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Experimental Dermatology, ISSN 0906-6705, 02/2012, Volume 21, Issue 2, pp. 104 - 110
:  Atopic eczema and psoriasis are common skin diseases. While it is well established that the pathogenesis of these diseases varies, both are characterized by... 
keratinocytes | IL‐17 | atopic eczema | epidermal barrier | filaggrin | Keratinocytes | Epidermal barrier | Filaggrin | Atopic eczema | IL-17 | EPICUTANEOUS SENSITIZATION | OF-FUNCTION MUTATIONS | SKIN BARRIER FUNCTION | FUNCTION VARIANTS | POLYETHYLENE-GLYCOLS | CULTURED KERATINOCYTES | DERMATOLOGY | ATOPIC-DERMATITIS | SODIUM LAURYL SULFATE | TIGHT JUNCTION PROTEINS | TH17 CELLS | Cathepsin L - genetics | Cell Adhesion Molecules - genetics | Cadherins - metabolism | Gene Expression - drug effects | Oligonucleotide Array Sequence Analysis | Cytoskeletal Proteins - genetics | Gene Expression - genetics | Cathepsin B - genetics | Humans | Interleukin-17 - pharmacology | Calpain - genetics | Phosphoproteins - metabolism | Cell Differentiation - genetics | S100 Proteins - genetics | Intermediate Filament Proteins - genetics | Membrane Proteins - metabolism | Cadherins - genetics | Cell Line | Claudins - genetics | Membrane Proteins - genetics | Cells, Cultured | gamma Catenin - genetics | gamma Catenin - metabolism | Up-Regulation - genetics | Phosphoproteins - genetics | Down-Regulation - genetics | Zonula Occludens-1 Protein | Keratinocytes - drug effects | Keratinocytes - metabolism | Cathepsin D - genetics | Intermediate Filament Proteins - metabolism | Zonula Occludens-2 Protein | Enzymes | Messenger RNA | Psoriasis | Interleukins | Analysis | Genes | Genetic research | Genetic aspects | Skin
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2013, Volume 19, Issue 1, pp. 57 - 64
Chemotherapeutic agents are widely used for cancer treatment. In addition to their direct cytotoxic effects, these agents harness the host's immune system,... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER-CHEMOTHERAPY | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GEMCITABINE | BETA | CELL BIOLOGY | 5-FLUOROURACIL | INHIBITION | MICROENVIRONMENT | ANTITUMOR IMMUNITY | BEARING MICE | T-CELLS | Neoplasms - metabolism | Cell Proliferation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Cathepsin B - genetics | Humans | Caspase 1 - metabolism | Deoxycytidine - pharmacology | Signal Transduction - immunology | Neoplasms - genetics | RNA Interference | Female | Antineoplastic Agents - pharmacology | Interleukin-1beta - biosynthesis | Dendritic Cells - metabolism | bcl-2-Associated X Protein - genetics | Interleukin-17 - secretion | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cathepsin B - metabolism | Mice, Knockout | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Cell Line, Tumor | Fluorouracil - pharmacology | Mice | Mice, Inbred BALB C | RNA, Small Interfering | Receptors, Interleukin-1 - antagonists & inhibitors | Deoxycytidine - analogs & derivatives | Chemotherapy | Gemcitabine | Cathepsins | Physiological aspects | Dosage and administration | Research | Health aspects | Fluorouracil | Cancer | Cells | Inflammatory diseases | Tumors | Engineering Sciences | Automatic
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2012, Volume 45, Issue 6, pp. 764 - 776
Aberrant ErbB2 receptor tyrosine kinase activation in breast cancer is strongly linked to an invasive disease. The molecular basis of ErbB2-driven invasion is... 
PATHWAYS | ONCOGENE | METASTASIS | EPITHELIAL-CELLS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | CYSTEINE CATHEPSINS | FIBROBLASTS | MULTISTAGE TUMORIGENESIS | ERBB RECEPTORS | CELL BIOLOGY | Cathepsin L - genetics | Protein Kinase C-alpha - metabolism | Proto-Oncogene Protein c-ets-1 - metabolism | Receptor, ErbB-2 - genetics | Protein-Tyrosine Kinases - metabolism | Cathepsin B - genetics | Humans | Protein Kinase C-alpha - genetics | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Cathepsin L - metabolism | Breast Neoplasms - metabolism | Protein-Tyrosine Kinases - genetics | Kruppel-Like Transcription Factors - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Female | Promoter Regions, Genetic | p21-Activated Kinases - genetics | Myotonin-Protein Kinase | Response Elements | Signal Transduction | Neoplasm Invasiveness | Cathepsin B - metabolism | p21-Activated Kinases - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Proto-Oncogene Protein c-ets-1 - genetics | Kruppel-Like Transcription Factors - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Tyrosine | Cysteine | Oncology, Experimental | Genes | Cathepsins | Breast cancer | DNA binding proteins | Genetic transcription | Research | Cystine | Analysis | Universities and colleges | Protein kinases | Phosphotransferases | Protein binding | Cancer | Protein kinase C | Transcription factors | Introns | Invasiveness | cathepsins | AKT protein | ErbB-2 protein | Zinc | Enhancers | Cathepsin B | Protein-tyrosine kinase receptors | Protein-serine/threonine kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2012, Volume 287, Issue 47, pp. 39834 - 39841
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 42, pp. 30094 - 30104
Journal Article
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 05/2017, Volume 100, Issue 5, pp. 737 - 750
Journal Article
Spine, ISSN 0362-2436, 2015, Volume 40, Issue 11, pp. 773 - 782
Study Design. Autophagy-related gene expression and ultrastructural features of autophagy were studied in human discs. Objective. To obtain... 
