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Molecular Cancer, ISSN 1476-4598, 06/2014, Volume 13, Issue 1, pp. 136 - 136
Background: Insulin-like growth factor I (IGF-I) can induce epithelial mesenchymal transition (EMT) in many epithelial tumors; however, the molecular mechanism... 
IGF-I | ZEB2 | Cbl-b | EMT | microRNA-200c | ACTIVATION | C-CBL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT ROLES | E-CADHERIN | MIR-200 FAMILY | CHEMOTHERAPY | GROWTH-FACTOR RECEPTOR | INVASION | ONCOLOGY | TRAIL-INDUCED APOPTOSIS | UP-REGULATION | RNA, Small Interfering - genetics | Insulin-Like Growth Factor I - pharmacology | Proto-Oncogene Proteins c-cbl - metabolism | Adenocarcinoma - pathology | Homeodomain Proteins - metabolism | Humans | Middle Aged | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Stomach Neoplasms - metabolism | Epithelial-Mesenchymal Transition - drug effects | Male | MicroRNAs - metabolism | Stomach Neoplasms - pathology | Zinc Finger E-box Binding Homeobox 2 | Proto-Oncogene Proteins c-akt - genetics | Adenocarcinoma - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Female | Adenocarcinoma - genetics | Proto-Oncogene Proteins c-akt - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins c-cbl - genetics | Stomach Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Repressor Proteins - genetics | Lymphatic Metastasis | Homeodomain Proteins - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Aged | MicroRNAs - genetics | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Neoplasm Staging | Insulin-Like Growth Factor I - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | RNA, Small Interfering - metabolism | Personal narratives | Genetic transcription | Metastasis | Analysis
Journal Article
Cell Death and Disease, ISSN 2041-4889, 2017, Volume 8, Issue 5, pp. e2763 - e2763
Sepsis is a systemic inflammation caused by infection. The balance between M1-M2 macrophage polarization has an essential role in the pathogenesis of sepsis.... 
ACUTE KIDNEY INJURY | REGULATOR | M2 MACROPHAGES | RECEPTOR 2 | INFLAMMATION | DIFFERENTIATION | MAPK | NF-KAPPA-B | CBL-B | MASL1 | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Oncogene Proteins - genetics | Lipopeptides - pharmacology | Humans | Tumor Necrosis Factor-alpha - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Inflammation - metabolism | Ubiquitination - drug effects | HEK293 Cells | Cell Cycle Proteins - genetics | Cell Polarity - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Interleukin-6 - genetics | Oncogene Proteins - chemistry | Cell Cycle Proteins - metabolism | Oncogene Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Imidazoles - pharmacology | Macrophages - cytology | Toll-Like Receptor 2 - metabolism | DNA-Binding Proteins - genetics | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Macrophages - metabolism | Animals | Nitric Oxide Synthase Type II - genetics | Signal Transduction - drug effects | Macrophages - drug effects | RAW 264.7 Cells | Mice | Pyridines - pharmacology | Nitric Oxide Synthase Type II - metabolism | Ubiquitin | Polarization | Transcription factors | Transformation | Immunoprecipitation | Pathogenesis | c-Jun protein | Inflammation | Macrophages | Histiocytoma | Signal transduction | TLR2 protein | Toll-like receptors | Sepsis | Ubiquitin-protein ligase
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4782 - 14
Incomplete understanding of the metastatic process hinders personalized therapy. Here we report the most comprehensive whole-genome study of colorectal... 
HUMAN COLON | MUTATIONAL PROCESSES | SOMATIC ALTERATIONS | GASTRIC-CANCER | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | RECEPTOR | CBL-B | PROGRESSION | ENDOTHELIAL GROWTH-FACTOR | Anoctamins - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | 3' Untranslated Regions - genetics | Hepatic Stellate Cells - metabolism | Male | Proto-Oncogene Proteins c-akt - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Extracellular Matrix - genetics | Colorectal Neoplasms - therapy | Neoplasm Metastasis | Membrane Transport Proteins - genetics | Female | Adenocarcinoma - genetics | Liver Neoplasms - secondary | Nuclear Proteins - genetics | Precision Medicine | Proto-Oncogene Proteins c-cbl - genetics | Cell Adhesion - genetics | Liver Neoplasms - genetics | Signal Transduction | RNA, Untranslated | Rho Guanine Nucleotide Exchange Factors - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Adenocarcinoma - secondary | Whole Genome Sequencing | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adaptor Proteins, Signal Transducing - genetics | TRPM Cation Channels - genetics | Aged | Colorectal Neoplasms - pathology | BRCA2 Protein - genetics | Therapy | Colorectal carcinoma | Colorectal cancer | AKT protein | Genomes | Metastasis | Metastases | Cell adhesion & migration | Gene sequencing | Transient receptor potential proteins | Foxp2 protein | Transcription activation | Cell adhesion | Evolution | Extracellular matrix | Lesions | BRCA2 protein | Fibroblast growth factor 1 | AKT2 protein | Breast cancer | 1-Phosphatidylinositol 3-kinase | Genetic programs | Immunosuppression | Hypotheses | PD-L1 protein | Mutation | Colonization | Tumors
Journal Article
Cell Reports, ISSN 2211-1247, 05/2012, Volume 1, Issue 5, pp. 472 - 482
E3 ubiquitin ligase Cbl-b plays a crucial role in T cell activation and tolerance induction. However, the molecular mechanism by which Cbl-b inhibits T cell... 
ACTIVATION | TUMOR SUPPRESSION | AUTOIMMUNITY | PHOSPHATIDYLINOSITOL 3-KINASE | NEGATIVE REGULATION | RECEPTOR | DEGRADATION | MICE | CD28 COSTIMULATION | CUTTING EDGE | CELL BIOLOGY | Proto-Oncogene Proteins c-cbl - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | Molecular Sequence Data | Male | Phosphatidylinositol 3-Kinases - metabolism | CD28 Antigens - metabolism | T-Lymphocytes - metabolism | Female | Models, Animal | Nedd4 Ubiquitin Protein Ligases | Proto-Oncogene Proteins c-cbl - deficiency | T-Lymphocytes - pathology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-cbl - genetics | Receptors, Antigen, T-Cell - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | PTEN Phosphohydrolase - metabolism | Endosomal Sorting Complexes Required for Transport - deficiency | Mice, Knockout | Animals | Adaptor Proteins, Signal Transducing - deficiency | Adaptor Proteins, Signal Transducing - genetics | Ubiquitin-Protein Ligases - deficiency | Signal Transduction - physiology | Mice | Mice, Inbred BALB C | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Lymphocyte Activation - physiology | T-cell receptor | Cell activation | Molecular modelling | Cbl-b protein | AKT protein | Data processing | Lymphocytes T | CD28 antigen | Immunological tolerance | PTEN protein | Ubiquitin-protein ligase | 1-Phosphatidylinositol 3-kinase
Journal Article