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Journal of Experimental Medicine, ISSN 0022-1007, 07/2009, Volume 206, Issue 7, pp. 1495 - 1503
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 7/2006, Volume 55, Issue 7, pp. 808 - 818
This study was designed to determine the characteristics of tumour cell-derived microvesicles (TMV) and their interactions with human monocytes. TMV were shed... 
Monocytes | Biomedicine | Immunology | Transfer | Oncology | Cancer Research | mRNA | CCR6 | Tumour-derived microvesicles | CANCER-CELLS | monocytes | ACTIVATION | POLYMORPHONUCLEAR LEUKOCYTES | ADHESION MOLECULES | IMMUNOLOGY | IN-VITRO | transfer | PLATELET MICROPARTICLES | ONCOLOGY | MEMBRANE-VESICLES | GENE-EXPRESSION | MELANOMA-CELLS | ENDOTHELIAL MICROPARTICLES | tumour-derived microvesicles | RNA, Messenger - immunology | Adenocarcinoma - ultrastructure | Tetradecanoylphorbol Acetate - pharmacology | Humans | Neoplasm Proteins - immunology | RNA, Messenger - analysis | Cell Line, Tumor - drug effects | Gene Expression Profiling | Monocytes - immunology | Membrane Proteins - analysis | Basigin - genetics | Basigin - immunology | Antigens, Neoplasm - analysis | Neoplasm Proteins - genetics | Receptors, Chemokine | Receptors, Cytokine - genetics | Antigens, Neoplasm - immunology | Cell Survival | Adenocarcinoma - immunology | RNA, Messenger - genetics | HLA Antigens - immunology | Pancreatic Neoplasms - ultrastructure | Immunophenotyping | Membrane Proteins - immunology | Cell Membrane - ultrastructure | Neoplasms - ultrastructure | Chemotaxis | Hyaluronan Receptors - genetics | Particle Size | Cell Line, Tumor - ultrastructure | Lung Neoplasms - immunology | Colorectal Neoplasms - immunology | Neoplasms - immunology | Cell Line, Tumor - immunology | Pancreatic Neoplasms - immunology | Colorectal Neoplasms - ultrastructure | Lung Neoplasms - ultrastructure | Neoplasm Proteins - analysis | Receptors, Cytokine - immunology | Cell Membrane - immunology | Genes, MHC Class I | Hyaluronan Receptors - immunology | Apoptosis | Growth factors | Messenger RNA | Tumors
Journal Article
Blood, ISSN 0006-4971, 2013, Volume 122, Issue 20, pp. 3461 - 3472
Genetically targeted T cells promise to solve the feasibility and efficacy hurdles of adoptive T-cell therapy for cancer. Selecting a target expressed in... 
STEM-CELLS | ADVERSE EVENT | CLINICAL-TRIAL | GRAFT-VERSUS-LEUKEMIA | CHIMERIC-ANTIGEN-RECEPTOR | BONE-MARROW | GENE-THERAPY | HEMATOLOGY | PHASE-I | ADOPTIVE IMMUNOTHERAPY | DONOR LYMPHOCYTES | Graft vs Host Disease - therapy | Recombinant Fusion Proteins - immunology | T-Lymphocyte Subsets - immunology | Neoplasm Transplantation | Humans | Interleukin-7 - pharmacology | Multiple Myeloma - immunology | Cell Line, Tumor - transplantation | Leukemia, Myeloid, Acute - immunology | Molecular Targeted Therapy | Interleukin-15 - immunology | Multiple Myeloma - therapy | Leukemia, Myelomonocytic, Acute - therapy | Leukemia, Myeloid, Acute - therapy | Protein Structure, Tertiary | Antigens, Neoplasm - genetics | Genes, Transgenic, Suicide | Immunotherapy, Adoptive | Antigens, Neoplasm - immunology | Leukemia, Myeloid, Acute - pathology | Lymphocyte Activation | RNA, Small Interfering - pharmacology | CD28 Antigens - immunology | Hyaluronan Receptors - genetics | Xenograft Model Antitumor Assays | Interleukin-15 - pharmacology | Multiple Myeloma - pathology | Animals | Interleukin-7 - immunology | Leukemia, Myelomonocytic, Acute - pathology | Cell Line, Tumor - immunology | CD3 Complex - immunology | Leukemia, Myelomonocytic, Acute - immunology | T-Cell Antigen Receptor Specificity | Hyaluronan Receptors - immunology | Mice | Cytotoxicity, Immunologic | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3718 - 3730
