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The Journal of Bone & Joint Surgery, ISSN 0021-9355, 02/2013, Volume 95, Issue 4, pp. 291 - 296
BACKGROUND:Appropriate pain management affects outcome after hip fracture surgery. Although multimodal pain management is commonly used for pain control for... 
KNEE | SURGERY | DEMENTIA | TOTAL JOINT ARTHROPLASTY | DELIRIUM | HOSPITAL STAY | LOCAL INFILTRATION ANALGESIA | ELDERLY PATIENTS | ORTHOPEDICS | PUMP | CONSUMPTION | POSTOPERATIVE PAIN | Fentanyl - administration & dosage | Single-Blind Method | Hip Fractures - surgery | Pyrazoles - therapeutic use | Prospective Studies | Fentanyl - therapeutic use | Humans | Male | Adrenergic alpha-Agonists - therapeutic use | Arthroplasty, Replacement, Hip - methods | Adrenergic alpha-Agonists - administration & dosage | Epinephrine - therapeutic use | Cyclooxygenase 2 Inhibitors - therapeutic use | Statistics, Nonparametric | Aged, 80 and over | Anesthetics, Local - therapeutic use | Anesthetics, Local - administration & dosage | Oxycodone - therapeutic use | Oxycodone - administration & dosage | Cyclooxygenase 2 Inhibitors - administration & dosage | Pain Management - methods | Analgesics, Opioid - therapeutic use | Anti-Bacterial Agents - administration & dosage | Morphine - administration & dosage | Sulfonamides - administration & dosage | Ketorolac - therapeutic use | Pain, Postoperative - drug therapy | Epinephrine - administration & dosage | Patient Satisfaction | Anti-Bacterial Agents - therapeutic use | Cefmetazole - therapeutic use | Female | Drug Therapy, Combination | Analgesia, Patient-Controlled | Treatment Outcome | Amides - therapeutic use | Celecoxib | Chi-Square Distribution | Pyrazoles - administration & dosage | Sulfonamides - therapeutic use | Analgesics, Opioid - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Injections, Intra-Articular | Aged | Ketorolac - administration & dosage | Pain Measurement | Amides - administration & dosage | Morphine - therapeutic use | Cefmetazole - administration & dosage | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
Medicine, ISSN 0025-7974, 09/2018, Volume 97, Issue 37, pp. e12391 - e12391
Nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for multimodal postoperative pain management. The purpose of this study was to evaluate the... 
MEDICINE, GENERAL & INTERNAL | HIP-ARTHROPLASTY | EFFICACY | celecoxib | postoperative pain | analgesia | total-knee arthroplasty | preemptive analgesia | flurbiprofen axetil | Care and treatment | Pain | Pain, Postoperative | Dosage and administration | Celecoxib | Drug therapy | Comparative analysis | Risk factors | Methods | Flurbiprofen | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Arthroplasty, The, ISSN 0883-5403, 2012, Volume 27, Issue 9, pp. 1731 - 1736.e1
Abstracts We investigated the safety and efficacy of the bilateral periarticular multimodal drug injection (PMDI) at a reduced dosage in patients undergoing... 
Orthopedics | pain management | periarticular multimodal drug injection | simultaneous bilateral total knee arthroplasty | Simultaneous bilateral total knee arthroplasty | Pain management | Periarticular multimodal drug injection | INTERVAL | SURGERY | INFILTRATION ANALGESIA | EFFICACY | PROTOCOL | BUPIVACAINE | HIP | TRIAL | ROPIVACAINE | ORTHOPEDICS | Fentanyl - administration & dosage | Prospective Studies | Humans | Epinephrine - administration & dosage | Male | Anesthesia, Spinal | Case-Control Studies | Incidence | Statistics, Nonparametric | Arthroplasty, Replacement, Knee | Female | Cefuroxime - administration & dosage | Anesthetics, Local - administration & dosage | Drug Therapy, Combination | Oxycodone - administration & dosage | Cyclooxygenase 2 Inhibitors - administration & dosage | Pain Management - methods | Ketoprofen - administration & dosage | Bupivacaine - administration & dosage | Treatment Outcome | Postoperative Complications - epidemiology | Celecoxib | Pyrazoles - administration & dosage | Injections, Intra-Articular - adverse effects | Analgesics, Opioid - administration & dosage | Aged | Pain Measurement | Amides - administration & dosage | Anti-Bacterial Agents - administration & dosage | Morphine - administration & dosage | Sulfonamides - administration & dosage | Care and treatment | Pain | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, 6/2019, Volume 145, Issue 6, pp. 1495 - 1507
Constructed from a theoretical framework, the coordinated undermining of survival paths in glioblastoma (GBM) is a combination of nine drugs approved for... 
