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Publication DateAmerican Journal of Orthodontics and Dentofacial Orthopedics, ISSN 0889-5406, 2011, Volume 139, Issue 4, pp. e323 - e329
Introduction Histamine (H1 ) receptor antagonists are widely used drugs for treatment of allergic conditions. Although histamine was shown to be involved in...
Dentistry | OVARIECTOMY | DIFFERENTIATION | DECREASES | EXPRESSION | STAGE | DENTISTRY, ORAL SURGERY & MEDICINE | Orthodontic Wires | Cetirizine - pharmacology | Maxilla - drug effects | Rats, Wistar | Cell Count | Osteoblasts - drug effects | Alveolar Process - drug effects | Rats | Male | Bone Remodeling - drug effects | Bone Resorption - prevention & control | Bone Density - drug effects | Animals | Time Factors | Cathepsin K - analysis | Histamine H1 Antagonists - pharmacology | Bone Resorption - pathology | Maxilla - pathology | Tooth Movement Techniques - instrumentation | Osteocalcin - analysis | Osteoclasts - drug effects | Histamine | Universities and colleges | Orthodontics | Pharmacy
Dentistry | OVARIECTOMY | DIFFERENTIATION | DECREASES | EXPRESSION | STAGE | DENTISTRY, ORAL SURGERY & MEDICINE | Orthodontic Wires | Cetirizine - pharmacology | Maxilla - drug effects | Rats, Wistar | Cell Count | Osteoblasts - drug effects | Alveolar Process - drug effects | Rats | Male | Bone Remodeling - drug effects | Bone Resorption - prevention & control | Bone Density - drug effects | Animals | Time Factors | Cathepsin K - analysis | Histamine H1 Antagonists - pharmacology | Bone Resorption - pathology | Maxilla - pathology | Tooth Movement Techniques - instrumentation | Osteocalcin - analysis | Osteoclasts - drug effects | Histamine | Universities and colleges | Orthodontics | Pharmacy
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Loading RightsNeuroscience, ISSN 0306-4522, 2002, Volume 112, Issue 4, pp. 827 - 840
Many synapses contain two types of receptors - integrins and N-methyl-D-aspartate (NMDA) receptors - that have been implicated in peptide internalization. The...
internalization | disintegrin | Alzheimer’s disease | hippocampus | cathepsin D | microglia | Cathepsin D | Disintegrin | Alzheimer's disease | Internalization | Hippocampus | Microglia | NEUROFIBRILLARY TANGLES | ARG-GLY-ASP | ALZHEIMERS-DISEASE | NEUROSCIENCES | ADULT-RAT BRAIN | SIGNAL-TRANSDUCTION | CENTRAL-NERVOUS-SYSTEM | LONG-TERM POTENTIATION | PRECURSOR PROTEIN | CATHEPSIN-D | GRANULE CELL DEGENERATION | Immunohistochemistry | Microglia - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Peptide Fragments - metabolism | Culture Techniques | 2-Amino-5-phosphonovalerate - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Rats | Cathepsin D - metabolism | Integrins - metabolism | Rats, Sprague-Dawley | Amyloid beta-Peptides - adverse effects | Hippocampus - metabolism | Animals | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Peptide Fragments - adverse effects | Oligopeptides - pharmacology | Integrins - antagonists & inhibitors
internalization | disintegrin | Alzheimer’s disease | hippocampus | cathepsin D | microglia | Cathepsin D | Disintegrin | Alzheimer's disease | Internalization | Hippocampus | Microglia | NEUROFIBRILLARY TANGLES | ARG-GLY-ASP | ALZHEIMERS-DISEASE | NEUROSCIENCES | ADULT-RAT BRAIN | SIGNAL-TRANSDUCTION | CENTRAL-NERVOUS-SYSTEM | LONG-TERM POTENTIATION | PRECURSOR PROTEIN | CATHEPSIN-D | GRANULE CELL DEGENERATION | Immunohistochemistry | Microglia - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Peptide Fragments - metabolism | Culture Techniques | 2-Amino-5-phosphonovalerate - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Rats | Cathepsin D - metabolism | Integrins - metabolism | Rats, Sprague-Dawley | Amyloid beta-Peptides - adverse effects | Hippocampus - metabolism | Animals | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Peptide Fragments - adverse effects | Oligopeptides - pharmacology | Integrins - antagonists & inhibitors
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Loading RightsBlood, ISSN 0006-4971, 2009, Volume 113, Issue 24, pp. 6206 - 6214
The CXCR4-SDF-1 axis plays a central role in the trafficking and retention of normal and malignant stem cells in the bone marrow (BM) microenvironment. Here,...
