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Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2009, Volume 119, Issue 5, pp. 1109 - 1123
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANT GLIOMA-CELLS | BLAST CRISIS | CLINICAL RESISTANCE | BCR-ABL MUTATIONS | ENDOPLASMIC-RETICULUM | CYTOCHROME-C RELEASE | CASPASE ACTIVATION | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Transcription Factor CHOP - genetics | Neoplastic Stem Cells - cytology | Gene Expression - drug effects | Calcium - metabolism | Gene Expression - genetics | Microtubule-Associated Proteins - metabolism | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Endoplasmic Reticulum - metabolism | Antineoplastic Agents - therapeutic use | Autophagy - physiology | Thiazoles - therapeutic use | Autophagy - drug effects | Chloroquine - pharmacology | Neoplastic Stem Cells - metabolism | RNA Interference | Endoplasmic Reticulum - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Dasatinib | Chloroquine - therapeutic use | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Mice, Inbred C3H | Xenograft Model Antitumor Assays | Fusion Proteins, bcr-abl - genetics | Animals | Cell Death - physiology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Macrolides - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Causes of | Physiological aspects | Genetic aspects | Chronic myeloid leukemia | Research | Drug therapy | Phagocytosis
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 1999, Volume 6, Issue 11, pp. 1081 - 1086
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 1387 - 1395
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2016, Volume 22, Issue 10, pp. 1101 - 1107
Journal Article
Apoptosis, ISSN 1360-8185, 9/2007, Volume 12, Issue 9, pp. 1543 - 1568
Apoptosis has been accepted as a fundamental component in the pathogenesis of cancer, in addition to other human diseases including neurodegeneration, coronary... 
Biochemistry, general | TNFR | TRAF | Oncology | NFkB | Virology | Cell Biology | Biomedicine | Cancer Research | IAPs | Caspases | Smac | Knock out mice | Apoptosis | Cancer | NEURONAL APOPTOSIS | X-LINKED INHIBITOR | SERINE-PROTEASE OMI/HTRA2 | MITOCHONDRIA-DERIVED ACTIVATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | knock out mice | INDUCED PROXIMITY MODEL | apoptosis | CELL BIOLOGY | CELL LUNG-CANCER | SPINAL MUSCULAR-ATROPHY | IN-VIVO | cancer | CYTOCHROME-C RELEASE | caspases | CASPASE ACTIVATION | Caspases - physiology | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Neoplasm Proteins - physiology | Serine Endopeptidases - physiology | Neoplasm Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - physiology | X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors | Neoplasms - genetics | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Oligonucleotides, Antisense - therapeutic use | Intracellular Signaling Peptides and Proteins - therapeutic use | Mitochondrial Proteins - therapeutic use | Peptide Termination Factors - physiology | Mitochondrial Proteins - physiology | Neoplasm Proteins - therapeutic use | Microtubule-Associated Proteins - antagonists & inhibitors | Caspase Inhibitors | High-Temperature Requirement A Serine Peptidase 2 | Neoplasms - drug therapy | Animals | Protein Kinases - physiology | Checkpoint Kinase 1 | Enzyme Activation | Genetic Vectors | Intracellular Signaling Peptides and Proteins - physiology | Proteins | Cancer therapies
Journal Article
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2018, Volume 142, Issue 1, pp. 202 - 213
Mantle cell lymphoma (MCL) is an aggressive and incurable malignant disease. Despite of general chemotherapy, relapse and mortality are common, highlighting... 
mTOR inhibitor | targeted therapy | BTK inhibitor | drug combination | Mantle cell lymphoma | UNITED-STATES | ACTIVATION | PHOSPHORYLATION | PLUS RITUXIMAB | IBRUTINIB | PROLIFERATION | COMBINATION | ONCOLOGY | RESISTANCE | CHRONIC LYMPHOCYTIC-LEUKEMIA | SGK1 | Everolimus - pharmacology | Apoptosis - drug effects | Humans | Lymphoma, Mantle-Cell - drug therapy | Drug Synergism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Cell Proliferation - drug effects | Mice | Acrylamides - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Tyrosine | Chemotherapy | Analysis | Mortality | Phenols | Lymphomas | Drug therapy, Combination | Gene expression | Cancer | Drugs | Regulators | Animal models | Bax protein | AKT protein | Drug development | Kinases | B-cell receptor | Cyclin D1 | Caspase-3 | Phase transitions | Cyclin-dependent kinase 4 | Anticancer properties | Signal transduction | Antitumor agents | Bcl-x protein | Xenografts | Cell cycle | Inhibition | Mantle | G1 phase | Poly(ADP-ribose) polymerase | Caspase | Pharmacology | Rapamycin | Lymphoma | Bruton's tyrosine kinase | Cyclin-dependent kinase 2 | Signaling | Inhibitors | Lymphocytes B | Cell lines | Bcl protein | Synergistic effect | Apoptosis | Index Medicus
Journal Article