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Nature (London), ISSN 1476-4687, 2016, Volume 539, Issue 7629, pp. 443 - 447
Journal Article
Cancer cell, ISSN 1535-6108, 2017, Volume 31, Issue 6, pp. 848 - 848.e1
Immunotherapy has changed the landscape of cancer treatment. Checkpoint blockade therapies unleash breaks in the immune system and induce long-lasting responses... 
ACQUIRED-RESISTANCE | ONCOLOGY | PD-1 BLOCKADE | CELL BIOLOGY | Immunotherapy - methods | Adaptive Immunity - drug effects | Cell Cycle Checkpoints - drug effects | Neoplasms - immunology | Humans | Drug Resistance, Neoplasm - immunology | Interferons - physiology | Interferons - drug effects | Neoplasms - drug therapy | Immunotherapy
Journal Article
Cell Cycle, ISSN 1551-4005, 2014, Volume 9, Issue 6, pp. 1112 - 1121
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 9, p. e107142
.... A stable shRNA knockdown model for ALDH1A1 was utilized to determine its effect on cancer stem cell-like properties, cell cycle checkpoints, and DNA repair mediators. Results... 
BREAST-CANCER | TRANSITION | CISPLATIN | ALDEHYDE DEHYDROGENASE | MARKER | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | RESISTANCE | IDENTIFICATION | COMBINATION | CARCINOMA | DNA Repair - drug effects | Platinum - therapeutic use | Neoplastic Stem Cells - drug effects | Humans | Ovarian Neoplasms - pathology | Down-Regulation - drug effects | Gene Knockdown Techniques | Disease-Free Survival | Phenotype | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Isoenzymes - metabolism | Kruppel-Like Transcription Factors - metabolism | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Neoplastic Stem Cells - pathology | Female | Aldehyde Dehydrogenase - metabolism | Neoplastic Stem Cells - enzymology | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Drug Resistance, Neoplasm - drug effects | Flow cytometry | GTP-binding protein | Dehydrogenases | Ovarian carcinoma | Bax protein | DNA damage | G2 phase | Genomes | Kinases | DNA repair | Aldehyde dehydrogenase | Cancer therapies | Ovarian cancer | Proteins | Genotype & phenotype | KLF4 protein | Platinum | Cell cycle | PARP-1 protein | Repair | Deoxyribonucleic acid--DNA | Cell survival | BRCA1 protein | Anemia | CHK1 protein | Poly(ADP-ribose) polymerase | Breast cancer | Tumor cell lines | Gene expression | Fanconi syndrome | Patients | Survival | Cytometry | Signaling | Poly(ADP-ribose) Polymerase 1 | Properties (attributes) | Chemotherapy | Medical prognosis | Stem cells | Response rates | Replication | Head & neck cancer | Ascites | Apoptosis | Cancer | Deoxyribonucleic acid | DNA
Journal Article
Molecular cell, ISSN 1097-2765, 10/2010, Volume 40, Issue 1, pp. 34 - 49
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair... 
CANCER-CELLS | GADD45 | CHK1 | AU-RICH ELEMENTS | MEDIATE ACTIVATION | PHOSPHORYLATION | MAPKAP KINASE-2 | NUCLEAR EXPORT | ONCOGENE-INDUCED SENESCENCE | STRESS | UMCG Approved | P38 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE ACTIVATION | CELL BIOLOGY | Protein Kinases - metabolism | Cell Cycle - genetics | Phosphorylation | Antibiotics, Antineoplastic - pharmacology | RNA Processing, Post-Transcriptional - radiation effects | Mitosis | Humans | Intracellular Signaling Peptides and Proteins - metabolism | RNA Stability - drug effects | RNA, Messenger - metabolism | Cell Nucleus - enzymology | Transfection | Ultraviolet Rays | RNA Interference | Time Factors | Cell Cycle Proteins - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Active Transport, Cell Nucleus | Head and Neck Neoplasms - enzymology | cdc25 Phosphatases - metabolism | 3' Untranslated Regions | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytoplasm - enzymology | Signal Transduction | RNA Processing, Post-Transcriptional - drug effects | Cell Cycle - radiation effects | Protein-Serine-Threonine Kinases - genetics | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Feedback, Physiological | DNA Repair | Checkpoint Kinase 1 | Head and Neck Neoplasms - genetics | DNA Damage | HeLa Cells | Cell Cycle - drug effects | RNA Stability - radiation effects | Doxorubicin - pharmacology | Exoribonucleases - metabolism | RNA-Binding Proteins - metabolism | Messenger RNA | Oncology, Experimental | DNA | Genetics | Automated teller machines | Research | Universities and colleges | Tumor proteins | Gene expression | Cancer | Tumors
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 4, p. e62087
Silica nanoparticles have become promising carriers for drug delivery or gene therapy... 
