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Journal of Proteome Research, ISSN 1535-3893, 11/2015, Volume 14, Issue 11, pp. 4486 - 4501
Analysis of the cerebrospinal fluid (CSF) proteome has proven valuable to the study of neuro degenerative disorders. To identify new protein/pathway... 
LC-MS/MS | proteomics | cerebrospinal fluid | liquid chromatography-tandem mass spectrometry | mass spectrometry | biomarker | amyotrophic lateral sclerosis | extracellular matrix | MOTOR-NEURONS | ANTERIOR HORN NEURONS | PROTEIN | BIOCHEMICAL RESEARCH METHODS | ALS | CSF BIOMARKERS | FRONTOTEMPORAL LOBAR DEGENERATION | SEMAPHORIN 3A | GENE ONTOLOGY | DISCOVERY | MOUSE MODEL | Proteome - genetics | Humans | Middle Aged | Immunoglobulins - cerebrospinal fluid | Amyotrophic Lateral Sclerosis - diagnosis | Synapses - genetics | Cerebrospinal Fluid Proteins - genetics | Immunoglobulins - genetics | Support Vector Machine | Alzheimer Disease - pathology | Adaptor Proteins, Signal Transducing - cerebrospinal fluid | Motor Neuron Disease - genetics | Cell Adhesion Molecules - isolation & purification | Extracellular Matrix Proteins - isolation & purification | Proteomics - methods | Tandem Mass Spectrometry - methods | Amyotrophic Lateral Sclerosis - genetics | Extracellular Matrix Proteins - genetics | Motor Neuron Disease - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | Motor Neuron Disease - pathology | Amyotrophic Lateral Sclerosis - pathology | Calcium-Binding Proteins - isolation & purification | Biomarkers - cerebrospinal fluid | Calcium-Binding Proteins - cerebrospinal fluid | Proteome - metabolism | Calcium-Binding Proteins - genetics | Cell Adhesion Molecules - genetics | Adaptor Proteins, Signal Transducing - isolation & purification | Cerebrospinal Fluid Proteins - isolation & purification | Case-Control Studies | Extracellular Matrix - chemistry | Synaptic Transmission | Alzheimer Disease - diagnosis | Immunoglobulins - isolation & purification | Synapses - metabolism | Amyloid beta-Protein Precursor - cerebrospinal fluid | Amyotrophic Lateral Sclerosis - cerebrospinal fluid | Sensitivity and Specificity | Adult | Cerebrospinal Fluid Proteins - cerebrospinal fluid | Proteome - isolation & purification | Diagnosis, Differential | Cell Adhesion Molecules - cerebrospinal fluid | Inflammation | Amyloid beta-Protein Precursor - isolation & purification | Amyloid beta-Protein Precursor - genetics | Extracellular Matrix Proteins - cerebrospinal fluid | Adaptor Proteins, Signal Transducing - genetics | Alzheimer Disease - genetics | Chromatography, Liquid - methods | Motor Neuron Disease - diagnosis | LC-MS
Journal Article
Brain Research, ISSN 0006-8993, 2009, Volume 1265, pp. 158 - 170
Abstract Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive loss of cognitive... 
Neurology | Neurodegenerative disease | Liquid chromatography with tandem mass spectrometry (LC–MS/MS) | Cerebrospinal fluid (CSF) | Two-dimensional gel electrophoresis (2-DE) | Neuronal pentraxin receptor (NPR) | Liquid chromatography with tandem mass spectrometry (LC-MS/MS) | CELL-ADHESION MOLECULE | ALZHEIMERS-DISEASE | BINDING PROTEIN 49 | RECOGNITION MOLECULES | SCHIZOPHRENIA | DYSTROGLYCAN | SYNAPTIC PLASTICITY | NEUROSCIENCES | N-CAM | EXPRESSION | PARKINSONS-DISEASE | Nerve Tissue Proteins - blood | Contactins | Humans | Middle Aged | Dipeptidases - cerebrospinal fluid | Electrophoresis, Gel, Two-Dimensional | Tandem Mass Spectrometry | C-Reactive Protein - metabolism | Contactin 2 | Neural Cell Adhesion Molecules - cerebrospinal fluid | Contactin 1 | Parkinson Disease - cerebrospinal fluid | Chromatography, Liquid | Cell Adhesion Molecules, Neuronal - cerebrospinal fluid | Cognition Disorders - cerebrospinal fluid | Protein Isoforms - cerebrospinal fluid | Nerve Tissue Proteins - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | C-Reactive Protein - cerebrospinal fluid | Blotting, Western | Nerve Tissue Proteins - metabolism | Dystroglycans - cerebrospinal fluid | Extracellular Matrix Proteins - cerebrospinal fluid | Cell Line, Tumor | Aged | Biomarkers - cerebrospinal fluid | Calcium-Binding Proteins - cerebrospinal fluid | Nervous system diseases | Cysteine | Neurons | Analysis | Amyloid beta-protein | Liquid chromatography | Public radio | Mass spectrometry | Alzheimer's disease
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e57820
Pathology studies of progressive multiple sclerosis (MS) indicate a major role of inflammation including Th17-cells and meningeal inflammation with ectopic... 
