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PloS one, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e96239 - e96239
Glioblastoma is the most common and lethal primary brain tumor. Tumor initiation and recurrence are likely caused by a sub-population of glioblastoma stem... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplastic Stem Cells - cytology | Caspase 9 - genetics | Caspase 9 - metabolism | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | Glycoproteins - metabolism | Peptides - genetics | 3' Untranslated Regions - genetics | Cell Survival - genetics | MicroRNAs - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Flow Cytometry | Peptides - metabolism | Bcl-2-Like Protein 11 | Glioblastoma - genetics | Neoplastic Stem Cells - metabolism | Caspase 3 - genetics | Apoptosis Regulatory Proteins - genetics | Glioblastoma - metabolism | Membrane Proteins - metabolism | Cell Survival - physiology | Glycoproteins - genetics | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Proto-Oncogene Proteins - genetics | AC133 Antigen | Apoptosis Regulatory Proteins - metabolism | Cell Line, Tumor | MicroRNAs - genetics | DNA microarrays | MicroRNA | Analysis | Luciferase | Stem cells | Glioblastoma multiforme | Apoptosis | Brain | Flow cytometry | Brain tumors | Brain cancer | Glioblastoma | Fluorescence | Oncology | Biochemistry | Neurosurgery | Caspase-3 | Cancer therapies | Genetics | miRNA | Cell survival | Caspase | siRNA | Ribonucleic acid--RNA | Survival | Neurology | Brain research | Mutagenesis | 3' Untranslated regions | Cell number | MicroRNAs | Caspase-9 | Neural stem cells | Annexin V | BIM protein | Cancer | Tumors | Index Medicus | RNA | Ribonucleic acid
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 02/2003, Volume 23, Issue 4, pp. 1428 - 1440
Journal Article
Journal Article
Biochemical journal, ISSN 1470-8728, 06/2007, Volume 405, Issue 1, pp. 11 - 19
During apoptosis, the initiator caspase 9 is activated at the apoptosome after which it activates the executioner caspases 3 and 7 by proteolysis... 
Caspase 3 | Feedback loop | Caspase 9 | Second mitochondrial activator of caspases (Smac) | X-linked inhibitor of apoptosis protein (XIAP) | Apoptosis | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Caspase 9 - genetics | Caspase 9 - metabolism | Humans | Caspase 3 - metabolism | Peptides - genetics | Cysteine Proteinase Inhibitors - metabolism | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | Recombinant Proteins - genetics | Caspase Inhibitors | Thermodynamics | Peptides - metabolism | Mitochondrial Proteins - metabolism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Amino Acid Chloromethyl Ketones - metabolism | Aspartic Acid - metabolism | Apoptosis - physiology | Enzyme Activation | Intracellular Signaling Peptides and Proteins - genetics | Index Medicus | second mitochondrial activator of caspases (Smac) | CARD, caspase recruitment domain | ITC, isothermal titration calorimetry | apoptosis | MVPI, Met-Val-Pro-Ile | bEVD-aomk, biotinylhexanoyl-Asp-Glu-Val-acyloxymethane | caspase 3 | Afc, 7-amido-4-fluoromethylcoumarin | DTT, dithiothreitol | IAP, inhibitor of apoptosis protein | feedback loop | caspase 9 | HRP, horseradish peroxidase | Z-VAD-fmk, benzyloxycarbonyl-Val-Ala-Asp-fluoromethane | AVPI, Ala-Val-Pro-Ile | BIR, baculoviral inhibitory repeat | Smac, second mitochondrial activator of caspases | ICAD, inhibitor-of-caspase-activated DNAse | ABP, affinity-based probe | Apaf-1, apoptotic protease activating factor 1 | pNA, p-nitroanilide | cyt c, cytochrome c | XIAP, X-linked IAP | IBM, IAP-binding motif | His6, hexahistidine
Journal Article
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2011, Volume 141, Issue 1, pp. 358 - 369
... (apoptosis-associated speck-like protein containing a caspase recruitment domain [ASC], NLRP3, caspase-1), Toll-like receptor 9... 