DRUG-INDUCED APOPTOSIS | STEM-CELLS | HEMATOPOIETIC PROGENITOR CELLS | RESISTANCE CAM-DR | DIFFERENTIAL EXPRESSION | BONE-MARROW MICROENVIRONMENT | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | HEMATOLOGY | HUMAN MULTIPLE-MYELOMA | ACUTE PROMYELOCYTIC LEUKEMIA | Anti-HIV Agents - pharmacology | Cytarabine - pharmacology | Leukemia, Promyelocytic, Acute - pathology | Apoptosis - drug effects | Heterocyclic Compounds - pharmacology | Serine Endopeptidases - physiology | Tumor Cells, Cultured - transplantation | Leukemia, Promyelocytic, Acute - metabolism | Bone Marrow - metabolism | Stromal Cells - drug effects | Antimetabolites, Antineoplastic - pharmacology | Receptors, CXCR4 - genetics | Colony-Forming Units Assay | Hematopoietic Stem Cell Mobilization | Bone Marrow - drug effects | Leukemia, Experimental - pathology | Leukemia, Experimental - drug therapy | Receptors, CXCR4 - antagonists & inhibitors | Mice, Inbred C57BL | Stromal Cells - metabolism | Cathepsin G | Hematopoietic Stem Cells - metabolism | Cathepsins - physiology | Protein Transport | Receptors, CXCR4 - metabolism | Drug Synergism | Animals | Mice | Leukemia, Experimental - metabolism | Leukemia, Promyelocytic, Acute - drug therapy | Index Medicus | Abridged Index Medicus | Myeloid Neoplasia
DRUG-INDUCED APOPTOSIS | STEM-CELLS | HEMATOPOIETIC PROGENITOR CELLS | RESISTANCE CAM-DR | DIFFERENTIAL EXPRESSION | BONE-MARROW MICROENVIRONMENT | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | HEMATOLOGY | HUMAN MULTIPLE-MYELOMA | ACUTE PROMYELOCYTIC LEUKEMIA | Anti-HIV Agents - pharmacology | Cytarabine - pharmacology | Leukemia, Promyelocytic, Acute - pathology | Apoptosis - drug effects | Heterocyclic Compounds - pharmacology | Serine Endopeptidases - physiology | Tumor Cells, Cultured - transplantation | Leukemia, Promyelocytic, Acute - metabolism | Bone Marrow - metabolism | Stromal Cells - drug effects | Antimetabolites, Antineoplastic - pharmacology | Receptors, CXCR4 - genetics | Colony-Forming Units Assay | Hematopoietic Stem Cell Mobilization | Bone Marrow - drug effects | Leukemia, Experimental - pathology | Leukemia, Experimental - drug therapy | Receptors, CXCR4 - antagonists & inhibitors | Mice, Inbred C57BL | Stromal Cells - metabolism | Cathepsin G | Hematopoietic Stem Cells - metabolism | Cathepsins - physiology | Protein Transport | Receptors, CXCR4 - metabolism | Drug Synergism | Animals | Mice | Leukemia, Experimental - metabolism | Leukemia, Promyelocytic, Acute - drug therapy | Index Medicus | Abridged Index Medicus | Myeloid Neoplasia
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Loading RightsBioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2017, Volume 25, Issue 6, pp. 1787 - 1794
We describe here a novel chemotype with substituted benzimidazole scaffold for nonsteroidal farnesoid X receptor (FXR) antagonists starting from the...
