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Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 395 - 402
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1. (IL-1.) and IL-18. AIM2 has been shown to bind DNA and engage the... 
RECOGNITION | TOLL-LIKE RECEPTOR | INDUCIBLE GENES | INNATE IMMUNE-RESPONSE | INFECTION | VACCINIA VIRUS | IMMUNOLOGY | MURINE CYTOMEGALOVIRUS | FRANCISELLA-TULARENSIS | CASPASE-1 ACTIVATION | FAMILY | Tularemia - metabolism | Cytoskeletal Proteins - genetics | Humans | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Multiprotein Complexes - metabolism | Lymphocyte Activation - genetics | Transcription Factors - immunology | Cytokines - genetics | Macrophages - microbiology | DNA-Binding Proteins | DNA Viruses - pathogenicity | Macrophages - pathology | Killer Cells, Natural - virology | Listeriosis - genetics | Signal Transduction - genetics | DNA Virus Infections - genetics | Viral Load - immunology | Mice, Knockout | Macrophages - metabolism | DNA Virus Infections - immunology | Mice | Killer Cells, Natural - metabolism | Multiprotein Complexes - immunology | DNA Virus Infections - metabolism | Caspase 1 - immunology | Killer Cells, Natural - pathology | Signal Transduction - immunology | Macrophages - virology | Listeriosis - immunology | Tularemia - immunology | Killer Cells, Natural - immunology | Nuclear Proteins - genetics | Macrophages - immunology | Cytokines - immunology | Killer Cells, Natural - microbiology | Cell Line | Francisella tularensis - immunology | Listeriosis - metabolism | Cytokines - metabolism | DNA - immunology | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Transcription Factors - genetics | Immunity, Innate | Nuclear Proteins - immunology | Viral Load - genetics | DNA Viruses - immunology | Transcription Factors - metabolism | Animals | Apoptosis Regulatory Proteins | Caspase 1 - genetics | DNA Viruses - growth & development | CARD Signaling Adaptor Proteins | Francisella tularensis - pathogenicity | Bacterial infections | Immune response | Cytomegalovirus infections | Research | DNA viruses | Health aspects | Risk factors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 30, pp. 11181 - 11186
Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion... 
Glaucoma | Reperfusion | Messenger RNA | Ischemia | Toll like receptors | Central nervous system | Retina | Brain damage | Intraocular pressure | Microglia | Retinal ischemia/reperfusion injury | Cell apoptosis | BRAIN-INJURY | MICROGLIA ACTIVATION | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | REPERFUSION INJURY | POPULATIONS | retinal ischemia/reperfusion injury | ANGLE-CLOSURE GLAUCOMA | cell apoptosis | TOLL-LIKE RECEPTORS | CENTRAL-NERVOUS-SYSTEM | MICE | CEREBRAL-ISCHEMIA | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 8 - metabolism | Caspase 1 - metabolism | Interleukin-1beta - genetics | Caspase 8 - genetics | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Eye Proteins - genetics | Glaucoma - metabolism | Disease Models, Animal | Acute Disease | Rats | Toll-Like Receptor 4 - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Inflammasomes - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Eye Proteins - metabolism | Caspase 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | Enzyme Activation - genetics | Glaucoma - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Biological Sciences | reperfusion injury | retinal ischemia
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 36, pp. 24035 - 24048
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Index Medicus | Glycobiology and Extracellular Matrices
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2013, Volume 110, Issue 5, pp. 1851 - 1856
A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila .... 
