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Gastroenterology, ISSN 0016-5085, 2011, Volume 141, Issue 2, pp. 621 - 632
Background & Aims Epithelial cells that cover the intestinal mucosal surface maintain immune homeostasis and tolerance in the gastrointestinal tract. However,... 
Gastroenterology and Hepatology | IgA | Inflammatory Bowel Disease | T Cell | Immune Response | CELLS | COMPLEX | ACTIVATION | POLYMERIC IMMUNOGLOBULIN RECEPTOR | INTESTINAL EPITHELIUM | TRANSPORT | INFLAMMATORY-BOWEL-DISEASE | ADAPTER | HOST-DEFENSE | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | Tumor Necrosis Factor-alpha - metabolism | Intestinal Mucosa - metabolism | Adaptor Protein Complex mu Subunits - metabolism | Epithelial Cells - metabolism | Adaptor Protein Complex beta Subunits - deficiency | Humans | Cell Membrane Permeability | Crohn Disease - metabolism | Cell Membrane - physiology | Ribonucleases - metabolism | Adaptor Protein Complex 1 - metabolism | Th17 Cells - metabolism | Intestinal Mucosa - immunology | alpha-Defensins - metabolism | Adaptor Protein Complex beta Subunits - immunology | Cell Membrane - metabolism | beta-Defensins - metabolism | Colon | Receptors, Cytokine - metabolism | Colitis - immunology | Adaptor Protein Complex 1 - deficiency | Lipocalins - metabolism | Adaptor Protein Complex 1 - immunology | Immunoglobulin A - metabolism | Signal Transduction | Acute-Phase Proteins - metabolism | Down-Regulation | Oncogene Proteins - metabolism | Homeostasis - immunology | Epithelial Cells - pathology | S100 Proteins - metabolism | Muramidase - metabolism | Intestinal Mucosa - microbiology | Mice, Knockout | Interleukin-17 - metabolism | Adaptor Protein Complex beta Subunits - metabolism | Animals | Colitis - microbiology | Proteins - metabolism | Ribonuclease, Pancreatic - metabolism | Lipocalin-2 | Cathelicidins - metabolism | Epithelial Cells - immunology | Receptors, Cytokine - immunology | Mice | Intestinal Mucosa - pathology | Medical colleges | Fc receptors | Gastrointestinal diseases | Homeostasis | Biological response modifiers | Immunoglobulin A | T cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2010, Volume 107, Issue 52, pp. 22593 - 22598
We investigated the mechanisms by which T-cell cytokines are able to influence the Toll-like receptor (TLR)-induced, vitamin D-dependent antimicrobial pathway... 
T lymphocytes | Up regulation | Monocytes | Messenger RNA | Cytokines | Vitamin D | Mycobacterium tuberculosis | Antimicrobials | Small interfering RNA | Physiological regulation | Interleukin-4 | Interferon-γ | Innate immune response | interleukin-4 | MYCOBACTERIUM-TUBERCULOSIS | ACTIVATION | CATHELICIDIN | IFN-GAMMA | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | AUTOPHAGY | CUTTING EDGE | TOLL-LIKE RECEPTOR-2 | innate immune response | MICROBIAL LIPOPROTEINS | interferon-gamma | Steroid Hydroxylases - metabolism | Gene Expression - drug effects | Monocytes - cytology | Humans | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics | Monocytes - metabolism | Antimicrobial Cationic Peptides - metabolism | Th1 Cells - metabolism | Interleukin-4 - pharmacology | T-Lymphocytes - metabolism | Calcitriol - metabolism | beta-Defensins - metabolism | Antimicrobial Cationic Peptides - genetics | Steroid Hydroxylases - genetics | beta-Defensins - genetics | Toll-Like Receptor 1 - metabolism | Cells, Cultured | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism | Vitamin D3 24-Hydroxylase | Toll-Like Receptor 2 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Th2 Cells - metabolism | Blotting, Western | Monocytes - drug effects | Signal Transduction - drug effects | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Cytokines - pharmacology | Interferon-gamma - pharmacology | Immune response | Calcifediol | Regulation | Alfacalcidol | Research | T cells | Properties | Health aspects | Biological Sciences | interferon-γ
Journal Article
Cellular Microbiology, ISSN 1462-5814, 11/2010, Volume 12, Issue 11, pp. 1648 - 1665
Summary In human monocytes, Toll‐like receptor (TLR) 2/1 activation leads to vitamin D3‐dependent antimycobacterial activities, but the molecular mechanisms by... 
