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Molecular Cell, ISSN 1097-2765, 09/2016, Volume 63, Issue 5, pp. 781 - 795
Mutations in the human autophagy gene cause the multisystem disorder Vici syndrome. Here we demonstrated that EPG5 is a Rab7 effector that determines the... 
RAB effector | LC3 | autophagosome maturation | epg-5 | SNARE | MEMBRANE-FUSION | LYSOSOME FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACHINERY | MECHANISMS | SYNTAXIN 17 | MATURATION | VESICLE | C. ELEGANS | HOPS COMPLEX | CELL BIOLOGY | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Cataract - pathology | Qb-SNARE Proteins - metabolism | R-SNARE Proteins - metabolism | Caenorhabditis elegans Proteins - metabolism | Qb-SNARE Proteins - genetics | rab GTP-Binding Proteins - genetics | Endosomes - metabolism | Lysosomes - metabolism | Qc-SNARE Proteins - metabolism | Agenesis of Corpus Callosum - genetics | Endosomes - ultrastructure | Qa-SNARE Proteins - genetics | Autophagy - genetics | Synaptosomal-Associated Protein 25 - genetics | rab GTP-Binding Proteins - metabolism | Agenesis of Corpus Callosum - metabolism | Amino Acid Sequence | Caenorhabditis elegans - metabolism | Membrane Fusion | Signal Transduction | Caenorhabditis elegans - genetics | R-SNARE Proteins - genetics | Gene Expression Regulation | Autophagosomes - metabolism | Cataract - metabolism | Agenesis of Corpus Callosum - pathology | Autophagosomes - ultrastructure | Lysosomes - ultrastructure | Proteins - genetics | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Proteins - metabolism | Qa-SNARE Proteins - metabolism | Protein Binding | Qc-SNARE Proteins - genetics | Cataract - genetics | Synaptosomal-Associated Protein 25 - metabolism | HeLa Cells | Caenorhabditis elegans Proteins - genetics | Yuan (China) | Index Medicus
Journal Article
Investigative Ophthalmology & Visual Science, ISSN 0146-0404, 09/2006, Volume 47, Issue 9, pp. 3951 - 3959
Journal Article
Journal Article
Molecular vision, ISSN 1090-0535, 2019, Volume 25, Issue 1, pp. 118 - 128
Journal Article
Graefe's Archive for Clinical and Experimental Ophthalmology, ISSN 0721-832X, 7/2010, Volume 248, Issue 7, pp. 985 - 990
Journal Article
Aging Cell, ISSN 1474-9718, 04/2017, Volume 16, Issue 2, pp. 244 - 261
Age‐related cataractogenesis is associated with disulfide‐linked high molecular weight ( HMW ) crystallin aggregates. We recently found that the lens... 
mass spectrometry | aging | proteomics | cataractogenesis | disulfide | reactive oxygen species | HYPERBARIC-OXYGEN | OXIDATIVE DAMAGE | MIXED DISULFIDES | ALDEHYDE DEHYDROGENASE | CYSTEINE | EYE LENS | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | EPITHELIAL-CELLS | PROTEINS | PARKINSONS-DISEASE | AGE | Glutathione - metabolism | Antioxidants - metabolism | Humans | Cataract - pathology | Child, Preschool | Intermediate Filaments - metabolism | Lens, Crystalline - pathology | Sulfhydryl Compounds - metabolism | Peptides - metabolism | Cysteine - metabolism | Child | Amino Acid Sequence | Oxidation-Reduction | Peptides - chemistry | Protein Deglycase DJ-1 - metabolism | Lens, Crystalline - metabolism | Cataract - metabolism | Aging - pathology | Mice, Knockout | Cross-Linking Reagents - metabolism | Isotope Labeling - methods | Animals | Adolescent | Aged | Proteome - metabolism | Aging - metabolism | Enzymes | Cysteine | Cataract | Thiols | Analysis | Physiological aspects | Tubulins | Intermediate filament proteins | Mass spectrometry | Formaldehyde | Cystine | Protein binding | Cataracts | Vimentin | Sorbitol | Dehydrogenases | Aldehyde dehydrogenase | Molecular weight | Glutathione synthase | PARK7 protein | Proteins | Crystallin | Tubulin | Proteomics | Glyceraldehyde-3-phosphate dehydrogenase | Cytoskeleton | Oxidation | Glutathione | Index Medicus | Original
Journal Article
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 12/2013, Volume 93, Issue 6, pp. 1001 - 1014
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 03/2008, Volume 294, Issue 3, pp. 842 - 855
A diminished level of endogenous antioxidant in cells/tissues is associated with reduced resistance to oxidative stress. Peroxiredoxin 6 (PRDX6), a protective... 
Oxidative stress | α-smooth muscle actin | Reactive oxygen species | Transforming growth factor-β | βig-h3 | alpha-smooth muscle actin | PHYSIOLOGY | THIOL-SPECIFIC ANTIOXIDANT | LUNG PHOSPHOLIPID-METABOLISM | transforming growth factor-beta; beta ig-h3 | CELL BIOLOGY | HUMAN IMMUNODEFICIENCY VIRUS | GROWTH-FACTOR-BETA | SHUMIYA CATARACT RAT | 1-CYSTEINE PEROXIREDOXIN | reactive oxygen species | HYDROGEN-PEROXIDE | MAMMALIAN PEROXIREDOXIN | oxidative stress | ONE-CONSERVED CYSTEINE | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Apoptosis - drug effects | Antioxidants - metabolism | Epithelial Cells - drug effects | Transforming Growth Factor beta1 - metabolism | Actins - metabolism | Cataract - pathology | Lens, Crystalline - pathology | Recombinant Fusion Proteins - metabolism | Cataract - therapy | Peroxiredoxin VI - genetics | Peroxiredoxin VI - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Extracellular Matrix Proteins - metabolism | Disease Models, Animal | Hydrogen Peroxide - toxicity | Transduction, Genetic | tat Gene Products, Human Immunodeficiency Virus - genetics | Cells, Cultured | Oxidants - toxicity | Lens, Crystalline - metabolism | Rats | Epithelial Cells - pathology | Cataract - metabolism | Mice, Knockout | Animals | Cataract - genetics | Cataract - prevention & control | Mice | Lens, Crystalline - drug effects | Lipid Peroxidation | Transforming Growth Factor beta - metabolism | Genetic Therapy - methods | Proteins | Cataracts | Cell growth | Gene expression | Cells | Apoptosis | Index Medicus
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