Cell death | Innate immunity | Inflammasome | PATTERN-RECOGNITION | innate immunity | cell death | inflammasome | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME ACTIVATION | INFECTION | RECEPTORS | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Adaptor Proteins, Vesicular Transport - genetics | Caspase 1 - metabolism | Immunoblotting | Legionella pneumophila - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Necrosis | Caspases - metabolism | Flagellin - genetics | Flagellin - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Receptor, Interferon alpha-beta - genetics | Macrophages - microbiology | Receptor, Interferon alpha-beta - metabolism | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Caspases - genetics | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Macrophages - cytology | Legionella pneumophila - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Host-Pathogen Interactions | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Bone Marrow Cells - microbiology | Legionella pneumophila - physiology | Mice | Enzyme Activation | Mutation | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Apoptosis | Calcium-Binding Proteins - genetics | Legionella pneumophila | Genetic aspects | Research | Macrophages | Properties | Immunological research | Proteins | Bacteria | Medical treatment | Cells | Index Medicus | Biological Sciences
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 665 - 680
Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | GLUCOSE-METABOLISM | ATP-CITRATE LYASE | UCP2 | SEPTIC SHOCK | CELL-GROWTH | CRITICALLY-ILL PATIENTS | INTENSIVE INSULIN THERAPY | CANCER | MITOCHONDRIAL UNCOUPLING PROTEINS | Fatty Acid Synthase, Type I - genetics | Fatty Acid Synthase, Type I - biosynthesis | Lipids - genetics | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Ion Channels - genetics | Caspase 1 - metabolism | Mitochondrial Proteins - genetics | Interleukin-1beta - genetics | Lipids - biosynthesis | Sepsis - pathology | Interleukin-1beta - metabolism | Mitochondrial Proteins - metabolism | Sepsis - metabolism | Macrophages - pathology | Down-Regulation - genetics | Inflammasomes - genetics | Sepsis - genetics | Mice, Knockout | Carrier Proteins - genetics | Enzyme Induction - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Sepsis - chemically induced | Ion Channels - metabolism | Caspase 1 - genetics | Sepsis - therapy | Mice | Uncoupling Protein 2 | Interleukin-18 - genetics | Interleukin-18 - metabolism | Cellular proteins | Immune response | Synthesis | Sepsis | Development and progression | Lipids | Genetic aspects | Properties | Enzymes | Cytokines | Pathogenesis | Mortality | Glucose | Metabolism | Gene expression | Fatty acids | Proteins | Studies | Metabolites | Consent | Rodents | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1745 - 1755
Intracellular pathogens and endogenous danger signals in the cytosol engage NOD-like receptors (NLRs), which assemble inflammasome complexes to activate... 
MEDICINE, RESEARCH & EXPERIMENTAL | ASC | CANDIDA-ALBICANS | PROTEIN | MURAMYL DIPEPTIDE | ENTERICA SEROVAR TYPHIMURIUM | INFECTION | SECRETION | IMMUNOLOGY | CASPASE-1 ACTIVATION | IPAF | CELL-DEATH | Cytoplasmic Structures - genetics | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Salmonella Infections - immunology | Caspase 1 - metabolism | Blood - microbiology | Cytoplasmic Structures - drug effects | Interleukin-1beta - blood | Animal Structures - microbiology | Protein Transport - immunology | Cytoplasmic Structures - immunology | Immunity, Innate - physiology | Interleukin-1beta - metabolism | Flagellin - genetics | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Macrophages - microbiology | Interleukin-1 - metabolism | Interleukin-18 - blood | Salmonella typhimurium - genetics | Salmonella typhimurium - immunology | Membrane Proteins - genetics | Bacterial Proteins - genetics | Mice, Inbred Strains | Caspase Inhibitors | Protein Transport - genetics | Mice, Knockout | Protein Precursors - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Models, Immunological | Animals | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Cysteine Proteinase Inhibitors - pharmacology | Salmonella Infections - microbiology | Mice | Interleukin-18 - metabolism | Calcium-Binding Proteins - genetics | Cytoplasmic Structures - metabolism | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 385 - 393
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1... 
PHAGOSOMAL ESCAPE | ACTIVATION | CASPASE-1 | ASC PYROPTOSOME | IMMUNOLOGY | NF-KAPPA-B | PATHOGEN RECOGNITION | NALP3 INFLAMMASOME | CYTOPLASMIC DNA | CELL-DEATH | PYRIN | L-Lactate Dehydrogenase - metabolism | Tularemia - metabolism | Humans | Protein Multimerization | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Caspase 1 - immunology | Interleukin-1beta - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Multiprotein Complexes - metabolism | L-Lactate Dehydrogenase - immunology | Tularemia - immunology | Calcium Signaling - immunology | Interleukin-1beta - biosynthesis | Nuclear Proteins - genetics | Macrophages - immunology | DNA-Binding Proteins | Interferon Regulatory Factor-3 - immunology | Francisella tularensis - immunology | Macrophages - pathology | Cells, Cultured | Interleukin-1beta - immunology | Nuclear Proteins - metabolism | Immunity, Innate | Nuclear Proteins - immunology | Mice, Knockout | Macrophages - metabolism | Animals | L-Lactate Dehydrogenase - genetics | Caspase 1 - genetics | Interferon Regulatory Factor-3 - metabolism | Francisella tularensis - pathogenicity | Mice | Multiprotein Complexes - immunology | Interleukins | Bacterial proteins | Tularemia | Physiological aspects | Causes of | Genetic aspects | Research | Health aspects | Francisella tularensis | Index Medicus
Journal Article
Lancet, The, ISSN 0140-6736, 2010, Volume 375, Issue 9732, pp. 2143 - 2151
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 738 - 748
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2009, Volume 206, Issue 1, pp. 79 - 87
Influenza virus infection is recognized by the innate immune system through Toll like receptor (TLR) 7 and retinoic acid inducible gene I. These two... 
