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PloS one, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e48619 - e48619
DNA damage and repair are hallmarks of cellular responses to ionizing radiation. We hypothesized that monitoring the expression of DNA repair-associated genes... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Cycle - genetics | Predictive Value of Tests | Transcription, Genetic - drug effects | Humans | Middle Aged | Transcription, Genetic - radiation effects | DNA Repair - radiation effects | Male | DNA Repair - genetics | RNA, Messenger - metabolism | Inflammation - blood | Stress, Physiological - radiation effects | Young Adult | Time Factors | Adult | Female | Stress, Physiological - drug effects | Phosphorylation - drug effects | DNA Repair - drug effects | Reproducibility of Results | Stress, Physiological - genetics | Cell Cycle - radiation effects | RNA, Messenger - genetics | Biomarkers - blood | Gene Expression Regulation - drug effects | Phosphorylation - radiation effects | X-Rays | Lipopolysaccharides - pharmacology | Gene Expression Regulation - radiation effects | Inflammation - genetics | Cell Cycle - drug effects | Dose-Response Relationship, Radiation | Ionizing radiation | DNA damage | Genes | DNA | Inflammation | Gene expression | DNA repair | Mitogens | Stress (physiology) | Bax protein | Transcription | Laboratories | Radiation | Kinases | Blood | Lipopolysaccharides | Proteins | Proliferating cell nuclear antigen | Cell cycle | Bacteria | XPC protein | Life sciences | Bioindicators | Repair | Deoxyribonucleic acid--DNA | Stresses | Radiation effects | Exposure | Stress | Human subjects | Gadd45A protein | Biomarkers | Radiation damage | Smoking | Cancer | Apoptosis | Index Medicus | Deoxyribonucleic acid
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 04/2011, Volume 103, Issue 8, pp. 645 - 661
Background Ionizing radiation (IR) is effectively used in cancer therapy. However, in subsets of patients, a few radioresistant cancer cells survive and cause disease relapse with metastatic progression... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Humans | Neoplasm Invasiveness - prevention & control | Radiation Tolerance | Receptors, Growth Factor - antagonists & inhibitors | NF-kappa B - metabolism | RNA, Messenger - metabolism | NF-kappa B - radiation effects | Receptors, Growth Factor - genetics | Proto-Oncogene Proteins c-met - radiation effects | Signal Transduction - radiation effects | Protein-Serine-Threonine Kinases - metabolism | Radiation, Ionizing | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - radiation effects | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Cell Cycle Proteins - radiation effects | Receptors, Growth Factor - radiation effects | Proto-Oncogene Proteins c-met - drug effects | Ataxia Telangiectasia Mutated Proteins | Phosphorylation - radiation effects | Cell Line, Tumor | Mice | RNA, Small Interfering | Tumor Suppressor Proteins - radiation effects | Receptors, Growth Factor - metabolism | Neoplasms - metabolism | Proto-Oncogene Proteins c-met - metabolism | Apoptosis - radiation effects | Up-Regulation - radiation effects | Transcription, Genetic - radiation effects | Transplantation, Heterologous | Sulfones - pharmacology | DNA-Binding Proteins - metabolism | Chromatin Immunoprecipitation | Protein-Serine-Threonine Kinases - radiation effects | Tumor Suppressor Proteins - genetics | Polymerase Chain Reaction | Cell Cycle Proteins - genetics | Indoles - pharmacology | Neoplasms - radiotherapy | Gene Expression Regulation, Neoplastic - drug effects | In Situ Nick-End Labeling | Enzyme-Linked Immunosorbent Assay | Radiation-Sensitizing Agents - pharmacology | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | DNA-Binding Proteins - genetics | Cell Survival - radiation effects | Cell Movement - radiation effects | Proto-Oncogene Proteins c-met - genetics | Blotting, Northern | Animals | NF-kappa B - genetics | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Receptors, Growth Factor - drug effects | DNA Damage - radiation effects | Mitogen-Activated Protein Kinases - metabolism | Ionizing radiation | Physiological aspects | Genetic aspects | Cancer invasiveness | Research | Gene expression | Radiotherapy | Health aspects | Radiation therapy | Kinases | Index Medicus
Journal Article
Molecular cancer, ISSN 1476-4598, 07/2013, Volume 12, Issue 1, pp. 81 - 81
Background: Radiation exerts direct antitumor effects and is widely used in clinics, but the efficacy is severely compromised by tumor resistance... 
mTOR | Radiation resistance | AZD8055 | Pancreatic cancer | Biochemistry & Molecular Biology | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Cycle - genetics | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Apoptosis - radiation effects | Humans | Up-Regulation - radiation effects | Apoptosis - genetics | MicroRNAs - metabolism | Down-Regulation - radiation effects | Pancreatic Neoplasms - drug therapy | Radiation Tolerance - radiation effects | TOR Serine-Threonine Kinases - genetics | Female | Gene Expression Regulation, Neoplastic - drug effects | Morpholines - therapeutic use | Radiation, Ionizing | Cell Cycle - radiation effects | Pancreatic Neoplasms - pathology | Morpholines - pharmacology | Pancreatic Neoplasms - radiotherapy | Radiation Tolerance - genetics | Pancreatic Neoplasms - genetics | Treatment Outcome | Up-Regulation - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Radiation Tolerance - drug effects | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Phosphorylation - radiation effects | Animals | Mice, Nude | Cell Line, Tumor | Gene Expression Regulation, Neoplastic - radiation effects | MicroRNAs - genetics | Cell Cycle - drug effects | Ionizing radiation | MicroRNA | Drug resistance | Genetic regulation | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 09/2011, Volume 7, Issue 9, pp. 1045 - 1051
Multiple stress pathways result in the induction of autophagy and apoptosis. Current methods (e.g., protein gel blot, microscopy) do not offer quantitative... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Autophagy | Multispectral imaging cytometry | Influenza | New methodology | Apoptosis | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Leukocytes, Mononuclear - metabolism | Image Cytometry - methods | Apoptosis - drug effects | Apoptosis - radiation effects | Autophagy - radiation effects | Microtubule-Associated Proteins - metabolism | Humans | Autophagy - drug effects | Lysosomes - radiation effects | Chloroquine - pharmacology | Lysosomes - metabolism | Ultraviolet Rays | Time Factors | Leukocytes, Mononuclear - radiation effects | Signal Transduction - radiation effects | Fibroblasts - metabolism | Lysosomes - drug effects | Leukocytes, Mononuclear - drug effects | Animals | Fibroblasts - radiation effects | Signal Transduction - drug effects | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Leukocytes, Mononuclear - cytology | Fibroblasts - cytology | Mice | Index Medicus | Autophagy/radiation effects | Signal Transduction/radiation effects | Image Cytometry/methods | Autophagy/drug effects | Life Sciences | Lysosomes/drug effects | Immunology | Fibroblasts/metabolism | Leukocytes, Mononuclear/radiation effects | Fibroblasts/drug effects | Leukocytes, Mononuclear/metabolism | Apoptosis/radiation effects | Leukocytes, Mononuclear/drug effects | Fibroblasts/cytology | Apoptosis/drug effects | Fibroblasts/radiation effects | Lysosomes/metabolism | Leukocytes, Mononuclear/cytology | Signal Transduction/drug effects | Chloroquine/pharmacology | Embryo, Mammalian/cytology | Lysosomes/radiation effects | Microtubule-Associated Proteins/metabolism
Journal Article
Journal Article
Cell death & disease, ISSN 2041-4889, 10/2014, Volume 5, Issue 10, pp. e1437 - e1437
Journal Article