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Nature (London), ISSN 1476-4687, 2017, Volume 548, Issue 7668, pp. 471 - 475
...). Pharmacological inhibitors of CDK4/6 have shown significant activity against several solid tumours... 
BREAST-CANCER | CELLS | METHYLATION | MULTIDISCIPLINARY SCIENCES | SENESCENCE | EXPRESSION | REQUIREMENT | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Viruses - genetics | Breast Neoplasms - immunology | Humans | Transcriptome | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - cytology | Female | Biological Mimicry - drug effects | Phosphorylation - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Disease Models, Animal | Viruses - drug effects | Viruses - immunology | Antigen Presentation - immunology | Breast Neoplasms - drug therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Breast Neoplasms - genetics | Repressor Proteins - biosynthesis | Signal Transduction - drug effects | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Protein Kinase Inhibitors - therapeutic use | RNA, Double-Stranded - genetics | Cell Line, Tumor | Interferons - metabolism | Antigen Presentation - drug effects | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Cancer cells | Physiological aspects | Research | Protein kinases | Immunity | Cyclins | Cancer | Cell proliferation | Flow cytometry | Animal models | Phosphorylation | Senescence | Peptides | Genomics | Immune clearance | Cytotoxicity | Lymphocytes T | Genomes | Kinases | Cancer therapies | Cyclin-dependent kinase 4 | E2F protein | Breast carcinoma | Cell growth | Lymphocytes | New combinations | Cell cycle | Inhibition | Deoxyribonucleic acid--DNA | Immune system | Antigen presentation | Medical research | Immune response | Immunoregulation | Intracellular levels | Double-stranded RNA | Breast cancer | Pharmacology | Gene expression | Ribonucleic acid--RNA | Inhibitors | Immune checkpoint | Immunogenicity | DNA methyltransferase | Interferon | Retinoblastoma | Tumors | Apoptosis
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2011, Volume 141, Issue 4, pp. 1486 - 1497.e14
.... Methods PSCs and cancer cell lines (AsPc1 and Capan1) were exposed to doses and isoforms of retinoic acid (RA... 
Gastroenterology and Hepatology | 9RA | Therapy | Secreted Frizzled-Related Protein 4 | 13RA | Mouse Model | ACTIVATION | CANCER CELLS | TRANSCRIPTOME | ADENOCARCINOMA | STABILIZATION | MODEL | CULTURE | IN-VITRO | GASTROENTEROLOGY & HEPATOLOGY | IMMORTALIZATION | EXPRESSION | Transcription, Genetic - drug effects | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Pancreatic Stellate Cells - drug effects | Carcinoma, Pancreatic Ductal - metabolism | Cellular Senescence - drug effects | Wnt Proteins - metabolism | Carcinoma, Pancreatic Ductal - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | RNA Interference | Time Factors | Mice, Mutant Strains | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Pancreatic Stellate Cells - pathology | Disease Models, Animal | Tretinoin - pharmacology | Proto-Oncogene Proteins - metabolism | Isotretinoin - pharmacology | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | beta Catenin - metabolism | Disease Progression | Carcinoma, Pancreatic Ductal - drug therapy | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Paracrine Communication - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Pancreatic Stellate Cells - metabolism
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 3, pp. 262 - 269
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 520, Issue 7547, pp. 368 - 372
.... In situ transcriptome analysis of drug-resistant melanoma cells responding to the regressing tumour microenvironment revealed hyperactivation of several... 
CNS CELL-TYPES | MELANOMA | METASTASIS | MICROENVIRONMENT | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | RAF INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | KINASE INHIBITORS | DRUG-RESISTANCE | CANCER CHEMORESISTANCE | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Clone Cells - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-fos - deficiency | Adenocarcinoma - metabolism | Anaplastic Lymphoma Kinase | Neoplasm Metastasis - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Tumor Microenvironment - drug effects | Cell Survival - drug effects | ErbB Receptors - antagonists & inhibitors | Melanoma - pathology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Animals | Clone Cells - pathology | Metabolome - drug effects | Signal Transduction - drug effects | Neoplasm Metastasis - pathology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Pharmaceutical research | Care and treatment | Oncology, Experimental | Dosage and administration | Research | Drug therapy | Drug resistance | Antineoplastic agents | Tumors | Cancer | Melanoma | Mutation | Metastasis | Kinases | Cancer therapies
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2011, Volume 99, Issue 3, pp. 287 - 292
Journal Article
Nature nanotechnology, ISSN 1748-3395, 2016, Volume 11, Issue 11, pp. 986 - 994
Journal Article
Biomaterials, ISSN 0142-9612, 2010, Volume 31, Issue 10, pp. 2882 - 2892
Journal Article
by Qi, W and Chan, H and Teng, L and Li, L and Chuai, S and Zhang, R and Zeng, J and Li, M and Fan, H and Lin, Y and Gu, J and Ardayfio, O and Zhang, J.-H and Yan, X and Fang, J and Mi, Y and Zhang, M and Zhou, T and Feng, G and Chen, Z and Li, G and Yang, T and Zhao, K and Liu, X and Yu, Z and Lu, C. X and Atadja, P and Li, E
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2012, Volume 109, Issue 52, pp. 21360 - 21365
.... To investigate if tumor growth is dependent on the enzymatic activity of Ezh2, we developed a potent and selective small molecule inhibitor... 
Cell growth | B lymphocytes | B cell lymphoma | Cell lines | Cell cycle | Stem cells | Histones | Methylation | English language learners | Genetic mutation | LYSINE 27 | B-CELLS | DEVELOPMENTAL REGULATORS | GENE | HISTONE H3 | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | LYMPHOMA | POLYCOMB | CANCER | SOMATIC MUTATIONS | Polycomb Repressive Complex 2 - antagonists & inhibitors | Small Molecule Libraries - pharmacology | Apoptosis - drug effects | Apoptosis - genetics | Gene Expression Profiling | Cell Cycle Checkpoints - genetics | Gene Expression Regulation, Neoplastic - drug effects | Fibroblasts - metabolism | Tumor Stem Cell Assay | Lymphoma, Large B-Cell, Diffuse - pathology | Up-Regulation - genetics | Down-Regulation - drug effects | Gene Knockout Techniques | Mutation - genetics | Down-Regulation - genetics | Enhancer of Zeste Homolog 2 Protein | Up-Regulation - drug effects | Small Molecule Libraries - chemistry | Phenotype | Animals | Histone-Lysine N-Methyltransferase - metabolism | Methylation - drug effects | Cell Cycle Checkpoints - drug effects | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Cell Proliferation - drug effects | Mice | Histones - metabolism | Polycomb Repressive Complex 2 - metabolism | Lymphoma, Large B-Cell, Diffuse - genetics | Cell proliferation | Development and progression | Care and treatment | Lymphomas | Research | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 6, pp. e0130348 - e0130348
Journal Article