FXR | Antagonists | Compound library | Benzimidazole scaffold | NATURAL-PRODUCT | ACTIVATION | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMIN INHIBITORS | CHEMISTRY, ORGANIC | IDENTIFICATION | NUCLEAR RECEPTOR | POTENT | HYDANTOIN MOIETY | BILE-ACIDS | CATHEPSIN-K INHIBITORS | SCAFFOLD | Cholesterol 7-alpha-Hydroxylase - genetics | Proton Magnetic Resonance Spectroscopy | Cholesterol 7-alpha-Hydroxylase - metabolism | Humans | RNA, Messenger - genetics | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Fluorescence Resonance Energy Transfer | Benzimidazoles - pharmacology | Structure-Activity Relationship | Benzimidazoles - chemistry | Drug Discovery | Fluorescence | Fluorides | Analysis | Cytochrome P-450 | Tretinoin | Deoxycholic acid
FXR | Antagonists | Compound library | Benzimidazole scaffold | NATURAL-PRODUCT | ACTIVATION | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMIN INHIBITORS | CHEMISTRY, ORGANIC | IDENTIFICATION | NUCLEAR RECEPTOR | POTENT | HYDANTOIN MOIETY | BILE-ACIDS | CATHEPSIN-K INHIBITORS | SCAFFOLD | Cholesterol 7-alpha-Hydroxylase - genetics | Proton Magnetic Resonance Spectroscopy | Cholesterol 7-alpha-Hydroxylase - metabolism | Humans | RNA, Messenger - genetics | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Fluorescence Resonance Energy Transfer | Benzimidazoles - pharmacology | Structure-Activity Relationship | Benzimidazoles - chemistry | Drug Discovery | Fluorescence | Fluorides | Analysis | Cytochrome P-450 | Tretinoin | Deoxycholic acid
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Loading RightsJournal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3582 - 3594
The Ebola virus (EBOV) causes severe human infection that lacks effective treatment. A recent screen identified a series of compounds that block EBOV-like...
antiviral drug screening | EBOV | QSAR | computer-aided drug design
antiviral drug screening | EBOV | QSAR | computer-aided drug design
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Loading RightsPLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0132478
Background Regular physical activities have a positive effect on the muscular skeletal system but over-strenuous exercise may be different. Transiently...
SCLEROSTIN | MINERAL DENSITY | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | MYOSTATIN | PHYSICAL-ACTIVITY | UP-REGULATION | EXPRESSION | HUMAN SKELETAL-MUSCLE | EXERCISE | BONE TURNOVER MARKERS | Collagen Type I - blood | Bone Resorption - etiology | Peptides - blood | Bone Resorption - blood | Humans | Middle Aged | Wnt Signaling Pathway - physiology | Male | Muscle, Skeletal - metabolism | Bone Morphogenetic Proteins - blood | Procollagen - blood | Genetic Markers | Intercellular Signaling Peptides and Proteins - blood | Running - physiology | Follistatin - blood | Cathepsin K - blood | Myostatin - blood | Peptide Fragments - blood | Biomarkers | Adult | Female | Cathepsins | Analysis | Exercise | Wnt protein | Homeostasis | Antagonists | SOST protein | Ultramarathon | Blood | Bone resorption | β-catenin | Signal transduction | Bone growth | Immunology | Race | Bone density | Growth factors | Cathepsin K | Follistatin | Markers | Muscles | Bone turnover | Metabolism | Gene expression | Serum levels | Studies | Musculoskeletal system | Signaling | Physical fitness | Track & field | Running | Sampling methods | Myostatin | Skeletal system | Marathons | Bone | Dkk1 protein | Osteogenesis
SCLEROSTIN | MINERAL DENSITY | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | MYOSTATIN | PHYSICAL-ACTIVITY | UP-REGULATION | EXPRESSION | HUMAN SKELETAL-MUSCLE | EXERCISE | BONE TURNOVER MARKERS | Collagen Type I - blood | Bone Resorption - etiology | Peptides - blood | Bone Resorption - blood | Humans | Middle Aged | Wnt Signaling Pathway - physiology | Male | Muscle, Skeletal - metabolism | Bone Morphogenetic Proteins - blood | Procollagen - blood | Genetic Markers | Intercellular Signaling Peptides and Proteins - blood | Running - physiology | Follistatin - blood | Cathepsin K - blood | Myostatin - blood | Peptide Fragments - blood | Biomarkers | Adult | Female | Cathepsins | Analysis | Exercise | Wnt protein | Homeostasis | Antagonists | SOST protein | Ultramarathon | Blood | Bone resorption | β-catenin | Signal transduction | Bone growth | Immunology | Race | Bone density | Growth factors | Cathepsin K | Follistatin | Markers | Muscles | Bone turnover | Metabolism | Gene expression | Serum levels | Studies | Musculoskeletal system | Signaling | Physical fitness | Track & field | Running | Sampling methods | Myostatin | Skeletal system | Marathons | Bone | Dkk1 protein | Osteogenesis
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Loading RightsJOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2015, Volume 58, Issue 5, pp. 2114 - 2134
Novel 2,5-dioxoimidazolidine-based conformationally constrained analogues of KN62 (1) were developed as P2X7 receptor (P2X7R) antagonists using a...
