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PloS one, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e96239
...-Oncology, Departments of Neurology, Microbiology, and Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, United... 
GLIOMA-CELLS | CANCER-CELLS | GROWTH-FACTOR RECEPTOR | NERVOUS-SYSTEM | IN-VITRO | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | AKT PATHWAY | SPHEROID CULTURES | PRECURSOR CELLS | BRAIN-TUMORS | Neoplastic Stem Cells - cytology | Caspase 9 - genetics | Caspase 9 - metabolism | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | Glycoproteins - metabolism | Peptides - genetics | 3' Untranslated Regions - genetics | Cell Survival - genetics | MicroRNAs - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Flow Cytometry | Peptides - metabolism | Bcl-2-Like Protein 11 | Glioblastoma - genetics | Neoplastic Stem Cells - metabolism | Caspase 3 - genetics | Apoptosis Regulatory Proteins - genetics | Glioblastoma - metabolism | Membrane Proteins - metabolism | Cell Survival - physiology | Glycoproteins - genetics | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Proto-Oncogene Proteins - genetics | AC133 Antigen | Apoptosis Regulatory Proteins - metabolism | Cell Line, Tumor | MicroRNAs - genetics | DNA microarrays | MicroRNA | Analysis | Luciferase | Stem cells | Glioblastoma multiforme | Apoptosis | Brain | Flow cytometry | Brain tumors | Brain cancer | Glioblastoma | Fluorescence | Oncology | Biochemistry | Neurosurgery | Caspase-3 | Cancer therapies | Genetics | miRNA | Cell survival | Caspase | siRNA | Ribonucleic acid--RNA | Survival | Neurology | Brain research | Mutagenesis | 3' Untranslated regions | Cell number | MicroRNAs | Caspase-9 | Neural stem cells | Annexin V | BIM protein | Cancer | Tumors | RNA | Ribonucleic acid
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 11/2008, Volume 283, Issue 48, pp. 33394 - 33405
Micro-RNAs are similar to 21-25-nucleotide-long noncoding RNAs that regulate gene expression primarily at the post-transcriptional level in animals. Here, we... 
SURVIVAL | C/EBP-ALPHA | MICRORNA FUNCTION | THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | TUMOR-SUPPRESSOR | TARGETS | DEGRADATION | HUMAN HEPATOCELLULAR CARCINOMAS | EXPRESSION | Lung Neoplasms - drug therapy | Histone Deacetylases - biosynthesis | Antibiotics, Antineoplastic - pharmacology | Caspase 7 - biosynthesis | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Apoptosis - genetics | MicroRNAs - metabolism | Proto-Oncogene Proteins - biosynthesis | RNA, Neoplasm - metabolism | Receptors, Growth Factor - genetics | Caspase 3 - genetics | Caspase 3 - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Lung Neoplasms - genetics | Forkhead Transcription Factors - biosynthesis | Histone Deacetylases - genetics | Caspase 7 - genetics | Cell Survival | Proto-Oncogene Proteins c-met | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Poly(ADP-ribose) Polymerases - biosynthesis | Down-Regulation - drug effects | Forkhead Transcription Factors - genetics | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Down-Regulation - genetics | Animals | Poly(ADP-ribose) Polymerases - genetics | Repressor Proteins - biosynthesis | Mice, Nude | Myeloid Cell Leukemia Sequence 1 Protein | Receptors, Growth Factor - biosynthesis | Cell Line, Tumor | Proto-Oncogene Proteins c-pim-1 - genetics | RNA, Neoplasm - genetics | Mice | MicroRNAs - genetics | Poly (ADP-Ribose) Polymerase-1 | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-pim-1 - biosynthesis | Doxorubicin - pharmacology | Cell Movement | RNA-Mediated Regulation and Noncoding Rnas
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 7/2014, Volume 111, Issue 30, pp. 11181 - 11186
Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion... 
