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Artificial Cells, Nanomedicine, and Biotechnology, ISSN 2169-1401, 12/2019, Volume 47, Issue 1, pp. 3896 - 3903
LINC00473 has been reported to be aberrantly expressed in diverse kinds of human malignancy. However, the function and underlying mechanisms of LINC00473 in... 
LINC00473 | CDK6 | Glioma | miR-637
Journal Article
Cancer discovery, ISSN 2159-8274, 2/2018, Volume 8, Issue 2, pp. 216 - 233
Immune checkpoint blockade, exemplified by antibodies targeting the programmed death-1 (PD-1) receptor, can induce durable tumor regressions in some patients.... 
CDK6 | CDK4 | Immunotherapy | PD-1 | NFAT
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 11, pp. 1375 - 1379
Development of selective kinase inhibitors that target the ATP binding site continues to be a challenge largely due to similar binding pockets. Palbociclib is... 
CDK6 degrader | CDK6 | PROTAC | Palbociclib | COMPLEX | CHEMISTRY, MEDICINAL | PROTEIN-DEGRADATION | CHEMISTRY, ORGANIC | DIFFERENTIATION | INHIBITORS | EXPRESSION | Medicine, Experimental | Medical research | Enzymes | Research institutes
Journal Article
Oncogene, ISSN 0950-9232, 05/2003, Volume 22, Issue 20, pp. 3092 - 3098
Journal Article
Cell Cycle, ISSN 1538-4101, 11/2019, Volume 18, Issue 21, pp. 3030 - 3043
This study was designed to purify molecules possess anti-cancer cell activity from the fruit body of Ganoderma leucocontextum. Bio-activity-guided purification... 
Ganoderiol F | cyclin D | Ganoderma leucocontextum | breast cancer | CDK4/CDK6
Journal Article
OncoTargets and Therapy, ISSN 1178-6930, 10/2019, Volume 12, pp. 8197 - 8205
Weidong Wu,1 Ningxian Wei,1 Gang Shao,1 Chunnan Jiang,1 Shaoru Zhang,2 Lihui Wang2 1Anesthesiology Department, Danyang People's Hospital of Jiangsu Province &... 
MiR-483-3p | CDK6 | Proliferation | CircZNF609 | Gastric cancer | Migration
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 1901, Volume 17, Issue 3, pp. 669 - 675
Cdk4-targeting drugs, such as palbociclib, are approved formetastatic ER/PR+, Her2(-) breast cancer. However, other than loss of retinoblastoma, which is very... 
CDK4/6 INHIBITION | RESISTANCE | CDK6 | ONCOLOGY | CELL BIOLOGY
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 9/2017, Volume 23, Issue 17, pp. 5218 - 5224
Journal Article
Oncotarget, ISSN 1949-2553, 2011, Volume 2, Issue 5, pp. 422 - 427
Journal Article
Oncotarget, ISSN 1949-2553, 08/2019, Volume 10, Issue 47, p. 4907
Although cyclin-dependent kinase (CDK) 4/6 inhibitors have exhibited remarkable results for patients with estrogen receptor (ER)-positive breast cancer in... 
Journal Article
Oncotarget, ISSN 1949-2553, 02/2019, Volume 10, Issue 14, pp. 1346 - 1359
The cyclin-dependent kinases CDK4 and CDK6 promote progression through the cell cycle, where their functions are considered to be redundant. Recent studies... 
PD0332991 | Angiogenesis | CDK6 | CDK4 | Melanoma
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 04/2019, Volume 60, Issue 5, pp. 1214 - 1223
Mantle cell lymphoma (MCL) represents an aggressive B-cell lymphoma with frequent relapse and poor survival. Recently, dysregulated histone-deacetylases... 
HDAC inhibitor | therapy-resistant MCL | Mantle cell lymphoma | CDK4/CDK6 inhibitor | PATHWAYS | APOPTOSIS | TUMOR | MECHANISMS | BORTEZOMIB | COMBINATION | PATHOGENESIS | IN-VITRO | ONCOLOGY | CDK4 | CDK6 inhibitor | HISTONE DEACETYLASE INHIBITORS | HEMATOLOGY | NF-KAPPA-B
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 04/2018, Volume 19, Issue 4, pp. 1013 - 1016
Background: CDK6 is the key factor in regulation of the cell cycle and essential for passage into the G1 phase. It also plays an important role in the... 
Immunohistochemistry | Squamous cell carcinoma | CDK6 | immunohistochemistry | squamous cell carcinoma
Journal Article
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, ISSN 1756-9966, 08/2019, Volume 38, Issue 1, pp. 380 - 13
Background Accumulating evidence demonstrates the oncogenic roles of lncRNA (long non-coding RNA) molecules in a wide variety of cancer types including glioma.... 
CELLS | Glioblastoma | Palbociclib | TUMOR | PROLIFERATION | MECHANISMS | miR-627-5p | CDK6 signaling | LUNG-CANCER | ONCOLOGY | lncRNA SNHG15 | CDK4/6 INHIBITOR | GROWTH | Microglial cells | Temozolomide resistance | NONCODING RNA SNHG15 | PROGRESSION | Tumorigenesis | lncRNA SNHG15/miR-627-5p/CDK6 signaling
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2018, Volume 24, Issue 23, pp. 6028 - 6039
Purpose: Ewing sarcoma (ES) is a rare and highly malignant cancer that occurs in the bone and surrounding tissue of children and adolescents. The EWS/ETS... 
FUSION | CDK6 | ONCOLOGY | SENSITIVITY | IRINOTECAN | SENESCENCE | INHIBITOR | COMBINATION | CANCER | EXPRESSION | TEMOZOLOMIDE
Journal Article
by Song, JP and Feng, W
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, ISSN 1940-5901, 2019, Volume 12, Issue 8, pp. 10270 - 10277
Background: Long noncoding RNAs (lncRNAs) HOXA-AS3 have been reported as potential oncogenes. Nevertheless, the molecular mechanism of HOXA-AS3 in pancreatic... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | pancreatic cancer | INVASION | CDK6 | lncRNA HOXA-AS3 | miR-29c | CELL-GROWTH | TARGETING CDK6
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 08/2018, Volume 78, Issue 16, pp. 4524 - 4532
Long noncoding RNA (lncRNA) is yet to be linked to cancer metabolism. Here, we report that upregulation of the lncRNA LINC00538 (YIYA) promotes glycolysis,... 
REGULATOR | ACTIVATION | CDK6 | METABOLISM | ONCOLOGY | 6-PHOSPHOFRUCTO-2-KINASE | HUMAN-CELLS | DEGRADATION | FRUCTOSE 2,6-BISPHOSPHATE | CYCLIN | INSIGHTS
Journal Article
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