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Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 36, pp. 24035 - 24048
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Glycobiology and Extracellular Matrices
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5719
Journal Article
Nature Immunology, ISSN 1529-2908, 2013, Volume 14, Issue 5, pp. 480 - 488
NOD2 receptor and the cytosolic protein kinase RIPK2 regulate NF-kappaB and MAP kinase signaling during bacterial infections, but the role of this immune axis... 
LISTERIA-MONOCYTOGENES | IMMUNE-RESPONSE | 1918 INFLUENZA-VIRUS | DOUBLE-STRANDED-RNA | IFN-GAMMA PRODUCTION | DENDRITIC CELLS | IL-1-BETA PRODUCTION | INNATE | AUTOPHAGY | IMMUNOLOGY | CD8(+) T-CELLS | Immune response | Influenza | Physiological aspects | Causes of | Genetic aspects | Cellular signal transduction | Research | Protein kinases | mitophagy | autophagy | RIPK2 | NLR | inflammasome | IL-18 | Caspase-1
Journal Article
Lancet, The, ISSN 0140-6736, 2010, Volume 375, Issue 9732, pp. 2143 - 2151
Journal Article
STEM CELLS, ISSN 1066-5099, 10/2012, Volume 30, Issue 10, pp. 2283 - 2296
Culturing cells in three dimension (3D) provides an insight into their characteristics in vivo. We previously reported that human mesenchymal stem/stromal... 
Sphere | Caspase | COX2 | MSC | LPS | Macrophage | PROTEIN TSG-6 | STEM-CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | IN-VITRO | MSCS | BACTERIAL CLEARANCE | ONCOLOGY | HUMAN BONE-MARROW | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INFLAMMATION | ENDOTHELIAL-CELLS | TNF-ALPHA | HEMATOLOGY | MARROW STROMAL CELLS | Mannose-Binding Lectins - metabolism | RNA, Small Interfering - genetics | Humans | NF-kappa B - metabolism | Spheroids, Cellular - cytology | Lectins, C-Type - genetics | Lectins, C-Type - metabolism | Dinoprostone - isolation & purification | Mesenchymal Stromal Cells - cytology | Caspases - metabolism | Cyclooxygenase 2 - genetics | Spheroids, Cellular - drug effects | Cell Culture Techniques | Fibroblasts - metabolism | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Receptors, Prostaglandin E, EP4 Subtype - genetics | Dinoprostone - pharmacology | Mesenchymal Stromal Cells - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Caspases - genetics | Spheroids, Cellular - metabolism | Mesenchymal Stromal Cells - metabolism | Receptors, Cell Surface - metabolism | Antibodies - pharmacology | Gene Expression Regulation - drug effects | Culture Media, Conditioned | Macrophages - metabolism | Mannose-Binding Lectins - genetics | NF-kappa B - genetics | Signal Transduction - drug effects | Fibroblasts - drug effects | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Dinoprostone - antagonists & inhibitors | Macrophage Activation - drug effects | Cytokines - biosynthesis | Receptors, Cell Surface - genetics | Anti-inflammatory drugs | RNA | Analysis | Prostaglandins E | Stem cells | Genetic aspects | Information management | Macrophages | Cytokines | Genotype & phenotype | Molecular weight | Antibodies | macrophage | spheroid | caspase
Journal Article
Cancer, ISSN 0008-543X, 01/2018, Volume 124, Issue 1, pp. 84 - 94
Head and neck squamous cell carcinoma in patients infected with human immunodeficiency virus (HIV) shows a specific pattern of DNA mutations in comparison with... 
