X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (78648) 78648
Newspaper Article (1178) 1178
Book Chapter (547) 547
Newsletter (458) 458
Book / eBook (133) 133
Dissertation (66) 66
Government Document (30) 30
Conference Proceeding (14) 14
Magazine Article (13) 13
Web Resource (12) 12
Publication (9) 9
Reference (9) 9
Book Review (4) 4
Streaming Video (4) 4
Transcript (2) 2
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (46738) 46738
animals (28192) 28192
cell biology (24102) 24102
cell cycle (21919) 21919
cancer (21609) 21609
oncology (19314) 19314
apoptosis (18304) 18304
proteins (17297) 17297
biochemistry & molecular biology (16213) 16213
mice (13916) 13916
research (13826) 13826
gene expression (13410) 13410
cell line, tumor (12766) 12766
female (12727) 12727
dna damage (12288) 12288
expression (11402) 11402
genetic aspects (11290) 11290
phosphorylation (10440) 10440
mutation (10188) 10188
kinases (9614) 9614
signal transduction (9390) 9390
male (9249) 9249
tumors (9229) 9229
genetics & heredity (8575) 8575
deoxyribonucleic acid--dna (8338) 8338
cell proliferation (8259) 8259
biology (8110) 8110
multidisciplinary sciences (7950) 7950
research article (7950) 7950
analysis (7828) 7828
dna repair (7675) 7675
genes (7188) 7188
physiological aspects (7136) 7136
dna (7090) 7090
cell cycle proteins - metabolism (6755) 6755
health aspects (6665) 6665
activation (6536) 6536
cells (6263) 6263
medicine (6055) 6055
protein (5972) 5972
p53 (5730) 5730
apoptosis - drug effects (5651) 5651
cell division (5627) 5627
mitosis (5419) 5419
chemotherapy (5348) 5348
genetics (5260) 5260
cell cycle proteins - genetics (5216) 5216
science (5058) 5058
cell line (5049) 5049
life sciences (4974) 4974
genomes (4918) 4918
gene expression regulation, neoplastic (4896) 4896
care and treatment (4857) 4857
breast cancer (4733) 4733
gene-expression (4718) 4718
cancer therapies (4689) 4689
cell growth (4670) 4670
stem cells (4645) 4645
metastasis (4618) 4618
dna-damage (4579) 4579
growth (4446) 4446
saccharomyces-cerevisiae (4435) 4435
review (4389) 4389
proliferation (4353) 4353
development and progression (4350) 4350
gene (4301) 4301
middle aged (4299) 4299
cell proliferation - drug effects (4293) 4293
protein-serine-threonine kinases - metabolism (4231) 4231
tumor suppressor protein p53 - metabolism (4208) 4208
chromosomes (4198) 4198
cell-cycle (4105) 4105
transcription (4024) 4024
immunology (3972) 3972
cells, cultured (3905) 3905
antineoplastic agents - pharmacology (3880) 3880
genomics (3816) 3816
protein binding (3782) 3782
dna replication (3711) 3711
inhibition (3696) 3696
biochemistry (3640) 3640
flow cytometry (3586) 3586
dna-binding proteins - metabolism (3581) 3581
molecular biology (3559) 3559
prognosis (3541) 3541
medicine, research & experimental (3529) 3529
studies (3503) 3503
rna interference (3485) 3485
adult (3475) 3475
cell death (3439) 3439
hela cells (3439) 3439
immunotherapy (3399) 3399
chromatin (3348) 3348
models, biological (3300) 3300
aged (3264) 3264
in-vivo (3262) 3262
in-vitro (3251) 3251
molecular sequence data (3249) 3249
down-regulation (3232) 3232
nuclear proteins - metabolism (3211) 3211