TNF-α | Disc degeneration | Intervertebral disc | PIM-2 oncogene | p62/SQSTM1 | Proinflammatory cytokines | IL-1β | Autophagy | WIPI49 | NUCLEUS PULPOSUS | intervertebral disc | proinflammatory cytokines | autophagy | TNF-alpha | TISSUE | IL-1 beta | 3-DIMENSIONAL CULTURE | MEDIATED APOPTOSIS | PROTEOGLYCAN | CLINICAL NEUROLOGY | PATHOGENESIS | OXYGEN | BIOENERGETICS | GENE-EXPRESSION | disc degeneration | SENESCENCE | ORTHOPEDICS | Protein-Serine-Threonine Kinases - analysis | RNA-Binding Proteins - genetics | Autophagy-Related Proteins | Interleukin-1beta - pharmacology | Gene Expression - drug effects | Microtubule-Associated Proteins - genetics | Cathepsin B - genetics | Humans | Middle Aged | Apoptosis Regulatory Proteins - analysis | RNA, Messenger - analysis | Infant | Male | Autophagy - drug effects | Membrane Proteins - analysis | Intervertebral Disc Degeneration - metabolism | Cysteine Endopeptidases - analysis | Intervertebral Disc Degeneration - pathology | Young Adult | Sacrum | Ubiquitin-Conjugating Enzymes - analysis | Apoptosis Regulatory Proteins - genetics | Adult | Female | Autophagy - genetics | Ubiquitin-Activating Enzymes - analysis | RNA-Binding Proteins - analysis | Intervertebral Disc Degeneration - genetics | Beclin-1 | Intervertebral Disc - ultrastructure | Ubiquitin-Activating Enzymes - genetics | Microtubule-Associated Proteins - analysis | Membrane Proteins - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Intervertebral Disc - chemistry | Presenilin-1 - genetics | Proto-Oncogene Proteins - genetics | Ubiquitin-Conjugating Enzymes - genetics | Up-Regulation - drug effects | Carrier Proteins - genetics | Tumor Necrosis Factor-alpha - pharmacology | Autophagy-Related Protein 7 | Cysteine Endopeptidases - genetics | Aged | Lumbar Vertebrae
Journal Article
Oncogene, ISSN 0950-9232, 06/2014, Volume 33, Issue 26, pp. 3392 - 3400
Journal Article
Human Genetics, ISSN 0340-6717, 1/2009, Volume 124, Issue 6, pp. 561 - 577
Osteopetrosis is the result of mutations affecting osteoclast function. Careful analyses of osteopetrosis have provided instrumental information on bone... 
Human Genetics | Gene Function | Molecular Medicine | Biomedicine | Metabolic Diseases | ALBERS-SCHONBERG-DISEASE | INFANTILE MALIGNANT OSTEOPETROSIS | EARLY POSTMENOPAUSAL WOMEN | CATHEPSIN-K DEFICIENCY | CARBONIC-ANHYDRASE-II | GENETICS & HEREDITY | RECEPTOR-RELATED PROTEIN-5 | CLCN7 GENE-MUTATIONS | RESISTANT ACID-PHOSPHATASE | AUTOSOMAL-DOMINANT OSTEOPETROSIS | MEDIATED EXTRACELLULAR ACIDIFICATION | Vacuolar Proton-Translocating ATPases - genetics | Osteopetrosis - physiopathology | Carbonic Anhydrase II - deficiency | Humans | Bone Remodeling - physiology | Chloride Channels - genetics | Receptor Activator of Nuclear Factor-kappa B - deficiency | Bone Resorption - genetics | Osteoclasts - physiology | Carbonic Anhydrase II - genetics | Osteopetrosis - genetics | Disease Models, Animal | Bone Resorption - physiopathology | Osteoclasts - pathology | Osteopetrosis - pathology | Cathepsin K | Membrane Proteins - genetics | Osteoblasts - physiology | Osteopetrosis - etiology | Membrane Glycoproteins - genetics | RANK Ligand - genetics | Osteoblasts - pathology | Animals | Cathepsins - genetics | Models, Biological | Adaptor Proteins, Signal Transducing - deficiency | Adaptor Proteins, Signal Transducing - genetics | Receptor Activator of Nuclear Factor-kappa B - genetics | RANK Ligand - deficiency | Mice | Bone Remodeling - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | Membrane Glycoproteins - deficiency
Journal Article
Journal Article