human papillomavirus (HPV) | mutation | head and neck cancer | human immunodeficiency virus (HIV) | gene | TP53 | TP53 gene | UNITED-STATES | HIV/AIDS | POPULATION | HUMAN-PAPILLOMAVIRUS | HIV PATIENTS | P53 | P53-MEDIATED APOPTOSIS | BREAST-CANCER | CIGARETTE-SMOKING | ONCOLOGY | INFECTION | Receptors, Transforming Growth Factor beta - genetics | Class I Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | ErbB Receptors - genetics | Male | Receptor, Notch2 - genetics | Case-Control Studies | Papillomaviridae - genetics | Tumor Suppressor Protein p53 - genetics | Caspase 8 - genetics | Kelch-Like ECH-Associated Protein 1 - genetics | F-Box-WD Repeat-Containing Protein 7 - genetics | Squamous Cell Carcinoma of Head and Neck | In Situ Hybridization | Receptor, Transforming Growth Factor-beta Type II | Tumor Suppressor Proteins - genetics | Adult | Female | NF-E2-Related Factor 2 - genetics | Cadherins - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Papillomavirus Infections - complications | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | Cyclin-Dependent Kinase Inhibitor p18 - genetics | Cyclin D1 - genetics | Carcinoma, Squamous Cell - complications | HIV Infections - complications | HLA-A Antigens - genetics | Head and Neck Neoplasms - complications | Head and Neck Neoplasms - genetics | LIM Domain Proteins - genetics | Aged | Receptor, Notch1 - genetics | Multiplexing | Pathogenesis | Exons | p53 Protein | Genes | Viruses | Genomes | Infections | Cdc4 protein | Gene sequencing | Biological effects | Human papillomavirus | Human immunodeficiency virus--HIV | Neck | Deoxyribonucleic acid--DNA | Head | Squamous cell carcinoma | Nucleotide sequence | Epidermal growth factor receptors | Data processing | Patients | Polymerase chain reaction | Head and neck cancer | Histocompatibility antigen HLA | Mutation | Tumors | DNA sequencing | Cancer
Journal Article
by Burk, Robert D and Chen, Zigui and Saller, Charles and Tarvin, Katherine and Carvalho, Andre L and Scapulatempo-Neto, Cristovam and Silveira, Henrique C and Fregnani, José H and Creighton, Chad J and Anderson, Matthew L and Castro, Patricia and Wang, Sophia S and Yau, Christina and Benz, Christopher and Gordon Robertson, A and Mungall, Karen and Lim, Lynette and Bowlby, Reanne and Sadeghi, Sara and Brooks, Denise and Sipahimalani, Payal and Mar, Richard and Ally, Adrian and Clarke, Amanda and Mungall, Andrew J and Tam, Angela and Lee, Darlene and Chuah, Eric and Schein, Jacqueline E and Tse, Kane and Kasaian, Katayoon and Ma, Yussanne and Marra, Marco A and Mayo, Michael and Balasundaram, Miruna and Thiessen, Nina and Dhalla, Noreen and Carlsen, Rebecca and Moore, Richard A and Holt, Robert A and Jones, Steven J. M and Wong, Tina and Pantazi, Angeliki and Parfenov, Michael and Kucherlapati, Raju and Hadjipanayis, Angela and Seidman, Jonathan and Kucherlapati, Melanie and Ren, Xiaojia and Xu, Andrew W and Yang, Lixing and Park, Peter J and Lee, Semin and Rabeno, Brenda and Huelsenbeck-Dill, Lori and Borowsky, Mark and Cadungog, Mark and Iacocca, Mary and Petrelli, Nicholas and Swanson, Patricia and Ojesina, Akinyemi I and Ojesina, Akinyemi I and Ojesina, Akinyemi I and Le, Xuan and Sandusky, George and Adebamowo, Sally N and Akeredolu, Teniola and Adebamowo, Clement and Reynolds, Sheila M and Shmulevich, Ilya and Shelton, Candace and Crain, Daniel and Mallery, David and Curley, Erin and Gardner, Johanna and Penny, Robert and Morris, Scott and Shelton, Troy and Liu, Jia and Lolla, Laxmi and Chudamani, Sudha and Wu, Ye and Birrer, Michael and McLellan, Michael D and Bailey, Matthew H and Miller, Christopher A and Wyczalkowski, Matthew A and Fulton, Robert S and Fronick, Catrina C and Lu, Charles and Mardis, Elaine R and Appelbaum, Elizabeth L and Schmidt, Heather K and Fulton, Lucinda A and Cordes, Matthew G and Li, Tiandao and Ding, Li and Wilson, Richard K and Rader, Janet S and Behmaram, Behnaz and ... and Canc Genome Atlas Res Network and Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University and Research Institute at Nationwide Children's Hospital and University of Alabama at Birmingham and McDonnell Genome Institute at Washington University and Washington University in St Louis and University of Wisconsin School of Medicine &Public Health and National Hospital, Abuja, Nigeria and Baylor College of Medicine and Barretos Cancer Hospital and Indiana University School of Medicine and Ontario Tumour Bank, The Ottawa Hospital and Massachusetts General Hospital and University of New Mexico Health Sciences Center and National Institute on Deafness &Other Communication Disorders and University of North Carolina at Chapel Hill and Buck Institute for Research on Aging and Cancer Genome Atlas Research Network and Medical College of Wisconsin and University of Abuja Teaching Hospital and University of Oklahoma Health Sciences Center and Institute of Human Virology and St Joseph's Candler Health System and University of Pittsburgh and University of Texas MD Anderson Cancer Center and National Cancer Institute and Montefiore Medical Center and University of Southern California and Institute for Systems Biology and University of Washington and Analytical Biological Services and Harvard Medical School and National Human Genome Research Institute and Memorial Sloan Kettering Cancer Center and Medical University of South Carolina and Ontario Tumour Bank, London Health Sciences Centre and SRA International and University of Kansas Medical Center and University of Lausanne and ILSbio, LLC and University of Bergen and University of California, Irvine and Canada's Michael Smith Genome Sciences Centre and International Genomics Consortium and Oregon Health &Science University and NantOmics and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University and University of São Paulo, Ribeir ão Preto Medical School and HudsonAlpha Institute for Biotechnology and Albert Einstein College of Medicine and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center and National Institute of Environmental Health Sciences and Van Andel Research Institute and Ontario Tumour Bank, Ontario Institute for Cancer Research and University of California Santa Cruz and Beckman Research Institute of City of Hope and Leidos Biomedical and Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7645, pp. 378 - 384
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary... 
