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1. Full Text Uptake and pathogenic effects of amyloid beta peptide 1–42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists
by Bi, X and Gall, C.M and Zhou, J and Lynch, G
Neuroscience, ISSN 0306-4522, 2002, Volume 112, Issue 4, pp. 827 - 840
internalization | disintegrin | Alzheimer’s disease | hippocampus | cathepsin D | microglia | Cathepsin D | Disintegrin | Alzheimer's disease | Internalization | Hippocampus | Microglia | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Biological and medical sciences | Medical sciences | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Immunohistochemistry | Microglia - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Peptide Fragments - metabolism | Culture Techniques | 2-Amino-5-phosphonovalerate - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Rats | Cathepsin D - metabolism | Integrins - metabolism | Rats, Sprague-Dawley | Amyloid beta-Peptides - adverse effects | Hippocampus - metabolism | Animals | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Peptide Fragments - adverse effects | Oligopeptides - pharmacology | Integrins - antagonists & inhibitors | Index Medicus
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2. Full Text Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
by Nervi, Bruno and Ramirez, Pablo and Rettig, Michael P and Uy, Geoffrey L and Holt, Matthew S and Ritchey, Julie K and Prior, Julie L and Piwnica-Worms, David and Bridger, Gary and Ley, Timothy J and DiPersio, John F
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 24, pp. 6206 - 6214
Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Anti-HIV Agents - pharmacology | Cytarabine - pharmacology | Leukemia, Promyelocytic, Acute - pathology | Apoptosis - drug effects | Heterocyclic Compounds - pharmacology | Serine Endopeptidases - physiology | Tumor Cells, Cultured - transplantation | Leukemia, Promyelocytic, Acute - metabolism | Bone Marrow - metabolism | Stromal Cells - drug effects | Antimetabolites, Antineoplastic - pharmacology | Receptors, CXCR4 - genetics | Colony-Forming Units Assay | Hematopoietic Stem Cell Mobilization | Bone Marrow - drug effects | Leukemia, Experimental - pathology | Leukemia, Experimental - drug therapy | Receptors, CXCR4 - antagonists & inhibitors | Mice, Inbred C57BL | Stromal Cells - metabolism | Cathepsin G | Hematopoietic Stem Cells - metabolism | Cathepsins - physiology | Protein Transport | Receptors, CXCR4 - metabolism | Drug Synergism | Animals | Mice | Leukemia, Experimental - metabolism | Leukemia, Promyelocytic, Acute - drug therapy | Index Medicus | Abridged Index Medicus | Myeloid Neoplasia
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3. Full Text Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors
by Capuzzi, Stephen J and Sun, Wei and Muratov, Eugene N and Martínez-Romero, Carles and He, Shihua and Zhu, Wenjun and Li, Hao and Tawa, Gregory and Fisher, Ethan G and Xu, Miao and Shinn, Paul and Qiu, Xiangguo and García-Sastre, Adolfo and Zheng, Wei and Tropsha, Alexander
Journal of medicinal chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3582 - 3594
Small Molecule Libraries - pharmacology | Antiviral Agents - pharmacology | Chlorocebus aethiops | Humans | Virus Internalization - drug effects | Drug Discovery | Ebolavirus - drug effects | Small Molecule Libraries - chemistry | Animals | Antiviral Agents - chemistry | Molecular Structure | HeLa Cells | Drug Evaluation, Preclinical | Vero Cells | Quantitative Structure-Activity Relationship | Index Medicus | antiviral drug screening | EBOV | QSAR | computer-aided drug design
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4. Full Text Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells
by Matsuyama, Shutoku and Matsuyama, Shutoku and Shirato, Kazuya and Kawase, Miyuki and Terada, Yutaka and Terada, Yutaka and Kawachi, Kengo and Fukushi, Shuetsu and Kamitani, Wataru
Journal of virology, ISSN 0022-538X, 10/2018, Volume 92, Issue 19
dec-RVKR-CMK | coronavirus | TMPRSS2 | cathepsin L | furin | Life Sciences & Biomedicine | Science & Technology | Virology | Cathepsin L - genetics | Cathepsin B - genetics | Humans | Cercopithecus aethiops | Cathepsin L - metabolism | Papain - genetics | Virus Internalization | Furin - genetics | Amino Acid Chloromethyl Ketones - pharmacology | Proteolysis | Serine Endopeptidases - genetics | Vero Cells | Furin - metabolism | Spike Glycoprotein, Coronavirus - genetics | Spike Glycoprotein, Coronavirus - metabolism | Cathepsin B - antagonists & inhibitors | Cathepsin B - metabolism | Cathepsin L - antagonists & inhibitors | Middle East Respiratory Syndrome Coronavirus - metabolism | Animals | Middle East Respiratory Syndrome Coronavirus - genetics | Papain - antagonists & inhibitors | Furin - antagonists & inhibitors | Serine Endopeptidases - metabolism | Papain - metabolism | Index Medicus
