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The Journal of immunology (1950), ISSN 1550-6606, 04/2015, Volume 194, Issue 8, pp. 3829 - 3839
We have examined the molecular pathways involved in the adjuvant action of cholera toxin (CT) and two novel nontoxic molecules, multiple-mutated CT (mmCT) and... 
Life Sciences & Biomedicine | Immunology | Science & Technology | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | Adjuvants, Immunologic - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Interleukin-1beta - immunology | Male | Caspase 1 - immunology | Enzyme Activation - drug effects | Enzyme Activation - immunology | Signal Transduction - immunology | Signal Transduction - drug effects | Calcium-Binding Proteins - immunology | Cyclic AMP-Dependent Protein Kinases - immunology | Cyclic AMP - immunology | Inflammasomes - immunology | Adaptor Proteins, Signal Transducing - immunology | Th17 Cells - immunology | Adult | Female | Th17 Cells - cytology | Cholera Toxin - pharmacology | Carrier Proteins - immunology | Index Medicus | Abridged Index Medicus | Calcium-Binding Proteins/immunology | Signal Transducing/immunology | Apoptosis Regulatory Proteins/immunology | Cyclic AMP/ immunology | Enzyme Activation/drug effects/immunology | Adjuvants | Immunologi inom det medicinska området | Interleukin-1beta/ immunology | Adaptor Proteins | Th17 Cells/cytology/ immunology | Signal Transduction/ drug effects/immunology | Caspase 1/immunology | Carrier Proteins/immunology | Cholera Toxin/ pharmacology | Cyclic AMP-Dependent Protein Kinases/ immunology | CARD Signaling Adaptor Proteins/immunology | Immunologic/ pharmacology | Immunology in the medical area | Inflammasomes/ immunology
Journal Article
Nature immunology, ISSN 1529-2916, 06/2014, Volume 15, Issue 8, pp. 727 - 737
Journal Article
Nature immunology, ISSN 1529-2916, 04/2012, Volume 13, Issue 5, pp. 449 - 456
...) or commensals but constitutively expressed the precursor to interleukin 1 beta (pro-IL-1 beta). After infection with pathogenic Salmonella or Pseudomonas, intestinal... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Inflammasomes - metabolism | Humans | Receptors, Interleukin-1 - genetics | Salmonella Infections - genetics | Salmonella Infections - immunology | Clonal Anergy | Caspase 1 - metabolism | Monocytes - metabolism | Monocytes - immunology | Intestines - immunology | Host-Pathogen Interactions - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Tumor Necrosis Factor-alpha - immunology | Apoptosis Regulatory Proteins - genetics | Pseudomonas - immunology | Toll-Like Receptors - metabolism | Neutrophil Infiltration - immunology | Neutrophils - pathology | Apoptosis Regulatory Proteins - immunology | Flagellin - immunology | Receptors, Interleukin-1 - immunology | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Neutrophils - immunology | Salmonella - genetics | Signal Transduction - genetics | Phagocytes - immunology | Neutrophil Infiltration - genetics | Mice, Knockout | Pseudomonas Infections - immunology | Salmonella - immunology | Animals | Intestines - microbiology | Phagocytes - microbiology | Inflammasomes - immunology | Interleukin-6 - immunology | Interleukin-6 - biosynthesis | Mice | Mice, Inbred BALB C | Tumor Necrosis Factor-alpha - biosynthesis | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
... disorders by facilitating the secretion of proinflammatory cytokines (1). Core components of each inflammasome are pro-caspase-1 and a cytosolic pattern-recognition... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases | Index Medicus
Journal Article
Clinical and experimental immunology, ISSN 0009-9104, 10/2011, Volume 166, Issue 1, pp. 1 - 15
Summary While interleukin (IL)‐1β plays an important role in combating the invading pathogen as part of the innate immune response, its dysregulation is responsible for a number of autoinflammatory disorders. Large IL‐1β... 