EPITHELIAL-MESENCHYMAL-TRANSITION | TRANSCRIPTION FACTORS | BREAST-CANCER | ACCURATE | DNA METHYLATION | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | 14-3-3-SIGMA | RESISTANCE | EXPRESSION | SIGNATURE | Receptors, Transforming Growth Factor beta - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Squamous Cell - genetics | Genomics | Humans | APOBEC-1 Deaminase - genetics | Phosphatidylinositol 3-Kinases - metabolism | Molecular Targeted Therapy | Caspase 8 - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Human papillomavirus 16 - isolation & purification | Receptor, Transforming Growth Factor-beta Type II | Female | Adenocarcinoma - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | PTEN Phosphohydrolase - genetics | Signal Transduction | Programmed Cell Death 1 Ligand 2 Protein - genetics | Protein-Serine-Threonine Kinases - genetics | Uterine Cervical Neoplasms - drug therapy | RNA, Long Noncoding - genetics | Receptor, ErbB-3 - genetics | Transcription Factors - genetics | Uterine Cervical Neoplasms - genetics | Virus Integration | B7-H1 Antigen - genetics | Receptors, Transforming Growth Factor beta - metabolism | HLA-A Antigens - genetics | Proteomics | Mutation | Keratins - genetics | Human papillomavirus 16 - genetics | Uterine Cervical Neoplasms - classification | Causes of | Care and treatment | Genetic aspects | Gene mutations | Health aspects | Cervical cancer | Human papillomavirus | Gynecology | Molecular biology | Cancer therapies | Tumors | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 451 - 462
Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through... 
LISTERIA-MONOCYTOGENES | CYTOCHROME-C | MESSENGER-RNA | BRUCELLA-ABORTUS | INDUCED APOPTOSIS | ER STRESS | THIOREDOXIN-INTERACTING PROTEIN | SECRETION | IMMUNOLOGY | TRANSCRIPTION FACTOR | CELL-DEATH | Caspase 2 - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Brucella abortus - physiology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Caspase 2 - metabolism | Mitochondria - immunology | Endoplasmic Reticulum Stress - genetics | Endoplasmic Reticulum Stress - immunology | Caspase 2 - immunology | Host-Pathogen Interactions - immunology | DNA-Binding Proteins - metabolism | Mitochondria - genetics | Brucella abortus - immunology | Interleukin-1beta - metabolism | Reactive Oxygen Species - immunology | HEK293 Cells | Transcription Factors - immunology | BH3 Interacting Domain Death Agonist Protein - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Protein-Serine-Threonine Kinases - metabolism | RNA Interference - immunology | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Interleukin-1beta - immunology | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Regulatory Factor X Transcription Factors | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | BH3 Interacting Domain Death Agonist Protein - immunology | Protein-Serine-Threonine Kinases - immunology | Endoribonucleases - immunology | Medical colleges | Stress (Physiology) | Mitochondrial DNA | Analysis | Cytochrome | Bacterial infections | Dehydrogenases | Infections | Inflammation | Proteins | Studies | Mitochondria | Rodents | Ligands | Endoplasmic reticulum | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article