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Current Drug Targets, ISSN 1389-4501, 03/2010, Volume 11, Issue 3, pp. 291 - 302
Poor therapeutic outcomes and serious side effects, together with acquired resistance to multiple drugs, are common problems of current cancer therapies.... 
Resistance | Therapy | Protein kinase | DNA damage | Oncology | Inhibitor | CDK | P53 | RNA-POLYMERASE-II | WILD-TYPE P53 | therapy | DOWN-REGULATION | TUMOR-CELLS | RIBOSOMAL-PROTEIN L11 | MULTIPLE-MYELOMA CELLS | protein kinase | oncology | resistance | p53 | BREAST-CANCER CELLS | inhibitor | CYC202 R-ROSCOVITINE | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2010, Volume 9, Issue 8, pp. 2344 - 2353
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2018, Volume 62, Issue 9, pp. 4233 - 4251
Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal... 
POTENT ANTITUMOR-ACTIVITY | IN-VITRO | CHEMISTRY, MEDICINAL | DINACICLIB SCH 727965 | X-RAY CRYSTALLOGRAPHY | STRUCTURE-BASED DISCOVERY | DISTINCT ACTIVATION PATHWAYS | CELL-CYCLE | CDK INHIBITOR | CDK2-DEPENDENT PHOSPHORYLATION | STRUCTURE-BASED DESIGN
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 46, pp. 35932 - 35943
Angiogenesis contributes to various pathological conditions. Due to the resistance against existing antiangiogenic therapy, an urgent need exists to understand... 
NEURONAL MIGRATION | ROSCOVITINE | METASTASIS | CDK5 | PHOSPHORYLATION | ACTIN POLYMERIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL ADHESION KINASE | RHO-GTPASES | CANCER | RAC1 ACTIVITY | Neovascularization, Physiologic - drug effects | Humans | Cell Movement - physiology | Cyclin-Dependent Kinase 5 - genetics | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Microtubules - metabolism | RNA Interference | Chorioallantoic Membrane - drug effects | Female | Phosphorylation - drug effects | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Chorioallantoic Membrane - blood supply | Purines - pharmacology | Mice, Inbred C57BL | Umbilical Cord - enzymology | Cells, Cultured | Cell Adhesion | Chick Embryo | Serine - metabolism | Blotting, Western | Cyclin-Dependent Kinase 5 - metabolism | Cell Movement - drug effects | Microscopy, Confocal | Neovascularization, Physiologic - physiology | Cyclin-Dependent Kinase 5 - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Endothelial Cells - cytology | Mice | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - enzymology | Index Medicus | CDK (Cyclin-dependent Kinase) | Protein Kinases | Signal Transduction | Tumor Therapy | Cell Motility | Rho | Cytoskeleton | Confocal Microscopy | Chemotaxis | Cell Biology | Endothelium
Journal Article
The Plant Cell, ISSN 1040-4651, 7/2001, Volume 13, Issue 7, pp. 1653 - 1667
Cyclin-dependent kinase inhibitors, such as the mammalian p27 Kip1 protein, regulate correct cell cycle progression and the integration of developmental... 
Proteins | Leaves | Yeasts | Epidermal cells | Cell cycle | Cell division | Plants | Transgenic plants | Cyclins | Plant cells | FISSION YEAST | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIATED TRANSFORMATION | ROOT-GROWTH | P27(KIP1) | PLANT SCIENCES | CELL BIOLOGY | CDK INHIBITORS | THALIANA | PLANTS | CELL-CYCLE | EXPRESSION | Cyclin-Dependent Kinases - metabolism | Mitosis | Molecular Sequence Data | Calcium-Binding Proteins - antagonists & inhibitors | Sequence Homology | Arabidopsis Proteins | Enzyme Inhibitors - chemistry | Plants, Genetically Modified | Cloning, Molecular | Gene Expression Regulation, Plant | Muscle Proteins - metabolism | Muscle Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Cyclin-Dependent Kinases - genetics | Kinesin | Calcium-Binding Proteins - metabolism | Amino Acid Sequence | Arabidopsis - chemistry | Enzyme Inhibitors - metabolism | Cell Cycle Proteins - metabolism | Plant Leaves - cytology | Arabidopsis - metabolism | Cyclin-Dependent Kinase Inhibitor p27 | Arabidopsis - genetics | Muscle Proteins - genetics | Phenotype | Plant Leaves - physiology | Tumor Suppressor Proteins | Calcium-Binding Proteins - genetics | Physiological aspects | Genetic aspects | Research | Growth (Plants) | Arabidopsis | Kip-related protein | KRP gene | Kip1 gene | cyclin-dependent kinase | p27 protein | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 11/2004, Volume 3, Issue 11, pp. 1427 - 1437
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2018, Volume 293, Issue 51, pp. 19672 - 19685
With the rapid increase in cancer survival because of improved diagnosis and therapy in the past decades, cancer treatment-related cardiotoxicity is becoming... 
cardiovascular disease | anticancer drug | cardiotoxicity | anthracycline | cell death | cell cycle | mitochondria | Bim | cyclin-dependent kinase (CDK) | chemotherapy | ACTIVATION | SELICICLIB CYC202 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-DEATH | HYPOXIA-INDUCED APOPTOSIS | R-ROSCOVITINE | GROWTH | CDK2 | Index Medicus
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 06/2010, Volume 24, Issue 12, pp. 1208 - 1219
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2005, Volume 48, Issue 7, pp. 2388 - 2406
Journal Article
Journal of Experimental Botany, ISSN 0022-0957, 02/2019, Volume 70, Issue 3, pp. 731 - 733
This article comments on the following paper: Zachleder V, Ivanov I, Vítová M, and Bišová K. 2019. Effects of cyclin-dependent kinase activity on the... 
DNA replication | RNA | starch accumulation | Cyclin-dependent kinase (CDK) activity | protein | Desmodesmus quadricauda | temperature | nuclear and cellular division | light/dark intervals | G1/S | PLANT SCIENCES | dark intervals | eXtra Botany | light
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 06/2011, Volume 193, Issue 6, pp. 995 - 1007
Journal Article