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PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e96239 - e96239
Glioblastoma is the most common and lethal primary brain tumor. Tumor initiation and recurrence are likely caused by a sub-population of glioblastoma stem... 
GLIOMA-CELLS | CANCER-CELLS | GROWTH-FACTOR RECEPTOR | NERVOUS-SYSTEM | IN-VITRO | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | AKT PATHWAY | SPHEROID CULTURES | PRECURSOR CELLS | BRAIN-TUMORS | Neoplastic Stem Cells - cytology | Caspase 9 - genetics | Caspase 9 - metabolism | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | Glycoproteins - metabolism | Peptides - genetics | 3' Untranslated Regions - genetics | Cell Survival - genetics | MicroRNAs - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Flow Cytometry | Peptides - metabolism | Bcl-2-Like Protein 11 | Glioblastoma - genetics | Neoplastic Stem Cells - metabolism | Caspase 3 - genetics | Apoptosis Regulatory Proteins - genetics | Glioblastoma - metabolism | Membrane Proteins - metabolism | Cell Survival - physiology | Glycoproteins - genetics | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Proto-Oncogene Proteins - genetics | AC133 Antigen | Apoptosis Regulatory Proteins - metabolism | Cell Line, Tumor | MicroRNAs - genetics | DNA microarrays | MicroRNA | Analysis | Luciferase | Stem cells | Glioblastoma multiforme | Apoptosis | Brain | Flow cytometry | Brain tumors | Brain cancer | Glioblastoma | Fluorescence | Oncology | Biochemistry | Neurosurgery | Caspase-3 | Cancer therapies | Genetics | Cell survival | MiRNA | Caspase | siRNA | Survival | Neurology | Brain research | Mutagenesis | Ribonucleic acids | Cell number | MicroRNAs | Cell lines | Caspase-9 | Neural stem cells | Annexin V | BIM protein | Cancer | Tumors | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 11/2010, Volume 70, Issue 22, pp. 9185 - 9196
Increasing evidence points to the functional importance of alternative splice variations in cancer pathophysiology. Two splice variants are derived from the... 
CELL LUNG-CANCER | GROWTH-FACTOR RECEPTOR | EPITHELIAL-CELLS | ONCOLOGY | BCL-X | SR PROTEINS | APOPTOTIC PATHWAY | NF-KAPPA-B | GENE COPY NUMBER | RESPIRATORY SYNCYTIAL VIRUS | PRE-MESSENGER-RNA | Erlotinib Hydrochloride | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Caspase 9 - genetics | Caspase 9 - metabolism | Alternative Splicing | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Phosphatidylinositol 3-Kinases - metabolism | RNA-Binding Proteins | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Receptor, Epidermal Growth Factor - metabolism | RNA Interference | Isoenzymes - metabolism | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Isoenzymes - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Nuclear Proteins - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Expression Regulation, Enzymologic | Serine-Arginine Splicing Factors | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Mutation | Quinazolines - pharmacology | Index Medicus
Journal Article
Ophthalmology, ISSN 0161-6420, 2015, Volume 122, Issue 1, pp. 62 - 71
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 141, Issue 1, pp. 358 - 369
Background & Aims Acute pancreatitis is characterized by early activation of intracellular proteases followed by acinar cell death and inflammation. Activation... 
Gastroenterology and Hepatology | ASC | Inflammasome | Pancreatitis | Caspase-1 | MORTALITY | ACTIVATION | NEUTROPHILS | DISORDERS | RECEPTOR | MODEL | DANGER SIGNALS | DNA | MICE | BLOCKADE | GASTROENTEROLOGY & HEPATOLOGY | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | Neutrophil Infiltration | RNA, Messenger - metabolism | Receptors, Purinergic P2X7 - genetics | Pneumonia - immunology | Inflammasomes - deficiency | Disease Models, Animal | Acute Disease | Anti-Inflammatory Agents - pharmacology | DNA - pharmacology | Pancreas - pathology | Pancreas - immunology | Mice, Knockout | Protein Precursors - metabolism | Signal Transduction - drug effects | Mice | Toll-Like Receptor 9 - metabolism | Pneumonia - prevention & control | Toll-Like Receptor 9 - genetics | Purinergic P2X Receptor Antagonists - pharmacology | Pancreatitis - prevention & control | Necrosis | Pancreatitis - genetics | Taurolithocholic Acid - analogs & derivatives | Pancreatitis - immunology | Cytoskeletal Proteins - metabolism | Macrophages - immunology | Severity of Illness Index | Interleukin-1 - metabolism | Toll-Like Receptor 9 - antagonists & inhibitors | Mice, Inbred C57BL | Toll-Like Receptor 9 - deficiency | Pancreas - drug effects | Pancreatitis - chemically induced | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Receptors, Purinergic P2X7 - metabolism | Pancreatitis - pathology | Ceruletide | Apoptosis | Messenger RNA | Cell death | Proteases | Gastrointestinal diseases | Biochemistry | Inflammation | Muscle proteins | Adenosine triphosphate | Index Medicus | Abridged Index Medicus | TLR9
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 06/2012, Volume 51, Issue 6, pp. 475 - 490
Nimbolide, a plant‐derived limonoid has been shown to exert its antiproliferative effects in various cell lines. We demonstrate that nimbolide effectively... 
