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Circulation, ISSN 0009-7322, 04/2013, Volume 127, Issue 16, pp. 1677 - 1691
Background-Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths.... 
arrhythmias, cardiac | stem cells | induced pluripotent stem cells | LONG-QT | INDUCED ARRHYTHMIAS | POLYMORPHIC VENTRICULAR-TACHYCARDIA | CARDIAC & CARDIOVASCULAR SYSTEMS | SUDDEN-DEATH | QT INTERVAL PROLONGATION | DISCOVERY | CHANNEL | MODELS | TORSADE-DE-POINTES | PERIPHERAL VASCULAR DISEASE | MOLECULAR-BASIS | Cardiomyopathy, Dilated - pathology | Embryonic Stem Cells - cytology | Kidney - embryology | Cardiomyopathy, Hypertrophic, Familial - genetics | Humans | Ion Channels - genetics | Verapamil - toxicity | Gene Expression Profiling | HEK293 Cells - drug effects | Cell Line - drug effects | Nicorandil - toxicity | Cell Line - physiology | Myofibrils - ultrastructure | Drug-Related Side Effects and Adverse Reactions - genetics | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Action Potentials - drug effects | Cardiomyopathy, Dilated - genetics | Drug Evaluation, Preclinical - methods | Genetic Predisposition to Disease | Ion Channels - biosynthesis | Cardiomyopathy, Hypertrophic, Familial - pathology | Cell Size | Kidney - cytology | Long QT Syndrome - pathology | Embryonic Stem Cells - physiology | Embryoid Bodies - drug effects | Patch-Clamp Techniques | Myocytes, Cardiac - drug effects | Quinazolines - toxicity | HEK293 Cells - physiology | Myocytes, Cardiac - physiology | Long QT Syndrome - genetics | Cisapride - toxicity | In Vitro Techniques | Drugs | Usage | Analysis | Heart cells | Stem cells | Product/Service Evaluations | Research | Health aspects | Methods | cardiotoxicity | Induced pluripotent stem cells | arrhythmia
Journal Article
Oncogene, ISSN 0950-9232, 01/2009, Volume 28, Issue 2, pp. 195 - 208
Effective control of both cell survival and cell proliferation is critical to the prevention of oncogenesis and to successful cancer therapy. Using functional... 
Oncogenesis | Breast cancer | Growth arrest | Drug resistance | snoRNA | Apoptosis | HUMAN PROSTATIC-CARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | breast cancer | CELL BIOLOGY | B-CELL LYMPHOMA | IN-VITRO | ONCOLOGY | SNORNA HOST GENE | NONCODING RNAS | SMALL NUCLEOLAR RNAS | FUNCTIONAL EXPRESSION | oncogenesis | GROWTH-ARREST | GENETICS & HEREDITY | growth arrest | MOLECULAR REGULATION | drug resistance | EXPRESSION CLONING REVEALS | Carcinoma, Ductal, Breast - genetics | RNA, Small Nucleolar - physiology | Apoptosis - drug effects | Apoptosis - radiation effects | Humans | Gene Expression Regulation, Neoplastic | RNA, Small Nucleolar - biosynthesis | Cell Line, Tumor - drug effects | Breast Neoplasms - metabolism | Cell Line - drug effects | Dexamethasone - pharmacology | Ultraviolet Rays | Thymus Neoplasms - pathology | Carcinoma, Ductal, Breast - pathology | Female | Antineoplastic Agents - pharmacology | Thymoma - pathology | Carcinoma, Ductal, Breast - metabolism | Cell Line, Tumor - metabolism | Cell Line, Tumor - radiation effects | Expressed Sequence Tags | Cell Line - metabolism | Tumor Stem Cell Assay | RNA, Neoplasm - physiology | Down-Regulation | Radiation Tolerance - genetics | Cell Adhesion | RNA, Small Nucleolar - genetics | Thymus Neoplasms - metabolism | Cell Line - radiation effects | Thymoma - metabolism | Animals | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Breast Neoplasms - pathology | RNA, Neoplasm - genetics | Mice | Control | Care and treatment | RNA | Physiological aspects | Genetic aspects | Research | Health aspects | Oncology | Cell growth | Gene expression
Journal Article
Journal Article
Blood, ISSN 0006-4971, 01/2007, Volume 109, Issue 1, pp. 353 - 358
Journal Article
Journal Article
Journal of Nanobiotechnology, ISSN 1477-3155, 01/2015, Volume 13, Issue 1, pp. 1 - 1
Journal Article
European Journal of Immunology, ISSN 0014-2980, 05/2010, Volume 40, Issue 5, pp. 1496 - 1503
Zinc signals, i.e. a change of the intracellular concentration of free zinc ions in response to receptor stimulation, are involved in signal transduction in... 
