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Oncogene, ISSN 0950-9232, 10/2016, Volume 35, Issue 41, pp. 5362 - 5376
Journal Article
Journal Article
Experimental Dermatology, ISSN 0906-6705, 02/2012, Volume 21, Issue 2, pp. 104 - 110
Atopic eczema and psoriasis are common skin diseases. While it is well established that the pathogenesis of these diseases varies, both are characterized by... 
keratinocytes | IL‐17 | atopic eczema | epidermal barrier | filaggrin | Keratinocytes | Epidermal barrier | Filaggrin | Atopic eczema | IL-17 | EPICUTANEOUS SENSITIZATION | OF-FUNCTION MUTATIONS | SKIN BARRIER FUNCTION | FUNCTION VARIANTS | POLYETHYLENE-GLYCOLS | CULTURED KERATINOCYTES | DERMATOLOGY | ATOPIC-DERMATITIS | SODIUM LAURYL SULFATE | TIGHT JUNCTION PROTEINS | TH17 CELLS | Cathepsin L - genetics | Cell Adhesion Molecules - genetics | Cadherins - metabolism | Gene Expression - drug effects | Oligonucleotide Array Sequence Analysis | Cytoskeletal Proteins - genetics | Gene Expression - genetics | Cathepsin B - genetics | Humans | Interleukin-17 - pharmacology | Calpain - genetics | Phosphoproteins - metabolism | Cell Differentiation - genetics | S100 Proteins - genetics | Intermediate Filament Proteins - genetics | Membrane Proteins - metabolism | Cadherins - genetics | Cell Line | Claudins - genetics | Membrane Proteins - genetics | Cells, Cultured | gamma Catenin - genetics | gamma Catenin - metabolism | Up-Regulation - genetics | Phosphoproteins - genetics | Down-Regulation - genetics | Zonula Occludens-1 Protein | Keratinocytes - drug effects | Keratinocytes - metabolism | Cathepsin D - genetics | Intermediate Filament Proteins - metabolism | Zonula Occludens-2 Protein | Enzymes | Messenger RNA | Psoriasis | Interleukins | Analysis | Genes | Genetic research | Genetic aspects | Skin | Index Medicus
Journal Article
by Robak, Laurie A and Jansen, Iris E and Rooij, Jeroen van and Uitterlinden, André G and Kraaij, Robert and Jankovic, Joseph and Heutink, Peter and Shulman, Joshua M and Nalls, Mike A and Plagnol, Vincent and Hernandez, Dena G and Sharma, Manu and Sheerin, Una-Marie and Saad, Mohamad and Simón-Sánchez, Javier and Schulte, Claudia and Lesage, Suzanne and Sveinbjörnsdóttir, Sigurlaug and Arepalli, Sampath and Barker, Roger and Ben, Yoav and Berendse, Henk W and Berg, Daniela and Bhatia, Kailash and de Bie, Rob M. A and Biffi, Alessandro and Bloem, Bas and Bochdanovits, Zoltan and Bonin, Michael and Bras, Jose M and Brockmann, Kathrin and Brooks, Janet and Burn, David J and Majounie, Elisa and Charlesworth, Gavin and Lungu, Codrin and Chen, Honglei and Chinnery, Patrick F and Chong, Sean and Clarke, Carl E and Cookson, Mark R and Cooper, J. Mark and Corvol, Jean Christophe and Counsell, Carl and Damier, Philippe and Dartigues, Jean-François and Deloukas, Panos and Deuschl, Günther and Dexter, David T and van Dijk, Karin D and Dillman, Allissa and Durif, Frank and Dürr, Alexandra and Edkins, Sarah and Evans, Jonathan R and Foltynie, Thomas and Dong, Jing and Gardner, Michelle and Gibbs, J. Raphael and Goate, Alison and Gray, Emma and Guerreiro, Rita and Harris, Clare and van Hilten, Jacobus J and Hofman, Albert and Hollenbeck, Albert and Holton, Janice and Hu, Michele and Huang, Xuemei and Wurster, Isabel and Mätzler, Walter and Hudson, Gavin and Hunt, Sarah E and Huttenlocher, Johanna and Illig, Thomas and Jónsson, Pálmi V and Lambert, Jean-Charles and Langford, Cordelia and Lees, Andrew and Lichtner, Peter and Limousin, Patricia and Lopez, Grisel and Lorenz, Delia and Lungu, Codrin and McNeill, Alisdair and Moorby, Catriona and Moore, Matthew and Morris, Huw R and Morrison, Karen E and Escott-Price, Valentina and Mudanohwo, Ese and O’sullivan, Sean S and Pearson, Justin and Perlmutter, Joel S and Pétursson, Hjörvar and Pollak, Pierre and Post, Bart and Potter, Simon and Ravina, Bernard and Revesz, Tamas and ... and IPDGC and International Parkinson’s Disease Genomics Consortium (IPDGC)
Brain, ISSN 0006-8950, 12/2017, Volume 140, Issue 12, pp. 3191 - 3203
Journal Article
Journal Article
Cancer Science, ISSN 1347-9032, 06/2017, Volume 108, Issue 6, pp. 1185 - 1193
Vacuolar (H + )‐ ATP ases (V‐ ATP ases) have important roles in the supply of nutrients to tumors by mediating autophagy and the endocytic uptake of... 