DENDRITIC CELLS | MESSENGER-RNA | CD86 B7-2 | MULTIDISCIPLINARY SCIENCES | CHEMOKINE RECEPTOR | MENINGEAL INFLAMMATION | ADHESION MOLECULES | EXPRESSION | AUTOIMMUNE ENCEPHALOMYELITIS | LESIONS | CORTICAL PATHOLOGY | Inflammation - pathology | Cell Adhesion Molecules - genetics | Humans | Interleukins - cerebrospinal fluid | Middle Aged | Dendritic Cells - pathology | Male | Monocytes - metabolism | Lectins, C-Type - genetics | Interleukin-23 - genetics | Receptors, Interleukin - metabolism | Interleukins - genetics | Flow Cytometry | Interleukin-23 - cerebrospinal fluid | Th17 Cells - metabolism | Inducible T-Cell Co-Stimulator Protein - genetics | Monocytes - pathology | Adult | Female | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Dendritic Cells - metabolism | Multiple Sclerosis, Chronic Progressive - genetics | Th17 Cells - pathology | Multiple Sclerosis, Chronic Progressive - cerebrospinal fluid | Gene Expression | Lymphocyte Activation | Inflammation - cerebrospinal fluid | Cell Adhesion Molecules - cerebrospinal fluid | Multiple Sclerosis, Chronic Progressive - pathology | Receptors, Interleukin - genetics | Disease Progression | Interleukin-21 Receptor alpha Subunit - metabolism | Inflammation - genetics | Inducible T-Cell Co-Stimulator Protein - metabolism | Interleukin-21 Receptor alpha Subunit - genetics | Receptors, Cell Surface - genetics | Complications and side effects | Multiple sclerosis | Prognosis | Physiological aspects | Development and progression | Inflammation | Genetic aspects | Research | B cells | Flow cytometry | Neurosciences | Disease | CD8 antigen | Interleukin | Helper cells | Fluid flow | Interleukin 23 | Lymphocytes T | Cerebrospinal fluid | Follicles | Blood | Rodents | Peripheral blood | Interleukin 21 | Age | Cytokines | Dendritic cells | Blood cells | T cell receptors | Gene expression | Patients | CD4 antigen | DC-SIGN protein | Studies | CD83 antigen | Pathology | Neurology | Cytometry | Monocytes | Gene flow | Lymphocytes B | Correlation analysis | ICOS protein | Plasma cells
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2016, Volume 51, pp. 104 - 112
Abstract Blood-brain barrier (BBB) dysfunction might be an important component of many neurodegenerative disorders. In this study, we investigated its role in... 
Neurology | Internal Medicine | APOE ε4 | Amyloid | Diabetes | Blood-brain barrier | Vascular pathology | Dementia | ALZHEIMERS-DISEASE | COGNITIVE IMPAIRMENT | APOE epsilon 4 | FRONTOTEMPORAL LOBAR DEGENERATION | CEREBROSPINAL-FLUID | DEPENDENT MANNER | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | TIGHT JUNCTIONS | VASCULAR DEMENTIA | DYSFUNCTION | DIAGNOSTIC-CRITERIA | LEWY BODIES | Diabetes Mellitus - blood | Capillary Permeability | Humans | Middle Aged | Blood-Brain Barrier - physiopathology | Immunoglobulins - cerebrospinal fluid | Vascular Endothelial Growth Factor A - cerebrospinal fluid | Cell Adhesion Molecules - cerebrospinal fluid | Genotype | Male | Diabetes Mellitus - cerebrospinal fluid | Dementia - etiology | Serum Albumin | Cell Adhesion Molecule-1 | Apolipoproteins E - genetics | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Albumins - cerebrospinal fluid | Diabetes Mellitus - etiology | Female | Aged | Cohort Studies | Nervous system diseases | Neurosciences | PET imaging | Endothelial growth factors | Physiological aspects | Brain damage | Genetic aspects | Permeability | Apolipoproteins | Alzheimer's disease | Endothelium | Medical research | Medicine, Experimental | lewy bodies | vascular dementia | Geriatrics & Gerontology | Neurosciences & Neurology | dependent manner | dysfunction | cerebrospinal-fluid | Endokrinologi och diabetes | diagnostic-criteria | cognitive impairment | tight junctions | Geriatrik | frontotemporal lobar degeneration | Neurovetenskaper | Endocrinology and Diabetes | Geriatrics | alzheimers-disease
Journal Article
Journal Article
PROTEOMICS – Clinical Applications, ISSN 1862-8346, 01/2018, Volume 12, Issue 1, pp. 1700131 - n/a
Scope: The aim of this study was to develop and evaluate a parallel reaction monitoring mass spectrometry (PRM-MS) assay consisting of a panel of potential... 