A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance, such as cytotoxic T lymphocyte-associated protein 4... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | CTLA-4 BLOCKADE | LYMPHOCYTE ANTIGEN-4 | PHOSPHATIDYLINOSITOL 3-KINASE | IN-VIVO | COMBINATION IMMUNOTHERAPY | TUMOR-CELLS | NKG2D RECEPTOR | IMMUNOLOGICAL SYNAPSE | STOP-SIGNAL | Mammary Neoplasms, Experimental - immunology | Nucleocytoplasmic Transport Proteins - biosynthesis | NK Cell Lectin-Like Receptor Subfamily K - immunology | Antibodies, Monoclonal - therapeutic use | Cell Line, Tumor - transplantation | CD8-Positive T-Lymphocytes - radiation effects | Immunotherapy | Intercellular Adhesion Molecule-1 - biosynthesis | Female | Mammary Neoplasms, Experimental - secondary | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Cytotoxicity, Immunologic - drug effects | Neoplasm Proteins - biosynthesis | Receptors, CXCR - genetics | Antibodies, Monoclonal - pharmacology | Mammary Neoplasms, Experimental - radiotherapy | Combined Modality Therapy | Lymphocytes, Tumor-Infiltrating - drug effects | Nucleocytoplasmic Transport Proteins - genetics | Mammary Neoplasms, Experimental - therapy | Tumor Microenvironment - immunology | H-2 Antigens - immunology | Animals | NK Cell Lectin-Like Receptor Subfamily K - antagonists & inhibitors | Nuclear Matrix-Associated Proteins - genetics | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor - immunology | Intercellular Adhesion Molecule-1 - genetics | Gene Expression Regulation, Neoplastic - radiation effects | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Nuclear Matrix-Associated Proteins - biosynthesis | Cytotoxicity, Immunologic - radiation effects | Lymphocytes, Tumor-Infiltrating - radiation effects | Cell Movement | Drug Screening Assays, Antitumor | Lymphocytes, Tumor-Infiltrating - immunology | Receptors, CXCR6 | Care and treatment | Tumor-infiltrating lymphocytes | Physiological aspects | Research | T cells | Health aspects | Cancer
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5134 - 5143
Antibody-dependent cell cytotoxicity (ADCC) plays a critical role in monoclonal antibody (mAb)-mediated cancer therapy. ADCC, however, has not been directly... 
B-CELL | ONCOLOGY | CYCLOPHOSPHAMIDE | METASTATIC BREAST-CANCER | IN-VIVO | LYMPHOMA | MONOCLONAL-ANTIBODY | ANTITUMOR-ACTIVITY | C-RECEPTOR POLYMORPHISMS | T-CELLS | ANTIGEN | Mammary Neoplasms, Experimental - immunology | Antibody Specificity | Antibodies, Neoplasm - therapeutic use | Breast Neoplasms - immunology | Humans | Ovarian Neoplasms - pathology | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents, Alkylating - pharmacology | Antigens, Tumor-Associated, Carbohydrate - immunology | Cystadenocarcinoma, Serous - pathology | Cyclophosphamide - therapeutic use | Antibodies, Monoclonal, Humanized | Female | Cystadenocarcinoma, Serous - immunology | Macrophages - immunology | Mammary Neoplasms, Experimental - drug therapy | Immunological Synapses - ultrastructure | Antibody-Dependent Cell Cytotoxicity | Antibodies, Monoclonal - pharmacology | Neutrophils - immunology | Combined Modality Therapy | Receptors, IgG - immunology | Mammary Neoplasms, Experimental - therapy | Antineoplastic Agents, Alkylating - therapeutic use | Tumor Microenvironment - immunology | Animals | Breast Neoplasms - pathology | Cell Line, Tumor - immunology | Cyclophosphamide - pharmacology | Immunological Synapses - immunology | Immunization, Passive | Mice | Mice, Inbred BALB C | Trastuzumab | Ovarian Neoplasms - immunology | Index Medicus | Tumor Microenvironment | Macrophages | Breast Neoplasms | Life Sciences | Antigens, Tumor-Associated, Carbohydrate | Cystadenocarcinoma, Serous | Ovarian Neoplasms | Antibodies, Neoplasm | Antineoplastic Agents, Alkylating | Biochemistry, Molecular Biology | Neutrophils | Antibodies, Monoclonal | Immunological Synapses | Receptors, IgG | Cyclophosphamide | Mammary Neoplasms, Experimental | Cell Line, Tumor | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 11/2011, Volume 71, Issue 21, pp. 6621 - 6632
Breast cancer is the leading cause of death for women between the ages of 35 to 65. This is mostly due to intertumor heterogeneity and the lack of specific... 
