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cell cycle proteins - metabolism (16) 16
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Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7713, pp. 274 - 278
The maintenance of genome stability during mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex... 
CDC20 | UBIQUITINATION | COMPLEX | ACTIVATION | PARTICLE | ALIGNMENT | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | AAA-ATPASE | BINDING | INSIGHTS | Apoproteins - chemistry | Cdc20 Proteins - ultrastructure | M Phase Cell Cycle Checkpoints - drug effects | Mad2 Proteins - metabolism | Humans | Cell Cycle Proteins - metabolism | Cell Cycle Proteins - ultrastructure | Models, Molecular | Substrate Specificity | Apoproteins - ultrastructure | Mad2 Proteins - chemistry | ATPases Associated with Diverse Cellular Activities - chemistry | Cell Cycle Proteins - chemistry | Cryoelectron Microscopy | Cdc20 Proteins - chemistry | ATPases Associated with Diverse Cellular Activities - ultrastructure | Biocatalysis - drug effects | ATPases Associated with Diverse Cellular Activities - metabolism | Cdc20 Proteins - metabolism | Protein Conformation | Spindle Apparatus - drug effects | Mad2 Proteins - ultrastructure | Binding Sites | Apoproteins - metabolism | Observations | Structure | Adenosine triphosphatase | Cell cycle | Proteins | Chromosomes | Analysis | Adaptor proteins | Translocation | Deactivation | Mitosis | Kinetochores | Genomes | Topology | Electron microscopy | Remodeling | Inactivation | Anaphase-promoting complex | Substrates | Molecular modelling | Microscopy | ATP | Dismantling | Anaphase | Assembly | Crystal structure
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 536, Issue 7617, pp. 431 - 436
In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter cell inherits an identical set of chromosomes. The SAC... 
MAD2 | ANAPHASE-PROMOTING COMPLEX | MECHANISM | CDC20 BINDING | UCSF CHIMERA | PHOSPHORYLATION | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | RECOMBINANT EXPRESSION | MITOTIC CHECKPOINT | SACCHAROMYCES-CEREVISIAE | Spindle Apparatus - chemistry | Humans | Protein-Serine-Threonine Kinases - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - antagonists & inhibitors | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Ubiquitination | Spindle Apparatus - metabolism | Cdc20 Proteins - chemistry | Anaphase-Promoting Complex-Cyclosome - chemistry | Spindle Apparatus - ultrastructure | Protein-Serine-Threonine Kinases - metabolism | Cdc20 Proteins - ultrastructure | Chromosome Segregation | Biocatalysis | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cryoelectron Microscopy | Ubiquitin-Conjugating Enzymes - metabolism | Cdc20 Proteins - metabolism | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Protein-Serine-Threonine Kinases - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | M Phase Cell Cycle Checkpoints - physiology | Spindle (Cell division) | Physiological aspects | Research | Molecular biology | Ligases | Cell division | Kinases | Chromosomes | Binding sites | Crystal structure
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 533, Issue 7602, pp. 260 - 264
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7393, pp. 208 - 213
In mitosis, the spindle assembly checkpoint (SAC) ensures genome stability by delaying chromosome segregation until all sister chromatids have achieved bipolar... 
ANAPHASE-PROMOTING COMPLEX | FISSION YEAST | KEN BOX | BUDDING YEAST | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | PSEUDOSUBSTRATE INHIBITION | DESTRUCTION BOX | SACCHAROMYCES-CEREVISIAE | MAD2 ACTIVATION | SPINDLE-ASSEMBLY CHECKPOINT | Anaphase-Promoting Complex-Cyclosome | Schizosaccharomyces pombe Proteins - chemistry | M Phase Cell Cycle Checkpoints | Schizosaccharomyces - chemistry | Humans | Ubiquitin-Protein Ligase Complexes - antagonists & inhibitors | Substrate Specificity | Crystallography, X-Ray | Structure-Activity Relationship | Spindle Apparatus | Cell Cycle Proteins - chemistry | Multiprotein Complexes - metabolism | Cdh1 Proteins | Protein Structure, Quaternary | Schizosaccharomyces pombe Proteins - metabolism | Conserved Sequence | Mad2 Proteins | Cdc20 Proteins | Protein Structure, Tertiary | Cell Cycle Proteins - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - chemistry | Amino Acid Motifs | Multiprotein Complexes - chemistry | Ubiquitin-Protein Ligase Complexes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - ultrastructure | Proteins | Kinases | Binding sites | Crystal structure
Journal Article
eLife, ISSN 2050-084X, 2014, Volume 3, p. e03083
The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of... 
