Osteoarthritis - genetics | Animals | Aging - physiology | Receptors, Transforming Growth Factor beta - metabolism | Heparan Sulfate Proteoglycans - metabolism | Connective Tissue Growth Factor - genetics | Fibronectins - genetics | Connective Tissue Growth Factor - metabolism | Aging - metabolism | Index Medicus
Journal Article
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 24, Issue 2, pp. 315 - 324
Summary Objective The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since... 
Rheumatology | Smad1 | Human chondrocytes | Hip osteoarthritis | β-Catenin | Dedifferentiation | Leptin | Life Sciences & Biomedicine | Orthopedics | Science & Technology | Receptors, Transforming Growth Factor beta - genetics | Humans | Leptin - metabolism | Middle Aged | Male | Lymphotoxin-alpha - metabolism | RNA, Messenger - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Lymphotoxin-alpha - genetics | Cartilage, Articular - metabolism | Smad5 Protein - metabolism | Smad2 Protein - genetics | Aged, 80 and over | Smad2 Protein - drug effects | Protein-Serine-Threonine Kinases - metabolism | Collagen Type X - drug effects | SOX9 Transcription Factor - metabolism | Matrix Metalloproteinase 13 - genetics | Smad2 Protein - metabolism | Prednisolone - pharmacology | beta Catenin - metabolism | Matrix Metalloproteinase 13 - metabolism | Glycogen Synthase Kinase 3 - genetics | Receptors, Transforming Growth Factor beta - drug effects | Activin Receptors, Type II - genetics | Protein-Serine-Threonine Kinases - drug effects | Activin Receptors, Type II - metabolism | Osteoarthritis, Hip - metabolism | Glycogen Synthase Kinase 3 - drug effects | Activin Receptors, Type II - drug effects | Chondrocytes - drug effects | Collagen Type X - metabolism | beta Catenin - drug effects | Smad1 Protein - genetics | Adult | Female | Smad5 Protein - genetics | Chondrocytes - metabolism | RNA, Messenger - drug effects | Cell Dedifferentiation - drug effects | Cartilage, Articular - cytology | Lymphotoxin-alpha - drug effects | Protein-Serine-Threonine Kinases - genetics | Collagen Type X - genetics | SOX9 Transcription Factor - drug effects | Matrix Metalloproteinase 13 - drug effects | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - genetics | Osteoarthritis, Hip - genetics | Smad5 Protein - drug effects | Core Binding Factor Alpha 1 Subunit - drug effects | Wnt Signaling Pathway - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Wnt Signaling Pathway - genetics | Glucocorticoids - pharmacology | Smad1 Protein - metabolism | Aged | Smad1 Protein - drug effects | Cartilage, Articular - drug effects | In Vitro Techniques | Cell Dedifferentiation - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Index Medicus
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 01/2019, Volume 565, Issue 7740, pp. 511 - 515
Journal Article