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Nature, ISSN 0028-0836, 08/2009, Volume 460, Issue 7257, pp. 904 - 908
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function... 
TRANSFORMATION | PROTEIN | RETROVIRAL VECTOR GCDNSAP | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | V-CBL | MUTATIONS | UBIQUITIN LIGASES | MYELODYSPLASTIC SYNDROMES | P53 | NIH 3T3 Cells | Neoplasm Transplantation | ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Humans | Leukemia, Myeloid - genetics | Molecular Sequence Data | ras Proteins - metabolism | Male | Leukemia, Myeloid - pathology | Allelic Imbalance | Ubiquitination | Base Sequence | Female | Proto-Oncogene Proteins c-cbl - deficiency | Genes, Tumor Suppressor | Proto-Oncogene Proteins c-cbl - genetics | Amino Acid Sequence | Oncogenes - genetics | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Chromosomes, Human, Pair 11 - genetics | Proto-Oncogene Proteins c-cbl - chemistry | Mice, Knockout | Animals | Uniparental Disomy - genetics | Leukemia, Myeloid - metabolism | Mice, Nude | Mutant Proteins - chemistry | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Protein Conformation | Mice | Mutation | Gene mutations | Myelocytic leukemia | Physiological aspects | Tumor suppressor genes | Development and progression | Genetic aspects | Nonlymphoid leukemia | Research | Protein kinases | Proteins | Genes | Amino acids | Kinases | Cells | Clinical outcomes | Crystal structure | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7493, pp. 508 - 512
Tumour metastasis is the primary cause of mortality in cancer patients and remains the key challenge for cancer therapy(1). New therapeutic approaches to block... 
ACTIVATION | MOUSE NK CELLS | WARFARIN | AXL | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | TYROSINE KINASES | IDENTIFICATION | CELLULAR TARGETS | Mammary Neoplasms, Experimental - immunology | Proto-Oncogene Proteins c-cbl - metabolism | Melanoma, Experimental - drug therapy | Male | Mammary Neoplasms, Experimental - genetics | Warfarin - pharmacology | Warfarin - therapeutic use | Ubiquitination | Melanoma, Experimental - immunology | Neoplasm Metastasis - drug therapy | Neoplasm Metastasis - immunology | Neoplasm Metastasis - prevention & control | c-Mer Tyrosine Kinase | Mammary Neoplasms, Experimental - pathology | Killer Cells, Natural - immunology | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-cbl - deficiency | Mammary Neoplasms, Experimental - drug therapy | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins c-cbl - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Ubiquitin-Protein Ligases - metabolism | Melanoma, Experimental - pathology | Anticoagulants - therapeutic use | Receptor Protein-Tyrosine Kinases - metabolism | Animals | Melanoma, Experimental - genetics | Adaptor Proteins, Signal Transducing - deficiency | Anticoagulants - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Ubiquitin-Protein Ligases - deficiency | Killer Cells, Natural - drug effects | Mice | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Cell receptors | Killer cells | Ligases | Physiological aspects | Development and progression | Genetic aspects | Metastasis | Research | Proteins | Lungs | Rodents | Melanoma | Cytotoxicity | Ligands | Kinases | Immune system | Tumors | Cancer | Index Medicus
Journal Article
Journal Article
Plant Journal, ISSN 0960-7412, 01/2010, Volume 61, Issue 2, pp. 211 - 222
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. e29739 - e29739
Fibroblast growth factor receptor substrate 2 (FRS2 alpha) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine... 
