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Journal Article
Science, ISSN 0036-8075, 12/2008, Volume 322, Issue 5907, pp. 1511 - 1516
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 10/2018, Volume 79, pp. 317 - 330
Various drugs have been designed in the past to act on intracellular targets. For the desired effects to be exerted, these drugs should reach and accumulate in... 
Polydopamine | Cancer nanotechnology | Autophagy | Mesoporous silica | Nucleolus-targeting | VITRO | MATERIALS SCIENCE, BIOMATERIALS | VIVO | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | RIBOSOMAL-RNA TRANSCRIPTION | CONTROLLED-RELEASE | MESOPOROUS SILICA NANOPARTICLES | APTAMER | PEPTIDE | POLYMERASE I | PATHWAY | Cell Survival - drug effects | Transcription, Genetic - drug effects | Tissue Distribution - drug effects | Nanoparticles - chemistry | Benzothiazoles - pharmacology | Endocytosis - drug effects | Humans | Nanoparticles - ultrastructure | Mice, SCID | Nanoparticles - toxicity | RNA, Ribosomal - genetics | Autophagy - drug effects | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Models, Biological | Cell Nucleolus - metabolism | Naphthyridines - therapeutic use | Cell Nucleolus - drug effects | Female | Benzothiazoles - therapeutic use | HeLa Cells | Oligodeoxyribonucleotides - pharmacology | Naphthyridines - pharmacology | Antimitotic agents | Care and treatment | RNA | Cell death | Physiological aspects | Antineoplastic agents | Health aspects | Polyols | Cervical cancer | Nanotechnology | Cancer | Drugs | Transcription | Toxicity | Xenotransplantation | Cytotoxicity | Cancer therapies | DNA-directed RNA polymerase | Silica | Accumulation | Silicon dioxide | Immunosuppressive agents | Nucleoli | Polyethylene glycol | Animal tissues | Xenografts | Biocompatibility | Inhibition | Chemical synthesis | Polyethylene | Dopamine | rRNA | Mortality | Organs | Histology | Cervix | Ribonucleic acid--RNA | Organelles | Polymerase | Grafts | Silicas | Aptamers | Phagocytosis | Tumors
Journal Article
Oncogene, ISSN 0950-9232, 01/2016, Volume 35, Issue 4, pp. 415 - 426
The ubiquitin-like molecule NEDD8 is essential for viability, growth and development, and is a potential target for therapeutic intervention. We found that the... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | TRANSCRIPTION | CANCER-SPECIFIC ACTIVATION | ACTINOMYCIN | CELL BIOLOGY | REPLICATION | DISRUPTION | ONCOLOGY | GENETICS & HEREDITY | MDM2 | NEDD8-ACTIVATING ENZYME | RNA-POLYMERASE I | PROTEIN NEDDYLATION | Proto-Oncogene Proteins c-mdm2 - genetics | Ubiquitins - genetics | Humans | Ribosomes - metabolism | Ribosomal Proteins - metabolism | Cell Line - drug effects | Genes, p53 - drug effects | Mice, Mutant Strains | Cell Nucleolus - drug effects | Proto-Oncogene Proteins c-mdm2 - metabolism | Ubiquitins - metabolism | NEDD8 Protein | Caenorhabditis elegans Proteins | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - genetics | Ribosomal Proteins - genetics | Cyclopentanes - pharmacology | Pyrimidines - pharmacology | MCF-7 Cells - drug effects | Metabolic Networks and Pathways - genetics | Animals | Caenorhabditis elegans - cytology | Caenorhabditis elegans - drug effects | Ribosomes - genetics | Ribosomes - drug effects | Metabolic Networks and Pathways - drug effects | Ubiquitins - antagonists & inhibitors | Molecular targeted therapy | Ribosomal RNA | Innovations | Genetic transcription | Tumor proteins | Properties | Health aspects | Studies | Ribonucleic acid--RNA | Cancer therapies | Cancer | Index Medicus | Life Sciences | Cellular Biology | Biochemistry, Molecular Biology
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 09/2011, Volume 194, Issue 5, pp. 689 - 703
T he correlation between stress-induced nucleolar disruption and abrogation of p53 degradation is evident after a wide variety of cellular stresses. This link... 
