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Nature (London), ISSN 1476-4687, 2015, Volume 520, Issue 7547, pp. 368 - 372
Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2... 
CNS CELL-TYPES | MELANOMA | METASTASIS | MICROENVIRONMENT | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | RAF INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | KINASE INHIBITORS | DRUG-RESISTANCE | CANCER CHEMORESISTANCE | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Clone Cells - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-fos - deficiency | Adenocarcinoma - metabolism | Anaplastic Lymphoma Kinase | Neoplasm Metastasis - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Tumor Microenvironment - drug effects | Cell Survival - drug effects | ErbB Receptors - antagonists & inhibitors | Melanoma - pathology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Animals | Clone Cells - pathology | Metabolome - drug effects | Signal Transduction - drug effects | Neoplasm Metastasis - pathology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Pharmaceutical research | Care and treatment | Oncology, Experimental | Dosage and administration | Research | Drug therapy | Drug resistance | Antineoplastic agents | Tumors | Cancer | Melanoma | Mutation | Metastasis | Kinases | Cancer therapies
Journal Article
The Plant cell, ISSN 1532-298X, 2015, Volume 27, Issue 11, pp. 3228 - 3244
Abscisic acid (ABA) is a phytohormone that plays a fundamental role in plant development and stress response, especially in the regulation of stomatal closure... 
Leaves | Phosphorylation | RESEARCH ARTICLES | Ubiquitins | Guard cells | Gene expression regulation | Plants | Drought | Transgenic plants | Plant cells | Seedlings | BIOCHEMISTRY & MOLECULAR BIOLOGY | POSITIVE REGULATOR | SNRK2 PROTEIN-KINASES | PLANT SCIENCES | CELL BIOLOGY | SIGNAL-TRANSDUCTION | STRESS RESPONSES | HYDROGEN-PEROXIDE | GUARD-CELLS | RESPONSIVE GENE-EXPRESSION | ABSCISIC-ACID | TRANSCRIPTION FACTOR | KINASE-PHOSPHATASE PAIR | Protein Kinases - metabolism | Arabidopsis - physiology | Arabidopsis - enzymology | Reactive Oxygen Species - metabolism | Adaptation, Physiological - drug effects | Gene Expression Profiling | Protein Transport - drug effects | Phylogeny | Arabidopsis Proteins - metabolism | Ubiquitination - drug effects | Adaptation, Physiological - genetics | Droughts | Plants, Genetically Modified | Protein Binding - drug effects | Plant Stomata - drug effects | Lysine - metabolism | Stress, Physiological - drug effects | Phosphorylation - drug effects | Polyubiquitin - metabolism | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Stress, Physiological - genetics | Ubiquitin-Protein Ligases - metabolism | Arabidopsis - genetics | Abscisic Acid - pharmacology | Gene Expression Regulation, Plant - drug effects | Phenotype | Models, Biological | Ubiquitin-Protein Ligases - genetics | Plant Stomata - physiology | Arabidopsis thaliana | Ubiquitin | Botanical research | Hardiness | Physiological aspects | Stomata | Physiological research | Research
Journal Article
Journal Article
Plant physiology (Bethesda), ISSN 0032-0889, 7/2012, Volume 159, Issue 3, pp. 984 - 1000
.... Examining the movement of the silencing front revealed a largely unrecognized zone of tissue, below the apical meristem, that is resistant to the silencing signal and that may provide a gating... 
