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Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
Cancer Research, ISSN 0008-5472, 04/2017, Volume 77, Issue 8, pp. 1983 - 1996
The ErbB3 receptor-binding protein EBP1 encodes two alternatively spliced isoforms P48 and P42. While there is evidence of differential roles for these... 
EPITHELIAL-MESENCHYMAL TRANSITION | CYCLIN-E | ONCOLOGY | PHOSPHORYLATION | POOR-PROGNOSIS | TUMOR-SUPPRESSOR GENE | DEGRADATION | CELL-PROLIFERATION | EXPRESSION | F-BOX PROTEIN | FBW7 UBIQUITIN LIGASE | Immunohistochemistry | Neoplasms - metabolism | F-Box-WD Repeat-Containing Protein 7 | RNA-Binding Proteins - genetics | Humans | Cytoplasm - metabolism | Protein Interaction Maps | Heterografts | Neoplasms - genetics | HEK293 Cells | Cell Cycle Proteins - genetics | Binding Sites | F-Box Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Cell Cycle Proteins - deficiency | Glycogen Synthase Kinase 3 beta - metabolism | Phenotype | Animals | Mice, Nude | Protein Isoforms | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Ubiquitin-Protein Ligases - deficiency | Mice | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA-Binding Proteins - metabolism | Binding | Ubiquitin | Alternative splicing | Adapters | ErbB-3 protein | Cytosol | Substrates | Cdc4 protein | Degradation | Proteins | Isoforms | Tumor suppressor genes | Tumorigenesis | Ubiquitin-protein ligase | Cancer | EBP1 protein | Index Medicus | EBP1 P48 | colorectal cancer | BASIC BIOLOGICAL SCIENCES | FBXW7 | protein isoform | 60 APPLIED LIFE SCIENCES | EBP1 P42 | Protein isoform | Colorectal cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e68574
F-box and WD repeat domain-containing 7 (Fbxw7/hAgo/hCdc4/Fbw7) is a p53-dependent tumor suppressor and leads to ubiquitination-mediated suppression of several... 
FBXW7 EXPRESSION | NETWORK | P53 GENE | MULTIDISCIPLINARY SCIENCES | MUTATION | TUMOR-SUPPRESSOR | DIFFERENTIATION | FBW7 | HCDC4 | CANCER | CLINICAL-SIGNIFICANCE | F-Box-WD Repeat-Containing Protein 7 | Genetic Therapy | Liver - pathology | Humans | Gene Expression Regulation, Neoplastic | Liver Neoplasms - therapy | Cyclin E - genetics | Tumor Suppressor Protein p53 - genetics | Tumor Suppressor Protein p53 - therapeutic use | RNA Interference | Carcinoma, Hepatocellular - genetics | Cell Cycle Proteins - genetics | Female | Liver Neoplasms - pathology | Liver Neoplasms - genetics | Signal Transduction | F-Box Proteins - metabolism | Liver - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Animals | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adenoviruses, Human - genetics | Carcinoma, Hepatocellular - therapy | Mice | Mice, Inbred BALB C | Proto-Oncogene Proteins c-myc - genetics | Cyclin E - metabolism | Mutation | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Apoptosis | Carcinoma, Hepatocellular - metabolism | Ubiquitin | Hepatoma | Gene therapy | Tumor proteins | Adenoviruses | Cell culture | Biotechnology | Transcription factors | p53 Protein | c-Myc protein | Hepatocellular carcinoma | Myc protein | Tissues | Phase transitions | Cdc4 protein | Anticancer properties | Proteins | Liver cancer | Ubiquitination | Cell growth | Antitumor agents | Surgery | Cell cycle | Cyclin E | Recombinant | Enzymes | c-Jun protein | Pharmacology | Breast cancer | siRNA | Injection | Tumor cell lines | Chemical compounds | Medical prognosis | Cell lines | Proteasomes | Tumor suppressor genes | Protein expression
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, p. e0155911
A considerable proportion of protein-protein interactions (PPIs) in the cell are estimated to be mediated by very short peptide segments that approximately... 