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (42) 42
Online Resources - Online (16) 16
UofT at Mississauga - Stacks (14) 14
Collection Dvlpm't (Acquisitions) - Vendor file (10) 10
Earth Sciences (Noranda) - Stacks (6) 6
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (6) 6
Collection Dvlpm't (Acquisitions) - Closed Orders (5) 5
Trinity College (John W Graham) - Stacks (5) 5
UofT at Scarborough - Stacks (5) 5
St. Michael's College (John M. Kelly) - 2nd Floor (4) 4
Victoria University E.J. Pratt - Oversize (3) 3
Earth Sciences (Noranda) - Circulation Desk (2) 2
Earth Sciences (Noranda) - Oversize (2) 2
Gerstein Science - Circulation Desk (2) 2
Gerstein Science - Reserve desk (2) 2
UTL at Downsview - May be requested (2) 2
UofT at Mississauga - Circulation Desk (2) 2
Victoria University E.J. Pratt - Circulation Desk (2) 2
Gerstein Science - Missing (1) 1
Physics - Course Reserves (1) 1
Physics - New Books (1) 1
St. Michael's College (John M. Kelly) - Circulation Desk (1) 1
St. Michael's College (John M. Kelly) - On order (1) 1
St. Michael's Hospital - Circulation Desk (1) 1
St. Michael's Hospital - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (81036) 81036
Japanese (158) 158
Chinese (84) 84
Russian (41) 41
Portuguese (38) 38
German (36) 36
Norwegian (31) 31
French (24) 24
Spanish (12) 12
Polish (9) 9
Dutch (8) 8
Korean (6) 6
Czech (5) 5
Italian (2) 2
Turkish (2) 2
Danish (1) 1
Serbian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Cancer cell, ISSN 1535-6108, 2015, Volume 28, Issue 5, pp. 623 - 637
In normal cells, p53 is activated by DNA damage checkpoint kinases to simultaneously control the G1/S and G2/M cell cycle checkpoints through transcriptional induction of p21cip1 and Gadd45α... 
ADJUVANT CHEMOTHERAPY | MESSENGER-RNAS | NETWORK | ONCOLOGY | PHOSPHORYLATION | DNA-DAMAGE RESPONSE | ATM | IDENTIFICATION | INHIBITOR | P27(KIP1) | P53 | CELL BIOLOGY | Neoplasms - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Antineoplastic Agents - therapeutic use | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Neoplasms - genetics | RNA Interference | HEK293 Cells | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cell Cycle Checkpoints - genetics | Female | Nuclear Proteins - genetics | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Nuclear Proteins - metabolism | Genetic Pleiotropy | Reverse Transcriptase Polymerase Chain Reaction | Neoplasms - drug therapy | Heterogeneous-Nuclear Ribonucleoproteins - genetics | Drug Resistance, Neoplasm - genetics | Animals | Cisplatin - therapeutic use | Survival Analysis | Cell Line, Tumor | Aged | Mutation | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Chemotherapy | RNA | Lung cancer | Cell cycle | Tumor proteins | Phosphotransferases | Cancer | Protein binding | Tumors | Messenger RNA | Research institutes | Genetic transcription | Binding proteins | DNA repair
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2018, Volume 362, Issue 6411, pp. eaar3593 - 197
Programmed cell death protein–1 (PD-1) and programmed cell death ligand–1 (PD-L1) checkpoint blockade immunotherapy elicits durable antitumor effects in multiple cancers, yet not all patients respond... 