Gastroenterology and Hepatology | ASC | Inflammasome | Pancreatitis | Caspase-1 | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | Neutrophil Infiltration | RNA, Messenger - metabolism | Receptors, Purinergic P2X7 - genetics | Pneumonia - immunology | Inflammasomes - deficiency | Disease Models, Animal | Acute Disease | Anti-Inflammatory Agents - pharmacology | DNA - pharmacology | Pancreas - pathology | Pancreas - immunology | Mice, Knockout | Protein Precursors - metabolism | Signal Transduction - drug effects | Mice | Toll-Like Receptor 9 - metabolism | Pneumonia - prevention & control | Toll-Like Receptor 9 - genetics | Purinergic P2X Receptor Antagonists - pharmacology | Pancreatitis - prevention & control | Necrosis | Pancreatitis - genetics | Taurolithocholic Acid - analogs & derivatives | Pancreatitis - immunology | Cytoskeletal Proteins - metabolism | Macrophages - immunology | Severity of Illness Index | Interleukin-1 - metabolism | Toll-Like Receptor 9 - antagonists & inhibitors | Mice, Inbred C57BL | Toll-Like Receptor 9 - deficiency | Pancreas - drug effects | Pancreatitis - chemically induced | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Receptors, Purinergic P2X7 - metabolism | Pancreatitis - pathology | Ceruletide | Apoptosis | Messenger RNA | Cell death | Proteases | Gastrointestinal diseases | Biochemistry | Inflammation | Muscle proteins | Adenosine triphosphate | Index Medicus | Abridged Index Medicus | TLR9
Journal Article
PloS one, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e105070 - e105070
Nephrotoxicity is a dose-dependent side effect of cisplatin limiting its clinical usage in the field of cancer chemotherapy. Fisetin is a bioactive flavonoid... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Caspase 9 - genetics | Caspase 9 - metabolism | Kidney - pathology | Blood Urea Nitrogen | Tumor Necrosis Factor-alpha - genetics | Caspase 3 - metabolism | Male | Cytochromes c - genetics | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Transcription Factor RelA - genetics | Antineoplastic Agents - toxicity | Proto-Oncogene Proteins c-bcl-2 - metabolism | Kidney - metabolism | Cisplatin - toxicity | Caspase 3 - genetics | Flavonoids - pharmacology | Cisplatin - antagonists & inhibitors | NF-KappaB Inhibitor alpha | Kidney - drug effects | Signal Transduction | Cytochromes c - metabolism | Gene Expression Regulation | Rats | Antioxidants - pharmacology | Flavonoids - pharmacokinetics | Rats, Sprague-Dawley | Animals | Nitric Oxide Synthase Type II - genetics | Transcription Factor RelA - metabolism | Creatinine - blood | Peroxidase - genetics | Antioxidants - pharmacokinetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Nitric Oxide Synthase Type II - metabolism | Peroxidase - metabolism | Cytochrome | Oxidative stress | Enzyme activity | Bax protein | Bcl-2 protein | Syngeneic grafts | C protein | Cytotoxicity | Cytosol | Caspase-3 | NAD(P)H oxidase | Antioxidants | Proteins | Mitochondria | Enzymatic activity | Platinum | Rodents | Animal tissues | CYBB protein | Peroxidase | Pharmaceutical sciences | Creatinine | Translocation | Medical research | NF-κB protein | Kidneys | Committees | Caspase | Inflammation | Pharmacology | Gene expression | Anti-inflammatory agents | Cisplatin | Studies | Cytochrome c | Urea | Chemistry | Chemotherapy | Flavonoids | Acids | Caspase-9 | Biomarkers | Apoptosis | Kidney transplantation | Cancer | Index Medicus
Journal Article
Journal Article
Food & function, ISSN 2042-650X, 2018, Volume 9, Issue 11, pp. 5682 - 5696
EGCG reduces breast cancer growth through the inhibition of key enzymes that participate in the glycolytic pathway and the suppression of glucose metabolism... 
Food Science & Technology | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Caspase 9 - genetics | Caspase 9 - metabolism | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Caspase 3 - metabolism | Caspase 8 - metabolism | Polyphenols - pharmacology | Glucose Transporter Type 1 - metabolism | Autophagy-Related Protein 5 - genetics | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Autophagy - drug effects | Caspase 8 - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Caspase 3 - genetics | Female | Catechin - pharmacology | Cell Survival - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Glucose Transporter Type 1 - genetics | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Cell Line, Tumor | Glucose - metabolism | Catechin - analogs & derivatives | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Beclin-1 - metabolism | Tea - chemistry | Cell culture | mRNA | Glucose | Autophagy | Caspase-3 | Anticancer properties | Proteins | Depolarization | Glucose metabolism | Mitochondria | Cell growth | Hypoxia-inducible factor 1a | Inhibition | Vascular endothelial growth factor | Green tea | Growth factors | Phosphofructokinase | Glucose transporter | Enzymes | Pyruvate kinase | Epigallocatechin-3-gallate | Caspase | Breast cancer | Metabolism | Gene expression | Hexokinase | Weight | Caspase-8 | Tea | Cell death | Caspase-9 | Glycolysis | Hypoxia | Lactic acid | Annexin V | Transporter | Phagocytosis | Apoptosis | Cancer | Tumors | Index Medicus | glycolysis | green tea polyphenols | Epigallocatechin-3-Gallate
Journal Article