CUSP9 | Medicine & Public Health | Hematology | Glioblastoma | Repurposed drugs | Oncology | Cancer Research | Internal Medicine | Glioblastoma stem cells | Temozolomide | TARGETED THERAPY | INITIATING CELLS | INTRATUMORAL HETEROGENEITY | PHARMACODYNAMICS | CLINICAL PHARMACOKINETICS | ADJUVANT TEMOZOLOMIDE | MALIGNANT GLIOMA | DISULFIRAM | IN-VITRO | ONCOLOGY | ADULT HUMAN BRAIN | Celecoxib - administration & dosage | Captopril - pharmacology | Aprepitant - administration & dosage | Minocycline - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Temozolomide - pharmacology | Brain Neoplasms - metabolism | Itraconazole - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Auranofin - administration & dosage | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Female | Glioblastoma - metabolism | Itraconazole - administration & dosage | Minocycline - administration & dosage | Tumor Cells, Cultured | Quetiapine Fumarate - pharmacology | Aprepitant - pharmacology | Auranofin - pharmacology | Reproducibility of Results | Sertraline - pharmacology | Celecoxib - pharmacology | Brain Neoplasms - drug therapy | Mice, SCID | Xenograft Model Antitumor Assays | Captopril - administration & dosage | Quetiapine Fumarate - administration & dosage | Animals | Sertraline - administration & dosage | Signal Transduction - drug effects | Temozolomide - administration & dosage | Glioblastoma - pathology | Mice | Glioblastoma - drug therapy | Disulfiram - pharmacology | Disulfiram - administration & dosage | Drug Screening Assays, Antitumor | Original – Cancer Research
Journal Article
Oral Oncology, ISSN 1368-8375, 2014, Volume 51, Issue 3, pp. 279 - 286
Journal Article
Annals of Oncology, ISSN 0923-7534, 5/2008, Volume 19, Issue 5, pp. 920 - 926
Background: The study aimed to demonstrate the noninferiority of capecitabine to 5-fluorouracil (5-FU)/folinic acid (FA), in relation to progression-free... 
Irinotecan | Colorectal | Celecoxib | First line | Capecitabine | 5-FU | SURVIVAL | irinotecan | celecoxib | PHASE-III | first line | OXALIPLATIN | FLUOROURACIL | COMBINATION | AGENT | TRIAL | capecitabine | ORAL CAPECITABINE | THERAPY | ONCOLOGY | colorectal | CYCLOOXYGENASE-2 INHIBITOR | Leucovorin - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Prospective Studies | Shock, Septic - etiology | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Diarrhea - chemically induced | Cyclooxygenase 2 Inhibitors - adverse effects | Fluorouracil - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Colorectal Neoplasms - drug therapy | Adult | Camptothecin - administration & dosage | Deoxycytidine - adverse effects | Female | Camptothecin - analogs & derivatives | Pyrazoles - adverse effects | Camptothecin - adverse effects | Double-Blind Method | Fluorouracil - analogs & derivatives | Cyclooxygenase 2 Inhibitors - administration & dosage | Deoxycytidine - administration & dosage | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Pyrazoles - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Survival Analysis | Sulfonamides - adverse effects | Aged | Infusions, Intravenous | Pulmonary Embolism - chemically induced | Colorectal Neoplasms - pathology | Deoxycytidine - analogs & derivatives | Sulfonamides - administration & dosage | Index Medicus
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 07/2006, Volume 11, Issue 7, pp. 680 - 684
Signs of an inflammatory process, in particular increased pro-inflammatory cytokines and increased levels of prostaglandine E-2 ( PGE(2)), have repeatedly been... 