CELL LUNG-CANCER | MISMATCH-REPAIR DEFICIENCY | MUTATIONAL PROCESSES | METASTATIC MELANOMA | CTLA-4 BLOCKADE | MULTIDISCIPLINARY SCIENCES | COPY NUMBER | PROGRAMMED DEATH LIGAND-1 | SEQUENCING DATA | CLINICAL-RESPONSE | SOMATIC MUTATIONS | Antibodies, Monoclonal, Humanized - therapeutic use | Humans | Transcriptome | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Genetic Markers | Cell Cycle Checkpoints | Neoplasms - therapy | Neoplasms - genetics | Antineoplastic Agents, Immunological - therapeutic use | Immunotherapy | Inflammation - genetics | T-Lymphocytes - immunology | Tumor Burden - genetics | Biomarkers, Tumor - genetics | Mutation | Molecular Targeted Therapy - methods | Monoclonal antibodies | Genetic aspects | T cells | Biological markers | Gene expression | Cancer | Tumors | Apoptosis | Cell receptors | Physiological aspects | Diagnosis | Identification and classification | Methods | PD-1 protein | Genomics | Clinical trials | Genomes | Biology | Lymphocytes T | Microsatellite instability | Data bases | Subgroups | Anticancer properties | Proteins | Cell activation | Pembrolizumab | Databases | Antigenicity | Lymphocytes | Deoxyribonucleic acid--DNA | Medical research | Stability | Microsatellites | Mortality | Melanoma | Data processing | Inflammation | Patients | Immune checkpoint | Cell death | Correlation analysis | PD-L1 protein | Biomarkers | Ligands | Antitumor activity | Cutoffs | Solid tumors
Journal Article
Oncogene, ISSN 0950-9232, 10/2011, Volume 30, Issue 41, pp. 4261 - 4274
.... The checkpoint kinases Chk1/Chk2 and the CDK inhibitor p21 are known to have important complementary roles in this process, in G2 arrest and cell cycle exit, respectively... 
cyclin B1 | ATM | Chk2 | G2-M checkpoint | cell cycle | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOTIC CATASTROPHE | TRANSCRIPTIONAL REPRESSION | G CHECKPOINT | CELL BIOLOGY | GENOMIC INSTABILITY | RETINOBLASTOMA PROTEIN | ONCOLOGY | GENETICS & HEREDITY | P53-DEFICIENT CELLS | CELL-CYCLE EXIT | IONIZING-RADIATION | ATAXIA-TELANGIECTASIA | Protein Kinases - metabolism | G2 Phase Cell Cycle Checkpoints - physiology | Phosphorylation | Protein Kinases - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Immunoblotting | Male | Cyclin B1 - metabolism | Pyrones - pharmacology | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | G2 Phase Cell Cycle Checkpoints - drug effects | RNA Interference | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | HCT116 Cells | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin B1 - genetics | Morpholines - pharmacology | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Piperazines - pharmacology | G2 Phase Cell Cycle Checkpoints - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Checkpoint Kinase 2 | Bleomycin - pharmacology | Checkpoint Kinase 1 | Signal Transduction - physiology | DNA Damage | HeLa Cells | Cell division | Oxidative stress | Signal transduction | DNA damage | Cyclin-dependent kinases | Cell cycle | CHK2 protein | Epithelial cells | Mitosis | CHK1 protein | G2 phase | Genotoxicity | Osteosarcoma cells | p53 protein | Cyclin-dependent kinase | Chemotherapy | Fibroblasts | Cancer | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Cancer discovery, ISSN 2159-8290, 2017, Volume 7, Issue 3, pp. 264 - 276
Immune checkpoint inhibitors have shown significant therapeutic responses against tumors containing increased mutation-associated neoantigen load... 
