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Cell stem cell, ISSN 1934-5909, 2012, Volume 11, Issue 3, pp. 401 - 414
... the repopulating capacity of the epithelial stem cell compartment. This is frequently the case in cancer patients receiving radiation or chemotherapy, many of whom develop mucositis, a debilitating condition involving painful and deep mucosal ulcerations... 
MAMMALIAN TARGET | CANCER PATIENTS | RAPAMYCIN | HEAD | AGING PHENOTYPES | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RESPONSE | TUMOR | NECK | SKIN | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cell Death - radiation effects | TOR Serine-Threonine Kinases - metabolism | Keratinocytes - radiation effects | Carcinoma, Squamous Cell - pathology | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Cell Compartmentation - radiation effects | Mucositis - prevention & control | Mouth Mucosa - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Mouth Mucosa - radiation effects | Mucositis - pathology | Stem Cells - enzymology | Mucositis - enzymology | Cellular Senescence - radiation effects | Cytoprotection - drug effects | Clone Cells | Oxidative Stress - radiation effects | Cell Death - drug effects | Head and Neck Neoplasms - enzymology | Mouth Mucosa - pathology | Keratinocytes - enzymology | Superoxide Dismutase - metabolism | Radiation, Ionizing | Carcinoma, Squamous Cell - enzymology | Epithelial Cells - radiation effects | Cells, Cultured | Stem Cells - radiation effects | Epithelial Cells - pathology | Radiation Injuries - enzymology | Sirolimus - pharmacology | Head and Neck Neoplasms - pathology | Keratinocytes - pathology | Animals | Keratinocytes - drug effects | Radiation Injuries - prevention & control | Epithelial Cells - enzymology | Cell Compartmentation - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Radiation Injuries - pathology | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Cytoprotection - radiation effects | Cell Proliferation - radiation effects
Journal Article
Cell death and differentiation, ISSN 1476-5403, 2017, Volume 24, Issue 11, pp. 1853 - 1860
Ionizing radiation (IR) is one of the most widely used treatments for cancer. However, acute damage to the gastrointestinal tract or gastrointestinal acute radiation syndrome (GI-ARS... 
GASTROINTESTINAL-SYNDROME | STRAND BREAK REPAIR | P53-DEFICIENT MICE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | MITOTIC CATASTROPHE | DEPENDENT PROTEIN-KINASE | SMALL-INTESTINE | CHECKPOINT ACTIVATION | IONIZING-RADIATION | REPLICATION STRESS | CELL BIOLOGY | Stem Cell Niche - radiation effects | Receptors, G-Protein-Coupled - metabolism | Apoptosis - radiation effects | Mitosis | Gastrointestinal Tract - radiation effects | Stem Cells - metabolism | Gastrointestinal Tract - pathology | DNA-Binding Proteins - metabolism | Radiation Tolerance - radiation effects | Acute Radiation Syndrome - pathology | DNA-Activated Protein Kinase - metabolism | Acute Radiation Syndrome - metabolism | Inhibitor of Apoptosis Proteins - metabolism | Repressor Proteins - metabolism | Radiation, Ionizing | Paneth Cells - metabolism | Mice, Inbred C57BL | Stem Cells - radiation effects | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Survivin | Mitotic Index | Phenotype | Phosphorylation - radiation effects | Animals | Staining and Labeling | Stem Cells - pathology | DNA Damage | Histones - metabolism | Cell Proliferation - radiation effects | Cell proliferation | Animal models | Radiosensitivity | Epithelial cells | p53 Protein | DNA damage | DNA repair | Ionizing radiation | Intestine | Rodents | Cell cycle | Repair | Deoxyribonucleic acid--DNA | I.R. radiation | Gastrointestinal tract | Paneth cells | DNA-dependent protein kinase | Cell death | Stem cells | Tumor suppressor genes | Sensitivity enhancement | Mutation | Radiation damage | Tumors | Apoptosis | Cancer | Original Paper
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 8, p. e104016
.... In this study, the biological effects of low-dose radiation on stimulating osteoblast proliferation, differentiation and fracture healing were identified using in vitro cell culture and in vivo animal studies. First, low-dose (0.5 Gy... 
