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ACS chemical biology, ISSN 1554-8929, 11/2019, Volume 14, Issue 11, pp. 2335 - 2348
Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner... 
BREAST-CANCER | CASPASE-3 EXPRESSION | IN-VITRO | IMMUNOHISTOCHEMICAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SMALL-MOLECULE ACTIVATOR | SQUAMOUS-CELL CARCINOMA | BIOLOGICAL EVALUATION | PROGNOSTIC MARKERS | APOPTOSIS PROTEINS | ACTIVATING COMPOUND B-PAC-1 | Caspase Inhibitors - pharmacology | Signal Transduction | Caspase Inhibitors - chemistry | Humans | Caspase 3 - metabolism | Gene Expression Regulation | Zinc - chemistry | Enzyme Precursors - metabolism | Neoplasms - therapy | Animals | Caspase 3 - genetics | Cell Death | Cell Line, Tumor | Ligands | Chelation Therapy - methods | Apoptosis | Zymogen: refers to a precursor protein that upon an activating stimulus (e.g., proteolytic cleavage, liberation of inhibitory entities) forms a more active enzyme; often synonymous with the term proenzyme | Apoptosis: a process of programmed-cell death that culminates in the activation of executioner caspases (caspase-3 and −7) and the cleavage of essential proteins | Labile zinc: the amount of “free” zinc ions within a given system; these ions are in equilibrium with their binding partners and not sequestered in proteins | or sustains high levels of DNA damage (e.g., double-strand DNA breaks); this landscape is considered a hallmark of cancer as it promotes mutation, a major driver of cancer | Proteolysis: the enzyme-catalyzed hydrolysis of peptide bonds found in a protein | Overexpression: an abnormally high level of an entity in a cell, in the context of this review is through the comparison of noncancerous and cancerous tissue | Procaspase-3 (PC-3): the zymogen form of caspase-3 that has minor proteolytic activity and can autoactivate to form caspase-3 | Caspase-3: cysteine protease that cleaves a variety of cellular substrates, leading to phenotypes associated with apoptosis | Genomic instability: a cellular state where the machinery to repair damaged DNA has been compromised (e.g., BRCA mutations) and | PAC-1: acronym for the first procaspase-activating compound; a small molecule that binds labile zinc, promoting autoactivation of PC-3 to caspase-3 and apoptosis of cancer cells
Journal Article
Journal of veterinary medical science, ISSN 1347-7439, 2018, Volume 80, Issue 4, pp. 676 - 683
Journal Article
by Wang R and Song F and Li S and Wu B and Gu Y and Yuan Y
Drug design, development and therapy, ISSN 1177-8881, 05/2019, Volume 13, pp. 1889 - 1900
Rong Wang*, Fuxing Song*, Shengnan Li, Bin Wu, Yanqiu Gu, Yongfang YuanDepartment of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University... 
AKT/mTOR | Caspase-3/Cleaved caspase-3 | salvianolic acid A | Bcl-2/Bax | liver fibrosis
Journal Article
The Journal of cell biology, ISSN 0021-9525, 1/2003, Volume 160, Issue 2, pp. 235 - 243
Journal Article
Neuroscience Letters, ISSN 0304-3940, 03/2012, Volume 512, Issue 1, pp. 6 - 11
Journal Article
Bioscience reports, ISSN 1573-4935, 2019, Volume 39, Issue 6, p. 1
Endometrial cancer (EC) is one of the most common cancers in females. Although the diagnosis and treatment in early stages can greatly improve the survival... 
Cell proliferation | IAP protein | Matrix metalloproteinases | Endometrial cancer | Caspase | Poly(ADP-ribose) polymerase | XIAP protein | Radioresistance | Radiation therapy | Matrix metalloproteinase | Caspase-3 | Gelatinase B | Anticancer properties | Sensitivity | Sensitivity enhancement | Cyclin E | Inhibition | Cyclooxygenase-2 | Females | Cell migration | Endometrium | Cancer | Apoptosis
Journal Article
Chemical Society reviews, ISSN 1460-4744, 2009, Volume 38, Issue 8, pp. 2410 - 2433
Rhodamine dyes are widely used as fluorescent probes owing to their high absorption coefficient and broad fluorescence in the visible region of electromagnetic... 
CHEMOSENSOR | LATENT FLUOROPHORE | FLUOROGENIC PROBE | SELECTIVE FLUORESCENT | PICOSECOND FLUORESCENCE | CASPASE-3 SUBSTRATE | CHARGE-TRANSFER | HG2+ IONS | CHEMISTRY, MULTIDISCIPLINARY | AQUEOUS-SOLUTION | CHEMODOSIMETER
Journal Article
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 10, pp. 1611 - 1622
A series of pyrazoline derivatives 2a–e, 3a–e and 4a–e structurally related to combretastatin A4 (CA-4) were synthesized and characterized by spectroscopic... 
tubulin | cytotoxic activity | 2-pyrazoline | combretastatin A4 | caspase-3 | Combretastatin A4 | Tubulin | Caspase-3 | 2-Pyrazoline | Cytotoxic activity
Journal Article
Scientific reports, ISSN 2045-2322, 2018, Volume 8, Issue 1, pp. 12199 - 11
The cleavage of nuclear proteins by caspases promotes nuclear breakdown and, therefore, plays a key role in apoptosis execution. However, the detailed... 
