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Journal of Neuroscience, ISSN 0270-6474, 05/2010, Volume 30, Issue 20, pp. 6838 - 6851
alpha-Synuclein is central in Parkinson's disease pathogenesis. Although initially alpha-synuclein was considered a purely intracellular protein, recent data... 
FIBRIL FORMATION | PROTEIN | MULTIVESICULAR BODIES | HUMAN PLASMA | ACTIVATES MICROGLIA | CONGO RED | ENDOPLASMIC-RETICULUM | FAMILIAL PARKINSONS-DISEASE | RELEASE | BODY FORMATION | NEUROSCIENCES | Molecular Weight | Serum - metabolism | Calcium - metabolism | Microscopy, Electron, Transmission - methods | Humans | Culture Media, Conditioned - chemistry | Cell Survival - genetics | Brefeldin A - pharmacology | Neurons - ultrastructure | Piperidines - pharmacology | Neurons - metabolism | alpha-Synuclein - genetics | Protein Synthesis Inhibitors - pharmacology | Exosomes - ultrastructure | Cell Survival - drug effects | Calcium - pharmacology | Immunoprecipitation - methods | Multivesicular Bodies - pathology | Endocytosis - drug effects | Rats | Microscopy, Confocal - methods | Analysis of Variance | Cell Line, Tumor | beta-Galactosidase - genetics | Multivesicular Bodies - drug effects | Temperature | Chromatography, High Pressure Liquid - methods | Culture Media, Conditioned - pharmacology | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Subcellular Fractions - ultrastructure | Transfection | Exosomes - physiology | beta-Galactosidase - metabolism | Presenilin-1 - pharmacology | Cell Death - drug effects | Cytotoxicity Tests, Immunologic - methods | Gene Expression Regulation, Neoplastic - drug effects | Neurons - drug effects | Neuroblastoma - pathology | Pyrazoles - pharmacology | Subcellular Fractions - drug effects | Multivesicular Bodies - ultrastructure | Cells, Cultured | Hydrogen Peroxide - pharmacology | Receptors, Transferrin - metabolism | Subcellular Fractions - metabolism | Peptides - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Neuroblastoma - ultrastructure | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mass Spectrometry - methods | alpha-Synuclein - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 05/2012, Volume 8, Issue 5, pp. 812 - 825
Our study first proposed that curcumin could protect human endothelial cells from the damage caused by oxidative stress via autophagy. Furthermore, our results... 
autophagy | endothelial cell | FOXO1 | oxidative stress | curcumin | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Oxidative stress | Endothelial cell | Curcumin | Autophagy | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Protein Transport - drug effects | Autophagy - drug effects | Gene Knockdown Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Nucleus - metabolism | Forkhead Transcription Factors - metabolism | Protective Agents - pharmacology | Protein Binding - drug effects | Cytoprotection - drug effects | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Beclin-1 | Hydrogen Peroxide - toxicity | rab GTP-Binding Proteins - metabolism | Cell Survival - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Curcumin - pharmacology | Down-Regulation - drug effects | Ubiquitin-Activating Enzymes - metabolism | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Acetylation - drug effects | Autophagy-Related Protein 7 | Human Umbilical Vein Endothelial Cells - enzymology | Signal Transduction - drug effects | Models, Biological | Human Umbilical Vein Endothelial Cells - pathology | Forkhead Box Protein O1 | Oxidative Stress - drug effects | Cell Nucleus - drug effects | CELL BIOLOGY | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 03/2017, Volume 36, Issue 13, pp. 1770 - 1778
Journal Article
Neuron, ISSN 0896-6273, 2009, Volume 62, Issue 4, pp. 479 - 493
Understanding the physiopathology of affective disorders and their treatment relies on the availability of experimental models that accurately mimic aspects of... 