METASTATIC MELANOMA | CTLA-4 BLOCKADE | ONCOLOGY | PD-1 BLOCKADE | COLORECTAL-CANCER | PANCREATIC-CANCER | COPY NUMBER | RESISTANCE | MUTATIONS | SEQUENCING DATA | TUMOR PURITY | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Ipilimumab - pharmacology | Immunotherapy | Ipilimumab - therapeutic use | Janus Kinase 1 - genetics | Adult | Female | Receptors, Antigen, T-Cell - immunology | Cell Cycle Checkpoints - immunology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptors, Antigen, T-Cell - metabolism | Antigens, Neoplasm - immunology | Carcinoma, Non-Small-Cell Lung - genetics | Antibodies, Monoclonal - pharmacology | Janus Kinase 2 - genetics | CTLA-4 Antigen - genetics | Drug Resistance, Neoplasm - immunology | Lung Neoplasms - therapy | CTLA-4 Antigen - immunology | Antineoplastic Agents, Immunological - pharmacology | Carcinoma, Non-Small-Cell Lung - immunology | Carcinoma, Non-Small-Cell Lung - therapy | Drug Resistance, Neoplasm - genetics | Lung Neoplasms - immunology | Antineoplastic Agents, Immunological - therapeutic use | Cell Cycle Checkpoints - drug effects | Receptors, Antigen, T-Cell - genetics | Mutation | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Cohort Studies
Journal Article
Nature cell biology, ISSN 1465-7392, 07/2015, Volume 17, Issue 7, pp. 868 - 879
The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules... 
NDC80 COMPLEX | RECRUITMENT | BUDDING YEAST | MPS1 | PHOSPHORYLATION | CHROMOSOME CONGRESSION | KINASE | MICROTUBULE ATTACHMENT | MITOTIC SPINDLE | PROTEIN ARCHITECTURE | CELL BIOLOGY | Phosphorylation | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Saccharomyces cerevisiae - genetics | Tubulin Modulators - pharmacology | Nocodazole - pharmacology | Saccharomyces cerevisiae - drug effects | Saccharomyces cerevisiae - metabolism | Microtubules - metabolism | Spindle Apparatus - metabolism | Cell Cycle Proteins - genetics | Cell Cycle Checkpoints - genetics | Time-Lapse Imaging - methods | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Aurora Kinases - metabolism | Kinetochores - metabolism | Aurora Kinases - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Cell Cycle Checkpoints - physiology | Nuclear Proteins - metabolism | Signal Transduction - genetics | Saccharomyces cerevisiae Proteins - genetics | Sirolimus - pharmacology | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Luminescent Proteins - genetics | Signal Transduction - physiology | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Spindle (Cell division) | Cellular signal transduction | Genetic aspects | Properties | Kinetochores
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 551, Issue 7681, pp. 517 - 520
Checkpoint blockade immunotherapies enable the host immune system to recognize and destroy tumour cells(1... 
CELL LUNG-CANCER | CTLA-4 BLOCKADE | MELANOMA | THERAPY | LANDSCAPE | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | RESISTANCE | CLINICAL-RESPONSE | REPERTOIRES | Humans | Lung Neoplasms - pathology | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antigen Presentation | Melanoma - genetics | Immunotherapy | Cell Cycle Checkpoints - genetics | Cell Cycle Checkpoints - immunology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Antigens, Neoplasm - immunology | Carcinoma, Non-Small-Cell Lung - genetics | Lymphocyte Activation | CTLA-4 Antigen - genetics | Lung Neoplasms - therapy | Melanoma - pathology | CTLA-4 Antigen - immunology | Carcinoma, Non-Small-Cell Lung - immunology | Carcinoma, Non-Small-Cell Lung - therapy | Lung Neoplasms - immunology | Models, Immunological | Melanoma - immunology | Survival Analysis | T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - immunology | CTLA-4 Antigen - antagonists & inhibitors | Melanoma - therapy | Programmed Cell Death 1 Receptor - genetics | Cohort Studies | Evolution, Molecular | Antigens | Care and treatment | Patient outcomes | Models | Health aspects | Tumors | Medical research | Peptides | PD-1 protein | Lung cancer | Melanoma | Cytotoxicity | Lymphocytes T | Patients | Proteins | Cell recognition | CTLA-4 protein | Major histocompatibility complex | Immune checkpoint | Lymphocytes | Evolution | Mutation | Cancer | Immune system | Fitness
Journal Article
Nature cell biology, ISSN 1476-4679, 2014, Volume 16, Issue 12, pp. 1257 - 1264
Journal Article