CELLS | INNATE IMMUNE-RESPONSES | PATHWAY | PROTEIN-KINASE | HUMAN MACROPHAGES | TUBERCULOSIS | TOLL-LIKE RECEPTORS | MICROBIOLOGY | ANTIVIRAL IMMUNITY | HUMAN MONOCYTES | TLR2 | CELL BIOLOGY | Monocytes - microbiology | AMP-Activated Protein Kinases - metabolism | Calcium | Signal Transduction | Lipoproteins - genetics | Humans | Toll-Like Receptor 1 - metabolism | Bacterial Proteins - genetics | Cells, Cultured | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism | Receptors, Calcitriol - metabolism | Toll-Like Receptor 2 - metabolism | Antimicrobial Cationic Peptides - metabolism | Autophagy | CCAAT-Enhancer-Binding Protein-beta - metabolism | Lipopolysaccharide Receptors - metabolism | Mycobacterium tuberculosis | Lipoproteins - metabolism | Bacterial Proteins - metabolism | Vitamin D - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Antimicrobial Cationic Peptides - genetics | Monocytes - physiology | Medical colleges | Vitamin D | Cytochrome P-450 | Calcifediol | Protein C | Alfacalcidol | Protein kinases | Antibacterial agents | Antimicrobial activity | Calcium (intracellular) | cathelicidins | Hydroxylase | Data processing | MAP kinase | CCAAT/enhancer-binding protein | AMP-activated protein kinase | CD14 antigen | Signal transduction | Cell activation | Lipoproteins | Monocytes | Molecular modelling | TLR2 protein | Toll-like receptors | Vitamin D receptors | Phagocytosis
Journal Article
The Journal of Immunology, ISSN 0022-1767, 03/2010, Volume 184, Issue 5, pp. 2539 - 2550
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2013, Volume 19, Issue 1, pp. 65 - 73
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2011, Volume 7, Issue 5, p. e1002042
Over the last decade a significant number of studies have highlighted the central role of host antimicrobial (or defence) peptides in modulating the response... 
PROTEIN SECONDARY STRUCTURE | ENTERIC NEMATODE | MICROBIOLOGY | DEFENSE PEPTIDES | SIZE-DISTRIBUTION ANALYSIS | LPS | CIRCULAR-DICHROISM SPECTRA | ALTERNATIVELY ACTIVATED MACROPHAGES | VIROLOGY | CATHELICIDIN FAMILY | LIPOPOLYSACCHARIDE-BINDING | INHIBIT | PARASITOLOGY | Helminth Proteins - pharmacology | Membrane Glycoproteins - metabolism | Anti-Infective Agents - metabolism | Humans | Helminth Proteins - chemistry | Lipopolysaccharides - metabolism | Molecular Sequence Data | Antimicrobial Cationic Peptides - metabolism | Anti-Infective Agents - immunology | Inflammation - metabolism | Molecular Mimicry | Fasciola hepatica - chemistry | Fascioliasis - parasitology | Sepsis - metabolism | Carrier Proteins - pharmacology | Endotoxemia - immunology | Toll-Like Receptors - metabolism | Helminth Proteins - metabolism | Fasciola hepatica - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Sepsis - immunology | Acute-Phase Proteins - metabolism | Antimicrobial Cationic Peptides - chemistry | Membrane Glycoproteins - pharmacology | Toll-Like Receptors - immunology | Antimicrobial Cationic Peptides - pharmacology | Helminth Proteins - genetics | Inflammation - immunology | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Immunity, Innate | Fasciola hepatica - immunology | Animals | Carrier Proteins - metabolism | Fascioliasis - immunology | Lipopolysaccharides - pharmacology | Mice | Mice, Inbred BALB C | Endotoxemia - metabolism | Acute-Phase Proteins - pharmacology | Proteolysis | Antimicrobial peptides | Worms, Intestinal and parasitic | Physiological aspects | Research | Health aspects | Helminths | Medical research | Peptides | Cytokines | Rodents | Immune system
Journal Article
Circulation research, ISSN 0009-7330, 2013, Volume 112, Issue 5, pp. 792 - 801
Journal Article
Autophagy, ISSN 1554-8627, 09/2015, Volume 11, Issue 9, pp. 1688 - 1699
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 10/2014, Volume 53, Issue 41, pp. 6426 - 6429
A cathelin-related antimicrobial peptide (CRAMP) of 37 amino acid residues is thought to regulate innate immunity and provide a host defense mechanism in... 
MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSIGHTS | Hemolysis - drug effects | Cytoskeletal Proteins - antagonists & inhibitors | Hydrolysis - drug effects | Cytoskeletal Proteins - genetics | Escherichia coli - drug effects | Humans | Bacterial Proteins - chemistry | Peptide Fragments - pharmacology | Guanosine Triphosphate - metabolism | GTP Phosphohydrolases - antagonists & inhibitors | Antimicrobial Cationic Peptides - metabolism | GTP Phosphohydrolases - chemistry | Bacillus subtilis - growth & development | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Escherichia coli - metabolism | Cytoskeletal Proteins - metabolism | Escherichia coli - growth & development | Binding Sites | Cathelicidins - pharmacology | Mutant Proteins - antagonists & inhibitors | Cytokinesis - drug effects | Membrane Potentials - drug effects | Bacterial Proteins - antagonists & inhibitors | Microscopy, Electron, Transmission | Peptide Fragments - metabolism | Enzyme Inhibitors - metabolism | Antimicrobial Cationic Peptides - chemistry | Antimicrobial Cationic Peptides - pharmacology | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Anti-Bacterial Agents - metabolism | Mutant Proteins - metabolism | Cytoskeletal Proteins - chemistry | Cathelicidins - chemistry | Peptide Fragments - chemistry | Animals | GTP Phosphohydrolases - metabolism | Cathelicidins - metabolism | Mutant Proteins - chemistry | Bacterial Proteins - metabolism | Protein Conformation | Anti-Bacterial Agents - pharmacology | Mice | Molecular Docking Simulation | Bacillus subtilis - metabolism | Bacillus subtilis - drug effects
Journal Article
Journal Article