RECOGNITION | ROLES | MYC | MULTIDISCIPLINARY SCIENCES | BINDING SITES | INTERFACES | INTERACTION NETWORKS | LINEAR MOTIFS | IDENTIFICATION | WEB SERVER | DISCOVERY | Adenomatous Polyposis Coli Protein - genetics | Neoplasms - metabolism | Amino Acid Sequence | Computational Biology - methods | Proto-Oncogene Proteins c-mdm2 - genetics | Humans | Peptides - genetics | Neoplasm Proteins - chemistry | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-mdm2 - chemistry | Proto-Oncogene Proteins c-myc - metabolism | Adenomatous Polyposis Coli Protein - chemistry | Protein Interaction Mapping | Neoplasms - chemistry | Peptides - metabolism | Neoplasms - genetics | Adenomatous Polyposis Coli Protein - metabolism | Protein Binding | Proto-Oncogene Proteins c-myc - genetics | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-myc - chemistry | Binding Sites | Proto-Oncogene Proteins c-mdm2 - metabolism | Physiological aspects | Genetic aspects | Research | Tumor proteins | Protein-protein interactions | Ubiquitin | MDM2 protein | Peptides | Therapeutic applications | Identification | Myc protein | Modulators | Cdc4 protein | Data bases | Adenomatous polyposis coli | Proteins | Inhibitors | Acids | Computation | Computer applications | Cell cycle | Predictions | Proteasomes | Mutation | Protein interaction | Bioinformatics | Binding sites | Ubiquitin-protein ligase | Cancer
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2012, Volume 109, Issue 9, pp. 3287 - 3292
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e41116
Notch signaling controls fundamental aspects of angiogenic blood vessel growth including the selection of sprouting tip cells, endothelial proliferation and... 
TIP CELL-FORMATION | VASCULAR DEVELOPMENT | CARDIOVASCULAR DEVELOPMENT | PROTEIN | VEGF | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | DIFFERENTIATION | ZEBRAFISH EMBRYO | FBW7 UBIQUITIN LIGASE | NEGATIVE REGULATOR | F-Box-WD Repeat-Containing Protein 7 | Retina - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Zebrafish - embryology | Ubiquitin-Protein Ligase Complexes | Retina - cytology | Human Umbilical Vein Endothelial Cells - cytology | Cell Cycle Proteins - genetics | F-Box Proteins - metabolism | Proto-Oncogene Proteins c-jun - genetics | Zebrafish Proteins - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Mice, Transgenic | Proto-Oncogene Proteins c-myc - metabolism | Zebrafish - genetics | Neovascularization, Physiologic - physiology | Animals | Proto-Oncogene Proteins c-jun - metabolism | Morpholinos - pharmacology | Cell Proliferation - drug effects | Mice | Proto-Oncogene Proteins c-myc - genetics | Zebrafish Proteins - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Ubiquitin | Embryonic development | Neovascularization | Ligases | Endothelium | Cell proliferation | Transcription factors | Laboratories | Genes | c-Myc protein | Retina | Myc protein | Kinases | Inactivation | Blood | Cdc4 protein | Degradation | Morphogenesis | Proteins | Angiogenesis | SCF protein | Rodents | Ubiquitin-protein ligase | Deactivation | c-Jun protein | Blood vessels | Zebrafish | siRNA | Embryos | Substrates | Endothelial cells | Studies | Signaling | Microscopy | Proteasomes | Ligands | Notch protein
Journal Article
FEBS Letters, ISSN 0014-5793, 08/2012, Volume 586, Issue 17, pp. 2740 - 2750
The molecular architectures of intracellular signaling networks are largely unknown. Understanding their design principles and mechanisms of processing... 
