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Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7393, pp. 208 - 213
In mitosis, the spindle assembly checkpoint (SAC) ensures genome stability by delaying chromosome segregation until all sister chromatids have achieved bipolar... 
ANAPHASE-PROMOTING COMPLEX | FISSION YEAST | KEN BOX | BUDDING YEAST | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | PSEUDOSUBSTRATE INHIBITION | DESTRUCTION BOX | SACCHAROMYCES-CEREVISIAE | MAD2 ACTIVATION | SPINDLE-ASSEMBLY CHECKPOINT | Anaphase-Promoting Complex-Cyclosome | Schizosaccharomyces pombe Proteins - chemistry | M Phase Cell Cycle Checkpoints | Schizosaccharomyces - chemistry | Humans | Ubiquitin-Protein Ligase Complexes - antagonists & inhibitors | Substrate Specificity | Crystallography, X-Ray | Structure-Activity Relationship | Spindle Apparatus | Cell Cycle Proteins - chemistry | Multiprotein Complexes - metabolism | Cdh1 Proteins | Protein Structure, Quaternary | Schizosaccharomyces pombe Proteins - metabolism | Conserved Sequence | Mad2 Proteins | Cdc20 Proteins | Protein Structure, Tertiary | Cell Cycle Proteins - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - chemistry | Amino Acid Motifs | Multiprotein Complexes - chemistry | Ubiquitin-Protein Ligase Complexes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - ultrastructure | Proteins | Kinases | Binding sites | Crystal structure
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 536, Issue 7617, pp. 431 - 436
In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter cell inherits an identical set of chromosomes. The SAC... 
MAD2 | ANAPHASE-PROMOTING COMPLEX | MECHANISM | CDC20 BINDING | UCSF CHIMERA | PHOSPHORYLATION | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | RECOMBINANT EXPRESSION | MITOTIC CHECKPOINT | SACCHAROMYCES-CEREVISIAE | Spindle Apparatus - chemistry | Humans | Protein-Serine-Threonine Kinases - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - antagonists & inhibitors | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Ubiquitination | Spindle Apparatus - metabolism | Cdc20 Proteins - chemistry | Anaphase-Promoting Complex-Cyclosome - chemistry | Spindle Apparatus - ultrastructure | Protein-Serine-Threonine Kinases - metabolism | Cdc20 Proteins - ultrastructure | Chromosome Segregation | Biocatalysis | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cryoelectron Microscopy | Ubiquitin-Conjugating Enzymes - metabolism | Cdc20 Proteins - metabolism | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Protein-Serine-Threonine Kinases - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | M Phase Cell Cycle Checkpoints - physiology | Spindle (Cell division) | Physiological aspects | Research | Molecular biology | Ligases | Cell division | Kinases | Chromosomes | Binding sites | Crystal structure
Journal Article
Developmental Cell, ISSN 1534-5807, 01/2009, Volume 16, Issue 1, pp. 105 - 117
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 533, Issue 7602, pp. 260 - 264
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 575 - 578
Presynaptic axonal differentiation is essential for synapse formation and the establishment of neuronal circuits. However, the mechanisms that coordinate... 
Axons | Brain | Synapsins | Neurons | Plasmids | Developmental biology | Ubiquitins | Antibodies | Reports | Post hoc | T tests | MULTIDISCIPLINARY SCIENCES | GROWTH | Anaphase-Promoting Complex-Cyclosome | Synaptic Vesicles - metabolism | Cerebellar Cortex - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Ubiquitin - metabolism | Ubiquitin-Protein Ligase Complexes - genetics | Axons - physiology | Adaptor Proteins, Vesicular Transport - metabolism | Synapsins - metabolism | Gene Knockdown Techniques | Synapses - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Axons - ultrastructure | Cell Cycle Proteins - genetics | Cdc20 Proteins | Neuropeptides - genetics | Synaptic Vesicles - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Cerebellar Cortex - cytology | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Axons - metabolism | Rats | Cerebellar Cortex - ultrastructure | Mutant Proteins - metabolism | Neuropeptides - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Ubiquitin-Protein Ligase Complexes - metabolism | Presynaptic Terminals - metabolism | Ubiquitin | Neuroplasticity | Physiological aspects | Cellular signal transduction | Research | Cell differentiation | Synapses | Proteins | Signal transduction | Cellular biology | Gene expression
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 9/2001, Volume 154, Issue 5, pp. 925 - 936
The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase-promoting complex/cyclosome... 
Gels | Mitosis | Interphase | Kinetochores | Ubiquitins | Cell cycle | HeLa cells | Antibodies | Chromosomes | Anaphase | MAD2 | Kinetochore | Anaphase promoting complex | Mitotic checkpoint | hBUBR1 | mitotic checkpoint | ANAPHASE-PROMOTING COMPLEX | BUDDING YEAST | UBIQUITIN LIGASE | PROTEIN-KINASE | CYCLIN-B | SPINDLE ASSEMBLY CHECKPOINT | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | kinetochore | anaphase promoting complex | CENP-E | UNATTACHED KINETOCHORES | Protein Kinases - metabolism | Anaphase-Promoting Complex-Cyclosome | Cell Fractionation | Ligases - isolation & purification | Humans | Protein-Serine-Threonine Kinases | Immunoblotting | Recombinant Fusion Proteins - metabolism | Ubiquitin-Protein Ligase Complexes | Poly-ADP-Ribose Binding Proteins | Genes, cdc - physiology | Mad2 Proteins | Cdc20 Proteins | Carrier Proteins | Calcium-Binding Proteins - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Ligases - metabolism | Genes, Reporter - genetics | Macromolecular Substances | Nuclear Proteins | Ubiquitin-Protein Ligases | Proteins - metabolism | Ligases - antagonists & inhibitors | Mitosis - physiology | Saccharomyces cerevisiae Proteins | Recombinant Fusion Proteins - genetics | HeLa Cells | Fungal Proteins - metabolism | Physiological aspects | Chromosomal proteins | Research | kinetochore; hBUBR1; anaphase promoting complex; MAD2; mitotic checkpoint
Journal Article