POTENT ANTAGONIST | RHEUMATOID-ARTHRITIS | CHEMISTRY, MEDICINAL | LARGE-PORE FORMATION | TYROSINE | BIOLOGICAL-ACTIVITY | THERAPEUTIC TARGET | P2X7 RECEPTORS | PURINERGIC RECEPTOR | DERIVATIVES | CATHEPSIN-B | Inflammation - chemically induced | Arthritis, Experimental - drug therapy | Purinergic P2X Receptor Antagonists - pharmacokinetics | Monocytes - cytology | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Immunoblotting | Male | Purinergic P2X Receptor Antagonists - pharmacology | Structure-Activity Relationship | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - chemistry | Sulfonic Acids - chemistry | Tissue Distribution | Arthritis, Experimental - chemically induced | Cattle | Inflammation - drug therapy | Interleukin-1beta - metabolism | HEK293 Cells | Neuralgia - etiology | Mice, Inbred DBA | Molecular Structure | Carrageenan - toxicity | Enzyme-Linked Immunosorbent Assay | Hydantoins - pharmacology | Rats | Edema - drug therapy | Macrophages - cytology | Sulfonic Acids - pharmacology | Drug Discovery | Rats, Sprague-Dawley | Neuralgia - drug therapy | Monocytes - drug effects | Animals | Purinergic P2X Receptor Antagonists - chemistry | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Long-Term Potentiation | Collagen Type II - toxicity | Macrophages - drug effects | Edema - chemically induced | Receptors, Purinergic P2X7 - chemistry | Hydantoins - chemistry
POTENT ANTAGONIST | RHEUMATOID-ARTHRITIS | CHEMISTRY, MEDICINAL | LARGE-PORE FORMATION | TYROSINE | BIOLOGICAL-ACTIVITY | THERAPEUTIC TARGET | P2X7 RECEPTORS | PURINERGIC RECEPTOR | DERIVATIVES | CATHEPSIN-B | Inflammation - chemically induced | Arthritis, Experimental - drug therapy | Purinergic P2X Receptor Antagonists - pharmacokinetics | Monocytes - cytology | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Immunoblotting | Male | Purinergic P2X Receptor Antagonists - pharmacology | Structure-Activity Relationship | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - chemistry | Sulfonic Acids - chemistry | Tissue Distribution | Arthritis, Experimental - chemically induced | Cattle | Inflammation - drug therapy | Interleukin-1beta - metabolism | HEK293 Cells | Neuralgia - etiology | Mice, Inbred DBA | Molecular Structure | Carrageenan - toxicity | Enzyme-Linked Immunosorbent Assay | Hydantoins - pharmacology | Rats | Edema - drug therapy | Macrophages - cytology | Sulfonic Acids - pharmacology | Drug Discovery | Rats, Sprague-Dawley | Neuralgia - drug therapy | Monocytes - drug effects | Animals | Purinergic P2X Receptor Antagonists - chemistry | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Long-Term Potentiation | Collagen Type II - toxicity | Macrophages - drug effects | Edema - chemically induced | Receptors, Purinergic P2X7 - chemistry | Hydantoins - chemistry
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Loading RightsJournal of Leukocyte Biology, ISSN 0741-5400, 06/2016, Volume 99, Issue 6, pp. 863 - 868
Review of how proteolysis of albumin by acidic proteases generates a specific CXCR4 antagonist. The chemokine receptor CXCR4 is an important G protein‐coupled...