NUCLEAR-LOCALIZATION | POLY(ADP-RIBOSE) POLYMERASE | TRANSLOCATION | ACTIVATION | DNA FRAGMENTATION | ACTIVE CASPASE-3 | MULTIDISCIPLINARY SCIENCES | MECHANISMS | CLEAVAGE | PARP-1 | CELL-DEATH | Molecular modelling | Cell death | Proteolysis | DNA fragmentation | Caspase | Immunofluorescence | Caspase-3 | Nuclei | Caspase-2 | Cisplatin | Apoptosis
Journal Article
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 9/2013, Volume 52, Issue 40, pp. 10511 - 10514
An 18 F-labeled caspase-3 sensitive nano-aggregation PET tracer ([ 18 F]CSNAT) was prepared and evaluated for imaging caspase-3 activity in doxorubicin-treated... 
apoptosis | cyclization | PET | caspase-3
Journal Article
Journal Article
by Wang, AL and Jiang, HH and Liu, YY and Chen, J and Zhou, X and Zhao, CX and Chen, X and Lin, MB
JOURNAL OF CANCER, ISSN 1837-9664, 2020, Volume 11, Issue 2, pp. 500 - 507
Background: Liver cancer is one of the leading cancers in China. Rhein induces apoptosis in various human cancer cells, but the underlying mechanism is still... 
Rhein | ARREST | TRAIL | ONCOLOGY | ROS | apoptosis | liver cancer | JNK/Jun/caspase-3 signaling pathway
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 48, pp. 84237 - 84247
Buccal mucosa squamous cell carcinoma (BMSCC) is the most common oral cancer in Southeast Asia. Caspase-3, a key molecule in regulating apoptosis, promotes the... 
Buccal mucosa squamous cell carcinoma | Tumorigenesis | Prognosis | Caspase-3 | Cleaved caspase-3 | SURVIVAL | APOPTOSIS | buccal mucosa squamous cell carcinoma | PROLIFERATION | prognosis | CHEMOTHERAPY | CELL BIOLOGY | ACTIVITY PROMOTES MIGRATION | BREAST-CANCER | HEPATOCELLULAR-CARCINOMA | COLORECTAL-CANCER | DISEASE | cleaved caspase-3 | tumorigenesis | caspase-3
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2019, Volume 24, Issue 14, p. 2673
The stems of Dendrobium loddigesii, a Chinese herb, are often used to treat diabetes and its polar extract is rich in shihunine, a water-soluble Orchidaceae... 
ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | CHEMISTRY, MULTIDISCIPLINARY | RECEPTOR-ALPHA | 3T3-L1 cells | URSOLIC ACID | shihunine-rich extract of Dendrobium loddigesii | db/db mice | GLUCOSE-METABOLISM | INSULIN-RESISTANCE | type 2 diabetes mellitus | AMELIORATES HYPERGLYCEMIA | AMPK | toxic activity | DYSLIPIDEMIA | cleaved caspase-3/AMPK/GLUT4/PPAR alpha | EXPRESSION | Plant Extracts - chemistry | AMP-Activated Protein Kinases - metabolism | Deoxyglucose - metabolism | Diabetes Mellitus, Experimental - drug therapy | Glucose Transporter Type 4 - metabolism | Plant Extracts - pharmacology | Caspase 3 - metabolism | Diabetes Mellitus, Experimental - genetics | Male | Lactones - pharmacology | Pyrrolidines - pharmacology | Deoxyglucose - analogs & derivatives | Triglycerides - antagonists & inhibitors | Biological Transport | Caspase 3 - genetics | Pyrrolidines - isolation & purification | Plant Stems - chemistry | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Experimental - physiopathology | Lipid Droplets - chemistry | Lipid Droplets - drug effects | Glucose Tolerance Test | Fasting | Glucose Transporter Type 4 - genetics | Lactones - isolation & purification | Signal Transduction | Gene Expression Regulation | Mice, Transgenic | PPAR alpha - genetics | 3T3-L1 Cells | Dendrobium - chemistry | Hypoglycemic Agents - pharmacology | Triglycerides - metabolism | Blood Glucose - drug effects | 4-Chloro-7-nitrobenzofurazan - analogs & derivatives | Hypoglycemic Agents - isolation & purification | Animals | 4-Chloro-7-nitrobenzofurazan - metabolism | Mice | PPAR alpha - metabolism | Blood Glucose - metabolism | AMP-Activated Protein Kinases - genetics | cleaved caspase-3/AMPK/GLUT4/PPARα
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 59, pp. 31342 - 31354
Short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate are generated by microbial fermentation of indigestible fiber by gut flora. SCFAs are... 
GPR41 | Histone deacetylase | SCFA | GPR43 | Cleaved caspase-3
Journal Article