Glaucoma | Reperfusion | Messenger RNA | Ischemia | Toll like receptors | Central nervous system | Retina | Brain damage | Intraocular pressure | Microglia | Retinal ischemia/reperfusion injury | Cell apoptosis | BRAIN-INJURY | MICROGLIA ACTIVATION | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | REPERFUSION INJURY | POPULATIONS | retinal ischemia/reperfusion injury | ANGLE-CLOSURE GLAUCOMA | cell apoptosis | TOLL-LIKE RECEPTORS | CENTRAL-NERVOUS-SYSTEM | MICE | CEREBRAL-ISCHEMIA | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 8 - metabolism | Caspase 1 - metabolism | Interleukin-1beta - genetics | Caspase 8 - genetics | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Eye Proteins - genetics | Glaucoma - metabolism | Disease Models, Animal | Acute Disease | Rats | Toll-Like Receptor 4 - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Inflammasomes - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Eye Proteins - metabolism | Caspase 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | Enzyme Activation - genetics | Glaucoma - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Biological Sciences | reperfusion injury | retinal ischemia
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2016, Volume 290, pp. 43 - 53
Fibroblast growth factor 21 (FGF-21) is a secreted protein, which has anti-diabetic and lipocaic effects, but its ability to protect against hepatic fibrosis... 
NF-κB | Hepatic stellate cells | TGF-β | Fibroblast growth factor 21 | Hepatic fibrogenesis | FIBROSIS | PHOSPHORYLATION | MYOFIBROBLAST | MECHANISMS | BETA | TGF-beta | NONALCOHOLIC FATTY LIVER | NF-kappa B | STELLATE CELL APOPTOSIS | INHIBITION | METABOLISM | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION | Apoptosis - drug effects | Actins - metabolism | Caspase 3 - metabolism | Hepatic Stellate Cells - metabolism | Male | NF-kappa B - metabolism | Smad3 Protein - metabolism | Actins - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Smad3 Protein - genetics | Collagen Type I - genetics | Liver - drug effects | Smad2 Protein - genetics | Caspase 3 - genetics | bcl-2-Associated X Protein - genetics | Hepatic Stellate Cells - drug effects | Liver Cirrhosis - drug therapy | Collagen Type I - metabolism | Signal Transduction | Down-Regulation | Hydroxyproline - metabolism | Liver - metabolism | Smad2 Protein - metabolism | bcl-2-Associated X Protein - metabolism | Fibroblast Growth Factors - pharmacology | Mice, Inbred ICR | Animals | Transforming Growth Factor beta - genetics | NF-kappa B - genetics | Liver Cirrhosis - pathology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Transforming Growth Factor beta - metabolism | Dimethylnitrosamine - toxicity | Index Medicus | APOPTOSIS | BORON CHLORIDES | COLLAGEN | ACTIN | HYDROXYPROLINE | 60 APPLIED LIFE SCIENCES | FIBROBLASTS | GROWTH FACTORS | INJECTION | LIVER | ETHANOL | MICE | PLANT GROWTH
Journal Article
Oncogene, ISSN 0950-9232, 01/2009, Volume 28, Issue 4, pp. 509 - 517
Inactivation and silencing of PTEN have been observed in multiple cancers, including follicular thyroid carcinoma. PTEN (phosphatase and tensin homologue... 