COX-2 inhibition | Inflammation | Psychoneuroimmunology | Major depression | Immunity | SYSTEM | COX-2 | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | psychoneuroimmunology | SCHIZOPHRENIA | SICKNESS BEHAVIOR | SYMPTOMS | immunity | NEUROSCIENCES | INFLAMMATORY MARKERS | INTERFERON-ALPHA | PROSTAGLANDINS | inflammation | ROFECOXIB | major depression | BRAIN | Anti-Anxiety Agents - administration & dosage | Dinoprostone - analysis | Pyrazoles - therapeutic use | Adrenergic Uptake Inhibitors | Dinoprostone - biosynthesis | Humans | Middle Aged | Depressive Disorder - drug therapy | Male | Patient Dropouts | Lorazepam - therapeutic use | Inflammation - drug therapy | Cyclooxygenase 2 Inhibitors - therapeutic use | Adult | Female | Antidepressive Agents - pharmacology | Anti-Anxiety Agents - therapeutic use | Drug Therapy, Combination | Morpholines - therapeutic use | Pyrazoles - pharmacology | Severity of Illness Index | Cyclooxygenase 2 Inhibitors - pharmacology | Double-Blind Method | Cyclooxygenase 2 Inhibitors - administration & dosage | Morpholines - administration & dosage | Lorazepam - administration & dosage | Celecoxib | Sulfonamides - pharmacology | Antidepressive Agents - therapeutic use | Pilot Projects | Pyrazoles - administration & dosage | Sulfonamides - therapeutic use | Depressive Disorder - physiopathology | Serotonin - metabolism | Interleukin-6 - biosynthesis | Antidepressive Agents - administration & dosage | Psychological Tests | Sulfonamides - administration & dosage | Inflammation - physiopathology | Index Medicus
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 10/2006, Volume 33, Issue 10, pp. 917 - 924
SUMMARY • Non-steroidal anti-inflammatory drugs (NSAIDs) cause renal side-effects. In the present study, we tested the hypothesis that the extent of the renal... 
pharmacokinetics | kidney | non-steroidal anti-inflammatory drugs | cyclo-oxygenase-2 | sodium urinary excretion | cyclo‐oxygenase‐2 | non‐steroidal anti‐inflammatory drugs | Cyclo-oxygenase-2 | Pharmacokinetics | Kidney | Non-steroidal anti-inflammatory drugs | Sodium urinary excretion | GASTROINTESTINAL TOXICITY | PHYSIOLOGY | CYCLOOXYGENASE-2 | RAT | HYPERKALEMIA | PROTEIN-BINDING | MELOXICAM | INTERSPECIES DIFFERENCES | GENTAMICIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PHARMACOLOGY & PHARMACY | Thiazoles - blood | Area Under Curve | Thiazines - administration & dosage | Thiazines - adverse effects | Sulfones - adverse effects | Male | Thiazoles - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - blood | Thiazoles - adverse effects | Thiazoles - pharmacokinetics | Dose-Response Relationship, Drug | Cyclooxygenase 2 Inhibitors - adverse effects | Sulfonamides - blood | Lactones - blood | Lactones - pharmacokinetics | Sodium - urine | Lactones - administration & dosage | Pyrazoles - blood | Pyrazoles - pharmacokinetics | Sulfones - blood | Placebos - administration & dosage | Pyrazoles - adverse effects | Thiazines - pharmacokinetics | Kidney - drug effects | Administration, Oral | Cyclooxygenase 2 Inhibitors - administration & dosage | Rats | Thiazines - blood | Celecoxib | Lactones - adverse effects | Placebos - pharmacokinetics | Sulfones - pharmacokinetics | Cyclooxygenase 2 Inhibitors - pharmacokinetics | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Pyrazoles - administration & dosage | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Potassium - urine | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Sulfonamides - adverse effects | Sulfonamides - administration & dosage | Sulfones - administration & dosage | Kidney, drug effects | Lactones, adverse effects | Sulfones, administration and dosage | Thiazoles, administration and dosage | Anti-Inflammatory Agents, Non-Steroidal, pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal, adverse effects | Sodium, urine | Thiazines, blood | Anti-Inflammatory Agents, Non-Steroidal, blood | Lactones, administration and dosage | Cyclooxygenase 2 Inhibitors, adverse effects | Pyrazoles, blood | Sulfonamides, pharmacokinetics | Thiazines, pharmacokinetics | Pyrazoles, administration and dosage | Thiazoles, blood | Sulfonamides, administration and dosage | Cyclooxygenase 2 Inhibitors, administration and dosage | Lactones, pharmacokinetics | Sulfonamides, blood | Cyclooxygenase 2 Inhibitors, pharmacokinetics | Thiazines, adverse effects | Lactones, blood | Thiazoles, adverse effects | Thiazoles, pharmacokinetics | Sulfones, blood | Sulfonamides, adverse effects | Thiazines, administration and dosage | Placebos, pharmacokinetics | Sulfones, pharmacokinetics | Pyrazoles, adverse effects | Placebos, administration and dosage | Potassium, urine | Sulfones, adverse effects | Pyrazoles, pharmacokinetics | Index Medicus
Journal Article