HDM2 | RING-FINGER DOMAIN | INHIBITION | LEPTOMYCIN-B | MDM2 | NUCLEAR EXPORT | HDM2-MEDIATED DEGRADATION | RIBOSOMAL-PROTEIN L11 | U3 SNORNA | CELLULAR STRESS | CELL BIOLOGY | Active Transport, Cell Nucleus - physiology | Humans | Ubiquitin - metabolism | Intranuclear Space - metabolism | Cytoplasm - metabolism | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | Ribosomal Proteins - metabolism | Cell Fusion | Cell Nucleus - metabolism | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | DNA Damage - physiology | Cell Nucleus - radiation effects | Cell Nucleolus - metabolism | Cell Nucleolus - drug effects | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Ubiquitination - physiology | Proto-Oncogene Proteins c-mdm2 - metabolism | Photobleaching | Ribosomal Proteins - genetics | Demecolcine - pharmacology | Tumor Suppressor Protein p53 - metabolism | Fatty Acids, Unsaturated - pharmacology | Ubiquitin - genetics | Subcellular Fractions - metabolism | Cycloheximide - pharmacology | Leupeptins - pharmacology | Animals | Models, Biological | Active Transport, Cell Nucleus - drug effects | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Mice | Proteasome Endopeptidase Complex - metabolism | Cell Nucleus - drug effects | Nucleolus Organizer Region - drug effects | 3T3 Cells | DNA Damage - radiation effects | Physiological aspects | Tumor suppressor genes | Research | Cell nuclei | Cellular control mechanisms | Biochemistry | Cells | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7690, pp. 112 - 117
Many craniofacial disorders are caused by heterozygous mutations in general regulators of housekeeping cellular functions such as transcription or ribosome... 
PATHOGENESIS | CELLS | PROTEIN | ENDONUCLEASE | RNA HELICASE DDX21 | DNA | MULTIDISCIPLINARY SCIENCES | PREVENTION | TREACHER-COLLINS-SYNDROME | NEURAL CREST | P53 | Xenopus | Chromatin - metabolism | Cell Nucleolus - pathology | Embryonic Stem Cells - cytology | Mandibulofacial Dysostosis - embryology | Humans | Protein Transport - drug effects | DNA-Directed RNA Polymerases - deficiency | RNA, Ribosomal - genetics | RNA Polymerase I - antagonists & inhibitors | Mandibulofacial Dysostosis - genetics | Cell Nucleus - metabolism | Skull - pathology | Nuclear Proteins - deficiency | Cell Nucleolus - drug effects | Stress, Physiological - drug effects | Neural Crest - enzymology | Benzothiazoles - pharmacology | Phenotype | Zebrafish Proteins - deficiency | Ribosomes - genetics | Mice | DNA Damage | HeLa Cells | Embryonic Stem Cells - metabolism | RNA Helicases - metabolism | Mandibulofacial Dysostosis - pathology | Neural Crest - pathology | Ribosomal Proteins - biosynthesis | Ribosomes - metabolism | DNA, Ribosomal - metabolism | Phosphoproteins - metabolism | Zebrafish - embryology | Cell Nucleus - pathology | Cell Nucleolus - metabolism | DEAD-box RNA Helicases - deficiency | DEAD-box RNA Helicases - metabolism | Nuclear Proteins - genetics | DNA, Ribosomal - genetics | Cell Nucleolus - genetics | Ribosomal Proteins - genetics | Tumor Suppressor Protein p53 - metabolism | RNA, Ribosomal - metabolism | Nuclear Proteins - metabolism | Phosphoproteins - genetics | Organ Specificity | DEAD-box RNA Helicases - genetics | Animals | Phosphoproteins - deficiency | RNA, Ribosomal - biosynthesis | Cell Nucleus - drug effects | Naphthyridines - pharmacology | Apoptosis | Nucleolus organizer region | Genetic aspects | Gene mutations | Observations | Neural crest | Craniofacial dysostosis | Chromatin | Transcription | Genomics | p53 Protein | Genes | DNA damage | Ribosomal DNA | Disorders | Homeostasis | Biosynthesis | Genomes | DNA-directed RNA polymerase | Proteins | DNA helicase | Nucleoli | Embryogenesis | Cell activation | RNA processing | Chemical synthesis | Deoxyribonucleic acid--DNA | Anemia | rRNA | RNA polymerase | Embryonic growth stage | Polymerase | DNA biosynthesis | Craniofacial growth | Ribonucleic acids | Stem cells | Mutation | Developmental disabilities | Tumors | RNA helicase | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 16, pp. 12416 - 12425
Journal Article
Blood, ISSN 0006-4971, 03/2011, Volume 117, Issue 9, pp. 2567 - 2576
Journal Article
Cancer Research, ISSN 0008-5472, 10/2009, Volume 69, Issue 19, pp. 7653 - 7661
Journal Article
Journal Article