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Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7393, pp. 208 - 213
In mitosis, the spindle assembly checkpoint (SAC) ensures genome stability by delaying chromosome segregation until all sister chromatids have achieved bipolar... 
ANAPHASE-PROMOTING COMPLEX | FISSION YEAST | KEN BOX | BUDDING YEAST | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | PSEUDOSUBSTRATE INHIBITION | DESTRUCTION BOX | SACCHAROMYCES-CEREVISIAE | MAD2 ACTIVATION | SPINDLE-ASSEMBLY CHECKPOINT | Anaphase-Promoting Complex-Cyclosome | Schizosaccharomyces pombe Proteins - chemistry | M Phase Cell Cycle Checkpoints | Schizosaccharomyces - chemistry | Humans | Ubiquitin-Protein Ligase Complexes - antagonists & inhibitors | Substrate Specificity | Crystallography, X-Ray | Structure-Activity Relationship | Spindle Apparatus | Cell Cycle Proteins - chemistry | Multiprotein Complexes - metabolism | Cdh1 Proteins | Protein Structure, Quaternary | Schizosaccharomyces pombe Proteins - metabolism | Conserved Sequence | Mad2 Proteins | Cdc20 Proteins | Protein Structure, Tertiary | Cell Cycle Proteins - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - chemistry | Amino Acid Motifs | Multiprotein Complexes - chemistry | Ubiquitin-Protein Ligase Complexes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - ultrastructure | Proteins | Kinases | Binding sites | Crystal structure
Journal Article
Nature Cell Biology, ISSN 1465-7392, 11/2017, Volume 19, Issue 12, pp. 1433 - 1440
Journal Article
Developmental Cell, ISSN 1534-5807, 01/2009, Volume 16, Issue 1, pp. 105 - 117
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2011, Volume 30, Issue 16, pp. 3322 - 3336
The spindle assembly checkpoint (SAC) restrains anaphase until all chromosomes become bi‐oriented on the mitotic spindle. The SAC protein Mad2 can fold into... 
p31comet | Mad2 template model | mitotic timing | closed‐Mad2 | spindle assembly checkpoint | RAD52 | c-ABL | tyrosine phosphorylation | ssDNA annealing | DNA repair | ANAPHASE-PROMOTING COMPLEX | PROTEIN BUBR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONFORMATIONAL DIMERIZATION | MONOCLONAL-ANTIBODY | MAD2 ACTIVATION | CORE COMPLEX | CELL BIOLOGY | CDC20 | MITOSIS | closed-Mad2 | BINDING | UNATTACHED KINETOCHORES | Humans | Cell Cycle Proteins - chemistry | Repressor Proteins - physiology | Cell Cycle Proteins - immunology | Time Factors | Calcium-Binding Proteins - immunology | Adaptor Proteins, Signal Transducing - immunology | Mad2 Proteins | Cdc20 Proteins | Spindle Apparatus - physiology | Dimerization | Antibodies, Monoclonal - immunology | Calcium-Binding Proteins - chemistry | Rabbits | Repressor Proteins - chemistry | Kinetochores - metabolism | RNA, Small Interfering - pharmacology | Anaphase - physiology | Nuclear Pore - metabolism | Nuclear Proteins - chemistry | Nuclear Proteins - immunology | Protein Folding | Macromolecular Substances | Protein Interaction Mapping | Adaptor Proteins, Signal Transducing - physiology | Animals | Mitosis - drug effects | Mitosis - physiology | Calcium-Binding Proteins - physiology | Repressor Proteins - immunology | Protein Conformation | Mice | Mice, Inbred BALB C | Nuclear Proteins - physiology | Cell Cycle Proteins - physiology | Proteins | Cell division | Molecular biology | Signal to noise ratio
Journal Article
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7713, pp. 274 - 278
The maintenance of genome stability during mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex... 
CDC20 | UBIQUITINATION | COMPLEX | ACTIVATION | PARTICLE | ALIGNMENT | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | AAA-ATPASE | BINDING | INSIGHTS | Apoproteins - chemistry | Cdc20 Proteins - ultrastructure | M Phase Cell Cycle Checkpoints - drug effects | Mad2 Proteins - metabolism | Humans | Cell Cycle Proteins - metabolism | Cell Cycle Proteins - ultrastructure | Models, Molecular | Substrate Specificity | Apoproteins - ultrastructure | Mad2 Proteins - chemistry | ATPases Associated with Diverse Cellular Activities - chemistry | Cell Cycle Proteins - chemistry | Cryoelectron Microscopy | Cdc20 Proteins - chemistry | ATPases Associated with Diverse Cellular Activities - ultrastructure | Biocatalysis - drug effects | ATPases Associated with Diverse Cellular Activities - metabolism | Cdc20 Proteins - metabolism | Protein Conformation | Spindle Apparatus - drug effects | Mad2 Proteins - ultrastructure | Binding Sites | Apoproteins - metabolism | Observations | Structure | Adenosine triphosphatase | Cell cycle | Proteins | Chromosomes | Analysis | Adaptor proteins | Translocation | Deactivation | Mitosis | Kinetochores | Genomes | Topology | Electron microscopy | Remodeling | Inactivation | Anaphase-promoting complex | Substrates | Molecular modelling | Microscopy | ATP | Dismantling | Anaphase | Assembly | Crystal structure
Journal Article
PLoS Biology, ISSN 1544-9173, 03/2008, Volume 6, Issue 3, pp. 0643 - 0655
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 536, Issue 7617, pp. 431 - 436
In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter cell inherits an identical set of chromosomes. The SAC... 