infections | NLRP3 | interleukin‐1 | innate immunity | inflammasome | Innate immunity | Interleukin-1 | Infections | Inflammasome | Life Sciences & Biomedicine | Immunology | Science & Technology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Enzyme Precursors - genetics | Gout - drug therapy | Mycoses - microbiology | Caspase 1 - metabolism | Virus Diseases - virology | Caspase 1 - immunology | Interleukin-1beta - genetics | Signal Transduction - immunology | Bacterial Infections - immunology | Inflammation - drug therapy | Interleukin-1beta - metabolism | Diabetes Mellitus, Type 2 - immunology | Gout - immunology | Hereditary Autoinflammatory Diseases - pathology | Bacterial Infections - microbiology | Carrier Proteins - immunology | Molecular Targeted Therapy - methods | Virus Diseases - immunology | Anti-Inflammatory Agents - pharmacology | Enzyme Precursors - immunology | Gene Expression Regulation | Hereditary Autoinflammatory Diseases - immunology | Interleukin-1beta - immunology | Mice, Transgenic | Inflammation - immunology | Immunity, Innate | Hereditary Autoinflammatory Diseases - drug therapy | Inflammasomes - genetics | Neoplasms - drug therapy | Carrier Proteins - genetics | Enzyme Precursors - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Gout - pathology | Neoplasms - immunology | Inflammasomes - immunology | Mice | Diabetes Mellitus, Type 2 - pathology | Enzyme Activation | Diabetes Mellitus, Type 2 - drug therapy | Neoplasms - pathology | Mycoses - immunology | Medical research | Immune system | Index Medicus | Infection | Pathogens | Immune response | Diabetes mellitus | Gout | Interleukin 1 | Cancer | Caspase-1 | interleukin-1 | Review
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 03/2014, Volume 192, Issue 6, pp. 2837 - 2845
Inflammation is associated with development of atherosclerosis, and cholesterol crystals (CC) have long been recognized as a hallmark of atherosclerotic... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Complement C1q - immunology | Humans | Complement Pathway, Classical - drug effects | Complement C5a - metabolism | Complement System Proteins - immunology | Caspase 1 - metabolism | Monocytes - metabolism | Caspase 1 - immunology | Macrophage-1 Antigen - immunology | Monocytes - immunology | Interleukin-1beta - genetics | Complement Activation - immunology | Complement C1q - metabolism | Complement System Proteins - metabolism | Inflammasomes - drug effects | Reactive Oxygen Species - immunology | Complement C5 - immunology | Tumor Necrosis Factor-alpha - immunology | Macrophage-1 Antigen - metabolism | Complement Activation - drug effects | Cytokines - immunology | Interleukin-1beta - secretion | Complement C5 - metabolism | Tumor Necrosis Factor-alpha - secretion | Cells, Cultured | Cytokines - secretion | Phagocytosis - immunology | Interleukin-1beta - immunology | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Monocytes - drug effects | Complement Pathway, Classical - immunology | Microscopy, Confocal | Complement Pathway, Alternative - drug effects | Complement Pathway, Alternative - immunology | Inflammasomes - immunology | Cholesterol - pharmacology | Complement C5a - immunology | Index Medicus | Abridged Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0175153 - e0175153
...Author(s): Stephanie Zwicker 1,2, Eva Hattinger 1, Daniela Bureik 1, Aleksandra Batycka-Baran 1,3, Andreas Schmidt 4, Peter-Arne Gerber 5, Simon Rothenfusser 4... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Caspases - immunology | Humans | Interleukin-17 - immunology | Interleukin-17 - pharmacology | Interleukin-1beta - genetics | S100 Proteins - immunology | Psoriasis - genetics | S100 Proteins - genetics | Th17 Cells - drug effects | Transfection | Inflammasomes - drug effects | Psoriasis - pathology | Adaptor Proteins, Signal Transducing - immunology | Apoptosis Regulatory Proteins - genetics | Skin - pathology | Skin - immunology | Th17 Cells - pathology | Interleukin-1beta - secretion | Psoriasis - immunology | S100 Calcium Binding Protein A7 | Apoptosis Regulatory Proteins - immunology | DNA - immunology | Signal Transduction | Caspases - genetics | Cells, Cultured | Gene Expression Regulation | Interleukin-17 - genetics | Interleukin-1beta - immunology | Vitamin D - pharmacology | Keratinocytes - cytology | Keratinocytes - immunology | DNA - genetics | Interleukin-17 - antagonists & inhibitors | Keratinocytes - drug effects | Inflammasomes - immunology | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Interferon-gamma - pharmacology | Interleukins | Physiological aspects | Development and progression | Skin diseases | Genetic aspects | Inflammation | Research | Cell culture | Transcription | Interleukin | Helper cells | Lymphocytes T | Inflammatory diseases | Vitamin D | Lymphocytes | Interleukin 1 | Lesions | Deoxyribonucleic acid--DNA | Psoriasis | Cytokines | Dermatology | Keratinocytes | Caspase | Epidermis | Hazards | Gene expression | Caspase-5 | Hospitals | Biopsy | Interferon | Autoimmune diseases | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article