cell cycle | primary cilum | ubiquitin | retinal cell culture | UBIQUITIN CHAINS | ACTIVATION | PROTEIN | ELONGATION | KINASE | BIOLOGY | BOX | CILIOGENESIS | IDENTIFICATION | AURORA-A | Nek1 protein | Ubiquitin | Immunoglobulins | Phosphorylation | Kinases | Anaphase-promoting complex | Proteins | Cell growth | Plasmids | Proteolysis | Microtubules | Metaphase | Cell cycle | Regulation | Localization | Anaphase | Cilia
Journal Article
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 8/2002, Volume 158, Issue 3, pp. 487 - 496
The spindle checkpoint delays anaphase onset until all chromosomes have attached properly to the mitotic spindle. Checkpoint signal is generated at... 
Phosphorylation | Phosphatases | Interphase | Kinetochores | Metaphase | Antibodies | Ova | Chromosomes | Eggs | Mitotic spindle apparatus | Xenopus | Spindle checkpoint | Mad1 | Bub1 | BubR1 | ANAPHASE-PROMOTING COMPLEX | BUDDING YEAST | KINASE | CELL BIOLOGY | CDC20 | ASSEMBLY CHECKPOINT | GENE | COMPONENT | MUTATIONS | MITOTIC CHECKPOINT | spindle checkpoint | UNATTACHED KINETOCHORES | Protein Binding - genetics | Protein Kinases - genetics | Molecular Weight | Xenopus Proteins - genetics | Protein-Serine-Threonine Kinases | Eukaryotic Cells - metabolism | Phosphoproteins - metabolism | Oocytes | Spindle Apparatus - metabolism | Cell Cycle Proteins - genetics | Protein Kinases - isolation & purification | Female | Genes, cdc - physiology | Mad2 Proteins | Cdc20 Proteins | Spindle Apparatus - ultrastructure | Repressor Proteins - metabolism | Carrier Proteins | Xenopus Proteins - isolation & purification | Calcium-Binding Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Xenopus laevis | Cell Cycle Proteins - metabolism | Cells, Cultured | Repressor Proteins - genetics | Fungal Proteins - genetics | Phosphoproteins - genetics | Sequence Homology, Nucleic Acid | Chromosomal Proteins, Non-Histone - genetics | Nuclear Proteins | Sequence Homology, Amino Acid | Kinetochores - ultrastructure | Animals | Saccharomyces cerevisiae Proteins | Eukaryotic Cells - cytology | Calcium-Binding Proteins - genetics | Fungal Proteins - metabolism | Cell research | Carrier proteins | Analysis | Microtubules | Physiological aspects | Genetic aspects | Protein kinases | spindle checkpoint; Xenopus; BubR1; Mad1; Bub1
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 575 - 578
Presynaptic axonal differentiation is essential for synapse formation and the establishment of neuronal circuits. However, the mechanisms that coordinate... 
Axons | Brain | Synapsins | Neurons | Plasmids | Developmental biology | Ubiquitins | Antibodies | Reports | Post hoc | T tests | MULTIDISCIPLINARY SCIENCES | GROWTH | Anaphase-Promoting Complex-Cyclosome | Synaptic Vesicles - metabolism | Cerebellar Cortex - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Ubiquitin - metabolism | Ubiquitin-Protein Ligase Complexes - genetics | Axons - physiology | Adaptor Proteins, Vesicular Transport - metabolism | Synapsins - metabolism | Gene Knockdown Techniques | Synapses - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Axons - ultrastructure | Cell Cycle Proteins - genetics | Cdc20 Proteins | Neuropeptides - genetics | Synaptic Vesicles - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Cerebellar Cortex - cytology | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Axons - metabolism | Rats | Cerebellar Cortex - ultrastructure | Mutant Proteins - metabolism | Neuropeptides - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Ubiquitin-Protein Ligase Complexes - metabolism | Presynaptic Terminals - metabolism | Ubiquitin | Neuroplasticity | Physiological aspects | Cellular signal transduction | Research | Cell differentiation | Synapses | Proteins | Signal transduction | Cellular biology | Gene expression
Journal Article
Nature Communications, ISSN 2041-1723, 07/2014, Volume 5, Issue 1, p. 4418
Journal Article
Journal Article
Journal Article