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The Journal of Immunology, ISSN 0022-1767, 05/2009, Volume 182, Issue 10, pp. 6460 - 6469
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2019, Volume 116, Issue 33, pp. 16314 - 16319
Critical for diverse biological processes, proteases represent one of the largest families of pharmaceutical targets. To inhibit pathogenic proteases with... 
KALLIKREIN | MMP | protease inhibitor | ACTIVATION | functional selection | MATRIX METALLOPROTEINASE-14 | ROLES | BACE-1 | MULTIDISCIPLINARY SCIENCES | DISEASE | MECHANISMS | monoclonal antibody | Aspergillosis - therapy | Serine Proteases - genetics | Amyloid Precursor Protein Secretases - genetics | Amyloid Precursor Protein Secretases - immunology | Peptide Hydrolases - genetics | Antibodies, Monoclonal - biosynthesis | Cathepsin B - genetics | Humans | Matrix Metalloproteinase 9 - immunology | Amino Acid Sequence - genetics | Aspartic Acid Endopeptidases - genetics | Recombinant Proteins - biosynthesis | Protease Inhibitors - immunology | Protease Inhibitors - pharmacology | Proteolysis - drug effects | Neoplasms - therapy | Amyloid beta-Peptides - genetics | Matrix Metalloproteinase 9 - genetics | Periplasm - genetics | Matrix Metalloproteinase Inhibitors - immunology | Aspartic Acid Endopeptidases - immunology | Alzheimer Disease - immunology | Antibodies, Monoclonal - immunology | Antibodies, Monoclonal - pharmacology | Alzheimer Disease - therapy | Matrix Metalloproteinase 14 - immunology | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Matrix Metalloproteinase Inhibitors - metabolism | Peptide Hydrolases - chemistry | Peptide Hydrolases - immunology | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Recombinant Proteins - immunology | Escherichia coli - genetics | Neoplasms - immunology | Matrix Metalloproteinase 14 - genetics | Amyloid beta-Peptides - immunology | Cathepsin B - immunology | Mice | Serine Proteases - immunology | Aspergillosis - immunology | Cysteine | Peptides | Ampicillin | Immunoglobulin G | Escherichia coli | Monoclonal antibodies | Cathepsins | Beta lactamases | Recombinant proteins | Health aspects | Alzheimer's disease | Matrix metalloproteinases | Serine | Cysteine proteinase | Selectivity | Neuropathy | Matrix metalloproteinase | Metastases | Pain | E coli | Proteolysis | Protease | Aspartic endopeptidase | Periplasmic space | Cathepsin B | Inhibition | Recombinant | Binding | Cellular manufacture | b-Site APP cleaving enzyme 1 | Immunoglobulins | Neurodegenerative diseases | Pharmacology | Binders | Chemical compounds | Biological activity | Gelatinase B | Antibody libraries | Gelatinase A | Aspergillosis | Serine proteinase | b-Site APP cleaving enzyme | Alzheimers disease | Secretase | Biological Sciences
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6771
Lymphatic endothelial cells (LECs) directly express peripheral tissue antigens and induce CD8 T-cell deletional tolerance. LECs express MHC-II molecules,... 
DENDRITIC-CELLS | REPERTOIRE | THYMIC EPITHELIAL-CELLS | AIRE | MHC-CLASS-II | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | CLONAL DELETION | INVARIANT CHAIN | SELF-TOLERANCE | CUTTING EDGE | beta-Galactosidase - immunology | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - cytology | Cathepsin L - genetics | Cathepsin L - immunology | Dendritic Cells - immunology | Antigens, CD - genetics | Hemagglutinins - immunology | Peripheral Tolerance - genetics | CD4-Positive T-Lymphocytes - immunology | Bone Marrow Cells - immunology | Antigens, Differentiation, B-Lymphocyte - immunology | Antigens, Differentiation, B-Lymphocyte - genetics | Gene Expression | Signal Transduction | Bone Marrow Cells - cytology | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Antigen Presentation - genetics | Mice, Transgenic | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Endothelial Cells - immunology | Hemagglutinins - genetics | Animals | Histocompatibility Antigens Class II - immunology | Endothelial Cells - cytology | Clonal Anergy - genetics | Antigens - immunology | Dendritic Cells - cytology | Mice | Histocompatibility Antigens Class II - genetics | Primary Cell Culture | Programmed Cell Death 1 Receptor - immunology | beta-Galactosidase - genetics | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics | Antigens - genetics | Basic Medicine | Immunologi inom det medicinska området | Medical and Health Sciences | Medicin och hälsovetenskap | Immunology in the medical area | Medicinska och farmaceutiska grundvetenskaper
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2009, Volume 5, Issue 8, p. e1000559
The intraerythrocytic parasite Plasmodium-the causative agent of malaria-produces an inorganic crystal called hemozoin (Hz) during the heme detoxification... 