cellular migration | HIV‐1 | signaling | inflammation | metastasis | HIV-1 | Signaling | Inflammation | Metastasis | Cellular migration | CHEMOKINE RECEPTOR CXCR4 | IMMUNOLOGY | CANCER STEM-CELLS | CELL BIOLOGY | BREAST-CANCER | EXTRACELLULAR ACIDIFICATION | HIV-INFECTION | PROTEIN-COUPLED RECEPTOR | SDF-1-CXCR4 AXIS | CATHEPSIN-E | HEMATOLOGY | TUMOR-GROWTH | DISEASE PROGRESSION | Biomarkers - metabolism | Peptides - chemistry | HIV-1 - drug effects | Receptors, CXCR4 - antagonists & inhibitors | Humans | Peptide Fragments - pharmacology | Peptides - pharmacology | Receptors, CXCR4 - metabolism | Proteolysis - drug effects | Peptide Fragments - chemistry | Serum Albumin - pharmacology | Serum Albumin - chemistry | Serum Albumin - metabolism
cellular migration | HIV‐1 | signaling | inflammation | metastasis | HIV-1 | Signaling | Inflammation | Metastasis | Cellular migration | CHEMOKINE RECEPTOR CXCR4 | IMMUNOLOGY | CANCER STEM-CELLS | CELL BIOLOGY | BREAST-CANCER | EXTRACELLULAR ACIDIFICATION | HIV-INFECTION | PROTEIN-COUPLED RECEPTOR | SDF-1-CXCR4 AXIS | CATHEPSIN-E | HEMATOLOGY | TUMOR-GROWTH | DISEASE PROGRESSION | Biomarkers - metabolism | Peptides - chemistry | HIV-1 - drug effects | Receptors, CXCR4 - antagonists & inhibitors | Humans | Peptide Fragments - pharmacology | Peptides - pharmacology | Receptors, CXCR4 - metabolism | Proteolysis - drug effects | Peptide Fragments - chemistry | Serum Albumin - pharmacology | Serum Albumin - chemistry | Serum Albumin - metabolism
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Loading RightsCell Reports, ISSN 2211-1247, 05/2015, Volume 11, Issue 5, pp. 737 - 747
CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover...
EXTRACELLULAR ACIDIFICATION | CELLS | CORECEPTOR | CHEMOKINE RECEPTOR CXCR4 | DRUG DISCOVERY | INVOLVEMENT | HIV-1 ENTRY | SDF-1 | INHIBITOR | CATHEPSIN-D | CELL BIOLOGY | Biomarkers - urine | Humans | Half-Life | Molecular Sequence Data | Peptide Fragments - pharmacology | Peptide Library | Virus Internalization - drug effects | Renal Insufficiency, Chronic - metabolism | HIV-1 - physiology | Peptides - metabolism | HEK293 Cells | Serum Albumin - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Peptide Fragments - metabolism | Peptides - chemistry | Jurkat Cells | Receptors, CXCR4 - antagonists & inhibitors | Mice, Inbred C57BL | Peptides - pharmacology | Receptors, CXCR4 - metabolism | Renal Insufficiency, Chronic - pathology | Cell Movement - drug effects | Peptide Fragments - chemistry | Sequence Alignment | Animals | Serum Albumin - pharmacology | Signal Transduction - drug effects | Protein Binding | Mice | Serum Albumin - metabolism | Life Sciences | Cellular Biology
EXTRACELLULAR ACIDIFICATION | CELLS | CORECEPTOR | CHEMOKINE RECEPTOR CXCR4 | DRUG DISCOVERY | INVOLVEMENT | HIV-1 ENTRY | SDF-1 | INHIBITOR | CATHEPSIN-D | CELL BIOLOGY | Biomarkers - urine | Humans | Half-Life | Molecular Sequence Data | Peptide Fragments - pharmacology | Peptide Library | Virus Internalization - drug effects | Renal Insufficiency, Chronic - metabolism | HIV-1 - physiology | Peptides - metabolism | HEK293 Cells | Serum Albumin - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Peptide Fragments - metabolism | Peptides - chemistry | Jurkat Cells | Receptors, CXCR4 - antagonists & inhibitors | Mice, Inbred C57BL | Peptides - pharmacology | Receptors, CXCR4 - metabolism | Renal Insufficiency, Chronic - pathology | Cell Movement - drug effects | Peptide Fragments - chemistry | Sequence Alignment | Animals | Serum Albumin - pharmacology | Signal Transduction - drug effects | Protein Binding | Mice | Serum Albumin - metabolism | Life Sciences | Cellular Biology
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Loading RightsJournal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 40, pp. 27614 - 27624
Background: How LL-37 delivers double-stranded RNA (dsRNA) to activate TLR3 signaling is poorly understood. Results: LL-37 was found to traffic to endosomes...