CELL NUCLEAR ANTIGEN | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | MINERALIZATION | MC3T3-E1 CELLS | MICE | BONE | IONIZING-RADIATION | EXPRESSION | EXPOSURE | STRAND BREAKS | Bone Regeneration - physiology | Alkaline Phosphatase - metabolism | Osteocalcin - genetics | Male | Femoral Fractures - pathology | Core Binding Factor Alpha 1 Subunit - metabolism | Femoral Fractures - radiotherapy | Collagen Type I - genetics | Proliferating Cell Nuclear Antigen - genetics | Femoral Fractures - genetics | Fracture Healing - physiology | Osteoblasts - cytology | Biomarkers - metabolism | Cell Differentiation - radiation effects | Femur - injuries | Cell Line | Gene Expression | Alkaline Phosphatase - genetics | Collagen Type I - metabolism | Osteoblasts - radiation effects | Femur - metabolism | Osteocalcin - metabolism | Osteoblasts - physiology | Rats | Transcription Factors - genetics | Cell Survival - radiation effects | Rats, Sprague-Dawley | Femur - radiation effects | Femoral Fractures - metabolism | Transcription Factors - metabolism | Bone Regeneration - radiation effects | Animals | X-Rays | Mice | Proliferating Cell Nuclear Antigen - metabolism | Dose-Response Relationship, Radiation | Core Binding Factor Alpha 1 Subunit - genetics | Fracture Healing - radiation effects | Cell Proliferation - radiation effects | Cell proliferation | Cell culture | Alkaline phosphatase | Collagen (type I) | Femur | Callus | Genes | Radiation | Irradiated | Osteoblasts | X ray irradiation | Ossification | Cartilage | Biological effects | Biomedical materials | Mineralization | Proliferating cell nuclear antigen | Cell cycle | Bone marrow | Extracellular matrix | Biocompatibility | Deoxyribonucleic acid--DNA | Food irradiation | Cbfa-1 protein | Osteocalcin | Bone remodelling | Histology | Bone healing | Gene expression | Radiation dosage | Studies | Fractures | Osteoblastogenesis | X rays | Orthopedics | Stem cells | Irradiation | Healing | In vivo methods and tests | Laboratory animals | Differentiation | Cancer | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2013, Volume 68, Issue 1, pp. S10 - S19
.... Although UV exposure does exert certain beneficial effects on the skin, excessive exposure to UV radiation induces multiple cascades of molecular signaling events at the cellular level that produce... 
Dermatology | apoptosis | immunosuppression | keratinocyte carcinogenesis | actinic keratosis | p53 | EXPOSED HUMAN SKIN | MIGRATION INHIBITORY FACTOR | KINASE-C-DELTA | DERMATOLOGY | SIGNAL-TRANSDUCTION | GROWTH-FACTOR RECEPTOR | NONMELANOMA SKIN-CANCER | GENE NUMERICAL ABERRATIONS | IMMUNE SUPPRESSION | PLATELET-ACTIVATING-FACTOR | SQUAMOUS-CELL CARCINOMAS | Keratosis, Actinic - etiology | Apoptosis - drug effects | Keratinocytes - radiation effects | Humans | Platelet Activating Factor - physiology | Urocanic Acid - metabolism | fas Receptor - metabolism | DNA - radiation effects | Tumor Suppressor Protein p53 - genetics | T-Lymphocytes, Regulatory - immunology | Tumor Suppressor Protein p53 - physiology | Sunlight - adverse effects | Signal Transduction - radiation effects | Skin - pathology | Skin Neoplasms - pathology | Immune Tolerance - radiation effects | Ultraviolet Rays - adverse effects | Carcinoma, Squamous Cell - etiology | Keratinocytes - pathology | Skin - radiation effects | Skin Neoplasms - etiology | Cell Transformation, Neoplastic - pathology | Keratosis, Actinic - pathology | Cell Proliferation - radiation effects | Inflammation - physiopathology | Actinic keratosis | Squamous cell carcinoma | Skin | Nuclear radiation | Health aspects | Immunotherapy | Index Medicus
Journal Article
by Wu, SL and Li, YJ and Liao, K and Shi, L and Zhang, N and Liu, S and Hu, YY and Li, SL and Wang, Y
ONCOLOGY REPORTS, ISSN 1021-335X, 02/2017, Volume 37, Issue 2, pp. 793 - 802
Accumulating evidence indicates that cancer stem cells (CSCs) are a source of resistance to radiation therapy (RT... 
