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Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 24, pp. 6206 - 6214
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3582 - 3594
The Ebola virus (EBOV) causes severe human infection that lacks effective treatment. A recent screen identified a series of compounds that block EBOV-like... 
antiviral drug screening | EBOV | QSAR | computer-aided drug design
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0132478
Journal Article
by Park, JH and Lee, GE and Lee, SD and Hien, TT and Kim, S and Yang, JW and Cho, JH and Ko, H and Lim, SC and Kim, YG and Kang, KW and Kim, YC
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2015, Volume 58, Issue 5, pp. 2114 - 2134
Novel 2,5-dioxoimidazolidine-based conformationally constrained analogues of KN62 (1) were developed as P2X7 receptor (P2X7R) antagonists using a... 
POTENT ANTAGONIST | RHEUMATOID-ARTHRITIS | CHEMISTRY, MEDICINAL | LARGE-PORE FORMATION | TYROSINE | BIOLOGICAL-ACTIVITY | THERAPEUTIC TARGET | P2X7 RECEPTORS | PURINERGIC RECEPTOR | DERIVATIVES | CATHEPSIN-B | Inflammation - chemically induced | Arthritis, Experimental - drug therapy | Purinergic P2X Receptor Antagonists - pharmacokinetics | Monocytes - cytology | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Immunoblotting | Male | Purinergic P2X Receptor Antagonists - pharmacology | Structure-Activity Relationship | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - chemistry | Sulfonic Acids - chemistry | Tissue Distribution | Arthritis, Experimental - chemically induced | Cattle | Inflammation - drug therapy | Interleukin-1beta - metabolism | HEK293 Cells | Neuralgia - etiology | Mice, Inbred DBA | Molecular Structure | Carrageenan - toxicity | Enzyme-Linked Immunosorbent Assay | Hydantoins - pharmacology | Rats | Edema - drug therapy | Macrophages - cytology | Sulfonic Acids - pharmacology | Drug Discovery | Rats, Sprague-Dawley | Neuralgia - drug therapy | Monocytes - drug effects | Animals | Purinergic P2X Receptor Antagonists - chemistry | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Long-Term Potentiation | Collagen Type II - toxicity | Macrophages - drug effects | Edema - chemically induced | Receptors, Purinergic P2X7 - chemistry | Hydantoins - chemistry
Journal Article
Cell Reports, ISSN 2211-1247, 05/2015, Volume 11, Issue 5, pp. 737 - 747
Journal Article
Journal Article
Calcified Tissue International, ISSN 0171-967X, 2/2018, Volume 102, Issue 2, pp. 227 - 250
Cancer-induced bone disease is a major source of morbidity and mortality in cancer patients. Thus, effective bone-targeted therapies are essential to improve... 
Biochemistry, general | RANKL | c-Src inhibitors | Denosumab | DKK1 | Bisphosphonates | Cell Biology | Life Sciences | Radium 223 | Cathepsin k inhibitors | Bone metastasis | Orthopedics | mTOR inhibitors | Sclerostin | Romosozumab | Endocrinology | ADVANCED BREAST-CANCER | REFRACTORY MULTIPLE-MYELOMA | RANDOMIZED CONTROLLED-TRIAL | RENAL-CELL CARCINOMA | EVEROLIMUS PLUS EXEMESTANE | ZOLEDRONIC ACID | PHASE-II TRIAL | ENDOCRINOLOGY & METABOLISM | CATHEPSIN-K INHIBITOR | TYROSINE KINASE INHIBITOR | RESISTANT PROSTATE-CANCER | Humans | Bone Neoplasms - secondary | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Molecular Targeted Therapy | Proteasome Inhibitors - therapeutic use | Denosumab - therapeutic use | TOR Serine-Threonine Kinases - antagonists & inhibitors | Bortezomib - therapeutic use | Androgen Antagonists - therapeutic use | Diphosphonates - therapeutic use | Bone Neoplasms - drug therapy | Cathepsin K - antagonists & inhibitors | Integrins - antagonists & inhibitors | Radiopharmaceuticals - therapeutic use | Medical research | Care and treatment | Mortality | Phosphonates | Cathepsins | Medicine, Experimental | Metastasis | Health aspects | Cancer | Bone diseases | Osteoblasts | Cancer therapies | Morbidity | Proteasome inhibitors | Quality of life | Metastases | Bone resorption | Bone growth | Bone cancer | Osteoclasts | Osteogenesis | Tumors
Journal Article