Mutations | Mouse model | Thyroid cancer | Pten | Carcinogenesis | TRANSCRIPTION FACTORS | PROTEIN-KINASE-B | LIGAND-BINDING | mouse model | SUPPRESSOR GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | thyroid cancer | PHOSPHOINOSITIDE 3-KINASE | COWDEN-DISEASE | BETA-RECEPTOR | CELL BIOLOGY | mutations | HORMONE | carcinogenesis | ONCOLOGY | GENETICS & HEREDITY | GERMLINE MUTATIONS | RESISTANCE | Cyclin D1 - metabolism | Cell Proliferation | Chromosomes, Mammalian - genetics | Lung Neoplasms - metabolism | Caspase 3 - metabolism | Cell Survival - genetics | Apoptosis - genetics | Lung Neoplasms - pathology | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Thyroid Hormone Receptors beta - genetics | Neoplasm Metastasis | Lung Neoplasms - secondary | Forkhead Transcription Factors - metabolism | Mice, Mutant Strains | Caspase 3 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Lung Neoplasms - genetics | PTEN Phosphohydrolase - genetics | Thyroid Hormone Receptors beta - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Neoplasm Invasiveness | PTEN Phosphohydrolase - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Mice, Transgenic | Phosphotransferases (Alcohol Group Acceptor) - genetics | Signal Transduction - genetics | Forkhead Transcription Factors - genetics | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Phosphatidylinositol 3-Kinases - genetics | Carrier Proteins - genetics | Thyroid Neoplasms - genetics | Animals | Carrier Proteins - metabolism | Cyclin D1 - genetics | NF-kappa B - genetics | Mice | TOR Serine-Threonine Kinases | Chromosomes, Mammalian - metabolism | Enzyme Activation - genetics | Forkhead Box Protein O3 | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Development and progression | Tumor suppressor genes | Cellular signal transduction | Genetic aspects | Research | Health aspects | Risk factors | Oncology | Genetics | Rodents | Thyroid diseases | Tumors | Index Medicus
Journal Article
Journal Article
Carcinogenesis (New York), ISSN 0143-3334, 12/2013, Volume 34, Issue 12, pp. 2918 - 2928
Lung cancer is the leading cause of cancer deaths worldwide and current therapies fail to treat this disease in majority of cases. Antrodia camphorata is a... 
IN-VITRO | ACTIVATION | ANGIOGENESIS | ONCOLOGY | PATHWAY | ADENOCARCINOMA | GROWTH | INHIBITORS | JAK2 | STAT3 EXPRESSION | PROGRESSION | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Caspase 3 - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Apoptosis - genetics | Lactones - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Phosphorylation - genetics | Janus Kinase 2 - metabolism | Caspase 3 - genetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | bcl-2-Associated X Protein - genetics | Lung Neoplasms - genetics | Proto-Oncogene Proteins c-bcr - metabolism | Interleukin-6 - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Janus Kinase 2 - genetics | bcl-2-Associated X Protein - metabolism | Signal Transduction - genetics | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Antrodia - chemistry | Signal Transduction - drug effects | Proto-Oncogene Proteins c-bcr - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | MicroRNAs - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | Sesquiterpenes - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Agaricales - chemistry
Journal Article
Oncology reports, ISSN 1021-335X, 02/2016, Volume 35, Issue 2, pp. 1075 - 1082
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2009, Volume 284, Issue 36, pp. 24035 - 24048
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Glycobiology and Extracellular Matrices
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2013, Volume 110, Issue 5, pp. 1851 - 1856
A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila. Here... 
Cytoskeletal Proteins | Flagellin | Immunoblotting | Legionella pneumophila | Macrophages | Adaptor Proteins, Vesicular Transport | Necrosis | Receptor, Interferon alpha-beta | Caspase 1 | Carrier Proteins | Calcium-Binding Proteins | Cytokines | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 | Mice, Knockout | Host-Pathogen Interactions | Animals | Apoptosis Regulatory Proteins | Bone Marrow Cells | Mice | Caspases | Enzyme Activation | Mutation | Apoptosis | Cell death | Innate immunity | Inflammasome | PATTERN-RECOGNITION | innate immunity | cell death | inflammasome | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME ACTIVATION | INFECTION | RECEPTORS | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Adaptor Proteins, Vesicular Transport - genetics | Caspase 1 - metabolism | Legionella pneumophila - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Caspases - metabolism | Flagellin - genetics | Flagellin - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Receptor, Interferon alpha-beta - genetics | Macrophages - microbiology | Receptor, Interferon alpha-beta - metabolism | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Caspases - genetics | Myeloid Differentiation Factor 88 - genetics | Macrophages - cytology | Legionella pneumophila - metabolism | Apoptosis Regulatory Proteins - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Bone Marrow Cells - microbiology | Legionella pneumophila - physiology | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Calcium-Binding Proteins - genetics | Genetic aspects | Research | Properties | Immunological research | Biological Sciences
Journal Article
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