V‐ATPase | Cathepsin D | patient selection marker | colorectal cancer | vulnerability | V-ATPase | APOPTOSIS | ACTIVATION | ASPARTIC PROTEASE | PROTON PUMP | BREAST-CANCER | MTORC1 | ONCOLOGY | AMINO-ACIDS | H+-ATPASE | TRANSFER-RNA | CELL-LINE | RNA, Small Interfering - genetics | Vacuolar Proton-Translocating ATPases - genetics | Endoplasmic Reticulum Stress - drug effects | HCT116 Cells | Humans | Up-Regulation - genetics | Signal Transduction - genetics | Down-Regulation - drug effects | Endoplasmic Reticulum Stress - genetics | Autophagy - drug effects | Down-Regulation - genetics | Neoplasms - drug therapy | Up-Regulation - drug effects | Vacuolar Proton-Translocating ATPases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Neoplasms - genetics | Signal Transduction - drug effects | Cathepsin D - genetics | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Autophagy - genetics | Oncology, Experimental | Colorectal cancer | Cathepsins | Amino acids | Research | Health aspects | Adenosine triphosphatase | Cancer | TOR protein | Visualization | Peptides | Laboratories | Toxicity | Colorectal carcinoma | Amino acid starvation | Drug development | Kinases | Autophagy | D gene | Proteins | Cell growth | Antitumor agents | Nutrients | Pharmaceutical industry | Starvation | Capillary electrophoresis | Research & development--R&D | Therapeutic applications | Rapamycin | siRNA | Patients | Collagen | Scientific imaging | Intracellular | Endoplasmic reticulum | Mass spectrometry | Phagocytosis | Tumors | Index Medicus | Original
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 8, pp. 6602 - 6613
Cellular stress induced by nutrient deprivation, hypoxia, and exposure to many chemotherapeutic agents activates an evolutionarily conserved cell survival... 
DRUG | BREAST-CANCER CELLS | MALIGNANT GLIOMA-CELLS | LYSOSOMAL MEMBRANE PERMEABILIZATION | THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-EDGED-SWORD | DEATH | INDUCTION | CHLOROQUINE | TUMORIGENESIS | Schistosomicides - pharmacology | Microtubule-Associated Proteins - genetics | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Lysosomes - genetics | Gene Expression Profiling | Lucanthone - agonists | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Antineoplastic Agents - agonists | Lysosomes - metabolism | Schistosomicides - agonists | Antineoplastic Agents - pharmacology | Hydroxamic Acids - pharmacology | Permeability - drug effects | Phagosomes - metabolism | Tumor Suppressor Protein p53 - metabolism | Lucanthone - pharmacology | Cathepsin D - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Drug Synergism | Hydroxamic Acids - agonists | Breast Neoplasms - genetics | Adaptor Proteins, Signal Transducing - genetics | Cathepsin D - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - metabolism | Intracellular Membranes - metabolism | Phagosomes - genetics | Index Medicus | Caspase | Cancer Therapy | Signal Transduction | Autophagy | Breast Cancer | Apoptosis
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2017, Volume 359, Issue 2, pp. 374 - 383
Atherosclerosis is a common pathological basis of cardiovascular disease and remains the leading cause of mortality. Endothelial cell (EC) injury and autophagy... 
MiR-21 | Endothelial cell injury | Lysosomal function | Atherosclerosis | Autophagic flux | TARGET | APOPTOSIS | MECHANISM | INCREASES | PROTECTS | CELL BIOLOGY | BIOGENESIS | ONCOLOGY | PATHWAY | DYSFUNCTION | EXPRESSION | MicroRNAs - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Caspase 3 - metabolism | MicroRNAs - metabolism | Aorta - metabolism | Autophagy - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Molecular Mimicry | Lysosomes - metabolism | Oligoribonucleotides - metabolism | Caspase 3 - genetics | Autophagy - genetics | Sequestosome-1 Protein - metabolism | Lysosomes - drug effects | Cell Line | Cell Survival - drug effects | Lysosome-Associated Membrane Glycoproteins - metabolism | Signal Transduction | Endothelial Cells - metabolism | Aorta - drug effects | Gene Expression Regulation | Lipoproteins, LDL - pharmacology | Cathepsin D - metabolism | Sequestosome-1 Protein - genetics | Endothelial Cells - cytology | Cathepsin D - genetics | Beclin-1 - genetics | Lysosome-Associated Membrane Glycoproteins - genetics | MicroRNAs - genetics | Aorta - cytology | Beclin-1 - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Endothelial Cells - drug effects | Oligoribonucleotides - genetics | MicroRNA | Low density lipoproteins | Endothelium | Index Medicus
Journal Article