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Cell Reports, ISSN 2211-1247, 12/2015, Volume 13, Issue 11, pp. 2425 - 2439
To identify therapeutic targets for glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 knockout (KO) screens in patient-derived GBM stem-like cells... 
WEE1 | CRISPR-Cas9 | Glioblastoma | cancer therapeutics | functional genomics | PKMYT1 | gene editing | Myt1 | Cancer therapeutics | Gene editing | Functional genomics | ACTIVATION | PROTEIN | GENE-EXPRESSION | GOLGI | PHOSPHORYLATES CDC2 | HUMAN MYT1 | INHIBITORY KINASE | BRAIN | RNAI SCREEN | REQUIREMENT | CELL BIOLOGY | Neoplastic Stem Cells - cytology | Phosphorylation | Mitosis | Protein-Tyrosine Kinases - metabolism | Humans | Microscopy, Video | Time-Lapse Imaging | Tumor Suppressor Protein p53 - genetics | CDC2 Protein Kinase - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Receptor, Epidermal Growth Factor - metabolism | Neoplastic Stem Cells - metabolism | RNA Interference | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Glioblastoma - metabolism | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | Gene Library | CDC2 Protein Kinase - antagonists & inhibitors | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | CRISPR-Cas Systems - genetics | Membrane Proteins - antagonists & inhibitors | Glioblastoma - pathology | Nuclear Proteins - antagonists & inhibitors | Cyclin B - metabolism | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 8, pp. 2744 - 2754
Clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins provide microbial adaptive immunity against... 
INHIBITION | GENETIC ELEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYO-EM STRUCTURES | BACTERIAL IMMUNE-SYSTEM | CLASSIFICATION | MECHANISMS | SURVEILLANCE COMPLEX | REPEATS | VIRAL SUPPRESSORS | PROKARYOTES | Xanthomonas - metabolism | CRISPR-Associated Proteins - chemistry | Species Specificity | Protein Multimerization | Bacterial Proteins - chemistry | Crystallography, X-Ray | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Xanthomonas - immunology | CRISPR-Associated Proteins - antagonists & inhibitors | RNA, Small Interfering - chemistry | RNA Interference | Clustered Regularly Interspaced Short Palindromic Repeats | Protein Stability | RNA, Bacterial - metabolism | Bacterial Proteins - antagonists & inhibitors | CRISPR-Associated Proteins - genetics | Isoenzymes | Viral Proteins - chemistry | Bacterial Proteins - genetics | Enzyme Stability | Models, Molecular | Viral Proteins - genetics | Recombinant Fusion Proteins - chemistry | RNA Stability | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Xanthomonas - enzymology | Bacterial Proteins - metabolism | Protein Conformation | Kinetics | Mutation | Amino Acid Substitution | RNA, Small Interfering - metabolism | Index Medicus | X-ray crystallography | Protein Structure and Folding | CRISPR | anti-CRISPR | Cas | crystal structure | protein-protein interaction | protein complex | RNA-protein interaction | crRNA
Journal Article
Nature, ISSN 0028-0836, 12/2015, Volume 528, Issue 7582, pp. 422 - 426
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 10, pp. 1226 - 1236
Direct interactions between pro-and anti-apoptotic BCL-2 family members form the basis of cell death decision-making at the outer mitochondrial membrane (OMM).... 
SIGNAL | APOPTOSIS | ACTIVATION | SONIC HEDGEHOG | PATHWAY | MCL-1 | GENOMIC ANALYSIS | RESISTANCE | PROLIFERATION | MEDULLOBLASTOMA | CELL BIOLOGY | Neoplasms - metabolism | NIH 3T3 Cells | Transcription, Genetic - drug effects | Cell Proliferation | Zinc Finger Protein GLI1 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-X Protein - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Molecular Mimicry | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - deficiency | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Peptide Fragments - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Survival | Zinc Finger Protein GLI1 - genetics | Repressor Proteins - genetics | Genotype | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Neoplasms - drug therapy | Phenotype | Animals | Mice, Nude | CRISPR-Cas Systems | Mice | Neoplasms - pathology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Regulators | Cell survival | Bcl-2 protein | Transcription | Decision making | Homology | Drug resistance | Gene expression | Mcl-1 protein | Proteins | Signaling | Mitochondria | DNA-binding protein | Bcl-x protein | Cell death | Feedforward | Deoxyribonucleic acid--DNA | Tumors | Cancer | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 494 - 507
Chronic active B cell receptor (BCR) signaling, a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), engages the... 