ADAPTER PROTEINS | DOCKING PROTEINS | REGGIE/FLOTILLIN PROTEINS | RAFT DOMAINS | TYROSINE KINASE | GLUT4 TRANSLOCATION | BIOLOGY | AXON REGENERATION | NEURONAL DIFFERENTIATION | PC12 CELLS | ERK ACTIVATION | Adaptor Proteins, Signal Transducing - chemistry | Binding, Competitive | Protein Structure, Tertiary | Signal Transduction | Membrane Proteins - genetics | Humans | Gene Knockdown Techniques | Phosphotyrosine - metabolism | Protein Transport | Fibroblast Growth Factors - metabolism | Membrane Proteins - deficiency | Animals | Membrane Proteins - chemistry | Protein Binding | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Mice | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Tyrosine | Phosphatases | Cellular signal transduction | Fibroblast growth factors | Mitogens | Protein kinases | Protein binding | Cbl-associated protein | Fibroblast growth factor | Phosphorylation | Leukemia | Phosphotyrosine | Lipids | Homology | Biochemistry | Kinases | Cell adhesion & migration | Proteins | Signal transduction | Epidermal growth factor | Fibroblasts | Protein-tyrosine kinase receptors | Localization | Protein-tyrosine kinase | Binding | Adaptor proteins | Cbl protein | Threonine | Extracellular signal-regulated kinase | Insulin | Substrates | Signaling | Hypoxia | Transduction | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 36, pp. 26323 - 26334
Journal Article
Cell, ISSN 0092-8674, 10/2000, Volume 103, Issue 3, pp. 501 - 510
The Listeria monocytogenes surface protein InIB promotes bacterial entry into mammalian cells. Here, we identify a cellular surface receptor required for... 
Proto-Oncogene Proteins c-met - metabolism | Epithelial Cells - drug effects | Humans | Cell Aggregation - drug effects | Membrane Proteins - pharmacology | Phosphoproteins - metabolism | Kidney | Phosphotyrosine - metabolism | Dose-Response Relationship, Drug | Endocytosis | Proto-Oncogene Proteins c-cbl | Gene Deletion | Listeria monocytogenes - metabolism | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Listeria monocytogenes - physiology | Phosphorylation - drug effects | Epithelial Cells - cytology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Signal Transduction | Membrane Proteins - genetics | Bacterial Proteins - genetics | Precipitin Tests | Proto-Oncogene Proteins c-met - genetics | Ubiquitin-Protein Ligases | Adaptor Proteins, Signal Transducing | Bacterial Proteins - pharmacology | Animals | Hepatocytes | Epithelial Cells - microbiology | Epithelial Cells - enzymology | Listeria monocytogenes - genetics | Protein Binding | Avian Proteins | Bacterial Proteins - metabolism | Ligands | Kinetics | Proto-Oncogene Proteins c-met - chemistry | Cell receptors | Foodborne diseases | Physiological aspects | Listeria monocytogenes | Listeriosis | Protein tyrosine kinase | Research | Permeability | Cytochemistry | Mammals | Cells | InIB protein | Met protein | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2004, Volume 279, Issue 35, pp. 36440 - 36444
The human topoisomerase I- and p53-binding protein topors contains a highly conserved, N-terminal C3HC4-type RING domain that is homologous to the RING domains... 
LOCALIZATION | NUCLEAR-BODIES | DOMAIN | COMPLEX | C-CBL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOPOISOMERASE-I | DEGRADATION | RING FINGER | I BINDING-PROTEIN | NEGATIVE REGULATOR | Anaphase-Promoting Complex-Cyclosome | Green Fluorescent Proteins | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Multienzyme Complexes - metabolism | Tryptophan - chemistry | Immunoblotting | Iron-Binding Proteins - chemistry | Proteasome Endopeptidase Complex | Ubiquitin-Protein Ligases - physiology | Ubiquitin-Conjugating Enzymes - chemistry | DNA-Binding Proteins - metabolism | Immediate-Early Proteins - metabolism | Cysteine Endopeptidases - metabolism | Transfection | Mass Spectrometry | Neoplasm Proteins | Transcription, Genetic | Ubiquitin-Protein Ligase Complexes - biosynthesis | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Carrier Proteins - physiology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Drosophila | Electrophoresis, Polyacrylamide Gel | Silver Staining | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Glutathione Transferase - metabolism | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Plasmids - metabolism | Sequence Homology, Amino Acid | Transcription Factors - metabolism | Proto-Oncogene Proteins c-mdm2 | Animals | Carrier Proteins - metabolism | Cell Line, Tumor | Nuclear Proteins - physiology | Luminescent Proteins - metabolism | Index Medicus
Journal Article
Molecular Cancer, ISSN 1476-4598, 06/2014, Volume 13, Issue 1, pp. 136 - 136
Background: Insulin-like growth factor I (IGF-I) can induce epithelial mesenchymal transition (EMT) in many epithelial tumors; however, the molecular mechanism... 