Leaves | Hypocotyls | Phloem | Rootstocks | Plant roots | Graftage | Small interfering RNA | CELL BIOLOGY AND SIGNAL TRANSDUCTION | Plants | Scions | Plant cells | AUXIN TRANSPORT | GREEN FLUORESCENT PROTEIN | INTERCELLULAR MOVEMENT | SYSTEMIC SPREAD | MACROMOLECULAR TRAFFICKING | POTATO-VIRUS-X | PHLOEM TRANSPORT | ACTIN-FILAMENTS | INTEGRATIVE PLANT BIOLOGY | RNA-POLYMERASE | PLANT SCIENCES | Gene Silencing - drug effects | Plant Vascular Bundle - drug effects | Arabidopsis - growth & development | Plant Roots - genetics | Templates, Genetic | RNA, Messenger - metabolism | Plant Roots - drug effects | Dexamethasone - pharmacology | Time Factors | Phloem - drug effects | Phloem - metabolism | Plant Shoots - drug effects | Meristem - metabolism | Plant Vascular Bundle - genetics | Biological Transport - drug effects | Hypocotyl - metabolism | Meristem - drug effects | Plant Shoots - genetics | Germination - drug effects | Green Fluorescent Proteins - metabolism | Arabidopsis - drug effects | Indoleacetic Acids - metabolism | Arabidopsis - cytology | RNA, Messenger - genetics | Hypocotyl - growth & development | Phloem - cytology | Nucleotides - metabolism | Plant Shoots - cytology | Arabidopsis - genetics | Gene Expression Regulation, Plant - drug effects | Phenotype | Models, Biological | Plant Roots - chemistry | Plant Vascular Bundle - cytology | Cytoskeleton - metabolism | Hypocotyl - drug effects | Plant Growth Regulators - pharmacology | Cytoskeleton - drug effects | RNA, Small Interfering - metabolism | Gene silencing | Arabidopsis | Plant genetics | Vascular system of plants | Physiological aspects | Genetic aspects | Research
Journal Article
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2002, Volume 110, Issue 4, pp. 429 - 441
The adult brain is extremely vulnerable to various insults. The recent discovery of neural progenitors in adult mammals, however, raises the possibility of... 
RAT SPINAL-CORD | GERBIL HIPPOCAMPUS | STEM-CELLS | TRANSIENT FOREBRAIN ISCHEMIA | NEUROTROPHIC FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | FIBROBLAST-GROWTH-FACTOR | CENTRAL-NERVOUS-SYSTEM | ADULT MAMMALIAN BRAIN | SUBVENTRICULAR ZONE | SYNAPTIC PLASTICITY | CELL BIOLOGY | Neural Pathways - drug effects | Recovery of Function - drug effects | Nerve Regeneration - physiology | Neuronal Plasticity - drug effects | Male | Dendrites - ultrastructure | Nerve Degeneration - metabolism | Neuronal Plasticity - physiology | Recovery of Function - physiology | Hippocampus - ultrastructure | Pyramidal Cells - drug effects | Organ Culture Techniques | Dendrites - drug effects | Synapses - drug effects | Neural Pathways - growth & development | Rats | Synapses - ultrastructure | Brain Ischemia - physiopathology | Cell Division - drug effects | Stem Cells - ultrastructure | Cell Division - physiology | Cell Movement - drug effects | Brain Ischemia - drug therapy | Nerve Regeneration - drug effects | Growth Substances - pharmacology | Pyramidal Cells - metabolism | Rats, Wistar | Microtubule-Associated Proteins - metabolism | Nerve Degeneration - physiopathology | Brain Ischemia - metabolism | Hippocampus - drug effects | Stem Cells - metabolism | Excitatory Postsynaptic Potentials - drug effects | Cell Movement - physiology | Excitatory Postsynaptic Potentials - physiology | Synapses - metabolism | Up-Regulation - physiology | Hippocampus - growth & development | Pyramidal Cells - ultrastructure | Dendrites - metabolism | Transcription Factors - genetics | Microscopy, Electron | Transcription Factors - metabolism | Up-Regulation - drug effects | Animals | Growth Substances - therapeutic use | Stem Cells - drug effects | Neural Pathways - ultrastructure | Nerve Degeneration - drug therapy | Neural circuitry | Neurons | Growth | Physiological aspects | Hippocampus (Brain) | Developmental neurology | Research
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2018, Volume 67, Issue 1, pp. 216 - 231
Sorafenib remains the only approved drug for treating patients with advanced hepatocellular carcinoma (HCC... 