ANTAGONISTS INDUCE | APOPTOSIS | ACTIVATION | ONCOLOGY | CODING GENOME | CARD11 MUTATIONS | CHAIN ASSEMBLY COMPLEX | IKK COMPLEX | NF-KAPPA-B | SOMATIC MUTATIONS | SIGNALING COMPLEX | CELL BIOLOGY | Inhibitor of Apoptosis Proteins - genetics | Humans | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Receptors, Antigen, B-Cell - metabolism | Ubiquitin-Protein Ligases - physiology | Inhibitor of Apoptosis Proteins - physiology | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Ubiquitination - drug effects | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Neoplasm Proteins - genetics | B-Lymphocytes - metabolism | Triazoles - therapeutic use | NF-kappa B - antagonists & inhibitors | Dipeptides - therapeutic use | Lymphoma, Large B-Cell, Diffuse - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Mitochondrial Proteins - chemistry | Cell Line, Tumor | Indoles - therapeutic use | Mice, Inbred NOD | Mice | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Neoplasm Proteins - physiology | Ubiquitin-Protein Ligases - antagonists & inhibitors | Baculoviral IAP Repeat-Containing 3 Protein | Lymphoma, Large B-Cell, Diffuse - metabolism | Neoplasm Proteins - metabolism | Caspases - metabolism | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Dipeptides - pharmacology | Guanylate Cyclase - metabolism | Gene Dosage | Mice, SCID | Triazoles - pharmacology | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Animals | Intracellular Signaling Peptides and Proteins - chemistry | B-Cell CLL-Lymphoma 10 Protein | Lymphoma, Large B-Cell, Diffuse - classification | CRISPR-Cas Systems | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Care and treatment | Lymphomas | Ligases | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7664, pp. 413 - 418
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are... 
MELANOMA | T-CELL IMMUNITY | GENE | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | CD94/NKG2A | BLOCKADE | EXPRESSION | PD-1 | HLA-E | Tumor Escape - drug effects | Immunotherapy - methods | Loss of Function Mutation | Tumor Escape - genetics | Genomics | Humans | NF-kappa B - metabolism | Interferons - immunology | Melanoma, Experimental - immunology | T-Lymphocytes - drug effects | Tumor Escape - immunology | Melanoma, Experimental - therapy | Melanoma, Experimental - pathology | Antigen Presentation - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Antigen Presentation - immunology | Unfolded Protein Response | CRISPR-Cas Systems - genetics | Gene Editing | Xenograft Model Antitumor Assays | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Animals | Melanoma, Experimental - genetics | T-Lymphocytes - immunology | Mice | Care and treatment | Analysis | Immunotherapy | Diagnosis | Genetic screening | Methods | Cancer | Animal models | PD-1 protein | Genes | Genomes | Synergism | Proteins | Signal transduction | Clonal deletion | Lymphocytes | Protein folding | Tyrosine | Antigen presentation | NF-κB protein | CRISPR | Melanoma | Medical screening | Patients | Screening | Signaling | Immune checkpoint | PD-L1 protein | Interferon | Genetic testing | Tumors | Protein-tyrosine-phosphatase | PTPN2 protein | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 33, pp. 13745 - 13757
Messenger RNA alternative splicing (AS) regulates the expression of a variety of genes involved in both physiological and pathological processes. AS of the... 
TARGET | PREDICTS | MESSENGER-RNA | VARIANTS | SPECIFICITY | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SURVIVIN-DELTA-EX3 | CELL | EXPRESSION | RNA-Binding Proteins - genetics | Alternative Splicing | Exons | Inhibitor of Apoptosis Proteins - genetics | Humans | Neoplasm Proteins - antagonists & inhibitors | Transplantation, Heterologous | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | RNA Interference | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Gene Deletion | Clone Cells | Inhibitor of Apoptosis Proteins - metabolism | Neoplasm Proteins - genetics | RNA-Binding Proteins - antagonists & inhibitors | RNA, Neoplasm - chemistry | Recombinant Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Mutagenesis, Site-Directed | Response Elements | Recombinant Proteins - chemistry | Zebrafish | Tumor Burden | DNA-Binding Proteins - genetics | Point Mutation | Animals | Adaptor Proteins, Signal Transducing - genetics | CRISPR-Cas Systems | Embryo, Nonmammalian | RNA, Messenger - chemistry | Neoplasm Transplantation - pathology | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Protein Isoforms - antagonists & inhibitors | RNA-Binding Proteins - metabolism | Protein Isoforms - genetics | Index Medicus | survivin | KHDRBS1 | alternative splicing | survivin DEx3 | gene regulation | cancer | cancer biology | Sam68 | Cell Biology
Journal Article
Journal Article