NATURAL-KILLER-CELLS | ONCOLOGY | IN-VIVO | HLA-C | RECEPTOR | ACUTE MYELOID-LEUKEMIA | ANTITUMOR-ACTIVITY | CANCER | CYTOTOXICITY | NKG2D LIGAND EXPRESSION | LINES | Carcinoma, Ductal, Breast - genetics | Mammary Neoplasms, Experimental - immunology | Tumor Escape | Breast Neoplasms - immunology | Estrogens | Humans | Carcinoma, Ductal, Breast - immunology | NK Cell Lectin-Like Receptor Subfamily K - immunology | Gene Expression Profiling | Neoplasms, Hormone-Dependent - immunology | Mammary Neoplasms, Experimental - genetics | Neoplasms, Hormone-Dependent - genetics | Carcinoma, Ductal, Breast - classification | RNA, Messenger - biosynthesis | Killer Cells, Natural - immunology | Carcinoma, Ductal, Breast - pathology | Female | Receptors, Immunologic - immunology | Neoplasm Proteins - genetics | Cell Line, Tumor - metabolism | Breast Neoplasms - classification | Antigens, Differentiation, T-Lymphocyte - immunology | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | Self Tolerance | Killer Cells, Natural - classification | Animals | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Breast Neoplasms - pathology | Neoplasms, Hormone-Dependent - pathology | Cell Line, Tumor - immunology | RNA, Neoplasm - genetics | Ligands | Mice | Progesterone | Cytotoxicity, Immunologic | Life Sciences | Immunology | Immunotherapy | Cancer
Journal Article
Neoplasia, ISSN 1476-5586, 03/2006, Volume 8, Issue 3, pp. 190 - 198
B7-H1 molecule increases the apoptosis of tumorreactive T lymphocytes and reduces their immunogenicity. Breast cancer is the second most common cause of... 
tumor-infiltrating lymphocytes | Breast cancer | B7-H1 | prognostic factors | PD-1-1 | PD-L1 | Tumor-infiltrating lymphocytes | Prognostic factors | ACTIVATION | DENDRITIC CELLS | breast cancer | TUMOR-CELLS | POTENTIAL MECHANISM | ESCAPE | IMMUNE EVASION | ONCOLOGY | IMMUNOTHERAPY | tumor infiltrating lymphocytes | B7 FAMILY | BLOCKADE | SAUDI-ARABIA | Breast Neoplasms - surgery | Carcinoma, Ductal, Breast - epidemiology | Epithelial Cells - metabolism | Prognosis | Breast Neoplasms - immunology | Estrogens | Humans | Middle Aged | Carcinoma, Ductal, Breast - immunology | Receptors, Estrogen - analysis | Neoplasms, Hormone-Dependent - immunology | Carcinoma, Ductal, Breast - chemistry | Antigens, CD - analysis | Receptors, Progesterone - analysis | Breast Neoplasms - chemistry | Carcinoma, Ductal, Breast - drug therapy | Cell Line, Tumor - pathology | Mastectomy | Neoplasms, Hormone-Dependent - chemistry | Adult | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Neoadjuvant Therapy | Saudi Arabia - epidemiology | Breast Neoplasms - epidemiology | Tumor Escape - immunology | Neoplasms, Hormone-Dependent - surgery | Carcinoma, Ductal, Breast - surgery | B7-H1 Antigen | Risk Factors | Combined Modality Therapy | Lymphatic Metastasis | Tumor Burden | Breast Neoplasms - drug therapy | Cell Line, Tumor - chemistry | Neoplasms, Hormone-Dependent - pathology | Cell Line, Tumor - immunology | Neoplasm Proteins - analysis | Aged | Neoplasms, Hormone-Dependent - drug therapy | Progesterone
Journal Article
British Journal of Cancer, ISSN 0007-0920, 01/2010, Volume 102, Issue 1, pp. 115 - 123
Journal Article
12.