PATHWAYS | MAINTENANCE | AIR-POLLUTION | OXIDATIVE STRESS | CHK1 | PARTICLES | MULTIDISCIPLINARY SCIENCES | DISEASE | MITOCHONDRIA | SIZE-DEPENDENT CYTOTOXICITY | CANCER | Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Membrane Potential, Mitochondrial - drug effects | Necrosis | Flow Cytometry | G2 Phase Cell Cycle Checkpoints - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Intracellular Space - drug effects | Subcellular Fractions - drug effects | Endocytosis - drug effects | Nanoparticles - ultrastructure | Hydrodynamics | Static Electricity | Comet Assay | Nanoparticles - toxicity | Subcellular Fractions - metabolism | Particle Size | Human Umbilical Vein Endothelial Cells - enzymology | Silicon Dioxide - toxicity | Intracellular Space - metabolism | Checkpoint Kinase 1 | Human Umbilical Vein Endothelial Cells - pathology | DNA Damage | Oxidative Stress - drug effects | Drugs | Nanoparticles | Drug delivery systems | DNA | DNA damage | Superoxide | Radiation, Background | DNA repair | Silica | Vehicles | Endothelium | Cdc2 protein | Reactive oxygen species | Intravenous administration | Toxicity | Cytology | Cytotoxicity | Superoxide dismutase | Drug delivery | Kinases | Cyclin B1 | Silicon dioxide | Signal transduction | Mitochondria | Peroxidase | Membrane potential | Damage | Heart diseases | Deoxyribonucleic acid--DNA | Glutathione | Glutathione peroxidase | Outdoor air quality | Oxygen | CHK1 protein | Lactate dehydrogenase | Exposure | Hazards | Malondialdehyde | L-Lactate dehydrogenase | Endothelial cells | Signaling | Lactic acid | Mutation | Gene therapy | Cardiovascular diseases | Apoptosis | Deoxyribonucleic acid
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21557
.... To date, it is still unclear whether the spindle assembly checkpoint ( SAC) is required for the regulation of mitotic cell cycle progression to ensure mitotic fidelity during preimplantation development... 
MAD2 | CHROMOSOME INSTABILITY | PROTEIN | B DEGRADATION | AGING-ASSOCIATED PHENOTYPES | BUDDING YEAST | PREMATURE ANAPHASE | BIOLOGY | MICE | MOUSE OOCYTE MEIOSIS | MAMMALIAN-CELLS | Subcellular Fractions - drug effects | Blastocyst - metabolism | Nocodazole - pharmacology | Aneuploidy | Blastocyst - cytology | Protein Transport - drug effects | Metaphase - drug effects | Chromosome Segregation - drug effects | Blastocyst - drug effects | Subcellular Fractions - metabolism | Anaphase - drug effects | Chromatids - metabolism | Phenotype | Animals | Mitosis - drug effects | Spindle Apparatus - metabolism | RNA Interference | Embryo Transfer | Chromatids - drug effects | Mice | Spindle Apparatus - drug effects | Chromosomes, Mammalian - metabolism | Embryonic Development - drug effects | RNA | Embryo | Cell cycle | Gametes | BUBR1 protein | Fracture mechanics | Laboratories | Zoology | Biology | Kinases | Proteins | Depolymerization | Nocodazole | Clonal deletion | Misalignment | Metaphase | Fibroblasts | Cleavage | Life sciences | Localization | Chromosomes | Assembly | RNA-mediated interference | Implantation | Ductile-brittle transition | Gene expression | Ribonucleic acid--RNA | Embryos | Micronuclei | Epigenetics | Mutation | Aberration | Miscarriage | Anaphase | Chromosome aberrations | Ribonucleic acid
Journal Article
BioMed research international, ISSN 2314-6133, 9/2018, Volume 2018, pp. 2548378 - 11
Colon cancer represents the third most common malignancy worldwide. New drugs with high efficaciousness and safety for the treatment of colon cancer are urgently needed in clinical context... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | THERAPY | PATHWAY | PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | COLORECTAL-CANCER | KINASE | DEATH | INDUCTION | ERK | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | HCT116 Cells | Humans | Oleanolic Acid - analogs & derivatives | Oleanolic Acid - pharmacology | NF-kappa B - metabolism | Mitochondria - drug effects | Membrane Potential, Mitochondrial - drug effects | Colonic Neoplasms - metabolism | G2 Phase Cell Cycle Checkpoints - drug effects | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Interleukin-6 - metabolism | Saponins - pharmacology | Cytochrome | Bcl-2 protein | Nuclear engineering | Biochemistry | Caspase-3 | Cancer therapies | Anticancer properties | Proteins | Toxicology | Mitochondria | Tumorigenesis | Membrane potential | NF-κB protein | Immunoglobulins | Cytokines | Gene expression | Cytochrome c | Nuclear safety | Caspase-8 | Chemotherapy | Caspase-9 | Cytochromes | Disruption | Viability | Flow cytometry | Biotechnology | Phosphorylation | Bax protein | Interleukin | Colorectal cancer | mRNA | Malignancy | Kinases | Experiments | Cyclin B1 | Interleukin 6 | Colon cancer | Cell cycle | Colon | Translocation | Tumor cells | Extracellular signal-regulated kinase | Poly(ADP-ribose) polymerase | Caspase | Inflammation | Signaling | Antitumor activity | Cytoplasm | Apoptosis | Cancer
Journal Article