T cells | IL-2 | Zinc | PATHWAYS | HOMEOSTASIS | METALLOTHIONEIN | PHOSPHATASE | TRANSDUCTION | IMMUNOLOGY | INTRACELLULAR ZINC | INHIBITION | BINDING | EXPRESSION | FLUORESCENT-PROBE | MAP Kinase Signaling System - physiology | Humans | Fluorescent Dyes - analysis | Receptors, Interleukin-2 - drug effects | Polycyclic Compounds - analysis | Genes, fos - drug effects | T-Lymphocytes, Cytotoxic - drug effects | Cell Line - drug effects | Lysosomes - metabolism | Zinc - physiology | Quinolones - analysis | Tosyl Compounds - analysis | Extracellular Signal-Regulated MAP Kinases - physiology | Ionophores - pharmacology | Phosphoprotein Phosphatases - antagonists & inhibitors | Chelating Agents - pharmacology | Phosphoprotein Phosphatases - physiology | Cell Division - drug effects | Cell Compartmentation - physiology | Gene Expression Regulation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Interleukin-2 - pharmacology | Cytosol - metabolism | Signal Transduction - physiology | Mice | Pyridines - pharmacology | Receptors, Interleukin-2 - physiology | Thiones - pharmacology | Zinc - pharmacology | Ion Transport - physiology | T-Lymphocytes, Cytotoxic - cytology | Signal transduction | Gene expression | Kinases | Lymphocytes
Journal Article
Aquatic Toxicology, ISSN 0166-445X, 2006, Volume 76, Issue 2, pp. 122 - 159
Low levels of human medicines (pharmaceuticals) have been detected in many countries in sewage treatment plant (STP) effluents, surface waters, seawaters,... 
Environmental risk assessment | Ecotoxicological effects | Environmental toxicity | Pharmaceuticals | Chronic effects | SEWAGE-TREATMENT PLANTS | PERSONAL CARE PRODUCTS | ENVIRONMENTAL RISK-ASSESSMENT | PROLIFERATOR-ACTIVATED RECEPTORS | MINNOW PIMEPHALES-PROMELAS | WASTE-WATER CONTAMINANTS | pharmaceuticals | chronic effects | TANDEM MASS-SPECTROMETRY | ecotoxicological effects | environmental risk assessment | SEROTONIN REUPTAKE INHIBITORS | MARINE & FRESHWATER BIOLOGY | environmental toxicity | TOXICOLOGY | TROUT ONCORHYNCHUS-MYKISS | MEDAKA ORYZIAS-LATIPES | Pharmaceutical Preparations - isolation & purification | Hypolipidemic Agents - analysis | Antidepressive Agents - analysis | Humans | Sewage - analysis | Antineoplastic Agents - analysis | Water Pollutants, Chemical - analysis | Anticonvulsants - toxicity | Antineoplastic Agents - toxicity | Antidepressive Agents - toxicity | Cell Line - drug effects | Animals | Anticonvulsants - analysis | Water Pollutants, Chemical - toxicity | Drug-Related Side Effects and Adverse Reactions | Fishes | Invertebrates - drug effects | Pharmaceutical Preparations - supply & distribution | Hypolipidemic Agents - toxicity | Adrenergic beta-Antagonists - toxicity | Environment | Adrenergic beta-Antagonists - analysis | Drugs | Propranolol hydrochloride | Sewage | Purification | Environmental sciences | Fluoxetine | Analysis | Water, Underground | Aquatic resources
Journal Article