IGF-I | ZEB2 | Cbl-b | EMT | microRNA-200c | ACTIVATION | C-CBL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT ROLES | E-CADHERIN | MIR-200 FAMILY | CHEMOTHERAPY | GROWTH-FACTOR RECEPTOR | INVASION | ONCOLOGY | TRAIL-INDUCED APOPTOSIS | UP-REGULATION | RNA, Small Interfering - genetics | Insulin-Like Growth Factor I - pharmacology | Proto-Oncogene Proteins c-cbl - metabolism | Adenocarcinoma - pathology | Homeodomain Proteins - metabolism | Humans | Middle Aged | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Stomach Neoplasms - metabolism | Epithelial-Mesenchymal Transition - drug effects | Male | MicroRNAs - metabolism | Stomach Neoplasms - pathology | Zinc Finger E-box Binding Homeobox 2 | Proto-Oncogene Proteins c-akt - genetics | Adenocarcinoma - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Female | Adenocarcinoma - genetics | Proto-Oncogene Proteins c-akt - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins c-cbl - genetics | Stomach Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Repressor Proteins - genetics | Lymphatic Metastasis | Homeodomain Proteins - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Aged | MicroRNAs - genetics | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Neoplasm Staging | Insulin-Like Growth Factor I - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | RNA, Small Interfering - metabolism | Personal narratives | Genetic transcription | Metastasis | Analysis | Medical research | Chemotherapy | Breast cancer | Insulin-like growth factors | Kinases | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 02/2015, Volume 34, Issue 7, pp. 826 - 837
Nucleolin (NCL) participates in DNA transcription, ribosomal biogenesis and the regulation of RNA stability. However, the contribution of NCL to tumor... 
TARGET | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | LUNG-CANCER | IN-VITRO | ONCOLOGY | GASTRIC-CARCINOMA | PROSTATE-CANCER CELLS | GENETICS & HEREDITY | PROTEINS | BINDING | PROGRESSION | MATRILYSIN MMP-7 | Kruppel-Like Factor 6 | Proto-Oncogene Proteins c-cbl - metabolism | Humans | Lung Neoplasms - metabolism | Male | RNA, Messenger - metabolism | Autoantigens - genetics | RNA, Neoplasm - metabolism | Neoplasm Metastasis | Matrix Metalloproteinase 7 - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Matrix Metalloproteinase 9 - genetics | Proteolysis | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Cell Cycle Proteins - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | RNA Stability - genetics | Mice, Nude | RNA, Neoplasm - genetics | Mice | Kruppel-Like Transcription Factors - genetics | RNA-Binding Proteins - metabolism | RNA-Binding Proteins - genetics | Autoantigens - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Phosphoproteins - metabolism | Kruppel-Like Transcription Factors - metabolism | Cell Cycle Proteins - genetics | Female | Nuclear Proteins - genetics | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins c-cbl - genetics | Matrix Metalloproteinase 9 - biosynthesis | RNA, Messenger - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Gene Expression Regulation, Enzymologic | Proteins - genetics | Transcription Factors - metabolism | Matrix Metalloproteinase 7 - genetics | Animals | Proteins - metabolism | Receptor Protein-Tyrosine Kinases - genetics | Adaptor Proteins, Signal Transducing - genetics | Aged | Adaptor Proteins, Signal Transducing - metabolism | RNA | Phosphoproteins | Physiological aspects | Development and progression | Genetic aspects | Health aspects | Metalloproteins | Tumors | Signal transduction | Protein expression | Tumorigenesis | Lung cancer | Index Medicus
Journal Article
Journal Article
Frontiers in Plant Science, ISSN 1664-462X, 07/2017, Volume 8, pp. 1191 - 1191
The calcineurin B-like protein (CBL)-CBL-interacting protein kinase (CIPK) complex has been identified as a primary component in calcium sensors that perceives... 
BrrCBL | Turnip | BrrCIPK | Expression profiles | Functional differentiation | Preferential interactions | CIPKS | ABIOTIC STRESS | functional differentiation | expression profiles | preferential interactions | CALCIUM SENSOR | DROUGHT | CBL | PLANT SCIENCES | SALT | SIGNALING NETWORK | ARABIDOPSIS | COLD | turnip | ABSCISIC-ACID | BrrCBL-BrrCIPK | BrrCBL–BrrCIPK
Journal Article