MAD2 | ANAPHASE-PROMOTING COMPLEX | MECHANISM | CDC20 BINDING | UCSF CHIMERA | PHOSPHORYLATION | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | RECOMBINANT EXPRESSION | MITOTIC CHECKPOINT | SACCHAROMYCES-CEREVISIAE | Spindle Apparatus - chemistry | Humans | Protein-Serine-Threonine Kinases - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - antagonists & inhibitors | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Ubiquitination | Spindle Apparatus - metabolism | Cdc20 Proteins - chemistry | Anaphase-Promoting Complex-Cyclosome - chemistry | Spindle Apparatus - ultrastructure | Protein-Serine-Threonine Kinases - metabolism | Cdc20 Proteins - ultrastructure | Chromosome Segregation | Biocatalysis | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cryoelectron Microscopy | Ubiquitin-Conjugating Enzymes - metabolism | Cdc20 Proteins - metabolism | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Protein-Serine-Threonine Kinases - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | M Phase Cell Cycle Checkpoints - physiology | Spindle (Cell division) | Physiological aspects | Research | Molecular biology | Ligases | Cell division | Kinases | Chromosomes | Binding sites | Crystal structure
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 9/2001, Volume 154, Issue 5, pp. 925 - 936
The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase-promoting complex/cyclosome... 
Gels | Mitosis | Interphase | Kinetochores | Ubiquitins | Cell cycle | HeLa cells | Antibodies | Chromosomes | Anaphase | MAD2 | Kinetochore | Anaphase promoting complex | Mitotic checkpoint | hBUBR1 | mitotic checkpoint | ANAPHASE-PROMOTING COMPLEX | BUDDING YEAST | UBIQUITIN LIGASE | PROTEIN-KINASE | CYCLIN-B | SPINDLE ASSEMBLY CHECKPOINT | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | kinetochore | anaphase promoting complex | CENP-E | UNATTACHED KINETOCHORES | Protein Kinases - metabolism | Anaphase-Promoting Complex-Cyclosome | Cell Fractionation | Ligases - isolation & purification | Humans | Protein-Serine-Threonine Kinases | Immunoblotting | Recombinant Fusion Proteins - metabolism | Ubiquitin-Protein Ligase Complexes | Poly-ADP-Ribose Binding Proteins | Genes, cdc - physiology | Mad2 Proteins | Cdc20 Proteins | Carrier Proteins | Calcium-Binding Proteins - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Ligases - metabolism | Genes, Reporter - genetics | Macromolecular Substances | Nuclear Proteins | Ubiquitin-Protein Ligases | Proteins - metabolism | Ligases - antagonists & inhibitors | Mitosis - physiology | Saccharomyces cerevisiae Proteins | Recombinant Fusion Proteins - genetics | HeLa Cells | Fungal Proteins - metabolism | Physiological aspects | Chromosomal proteins | Research | Cell division | Cellular biology | Genes | Cells | kinetochore; hBUBR1; anaphase promoting complex; MAD2; mitotic checkpoint
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 26, pp. 10568 - 10573
The mitotic (or spindle assembly) checkpoint system prevents premature separation of sister chromatids in mitosis. When the checkpoint is turned on, the... 
Proteins | Spermatozoa | Phosphorylation | Immunoprecipitation | Chemical precipitation | Ubiquitins | HeLa cells | Antibodies | Immunoblotting | Ova | CDC20 | UBIQUITINATION | INACTIVATION | APC/C | ANAPHASE-PROMOTING COMPLEX/CYCLOSOME | MULTIDISCIPLINARY SCIENCES | BUBR1 | P31(COMET) | CELL-CYCLE | BINDING | SPINDLE-ASSEMBLY CHECKPOINT | Xenopus | Anaphase-Promoting Complex-Cyclosome | Humans | Xenopus Proteins - chemistry | Cell Cycle Proteins - chemistry | Multiprotein Complexes - metabolism | Poly-ADP-Ribose Binding Proteins | Female | Mad2 Proteins | Cdc20 Proteins | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Repressor Proteins - chemistry | Oocytes - metabolism | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Ubiquitin-Protein Ligase Complexes - chemistry | Multiprotein Complexes - chemistry | Animals | Ubiquitin-Protein Ligase Complexes - metabolism | Cell-Free System | Xenopus Proteins - metabolism | Protein-Serine-Threonine Kinases - chemistry | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | M Phase Cell Cycle Checkpoints - physiology | Ubiquitin | Research | Properties | Binding proteins | Mitosis | Frogs | Cell division | Binding sites | Adenosine triphosphatase | Biological Sciences
Journal Article