Intrinsic disorder | Macromolecular crowding | Signalosome | Molecular architecture | Signaling network | Signaling complex | SH3 domain | SH2 domain | Sic1 | hepatocyte growth-factor receptor | Frs | CDK | CRKL | growth factor receptor-bound protein 2 | T-cell receptor | GRIP1 | PI3K | signal transducer and activator of transcription 1 | eukaryotic linear motif | NFN hypothesis | glutamate receptor interacting protein 1 | ZBP1 | Dok | sarcoma kinase | CASK | p130Cas | CT-10 related kinase | NR2B | disrupted in schizophrenia 1 | sterile 5 protein | MALS | SLiM | cyclin-dependent kinase | epidermal growth factor | Src-homology 2 domain | Erk | MAPK/Erk kinase | JIP1 | cell division control protein 4 | IGFR | Abl | COP9 | Irs | cAMP | short linear motif | neuronal munc18-1 binding protein 1 | estrogen receptor beta 2 | caudal type homeobox 2 | PTB domain | San1 | insulin receptor substrate | large multi-site docking | ADAP1 | ApoER2 | Cdc4 | NMR | cyclic adenosine monophosphate | constitutive photomorphogenesis protein 9 | N-terminal folding nucleation hypothesis | arf-GAP with dual PH domain-containing protein 1 | Grb2 | Src-homology 3 domain | LAT | breast cancer anti-estrogen resistance 1 | c-Jun-amino-terminal kinase-interacting protein 1 | Mint1 | extracellular signal-regulated kinase | Abelson tyrosine-protein kinase 1 | Crk-associated substrate | PI3 kinase | ELM | SH2 containing protein tyrosine phosphatase 2 | UTR | insulin-like growth factor 1 receptor | Pbs2 | linker for activation of T-cells | Ste5 | ErB2 | calcium/calmodulin-dependent serine protein kinase | apolipoprotein E receptor 2 | PH domain | sterile 11 protein | phosphatidylinositol (3,4,5)-triphosphate | Crk-like protein | Gab | untranslated region | Rack1 | atomic force microscopy | MEK | aspartate receptor subtype 2B | PIP3 | small angle X-ray scattering | Crk | cryo-electron microscopy | DLK | TCR | Src | AFM | pleckstrin homology domain | phosphotyrosine-binding domain | zip code-binding protein 1 | SHP2 | substrate/subunit/inhibitor of cyclin-dependent protein kinase 1 | receptor of activated protein kinase C 1 | c-Met | methyl | DAP-like kinase | DISC1 | cryo-EM | sir antagonist 1 | fibroblast growth factor receptor substrate | LMD | mammalian lin-seven protein | Ste11 | Cdx2 | EGF | STAT1 | docking protein 1 | Rev/Rex activation domain-binding protein | nuclear magnetic resonance | SAXS | Polymyxin B resistance protein 2 | Rab | Grb2-associated-binding protein | insulin receptor | BCAR1 | UNSTRUCTURED PROTEINS | SRC FAMILY KINASE | TYROSINE PHOSPHORYLATION | MAP-KINASE | PROTEIN-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROCESSIVE PHOSPHORYLATION | MESSENGER-RNA LOCALIZATION | CELL BIOLOGY | BIOPHYSICS | COP9 SIGNALOSOME | IN-VIVO | Fungal Proteins - chemistry | Neoplasms - metabolism | Computational Biology - methods | Signal Transduction | Humans | Gene Expression Regulation | Phosphoproteins - metabolism | Protein Interaction Mapping - methods | Insulin - metabolism | Receptor, Epidermal Growth Factor - metabolism | Animals | Models, Biological | Insulin Receptor Substrate Proteins | Receptor, Insulin - metabolism | Tyrosine | Atomic force microscopy | Epidermal growth factor | Phosphatases | Sarcoma | Soups | Fibroblast growth factors | Glutamate | Adenylic acid | T cells | Protein kinases | Protein binding
Journal Article