HYPOXIA-INDUCIBLE FACTOR | nasopharyngeal carcinoma | ANGIOGENESIS | MICROTUBULES | radiosensitivity | KAPPA-B | MODEL | NF-kappa B p65 | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | THERAPY | ONCOLOGY | 2-methoxyestradiol | PROSTATE-CANCER CELLS | cancer stem cells | RADIOTHERAPY | Estradiol - analogs & derivatives | Nasopharyngeal Neoplasms - metabolism | Epithelial-Mesenchymal Transition - radiation effects | Apoptosis - drug effects | Apoptosis - radiation effects | Neoplastic Stem Cells - drug effects | Tubulin Modulators - pharmacology | Humans | Epithelial-Mesenchymal Transition - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | NF-kappa B - metabolism | Nasopharyngeal Neoplasms - pathology | Nasopharyngeal Neoplasms - radiotherapy | Flow Cytometry | Neoplastic Stem Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Nasopharyngeal Neoplasms - drug therapy | Signal Transduction - radiation effects | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Estradiol - pharmacology | Neoplastic Stem Cells - radiation effects | Cell Differentiation - radiation effects | NF-kappa B - antagonists & inhibitors | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Down-Regulation | RNA, Messenger - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Cell Movement - radiation effects | Radiation Tolerance - drug effects | Cell Movement - drug effects | NF-kappa B - genetics | Signal Transduction - drug effects | Cell Differentiation - drug effects | Fluorescent Antibody Technique | Cell Proliferation - drug effects | Cell Proliferation - radiation effects
Journal Article
Biomaterials, ISSN 0142-9612, 2009, Volume 30, Issue 6, pp. 1015 - 1025
Journal Article
by Yu, Z and Chen, T and Hebert, J and Li, E and Richard, S
Molecular and cellular biology, ISSN 0270-7306, 2009, Volume 29, Issue 11, pp. 2982 - 2996
Journal Article
Nature medicine, ISSN 1546-170X, 2018, Volume 24, Issue 2, pp. 239 - 246
...) pool and regenerate hematopoiesis after radiation injury from either cancer therapy or accidental exposure(1,2... 
PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | HOMEOSTASIS | ACTIVATION | DEFECTS | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUIESCENCE | SELF-RENEWAL | MICE | CELL BIOLOGY | Whole-Body Irradiation | Cell Self Renewal - radiation effects | Humans | Luteinizing Hormone - metabolism | Regeneration - radiation effects | Cell Self Renewal - drug effects | Hematopoiesis - drug effects | Cell Self Renewal - genetics | Hematopoiesis - radiation effects | Receptors, LH - genetics | Radiation Injuries, Experimental - drug therapy | Regeneration - genetics | Luteinizing Hormone - pharmacology | Signal Transduction - radiation effects | Hematopoietic Stem Cells - radiation effects | Radiation Injuries, Experimental - metabolism | Cell Differentiation - radiation effects | Hematopoietic Stem Cells - drug effects | Cell Proliferation - genetics | Cell Cycle - radiation effects | Hematopoiesis - genetics | Gonadotropin-Releasing Hormone - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Radiation Injuries, Experimental - pathology | Regeneration - drug effects | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mice | Cell Cycle - drug effects | Cell Proliferation - radiation effects | Care and treatment | Physiological aspects | Luteinizing hormone | Bone marrow | Genetic aspects | Research | Hematopoietic stem cells | Diseases | Lymphopoiesis | Radiation | Sex | Dimorphism | Hormones | Recovery | Lethal dose | Hematopoiesis | Rodents | Cell cycle | Radiation injuries | Inhibition | Sexual dimorphism | Hematology | Ablation | Radiation dosage | Hemopoiesis | Sex hormones | Regeneration | Exhaustion | Stem cells | Irradiation | Luteinizing hormone-releasing hormone | Steroid hormones | Steroids | Cancer
Journal Article