VITAMIN-D | pH Regulation | DOUBLE-STRANDED-RNA | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Innate Immunity | RESONANCE ENERGY-TRANSFER | RNA-binding Protein | Toll-like Receptor (TLR) | MICROSCOPY | CLEAVAGE | CATHEPSINS | ANTIMICROBIAL PEPTIDE | ASTHMA | Endosome | CATHELICIDIN LL-37 | Amino Acid Sequence | Up-Regulation | Antimicrobial Cationic Peptides - antagonists & inhibitors | Peptides - chemistry | Signal Transduction | Antimicrobial Cationic Peptides - chemistry | Humans | Molecular Sequence Data | Antimicrobial Cationic Peptides - metabolism | Toll-Like Receptor 3 - metabolism | Endosomes - metabolism | Peptides - metabolism | Toll-Like Receptor 3 - chemistry | RNA, Double-Stranded - metabolism | Toll-Like Receptor 3 - genetics | Antimicrobial Cationic Peptides - genetics | Binding Sites | Hydrogen-Ion Concentration | Immunology
VITAMIN-D | pH Regulation | DOUBLE-STRANDED-RNA | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Innate Immunity | RESONANCE ENERGY-TRANSFER | RNA-binding Protein | Toll-like Receptor (TLR) | MICROSCOPY | CLEAVAGE | CATHEPSINS | ANTIMICROBIAL PEPTIDE | ASTHMA | Endosome | CATHELICIDIN LL-37 | Amino Acid Sequence | Up-Regulation | Antimicrobial Cationic Peptides - antagonists & inhibitors | Peptides - chemistry | Signal Transduction | Antimicrobial Cationic Peptides - chemistry | Humans | Molecular Sequence Data | Antimicrobial Cationic Peptides - metabolism | Toll-Like Receptor 3 - metabolism | Endosomes - metabolism | Peptides - metabolism | Toll-Like Receptor 3 - chemistry | RNA, Double-Stranded - metabolism | Toll-Like Receptor 3 - genetics | Antimicrobial Cationic Peptides - genetics | Binding Sites | Hydrogen-Ion Concentration | Immunology
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Loading RightsJournal of virology, ISSN 0022-538X, 10/2018, Volume 92, Issue 19
Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes host cellular proteases to enter cells. A previous report shows that furin, which is...
dec-RVKR-CMK | coronavirus | TMPRSS2 | cathepsin L | furin | S PROTEIN | FUSION | RECEPTOR | CLEAVAGE | INHIBITION | TROPISM | VIROLOGY | SURFACE | INFECTION | LOVO | Cathepsin L - genetics | Cathepsin B - genetics | Humans | Cercopithecus aethiops | Cathepsin L - metabolism | Papain - genetics | Virus Internalization | Furin - genetics | Amino Acid Chloromethyl Ketones - pharmacology | Proteolysis | Serine Endopeptidases - genetics | Vero Cells | Furin - metabolism | Spike Glycoprotein, Coronavirus - genetics | Spike Glycoprotein, Coronavirus - metabolism | Cathepsin B - antagonists & inhibitors | Cathepsin B - metabolism | Cathepsin L - antagonists & inhibitors | Middle East Respiratory Syndrome Coronavirus - metabolism | Animals | Middle East Respiratory Syndrome Coronavirus - genetics | Papain - antagonists & inhibitors | Furin - antagonists & inhibitors | Serine Endopeptidases - metabolism | Papain - metabolism
dec-RVKR-CMK | coronavirus | TMPRSS2 | cathepsin L | furin | S PROTEIN | FUSION | RECEPTOR | CLEAVAGE | INHIBITION | TROPISM | VIROLOGY | SURFACE | INFECTION | LOVO | Cathepsin L - genetics | Cathepsin B - genetics | Humans | Cercopithecus aethiops | Cathepsin L - metabolism | Papain - genetics | Virus Internalization | Furin - genetics | Amino Acid Chloromethyl Ketones - pharmacology | Proteolysis | Serine Endopeptidases - genetics | Vero Cells | Furin - metabolism | Spike Glycoprotein, Coronavirus - genetics | Spike Glycoprotein, Coronavirus - metabolism | Cathepsin B - antagonists & inhibitors | Cathepsin B - metabolism | Cathepsin L - antagonists & inhibitors | Middle East Respiratory Syndrome Coronavirus - metabolism | Animals | Middle East Respiratory Syndrome Coronavirus - genetics | Papain - antagonists & inhibitors | Furin - antagonists & inhibitors | Serine Endopeptidases - metabolism | Papain - metabolism
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Loading RightsCalcified Tissue International, ISSN 0171-967X, 2/2018, Volume 102, Issue 2, pp. 227 - 250
Cancer-induced bone disease is a major source of morbidity and mortality in cancer patients. Thus, effective bone-targeted therapies are essential to improve...