APOPTOSIS | INNATE IMMUNE RECEPTORS | INTERLEUKIN-1-BETA | MACROPHAGES | CASPASE-1 INFLAMMASOME | MICROBIOLOGY | KAPPA-B | NALP3 INFLAMMASOME | RESPONSES | VIROLOGY | IN-VIVO | MICE | PARASITOLOGY | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Male | Caspase 1 - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Hemeproteins - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | Female | Interleukin-1beta - biosynthesis | Phosphorylation - immunology | Malaria - metabolism | Syk Kinase | Carrier Proteins - immunology | Disease Models, Animal | Neutrophil Infiltration - immunology | Calcium-Binding Proteins - metabolism | Carrier Proteins - physiology | Apoptosis Regulatory Proteins - immunology | Plasmodium chabaudi - chemistry | Hemeproteins - metabolism | Malaria - immunology | Mice, Inbred C57BL | Cathepsin B - metabolism | Inflammation - immunology | Plasmodium chabaudi - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Malaria - parasitology | Proteomics | HSP90 Heat-Shock Proteins - metabolism | Hemeproteins - physiology | Mice | Phagocytosis | Hostages | Inflammation | Malaria | Phosphotransferases | Medical research | Salmonella | Phosphorylation | Lipids | Parasites | Experiments | Fever | Tropical diseases
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2017, Volume 199, Issue 2, pp. 435 - 448
The efficacy of B cell depletion therapy in multiple sclerosis indicates their central pathogenic role in disease pathogenesis. The B lymphotropic EBV is a... 
ENCEPHALOMYELITIS | MYELIN OLIGODENDROCYTE GLYCOPROTEIN | CITRULLINATED PROTEINS | CATHEPSIN-G | MODEL | BASIC-PROTEIN | EXPRESSION | EPSTEIN-BARR-VIRUS | T-CELLS | LYMPHOCYTES | EPITOPE | DEPLETION | IMMUNOLOGY | Autoimmunity | Immunodominant Epitopes - immunology | Myelin-Oligodendrocyte Glycoprotein - immunology | Cathepsin G - immunology | Cathepsin G - genetics | Immunodominant Epitopes - chemistry | Humans | Multiple Sclerosis - virology | Cells, Cultured | Autophagosomes - metabolism | Autophagy - immunology | Cathepsin G - metabolism | Multiple Sclerosis - physiopathology | Animals | B-Lymphocytes - immunology | Myelin-Oligodendrocyte Glycoprotein - metabolism | Cross-Priming - immunology | Autophagosomes - immunology | B-Lymphocytes - virology | Multiple Sclerosis - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | B-Lymphocytes - metabolism | Cathepsin G - antagonists & inhibitors | Lymphocyte receptors | Multiple sclerosis | Oligodendrocyte-myelin glycoprotein | Peptides | Pathogenesis | CD8 antigen | Switches | Phagosomes | Cytotoxicity | Infections | Lymphocytes T | Autophagy | Machinery | Risk factors | Machinery and equipment | Degradation | Arginine | Proteolysis | Lymphocytes | CD56 antigen | Myelin | Glycoprotein | Cathepsin G | Citrulline | Epitopes | Experimental allergic encephalomyelitis | Major histocompatibility complex | Lymphocytes B | Antigen-presenting cells | Phagocytosis
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2015, Volume 195, Issue 1, pp. 317 - 328
Intestinal ischemia/reperfusion (I/R) injury, in which macrophages play a key role, can cause high morbidity and mortality. The switch from classically (M1) to... 
ISCHEMIA-REPERFUSION INJURY | TISSUE-INJURY | ALTERNATIVELY ACTIVATED MACROPHAGES | DENDRITIC CELLS | MESSENGER-RNA | INFLAMMATION | KIDNEY INJURY | PARASITE INFECTION | NITRIC-OXIDE | IMMUNOLOGY | RESIDENT MACROPHAGES | Intestines - drug effects | Receptors, CCR7 - immunology | Trichinella spiralis - immunology | Cathepsin B - genetics | Vaccination | Male | STAT6 Transcription Factor - genetics | Intestines - immunology | Arginase - immunology | Nitric Oxide Synthase Type II - immunology | Trichinella spiralis - chemistry | STAT6 Transcription Factor - antagonists & inhibitors | Reperfusion Injury - genetics | Macrophages - immunology | Intestines - pathology | Macrophages - classification | Cathepsin B - administration & dosage | Macrophages - pathology | Signal Transduction | Gene Expression Regulation | Receptors, CCR7 - genetics | Reperfusion Injury - mortality | Antigens, Helminth - genetics | Arginase - genetics | Recombinant Proteins - genetics | Pyrimidines - pharmacology | STAT6 Transcription Factor - immunology | Recombinant Proteins - administration & dosage | Antigens, Helminth - immunology | Phenotype | Animals | Reperfusion Injury - prevention & control | Nitric Oxide Synthase Type II - genetics | Recombinant Proteins - immunology | Reperfusion Injury - immunology | Survival Analysis | Macrophages - drug effects | Cathepsin B - immunology | Mice | Mice, Inbred BALB C | Antigens, Helminth - administration & dosage | Macrophage Activation - drug effects
Journal Article
The Journal of Pathology, ISSN 0022-3417, 12/2004, Volume 204, Issue 5, pp. 519 - 527
Journal Article
Vaccine, ISSN 0264-410X, 2014, Volume 33, Issue 2, pp. 346 - 353
Journal Article