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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 03/2013, Volume 110, Issue 10, pp. 4069 - 4074
Glial reaction is a common feature of neurodegenerative diseases. Recent studies have suggested that reactive astrocytes gain neurotoxic properties, but... 
Amyotrophic lateral sclerosis | Astrocytosis | MOTOR-NEURONS | ACUTE KIDNEY INJURY | astrocytosis | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | UBIQUITIN AGGREGATION | TRANSGENIC RATS | AMYOTROPHIC-LATERAL-SCLEROSIS | GELATINASE-ASSOCIATED LIPOCALIN | amyotrophic lateral sclerosis | GLUTAMATE TRANSPORTER | SPINAL-CORD-INJURY | DUAL ROLE | Frontotemporal Lobar Degeneration - pathology | Neurons - pathology | Superoxide Dismutase - genetics | Humans | DNA, Complementary - genetics | Nerve Degeneration - physiopathology | Nerve Degeneration - genetics | DNA-Binding Proteins - metabolism | Lipocalins - genetics | Base Sequence | Lipocalins - physiology | Neurons - physiology | Lipocalins - secretion | Cell Death - drug effects | Neurons - drug effects | Lipocalins - toxicity | Superoxide Dismutase - metabolism | Recombinant Proteins - metabolism | Animals, Genetically Modified | RNA-Binding Protein FUS - genetics | Rats | Neurotoxins - toxicity | RNA-Binding Protein FUS - metabolism | Recombinant Proteins - genetics | Frontotemporal Lobar Degeneration - physiopathology | DNA-Binding Proteins - genetics | Nerve Degeneration - pathology | Culture Media, Conditioned | Astrocytes - physiology | Animals | Cell Death - physiology | Lipocalin-2 | Neurotoxins - secretion | Superoxide Dismutase-1 | Proteins | Cell culture | Neurotoxicity | Neurons | Rodents | Gene expression | Binding sites | Index Medicus | Biological Sciences
Journal Article
Nature Communications, ISSN 2041-1723, 02/2014, Volume 5, Issue 1, pp. 3321 - 3321
Many naturally occurring peptides containing cationic and hydrophobic domains have evolved to interact with mammalian cell membranes and have been incorporated... 
Cell Line | Liposomes - chemistry | Microscopy, Electron, Scanning | Animals | Cell Death - physiology | Electron Spin Resonance Spectroscopy | Hydrophobic and Hydrophilic Interactions | Nanostructures - chemistry | Calorimetry, Differential Scanning | Mice | Cell Survival - physiology | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 09/2008, Volume 8, Issue 3, pp. 237 - 248
Oxidative stress in conjunction with glutathione depletion has been linked with various acute and chronic degenerative disorders, yet the molecular mechanisms... 
HUMDISEASE | SIGNALING | MOUSE DEVELOPMENT | APOPTOSIS-INDUCING FACTOR | PATHWAY | 12-LIPOXYGENASE | EMBRYONIC STEM-CELLS | ENDOCRINOLOGY & METABOLISM | ATHEROSCLEROSIS | MITOCHONDRIAL DYSFUNCTION | 15-LIPOXYGENASE | HYDROPEROXIDE GLUTATHIONE-PEROXIDASE | NUCLEAR FORM | CELL BIOLOGY | Neurons - pathology | Arachidonate 12-Lipoxygenase - metabolism | Humans | Oxidative Stress - physiology | Apoptosis Inducing Factor - antagonists & inhibitors | Fluorenes - pharmacology | Arachidonate 15-Lipoxygenase - deficiency | Neurons - metabolism | Cell Death - drug effects | Glutathione Peroxidase - deficiency | alpha-Tocopherol - pharmacology | Arachidonate 12-Lipoxygenase - deficiency | Apoptosis Inducing Factor - metabolism | Glutathione Peroxidase - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Genotype | Hippocampus - pathology | Arachidonate 15-Lipoxygenase - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Glutathione Peroxidase - genetics | Lipid Peroxidation - physiology | Mice, Knockout | Hippocampus - metabolism | Animals | Cell Death - physiology | Alleles | Mice | Mice, Congenic | Prevention | Oxidative stress | Neurosciences | Thiols | Active oxygen | Cell death | Environmental health | Tocopherols | Development and progression | Biochemistry | Peroxidase | Index Medicus
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 01/2014, Volume 66, Issue 1, pp. 40 - 48
Journal Article
Circulation Research, ISSN 0009-7330, 11/2010, Volume 107, Issue 11, pp. 1374 - 1386
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2009, Volume 119, Issue 5, pp. 1359 - 1372
Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that... 
INSULIN | PATHOGENESIS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | UNFOLDED PROTEIN RESPONSE | INDUCED APOPTOSIS | PHOSPHORYLATION | TUMOR-CELLS | ENDOPLASMIC-RETICULUM STRESS | CERAMIDE | CANCER | Ribosomal Protein S6 Kinases - metabolism | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Humans | Multiprotein Complexes | Caspase 3 - metabolism | Autophagy - physiology | Neoplasm Proteins - metabolism | Autophagy - drug effects | Glioma - metabolism | Mechanistic Target of Rapamycin Complex 1 | Proteins | Endoplasmic Reticulum - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Amino Acid Chloromethyl Ketones - pharmacology | Endoplasmic Reticulum - drug effects | Glioma - pathology | Eukaryotic Initiation Factor-2 - metabolism | Cell Death - drug effects | Phosphorylation - drug effects | Dronabinol - pharmacology | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Cannabinoids - pharmacology | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Cannabinoids - therapeutic use | Animals | Cell Death - physiology | Models, Biological | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | Apoptosis - physiology | Cell Line, Transformed | Dronabinol - therapeutic use | Glioma - drug therapy | Cannabinoids | Control | Cell death | Gliomas | Causes of | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Phagocytosis | Index Medicus | Abridged Index Medicus
Journal Article