Biochemistry, general | RANKL | c-Src inhibitors | Denosumab | DKK1 | Bisphosphonates | Cell Biology | Life Sciences | Radium 223 | Cathepsin k inhibitors | Bone metastasis | Orthopedics | mTOR inhibitors | Sclerostin | Romosozumab | Endocrinology | ADVANCED BREAST-CANCER | REFRACTORY MULTIPLE-MYELOMA | RANDOMIZED CONTROLLED-TRIAL | RENAL-CELL CARCINOMA | EVEROLIMUS PLUS EXEMESTANE | ZOLEDRONIC ACID | PHASE-II TRIAL | ENDOCRINOLOGY & METABOLISM | CATHEPSIN-K INHIBITOR | TYROSINE KINASE INHIBITOR | RESISTANT PROSTATE-CANCER | Humans | Bone Neoplasms - secondary | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Molecular Targeted Therapy | Proteasome Inhibitors - therapeutic use | Denosumab - therapeutic use | TOR Serine-Threonine Kinases - antagonists & inhibitors | Bortezomib - therapeutic use | Androgen Antagonists - therapeutic use | Diphosphonates - therapeutic use | Bone Neoplasms - drug therapy | Cathepsin K - antagonists & inhibitors | Integrins - antagonists & inhibitors | Radiopharmaceuticals - therapeutic use | Medical research | Care and treatment | Mortality | Phosphonates | Cathepsins | Medicine, Experimental | Metastasis | Health aspects | Cancer | Bone diseases | Osteoblasts | Cancer therapies | Morbidity | Proteasome inhibitors | Quality of life | Metastases | Bone resorption | Bone growth | Bone cancer | Osteoclasts | Osteogenesis | Tumors
Biochemistry, general | RANKL | c-Src inhibitors | Denosumab | DKK1 | Bisphosphonates | Cell Biology | Life Sciences | Radium 223 | Cathepsin k inhibitors | Bone metastasis | Orthopedics | mTOR inhibitors | Sclerostin | Romosozumab | Endocrinology | ADVANCED BREAST-CANCER | REFRACTORY MULTIPLE-MYELOMA | RANDOMIZED CONTROLLED-TRIAL | RENAL-CELL CARCINOMA | EVEROLIMUS PLUS EXEMESTANE | ZOLEDRONIC ACID | PHASE-II TRIAL | ENDOCRINOLOGY & METABOLISM | CATHEPSIN-K INHIBITOR | TYROSINE KINASE INHIBITOR | RESISTANT PROSTATE-CANCER | Humans | Bone Neoplasms - secondary | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Molecular Targeted Therapy | Proteasome Inhibitors - therapeutic use | Denosumab - therapeutic use | TOR Serine-Threonine Kinases - antagonists & inhibitors | Bortezomib - therapeutic use | Androgen Antagonists - therapeutic use | Diphosphonates - therapeutic use | Bone Neoplasms - drug therapy | Cathepsin K - antagonists & inhibitors | Integrins - antagonists & inhibitors | Radiopharmaceuticals - therapeutic use | Medical research | Care and treatment | Mortality | Phosphonates | Cathepsins | Medicine, Experimental | Metastasis | Health aspects | Cancer | Bone diseases | Osteoblasts | Cancer therapies | Morbidity | Proteasome inhibitors | Quality of life | Metastases | Bone resorption | Bone growth | Bone cancer | Osteoclasts | Osteogenesis | Tumors
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