MEDICINE, RESEARCH & EXPERIMENTAL | STRANDED-RNA | DYING CELLS | HUMAN MACROPHAGES | INTERLEUKIN-1-BETA | INFECTION | IMMUNOLOGY | A-VIRUS | CASPASE-1 ACTIVATION | CRYOPYRIN/NALP3 | T-CELLS | NALP3 INFLAMMASOME | CD8-Positive T-Lymphocytes - cytology | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Receptors, Interleukin-1 - genetics | Immunity, Innate - genetics | Cell Movement - genetics | Orthomyxoviridae - immunology | Orthomyxoviridae Infections - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Movement - immunology | Lung - virology | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Lung - metabolism | Dendritic Cells - virology | Dendritic Cells - metabolism | Macrophages, Alveolar - immunology | Macrophages, Alveolar - virology | Antibody Formation - immunology | Immunity, Cellular - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Mice, Knockout | Carrier Proteins - genetics | Immunity, Cellular - immunology | Immunity, Innate - immunology | Immunoglobulin Isotypes - blood | Animals | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Survival Analysis | Nasal Lavage Fluid - immunology | Immunoglobulin Isotypes - immunology | Mice | Macrophages, Alveolar - metabolism | CD8-Positive T-Lymphocytes - immunology | Orthomyxoviridae Infections - virology | Lung - immunology | Orthomyxoviridae Infections - immunology | Calcium-Binding Proteins - genetics | Multiprotein Complexes - immunology | Index Medicus | Brief Definitive Reports
Journal Article
Diabetes, ISSN 0012-1797, 03/2016, Volume 65, Issue 3, pp. 610 - 618
The innate immune cell sensor leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome controls the activation of caspase-1, and the... 
ACTIVATION | ADIPOCYTES | METABOLISM | ADIPONECTIN | CERAMIDE CONTENT | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | NLRP3 INFLAMMASOME | HEPATIC STEATOSIS | EXPRESSION | INDUCED INSULIN-RESISTANCE | Fatty Acid Synthase, Type I - genetics | Sirtuin 1 - metabolism | Glucose Transporter Type 4 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Obesity - immunology | Humans | Leptin - metabolism | Caspase 1 - metabolism | Male | Gene Expression Profiling | Interleukin-1beta - genetics | PPAR gamma - metabolism | Sirtuin 1 - genetics | Acetyl-CoA Carboxylase - genetics | Subcutaneous Fat - immunology | Subcutaneous Fat - metabolism | Lipogenesis - genetics | Interleukin-1beta - metabolism | Adiponectin - genetics | Adiponectin - metabolism | Female | Adipogenesis - genetics | Child | Lipoprotein Lipase - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | Glucose Transporter Type 4 - genetics | Inflammasomes | Lipoprotein Lipase - genetics | Down-Regulation | Insulin Resistance | Toll-Like Receptor 4 - genetics | Intra-Abdominal Fat - metabolism | Fatty Acid Synthase, Type I - metabolism | Subcutaneous Fat - pathology | Toll-Like Receptor 4 - metabolism | Abdomen | Obesity - metabolism | Carrier Proteins - genetics | Magnetic Resonance Imaging | Sterol Regulatory Element Binding Protein 1 - genetics | Caspase 1 - genetics | Adolescent | Intra-Abdominal Fat - pathology | Acetyl-CoA Carboxylase - metabolism | Adipose tissues | Overweight persons | Care and treatment | Inflammation | Research | Health aspects | Tissue | Insulin resistance | Nuclear magnetic resonance--NMR | Diabetes | Cytokines | Index Medicus | Abridged Index Medicus | Metabolism
Journal Article