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Cold Spring Harbor perspectives in biology, ISSN 1943-0264, 2013, Volume 5, Issue 8, pp. a008680 - a008680
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 10, pp. 1101 - 1107
Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2018, Volume 142, Issue 1, pp. 202 - 213
...) inhibitor ibrutinib, have demonstrated notable therapeutic effects in relapsed/refractory patients, which indicate that pharmacological inhibition of BCR pathway holds promise in MCL treatment... 
mTOR inhibitor | targeted therapy | BTK inhibitor | drug combination | Mantle cell lymphoma | UNITED-STATES | ACTIVATION | PHOSPHORYLATION | PLUS RITUXIMAB | IBRUTINIB | PROLIFERATION | COMBINATION | ONCOLOGY | RESISTANCE | CHRONIC LYMPHOCYTIC-LEUKEMIA | SGK1 | Everolimus - pharmacology | Apoptosis - drug effects | Humans | Lymphoma, Mantle-Cell - drug therapy | Drug Synergism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Cell Proliferation - drug effects | Mice | Acrylamides - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Tyrosine | Chemotherapy | Analysis | Mortality | Phenols | Lymphomas | Drug therapy, Combination | Gene expression | Cancer | Drugs | Regulators | Animal models | Bax protein | AKT protein | Drug development | Kinases | B-cell receptor | Cyclin D1 | Caspase-3 | Phase transitions | Cyclin-dependent kinase 4 | Anticancer properties | Signal transduction | Antitumor agents | Bcl-x protein | Xenografts | Cell cycle | Inhibition | Mantle | G1 phase | Poly(ADP-ribose) polymerase | Caspase | Pharmacology | Rapamycin | Lymphoma | Bruton's tyrosine kinase | Cyclin-dependent kinase 2 | Signaling | Inhibitors | Lymphocytes B | Bcl protein | Synergistic effect | Apoptosis | Index Medicus
Journal Article
Journal Article
Apoptosis (London), ISSN 1573-675X, 2017, Volume 22, Issue 7, pp. 898 - 919
Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control of programmed cell death (PCD... 
Chemotherapy resistance | Intrinsic apoptotic pathway | Combination therapy | Extrinsic apoptotic pathway | Inhibitors of apoptosis proteins | HEPATOCELLULAR-CARCINOMA CELLS | X-LINKED INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | EFFICIENTLY INDUCES APOPTOSIS | ORALLY-ACTIVE ANTAGONIST | ACUTE MYELOID-LEUKEMIA | CELL BIOLOGY | CELL LUNG-CANCER | SMAC MIMETIC BIRINAPANT | TRAIL-INDUCED APOPTOSIS | THORACIC RADIATION-THERAPY | NF-KAPPA-B | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mitochondrial Proteins - antagonists & inhibitors | Apoptosis - genetics | Mitochondrial Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - genetics | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - genetics | TNF-Related Apoptosis-Inducing Ligand - genetics | Proteins | Viral antibodies | Chemotherapy | Antibodies | Metastasis | Drug resistance | Cancer | Apoptosis | Biotechnology | XIAP protein | Infections | Metastases | Anticancer properties | Analogs | Mitochondria | Antagonism | Cell cycle | Cell survival | Mortality | Caspase | Survivin | Tumor cell lines | Survival | DIABLO protein | Inhibitors | Reviews | Cell death | TRAIL protein | Review
Journal Article
Oncogene, ISSN 0950-9232, 10/2006, Volume 25, Issue 47, pp. 6304 - 6318
Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs... 
Caspase | Indirubin | Cell death | Protein kinase | Autophagy | Cancer | APOPTOSIS | autophagy | cell death | INDIRUBIN DERIVATIVES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AH RECEPTOR | INDUCTION | protein kinase | caspase | CELL BIOLOGY | CYCLIN-DEPENDENT KINASES | indirubin | ONCOLOGY | ARYL-HYDROCARBON RECEPTOR | GENETICS & HEREDITY | SELECTIVE INHIBITORS | cancer | TYRIAN PURPLE | PROTEIN-KINASE INHIBITORS | Caspases - physiology | Phosphorylation | Proto-Oncogene Proteins c-bcl-2 - physiology | Humans | Indoles - chemical synthesis | Male | Cell Line, Tumor - drug effects | Structure-Activity Relationship | Quinolines - pharmacology | Spodoptera | Tumor Suppressor Protein p53 - physiology | Recombinant Fusion Proteins - antagonists & inhibitors | Amino Acid Chloromethyl Ketones - pharmacology | Swine | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Indoles - pharmacology | Starfish | Cell Death - drug effects | Cyclin-Dependent Kinases - antagonists & inhibitors | STAT3 Transcription Factor - metabolism | Cell Line | CDC2 Protein Kinase - antagonists & inhibitors | Cell Line, Tumor - enzymology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Oximes - chemical synthesis | Cell Nucleus - ultrastructure | Oximes - chemistry | Animals | Cysteine Proteinase Inhibitors - pharmacology | bcl-X Protein - physiology | Oximes - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Protein Processing, Post-Translational | Cell Cycle - drug effects | Indoles - chemistry | Proteins | Inhibitor drugs | Kinases | Leukemia | Apoptosis | Oximes | Quinolines | CDC2 Protein Kinase | Glycogen Synthase Kinase 3 | Recombinant Fusion Proteins | Life Sciences | Cell Death | Cyclin-Dependent Kinases | Indoles | bcl-X Protein | Cyclin-Dependent Kinase Inhibitor p21 | Biochemistry, Molecular Biology | Protein Kinase Inhibitors | Tumor Suppressor Protein p53 | Cell Cycle | Cysteine Proteinase Inhibitors | Amino Acid Chloromethyl Ketones | Cell Line, Tumor | STAT3 Transcription Factor | Proto-Oncogene Proteins c-bcl-2 | Caspases | Cell Nucleus
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2009, Volume 119, Issue 5, pp. 1109 - 1123
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANT GLIOMA-CELLS | BLAST CRISIS | CLINICAL RESISTANCE | BCR-ABL MUTATIONS | ENDOPLASMIC-RETICULUM | CYTOCHROME-C RELEASE | CASPASE ACTIVATION | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Transcription Factor CHOP - genetics | Neoplastic Stem Cells - cytology | Gene Expression - drug effects | Calcium - metabolism | Gene Expression - genetics | Microtubule-Associated Proteins - metabolism | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Endoplasmic Reticulum - metabolism | Antineoplastic Agents - therapeutic use | Autophagy - physiology | Thiazoles - therapeutic use | Autophagy - drug effects | Chloroquine - pharmacology | Neoplastic Stem Cells - metabolism | RNA Interference | Endoplasmic Reticulum - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Dasatinib | Chloroquine - therapeutic use | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Mice, Inbred C3H | Xenograft Model Antitumor Assays | Fusion Proteins, bcr-abl - genetics | Animals | Cell Death - physiology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Macrolides - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Causes of | Physiological aspects | Genetic aspects | Chronic myeloid leukemia | Research | Drug therapy | Phagocytosis
Journal Article