CANCER-CELLS | OVEREXPRESSION | ACTIVATION | SIGNALING PATHWAY | TYRO3 | PATTERNS | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | RECEPTOR TYROSINE KINASE | INTERLEUKIN-8 | Niacinamide - analogs & derivatives | Humans | Cell Survival - genetics | MicroRNAs - metabolism | Cell Line, Tumor - drug effects | Cell Movement - genetics | Carcinoma, Hepatocellular - drug therapy | Cell Line, Tumor - pathology | Liver Neoplasms - pathology | Gene Expression Regulation, Neoplastic - drug effects | RNA, Small Interfering - drug effects | Real-Time Polymerase Chain Reaction | Molecular Targeted Therapy - methods | Cell Proliferation - genetics | Liver Neoplasms - drug therapy | Blotting, Western | Cell Movement - drug effects | Drug Resistance, Neoplasm - genetics | Analysis of Variance | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Carcinoma, Hepatocellular - pathology | MicroRNAs - drug effects | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism | Tyrosine | Cell proliferation | Invasiveness | Hepatocellular carcinoma | AKT protein | Drug resistance | Kinases | Axl protein | Signal transduction | Liver cancer | MicroRNAs | Protein-tyrosine kinase receptors | Tumor suppressor genes | miRNA | Transduction | Cell migration | Index Medicus
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 14, pp. 4333 - 4344
Journal Article
PLoS biology, ISSN 1545-7885, 2018, Volume 16, Issue 4, pp. e2002909 - e2002909
.... Whether the RMTg is involved in sleep-wake regulation is unknown. In the present study, pharmacogenetic activation of rat RMTg neurons promoted non-rapid eye movement (NREM... 
GABAERGIC TAIL | AREA | WAKING CYCLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | MIDBRAIN DOPAMINE NEURONS | LATERAL HABENULA | SLOW-WAVE SLEEP | FREELY MOVING CATS | MICE | RECEPTORS | WAKEFULNESS | Dorsal Raphe Nucleus - physiology | Ibotenic Acid - toxicity | Neural Pathways - drug effects | gamma-Aminobutyric Acid - metabolism | Locus Coeruleus - anatomy & histology | Locus Coeruleus - drug effects | Male | Receptors, Muscarinic - metabolism | Electroencephalography | Optogenetics | Ventral Tegmental Area - physiology | Channelrhodopsins - metabolism | Neural Pathways - physiology | Dopaminergic Neurons - cytology | Clozapine - pharmacology | Mesencephalon - anatomy & histology | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Mesencephalon - drug effects | Mesencephalon - physiology | Sleep - physiology | Ventral Tegmental Area - anatomy & histology | Dopamine - metabolism | Genes, Reporter | Receptors, Muscarinic - genetics | Ventral Tegmental Area - drug effects | Eye Movements - physiology | Rats | Locus Coeruleus - physiology | Electrodes, Implanted | Clozapine - analogs & derivatives | Channelrhodopsins - genetics | Rats, Sprague-Dawley | Pars Compacta - drug effects | Stereotaxic Techniques | Neural Pathways - anatomy & histology | Sleep Deprivation - physiopathology | Animals | Dorsal Raphe Nucleus - drug effects | Pars Compacta - physiology | Wakefulness - physiology | Luminescent Proteins - genetics | Dorsal Raphe Nucleus - anatomy & histology | Luminescent Proteins - metabolism | Pars Compacta - anatomy & histology | Eye | Physiological aspects | Sleep | Neural circuitry | Movements | Observations | Neurosciences | Mesencephalon | Authorship | Laboratories | Substantia nigra | Neurobiology | Tegmental nucleus | Sleep (REM) | Optics | Rapid eye movement state | Eye movements | Inactivation | Sleep deprivation | Neurotoxicity | Control | γ-Aminobutyric acid | Sleep (NREM) | Dorsal raphe nucleus | Rodents | Genetics | Raphe nuclei | Lesions | Sleep and wakefulness | Locus coeruleus | Dopamine receptors | Ventral tegmentum | Deprivation | Dopamine | Deactivation | Neurons | Pharmacology | Collaboration | Information processing | Diabetes | Index Medicus
Journal Article