mass spectrometry | biomarker | Alzheimer's disease | parallel reaction monitoring | cerebrospinal fluid | DIAGNOSIS | NEURODEGENERATIVE DISORDERS | BETA PROTEIN | CHONDROITIN SULFATE PROTEOGLYCANS | BIOCHEMICAL RESEARCH METHODS | CHROMOGRANIN-A | AMYLOID PRECURSOR PROTEIN | SYNAPTIC PLASTICITY | CEREBROSPINAL-FLUID BIOMARKERS | HIGH-RESOLUTION | CYSTATIN-C | Cell Adhesion Molecules - genetics | Humans | Middle Aged | Male | Case-Control Studies | Alzheimer Disease - pathology | Secretogranin II - cerebrospinal fluid | Alzheimer Disease - diagnosis | Proteolysis | Chromatography, Liquid | Female | Nerve Growth Factors - cerebrospinal fluid | Chromogranin A - genetics | Proteomics - methods | Cell Adhesion Molecules, Neuronal - cerebrospinal fluid | Tandem Mass Spectrometry - methods | Amino Acid Sequence | Gene Expression | Chromogranin A - cerebrospinal fluid | Peptide Fragments - cerebrospinal fluid | Nerve Tissue Proteins - cerebrospinal fluid | Cell Adhesion Molecules - cerebrospinal fluid | C-Reactive Protein - genetics | Alzheimer Disease - cerebrospinal fluid | C-Reactive Protein - cerebrospinal fluid | Nerve Tissue Proteins - genetics | Cell Adhesion Molecules, Neuronal - genetics | Pilot Projects | Nerve Growth Factors - genetics | Aged | Secretogranin II - genetics | Biomarkers - cerebrospinal fluid | Alzheimer Disease - genetics | Biological markers | Mass spectrometry | Methods | Lysozyme | Amyloid beta-protein | Cystatin | Neurodegenerative diseases | Peptides | Neurocan | Mass spectroscopy | Cerebrospinal fluid | Coefficient of variation | Amyloid precursor protein | Neurological diseases | Proteins | Core protein | Experimental design | Cystatin C | Biomarkers | Bioindicators | Alzheimers disease | Monitoring | Pentraxins | Immune system | Neurosciences | Neurovetenskaper
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 1, p. e0146288
Background Encephalitis is parenchymal brain inflammation due to infectious or immune-mediated processes. However, in 15-60% the cause remains unknown. This... 
ACUTE LIMBIC ENCEPHALITIS | INTERLEUKIN-1 RECEPTOR ANTAGONIST | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MARKERS | MECHANISMS | CEREBROSPINAL-FLUID | HERPES-SIMPLEX ENCEPHALITIS | EXPRESSION | MANIFESTATIONS | CHILDREN | Chemokines - classification | Humans | Male | Encephalitis, Viral - diagnosis | Infectious Encephalitis - blood | Multicenter Studies as Topic | Toxoplasmosis, Cerebral - blood | England - epidemiology | Paraneoplastic Syndromes, Nervous System - diagnosis | Toxoplasmosis, Cerebral - cerebrospinal fluid | Adult | Female | Leukocyte Count | Mycoses - blood | Retrospective Studies | Mycoses - cerebrospinal fluid | Bacterial Infections - cerebrospinal fluid | Paraneoplastic Syndromes, Nervous System - cerebrospinal fluid | Cytokines - blood | Infectious Encephalitis - diagnosis | Cell Adhesion Molecules - blood | Diagnosis, Differential | Toxoplasmosis, Cerebral - diagnosis | Chemokines - cerebrospinal fluid | Infectious Encephalitis - cerebrospinal fluid | Cell Adhesion Molecules - cerebrospinal fluid | Encephalitis - immunology | Cytokines - cerebrospinal fluid | Peroxidase - cerebrospinal fluid | Encephalitis, Viral - cerebrospinal fluid | Paraneoplastic Syndromes, Nervous System - blood | Encephalitis - cerebrospinal fluid | Biomarkers | Mycoses - diagnosis | Encephalitis, Viral - blood | Bacterial Infections - blood | Peroxidase - blood | Encephalitis - blood | Encephalitis - etiology | Brain | Encephalitis | Disease | Cytokines | Research & development--R&D | Pathogenesis | Diagnostic tests | Neutrophils | Infections | Leukocytes (neutrophilic) | Inflammation | Cerebrospinal fluid | Multivariate analysis | Patients | Zoonoses | Infectious diseases | Influenza | Herpes viruses | Classification | Measurement methods | Peroxidase | Chemokines | Public health | Research & development | R&D
Journal Article
Journal Article