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Nature Communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, pp. 11150 - 11150
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 368 - 372
Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2). Here we show that targeted therapy with... 
CNS CELL-TYPES | MELANOMA | METASTASIS | MICROENVIRONMENT | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | RAF INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | KINASE INHIBITORS | DRUG-RESISTANCE | CANCER CHEMORESISTANCE | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Clone Cells - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-fos - deficiency | Adenocarcinoma - metabolism | Neoplasm Metastasis - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Melanoma - pathology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Lung Neoplasms - secretion | Melanoma - secretion | Animals | Clone Cells - pathology | Metabolome - drug effects | Signal Transduction - drug effects | Neoplasm Metastasis - pathology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Adenocarcinoma - secretion | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Pharmaceutical research | Care and treatment | Oncology, Experimental | Dosage and administration | Research | Drug therapy | Drug resistance | Antineoplastic agents | Tumors | Cancer | Melanoma | Mutation | Metastasis | Kinases | Cancer therapies | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 14, pp. 4333 - 4344
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e80883 - e80883
Background: Kaempferol has been proposed as a potential drug for cancer chemoprevention and treatment because it is a natural polyphenol contained in... 
MIGRATION | INACTIVATION | INVASION | COLORECTAL-CANCER | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | TISSUE INHIBITOR | FLAVONOIDS | PROGNOSTIC-SIGNIFICANCE | NF-KAPPA-B | CARCINOMA | Transcription, Genetic - drug effects | Protein Binding - genetics | Nitriles - pharmacology | DNA, Neoplasm - metabolism | Humans | Cell Survival - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Transcription Factor AP-1 - metabolism | Cell Movement - genetics | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Protein Binding - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Mouth Neoplasms - enzymology | Cell Survival - drug effects | Butadienes - pharmacology | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | RNA, Messenger - genetics | Signal Transduction - genetics | Down-Regulation - drug effects | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Matrix Metalloproteinase Inhibitors - pharmacology | Signal Transduction - drug effects | Cell Line, Tumor | Mouth Neoplasms - pathology | Kaempferols - pharmacology | Prevention | Medical research | Care and treatment | Squamous cell carcinoma | RNA | Analysis | Medicine, Experimental | Metastasis | Cardiovascular diseases | Mouth cancer | Cancer | Biotechnology | Food plants | Transcription factors | Tongue | Phosphorylation | Transcription | Oral cancer | Laboratories | Gene regulation | Colorectal cancer | Otolaryngology | Biochemistry | Matrix metalloproteinase | Tissue inhibitor of metalloproteinase 2 | Cancer therapies | Metastases | Angiogenesis | Signal transduction | Cell cycle | Physiology | Metalloproteinase | Food | Kaempferol | Activator protein 1 | Melanoma | Extracellular signal-regulated kinase | c-Jun protein | Plant protection | Breast cancer | Gene expression | Gelatinase A | Studies | Signaling | Bone cancer | Chemotherapy | Flavonoids | Hospitals | Molecular modelling | Cell migration | Apoptosis | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 08/2013, Volume 122, Issue 7, pp. 1192 - 1202
Journal Article
Journal Article
The Journal of Experimental Medicine, ISSN 0022-1007, 04/2008, Volume 205, Issue 4, pp. 869 - 882
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 11, pp. 1270 - 1278
Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongly positive for CD31... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | CORTICAL BONE | OSTEOCLASTS | RESORPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | MESENCHYMAL STEM-CELLS | CELL BIOLOGY | BONE-FORMATION | CATHEPSIN-K | MICE | DIFFERENTIATION | Neovascularization, Physiologic - drug effects | Cell Count | Tartrate-Resistant Acid Phosphatase | Osteoclasts - secretion | Culture Media, Conditioned - pharmacology | Femur - diagnostic imaging | X-Ray Microtomography | Protease Inhibitors - pharmacology | Acid Phosphatase - metabolism | Mesenchymal Stromal Cells - cytology | Isoenzymes - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cathepsin K - antagonists & inhibitors | Mesenchymal Stromal Cells - drug effects | Ovariectomy | Endothelial Cells - metabolism | Femur - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Mice, Inbred C57BL | Osteogenesis - drug effects | Mesenchymal Stromal Cells - metabolism | Femur - drug effects | Cell Movement - drug effects | Animals | Cathepsin K - metabolism | Endothelial Cells - cytology | Proto-Oncogene Proteins c-sis - secretion | Osteoclasts - enzymology | Osteoclasts - drug effects | Endothelial Cells - drug effects | Platelet-derived growth factor | Growth | Analysis | Physiological aspects | Bones | Research | Osteoclasts (Biology) | Homeostasis | Angiogenesis | Cell growth | Blood platelets | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2008, Volume 30, Issue 6, pp. 1015 - 1025
Journal Article