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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 33, pp. 10437 - 10442
Journal Article
NATURE BIOTECHNOLOGY, ISSN 1087-0156, 08/2018, Volume 36, Issue 8, pp. 765 - 765
CRISPR-Cas9 is poised to become the gene editing tool of choice in clinical contexts. Thus far, exploration of Cas9-induced genetic alterations has been... 
CRISPR/CAS9 | SPECIFICITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | EMBRYONIC STEM-CELLS | RNAS | CAS9 | MUTATIONS | NUCLEASES
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, pp. 15178 - 15178
CRISPR-Cas9 screens are powerful tools for high-throughput interrogation of genome function, but can be confounded by nuclease-induced toxicity at both on-and... 
RNA INTERFERENCE | ESSENTIAL GENES | CRISPR-CAS9 NUCLEASES | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | DIGENOME-SEQ | CRISPR/CAS9 SYSTEMS | ENDONUCLEASE CAS9 | MAMMALIAN-CELLS | FUNCTIONAL GENOMICS | REVEALS | Index Medicus
Journal Article
G3: Genes, Genomes, Genetics, ISSN 2160-1836, 05/2018, Volume 8, Issue 5, pp. 1627 - 1635
Genetically engineered mouse models (GEMMs) are powerful tools by which to probe gene function in vivo, obtain insight into disease etiology, and identify... 
Cas9 knock-in | Genome editing | Mouse model | CRISPR/Cas9 | Mouse | Conditional Cas9 | SYSTEM | genome editing | conditional Cas9 mouse | mouse model | GENE | MYC | MOUSE | GENETICS & HEREDITY | Index Medicus
Journal Article
NATURE, ISSN 0028-0836, 08/2017, Volume 548, Issue 7665, pp. 13 - 14
Journal Article
NATURE BIOTECHNOLOGY, ISSN 1087-0156, 06/2014, Volume 32, Issue 6, pp. 569 - 569
Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here we... 
ACTIVATION | ENDONUCLEASE | TALENS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CAS9
Journal Article
Molecular Therapy, ISSN 1525-0016, 05/2017, Volume 25, Issue 5, pp. 1168 - 1186
CRISPR-associated protein 9 (Cas9)-mediated genome editing provides a promising cure for HIV-1/AIDS; however, gene delivery efficiency in vivo remains an... 
genome editing | humanized BLT mice | animal models | viral latency | HIV | AAV | Tg26 mice | gene therapy | Cas9 | gRNA | EFFICIENT DELIVERY | MEDICINE, RESEARCH & EXPERIMENTAL | GENE EDITING TECHNOLOGIES | PACKAGING CAPACITY | LENTIVIRAL VECTORS | ADENOASSOCIATED VIRAL VECTORS | STAPHYLOCOCCUS-AUREUS CAS9 | CRISPR-CAS9 NUCLEASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRISPR/CAS9 SYSTEM | GENETICS & HEREDITY | MODULATES PROLIFERATION | NEURAL PRECURSOR CELLS | Oligonucleotides - genetics | Dependovirus - genetics | Endonucleases - genetics | Staphylococcus aureus - enzymology | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | HIV Long Terminal Repeat | pol Gene Products, Human Immunodeficiency Virus - metabolism | Endonucleases - metabolism | gag Gene Products, Human Immunodeficiency Virus - metabolism | HIV Infections - pathology | Proviruses - genetics | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats | gag Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - genetics | Disease Models, Animal | Genome, Viral | HIV-1 - metabolism | Dependovirus - metabolism | Genetic Vectors - chemistry | HIV Infections - virology | Bacterial Proteins - genetics | Genetic Vectors - metabolism | Mice, Transgenic | HIV-1 - genetics | Proviruses - metabolism | Staphylococcus aureus - chemistry | Oligonucleotides - metabolism | Animals | CRISPR-Cas Systems | HIV Infections - therapy | Bacterial Proteins - metabolism | Gene Editing - methods | Mice | Genetic Therapy - methods | Neuroimaging | Animal models | Bioluminescence | Intravenous administration | Genes | Liver | Clinical trials | Chronic infection | Infections | Genomes | Thymus | Acquired immune deficiency syndrome--AIDS | Efficiency | Transgenic animals | Human immunodeficiency virus--HIV | Bone marrow | Colon | Deoxyribonucleic acid--DNA | Spleen | CRISPR | Gene transfer | Advisors | Transgenic mice | Ribonucleic acid--RNA | Progenitor cells | Polymerase chain reaction | Studies | Genotyping | Neural stem cells | Index Medicus | Original
Journal Article
Plant and Cell Physiology, ISSN 0032-0781, 05/2016, Volume 57, Issue 5, pp. 1058 - 1068
Journal Article