nimbolide | ERK1/2 | invasion | MMP‐2/9 | colon cancer | Colon cancer | Nimbolide | Invasion | MMP-2/9 | APOPTOSIS | SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLE ARREST | MATRIX METALLOPROTEINASES | ERK1 | MMP-2 | INDICA | ONCOLOGY | COLORECTAL-CANCER | GENE-EXPRESSION | NEEM LIMONOIDS AZADIRACHTIN | MATRIX-METALLOPROTEINASE-9 EXPRESSION | Colonic Neoplasms - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Neovascularization, Pathologic | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Colonic Neoplasms - metabolism | Cyclin D1 - antagonists & inhibitors | Matrix Metalloproteinase 9 - metabolism | Caspases - metabolism | Matrix Metalloproteinase 9 - genetics | Antineoplastic Agents - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Cyclin A - antagonists & inhibitors | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Down-Regulation - drug effects | Cell Movement - drug effects | Limonins - chemistry | Limonins - pharmacology | Matrix Metalloproteinase 2 - genetics | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Colonic Neoplasms - enzymology | Index Medicus
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 01/2011, Volume 24, Issue 1, pp. 20 - 29
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 9, pp. e105070 - e105070
Nephrotoxicity is a dose-dependent side effect of cisplatin limiting its clinical usage in the field of cancer chemotherapy. Fisetin is a bioactive flavonoid... 
ACUTE KIDNEY INJURY | OXIDATIVE STRESS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL DYSFUNCTION | PATHOLOGICAL ROLE | MECHANISMS | MICE | RENAL INJURY | CELL-DEATH | PROTECTS | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Caspase 9 - genetics | Caspase 9 - metabolism | Kidney - pathology | Blood Urea Nitrogen | Tumor Necrosis Factor-alpha - genetics | Caspase 3 - metabolism | Male | Cytochromes c - genetics | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Transcription Factor RelA - genetics | Antineoplastic Agents - toxicity | Proto-Oncogene Proteins c-bcl-2 - metabolism | Kidney - metabolism | Cisplatin - toxicity | Caspase 3 - genetics | Flavonoids - pharmacology | Cisplatin - antagonists & inhibitors | NF-KappaB Inhibitor alpha | Kidney - drug effects | Signal Transduction | Cytochromes c - metabolism | Gene Expression Regulation | Rats | Antioxidants - pharmacology | Flavonoids - pharmacokinetics | Rats, Sprague-Dawley | Animals | Nitric Oxide Synthase Type II - genetics | Transcription Factor RelA - metabolism | Creatinine - blood | Peroxidase - genetics | Antioxidants - pharmacokinetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Nitric Oxide Synthase Type II - metabolism | Peroxidase - metabolism | Cytochrome | Bcl-2 protein | Syngeneic grafts | C protein | Cytotoxicity | Cytosol | Caspase-3 | NAD(P)H oxidase | Antioxidants | Proteins | Elevation | Mitochondria | Enzymatic activity | Animal tissues | Bioindicators | Medical research | NF-κB protein | Committees | Gene expression | Studies | Cytochrome c | Urea | Chemistry | Chemotherapy | Flavonoids | Caspase-9 | Biomarkers | Kidney transplantation | Oxidative stress | Enzyme activity | Bax protein | Platinum | Rodents | CYBB protein | Peroxidase | Pharmaceutical sciences | Creatinine | Translocation | Antiinflammatory agents | Kidneys | Caspase | Inflammation | Pharmacology | Cisplatin | Acids | Apoptosis | Cancer | Index Medicus
Journal Article