STEMCELL | HUMDISEASE | MOLNEURO | SEROTONIN-1A RECEPTOR FUNCTION | MESSENGER-RNA | BETA-ARRESTINS | PROTEIN-COUPLED RECEPTORS | ANTIDEPRESSANT TREATMENT | CELL-PROLIFERATION | ADULT MICE | MAJOR DEPRESSION | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | NEUROSCIENCES | Depression - pathology | Microtubule-Associated Proteins - metabolism | Radiation | Arrestins - genetics | GTP-Binding Protein alpha Subunit, Gi2 - metabolism | Male | Hippocampus - drug effects | Antidepressive Agents, Second-Generation - therapeutic use | RNA, Messenger - metabolism | Arrestins - metabolism | Hypothalamus - radiation effects | Corticosterone - toxicity | Depression - drug therapy | GTP-Binding Protein alpha Subunit, Gi2 - genetics | Anxiety - diet therapy | Depression - chemically induced | Reaction Time - drug effects | Exploratory Behavior - drug effects | Neurogenesis - radiation effects | Neurogenesis - drug effects | Bromodeoxyuridine - metabolism | Fluoxetine - therapeutic use | Hypothalamus - drug effects | Disease Models, Animal | Cell Survival - drug effects | Drug Administration Schedule | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Neuropeptides - metabolism | Hippocampus - pathology | Cell Survival - radiation effects | Anxiety - pathology | Feeding Behavior - drug effects | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Hypothalamus - metabolism | Analysis of Variance | beta-Arrestin 2 | beta-Arrestins | Hippocampus - radiation effects | Gene Expression Regulation - radiation effects | Anxiety - chemically induced | Cell Proliferation - drug effects | Mice | Arrestins - deficiency | Cell Proliferation - radiation effects | Neurosciences | Corticosterone | Neurons | Fluoxetine | Analysis | Depression, Mental | Models | Survival analysis | Genotype & phenotype | Brain research | Antidepressants | Anxieties | Rodents | Behavior | Feeds | Neurogenesis | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2013, Volume 16, Issue 5, pp. 543 - 551
Neurons require trophic support during neural circuit formation; however, how the cellular milieu contributes to neuronal survival remains unclear. We found... 
CORTICOSPINAL MOTOR-NEURONS | PURKINJE-CELLS | ACTIVATION | FRACTALKINE RECEPTOR | MACROPHAGES | IN-VIVO | GROWTH | PROJECTION NEURONS | NEUROSCIENCES | CEREBRAL-CORTEX | BRAIN | Diphtheria Toxin - pharmacology | Visual Cortex - growth & development | Apoptosis - drug effects | Embryo, Mammalian | Coculture Techniques | Humans | Cell Survival - genetics | Apoptosis - genetics | Insulin-Like Growth Factor I - genetics | Microglia - physiology | Neurons - physiology | Visual Cortex - embryology | Microfilament Proteins - metabolism | Neurons - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Calcium-Binding Proteins - metabolism | Cell Survival - drug effects | Microglia - drug effects | Visual Cortex - cytology | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Developmental - drug effects | Mice, Transgenic | Nerve Tissue Proteins - genetics | Receptors, Chemokine - deficiency | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Nerve Tissue Proteins - metabolism | Animals | Mice | Apoptosis - physiology | CD11b Antigen - metabolism | CX3C Chemokine Receptor 1 | Insulin-Like Growth Factor I - metabolism | Brain | Neurons | Growth | Neuroglia | Physiological aspects | Fetus | Health aspects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7344, pp. 466 - 470
Adult hippocampal neurogenesis is a unique form of neural circuit plasticity that results in the generation of new neurons in the dentate gyrus throughout... 
DEPRESSION | MODELS | MEMORY | MULTIDISCIPLINARY SCIENCES | NEURONS | DISORDER | DENTATE GYRUS | MATURATION | SYNAPTIC PLASTICITY | FLUOXETINE | BRAIN | Apoptosis - drug effects | Learning - drug effects | Neuronal Plasticity - drug effects | Male | Neural Stem Cells - cytology | Anxiety - therapy | Neuronal Plasticity - physiology | Long-Term Potentiation - drug effects | Exploratory Behavior - drug effects | Cognition - physiology | Long-Term Potentiation - physiology | Antidepressive Agents - pharmacology | bcl-2-Associated X Protein - deficiency | Extinction, Psychological - physiology | Cell Survival - drug effects | Synapses - drug effects | Conditioning, Classical - drug effects | Affect - physiology | bcl-2-Associated X Protein - metabolism | Anxiety - physiopathology | Mice, Transgenic | Hippocampus - pathology | Cognition - drug effects | Mice, Knockout | Dentate Gyrus - cytology | Aging - physiology | Dentate Gyrus - physiology | Mice | Dentate Gyrus - pathology | Hippocampus - physiopathology | Memory - physiology | Memory - drug effects | Aging - drug effects | Extinction, Psychological - drug effects | Fear - physiology | Dentate Gyrus - physiopathology | Exploratory Behavior - physiology | Synapses - metabolism | Fear - psychology | Female | Neurogenesis - drug effects | bcl-2-Associated X Protein - genetics | Neural Stem Cells - drug effects | Hippocampus - cytology | Physical Conditioning, Animal - physiology | Conditioning, Classical - physiology | Aging - pathology | Learning - physiology | Animals | Neurogenesis - physiology | Models, Neurological | Hippocampus - physiology | Neural Stem Cells - metabolism | Physiological aspects | Hippocampus (Brain) | Neurogenesis | Health aspects | Proteins | Studies | Young adults | Cognition & reasoning | Neurons | Anxieties | Rodents | Behavior | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2016, Volume 24, Issue 5, pp. 657 - 671
Journal Article