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5. Full Text Bone-Targeted Therapies in Cancer-Induced Bone Disease
by Sousa, Sofia and Sousa, Sofia and Clézardin, Philippe and Clézardin, Philippe
Calcified tissue international, ISSN 0171-967X, 2/2018, Volume 102, Issue 2, pp. 227 - 250
Biochemistry, general | RANKL | c-Src inhibitors | Denosumab | DKK1 | Bisphosphonates | Cell Biology | Life Sciences | Radium 223 | Cathepsin k inhibitors | Bone metastasis | Orthopedics | mTOR inhibitors | Sclerostin | Romosozumab | Endocrinology | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Humans | Bone Neoplasms - secondary | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Molecular Targeted Therapy | Proteasome Inhibitors - therapeutic use | Denosumab - therapeutic use | TOR Serine-Threonine Kinases - antagonists & inhibitors | Bortezomib - therapeutic use | Androgen Antagonists - therapeutic use | Diphosphonates - therapeutic use | Bone Neoplasms - drug therapy | Cathepsin K - antagonists & inhibitors | Integrins - antagonists & inhibitors | Radiopharmaceuticals - therapeutic use | Medical research | Care and treatment | Mortality | Phosphonates | Cathepsins | Medicine, Experimental | Metastasis | Health aspects | Cancer | Bone diseases | Osteoblasts | Cancer therapies | Morbidity | Proteasome inhibitors | Quality of life | Metastases | Bone resorption | Bone growth | Bone cancer | Osteoclasts | Osteogenesis | Tumors | Index Medicus
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6. Full Text Effect of cetirizine, a histamine (H1 ) receptor antagonist, on bone modeling during orthodontic tooth movement in rats
by Meh, Alja and Sprogar, Špela and Vaupotic, Tomaz and Cör, Andrej and Drevenšek, Gorazd and Marc, Janja and Drevenšek, Martina
American journal of orthodontics and dentofacial orthopedics, ISSN 0889-5406, 2011, Volume 139, Issue 4, pp. e323 - e329
Dentistry | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Orthodontic Wires | Cetirizine - pharmacology | Maxilla - drug effects | Rats, Wistar | Cell Count | Osteoblasts - drug effects | Alveolar Process - drug effects | Rats | Male | Bone Remodeling - drug effects | Bone Resorption - prevention & control | Bone Density - drug effects | Animals | Time Factors | Cathepsin K - analysis | Histamine H1 Antagonists - pharmacology | Bone Resorption - pathology | Maxilla - pathology | Tooth Movement Techniques - instrumentation | Osteocalcin - analysis | Osteoclasts - drug effects | Histamine | Universities and colleges | Orthodontics | Pharmacy | Index Medicus
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7. Full Text Chlorhexidine Inhibits the Activity of Dental Cysteine Cathepsins
by Scaffa, P.M.C and Vidal, C.M.P and Barros, N and Gesteira, T.F and Carmona, A.K and Breschi, L and Pashley, D.H and Tjäderhane, L and Tersariol, I.L.S and Nascimento, F.D and Carrilho, M.R
Journal of dental research, ISSN 0022-0345, 4/2012, Volume 91, Issue 4, pp. 420 - 425
collagen | cysteine cathepsins | degradation | chlorhexidine | dentin | proteolytic activity | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Leucine - pharmacology | Humans | Chlorhexidine - pharmacology | Recombinant Proteins | Dose-Response Relationship, Drug | Young Adult | Dentin - enzymology | Adult | Leucine - analogs & derivatives | Cathepsin K - antagonists & inhibitors | Cathepsins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Cathepsin B - antagonists & inhibitors | Coumarins | Models, Molecular | Spectrometry, Fluorescence | Cathepsin L - antagonists & inhibitors | Hydrolysis | Chlorhexidine - analogs & derivatives | Cysteine Proteinase Inhibitors - pharmacology | Dipeptides | Matrix Metalloproteinase Inhibitors | Protein Binding | Protein Conformation | Fluorescent Dyes | Dentin | Enzymes | Cysteine | Proteolysis | Proteolytic enzymes | Cathepsins | Chlorhexidine | Gene expression | Binding sites | Dental pulp | Index Medicus | Dentistry
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8. Full Text Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases
by Korkmaz, Brice and Horwitz, Marshall S and Jenne, Dieter E and Gauthier, Francis
Pharmacological reviews, ISSN 0031-6997, 12/2010, Volume 62, Issue 4, pp. 726 - 759
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Myeloblastin - chemistry | Catalytic Domain | Cathepsin G - physiology | Cathepsin G - chemistry | Humans | Myeloblastin - physiology | Leukocyte Elastase - antagonists & inhibitors | Lung Diseases - drug therapy | Molecular Targeted Therapy | Myeloblastin - antagonists & inhibitors | Neutropenia - drug therapy | Neutropenia - enzymology | Leukocyte Elastase - physiology | Animals | Leukocyte Elastase - chemistry | Papillon-Lefevre Disease - enzymology | Papillon-Lefevre Disease - drug therapy | Cathepsin G - antagonists & inhibitors | Lung Diseases - enzymology | Index Medicus | Review
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