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Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
OBJECTIVE—Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and... 
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2009, Volume 131, Issue 11, pp. 3828 - 3829
We demonstrate the use of a hybrid fluorescent protein semiconductor quantum dot (QD) sensor capable of specifically monitoring caspase 3 proteolytic activity.... 
APOPTOSIS | PEPTIDES | RESONANCE ENERGY-TRANSFER | FRET | INHIBITORS | CANCER | CHEMISTRY, MULTIDISCIPLINARY | PROBES | PAIRS | Quantum Dots | Caspase 3 - metabolism | Protein Engineering | Caspase 3 - analysis | Fluorescence Resonance Energy Transfer | Bacterial Proteins - analysis | Luminescent Proteins | Fluorescence | Energy transformation | Proteolysis | Analysis | Quantum electrodynamics
Journal Article
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 09/2010, Volume 62, Issue 9, pp. 1128 - 1136
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31783
3,3'-diindolylmethane (DIM), one of the active products derived from Brassica plants, is a promising antitumor agent. The present study indicated that DIM... 
BREAST-CANCER CELLS | PROTEIN-KINASE B/AKT | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | INHIBITION | PATHWAY | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | CYCLE ARREST | INDOLE-3-CARBINOL | Leukemia - pathology | Apoptosis - drug effects | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Dose-Response Relationship, Drug | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Cytoprotection - drug effects | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Leukemia - enzymology | Leukemia - drug therapy | Morpholines - pharmacology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Mice, SCID | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Animals | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Indoles - therapeutic use | Mice | Drug Screening Assays, Antitumor | Research | Oncology, Experimental | Cancer | Apoptosis | Cytochrome | Oxidative stress | Regulations | Transcription factors | Phosphorylation | Leukemia | Xenotransplantation | Leukocytes (mononuclear) | AKT protein | Lethality | Activation | Kinases | Inactivation | Anticancer properties | Proteins | Signal transduction | Toxicology | Cell activation | Cell growth | Xenografts | Cell cycle | Bone marrow | Drug dosages | Deactivation | Cytokines | Hematology | Cyclin-dependent kinases | Caspase | JNK protein | Pharmacology | Breast cancer | Tumor cell lines | Metabolism | Mcl-1 protein | 1-Phosphatidylinositol 3-kinase | Medicine | Brassica | Cyclin-dependent kinase inhibitor p21 | Pharmacy | Cell lines | Acute myeloid leukemia
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 12/2018, Volume 45, Issue 13, pp. 2285 - 2299
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 12/2017, Volume 21, Issue 12, pp. 3540 - 3551
Endothelial injury or dysfunction is an early event in the pathogenesis of atherosclerosis. Epidemiological and animal studies have shown that 2, 3, 7,... 
apoptosis | EP3 | Bcl‐2 | dioxin | p38 MAPK | endothelial cell | Bcl-2 | MEDICINE, RESEARCH & EXPERIMENTAL | TCDD-INDUCED APOPTOSIS | ATHEROSCLEROSIS | RECEPTOR | PROLIFERATION | INCREASES APOPTOSIS | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | CELL BIOLOGY | SIGNALING PATHWAY | GENE-EXPRESSION | DYSFUNCTION | E-DEFICIENT MICE | RNA, Small Interfering - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Endothelium, Vascular - drug effects | Re-Epithelialization - physiology | Dose-Response Relationship, Drug | Femoral Artery - injuries | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cyclooxygenase 2 - genetics | Caspase 3 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Environmental Pollutants - toxicity | Dinoprostone - agonists | Receptors, Prostaglandin E, EP3 Subtype - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Receptors, Prostaglandin E, EP3 Subtype - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Mice, Knockout | Dinoprostone - metabolism | Animals | Endothelium, Vascular - metabolism | Receptors, Prostaglandin E, EP3 Subtype - antagonists & inhibitors | Cyclooxygenase 2 - metabolism | Polychlorinated Dibenzodioxins - toxicity | Endothelium, Vascular - pathology | Human Umbilical Vein Endothelial Cells - pathology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Herbicides | COX-2 inhibitors | Enzymes | Dioxin | Prostaglandins E | Atherosclerosis | Genetic engineering | Epidemiology | Apoptosis | Endothelium | Phosphorylation | Femur | Femoral artery | Bcl-2 protein | Pathogenesis | Prostaglandin E2 | TCDD | Dioxins | Activation | Caspase-3 | Prostaglandin endoperoxide synthase | Cell activation | Rodents | Inhibition | Heart diseases | Injuries | Caspase | MAP kinase | Pharmacology | Exposure | Morbidity | Endothelial cells | Gene silencing | Cyclooxygenase-1 | Arteriosclerosis | Cyclooxygenase-2 | Cardiovascular diseases | Umbilical vein | Original
Journal Article