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Journal of the National Cancer Institute, ISSN 0027-8874, 04/2011, Volume 103, Issue 8, pp. 645 - 661
Background Ionizing radiation (IR) is effectively used in cancer therapy. However, in subsets of patients, a few radioresistant cancer cells survive and cause... 
STEM-CELLS | IN-VITRO | ONCOLOGY | TYROSINE KINASE | HGF | CELL INVASION | RECEPTOR | EPITHELIAL-MESENCHYMAL TRANSITIONS | NF-KAPPA-B | SCATTER-FACTOR | PROTOONCOGENE | Humans | Neoplasm Invasiveness - prevention & control | Radiation Tolerance | Receptors, Growth Factor - antagonists & inhibitors | NF-kappa B - metabolism | RNA, Messenger - metabolism | NF-kappa B - radiation effects | Receptors, Growth Factor - genetics | Proto-Oncogene Proteins c-met - radiation effects | Signal Transduction - radiation effects | Protein-Serine-Threonine Kinases - metabolism | Radiation, Ionizing | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - radiation effects | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Cell Cycle Proteins - radiation effects | Receptors, Growth Factor - radiation effects | Proto-Oncogene Proteins c-met - drug effects | Ataxia Telangiectasia Mutated Proteins | Phosphorylation - radiation effects | Cell Line, Tumor | Mice | RNA, Small Interfering | Tumor Suppressor Proteins - radiation effects | Receptors, Growth Factor - metabolism | Neoplasms - metabolism | Proto-Oncogene Proteins c-met - metabolism | Apoptosis - radiation effects | Up-Regulation - radiation effects | Transcription, Genetic - radiation effects | Transplantation, Heterologous | Sulfones - pharmacology | DNA-Binding Proteins - metabolism | Chromatin Immunoprecipitation | Protein-Serine-Threonine Kinases - radiation effects | Tumor Suppressor Proteins - genetics | Polymerase Chain Reaction | Cell Cycle Proteins - genetics | Indoles - pharmacology | Neoplasms - radiotherapy | Gene Expression Regulation, Neoplastic - drug effects | In Situ Nick-End Labeling | Enzyme-Linked Immunosorbent Assay | Radiation-Sensitizing Agents - pharmacology | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | DNA-Binding Proteins - genetics | Cell Survival - radiation effects | Cell Movement - radiation effects | Proto-Oncogene Proteins c-met - genetics | Blotting, Northern | Animals | NF-kappa B - genetics | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Receptors, Growth Factor - drug effects | DNA Damage - radiation effects | Mitogen-Activated Protein Kinases - metabolism | Ionizing radiation | Physiological aspects | Genetic aspects | Cancer invasiveness | Research | Gene expression | Radiotherapy | Health aspects | Oncology | Radiation therapy | Kinases | Index Medicus
Journal Article
STEM CELLS, ISSN 1066-5099, 02/2013, Volume 31, Issue 2, pp. 372 - 383
Hematopoietic stem and progenitor cells (HSPCs), which continuously maintain all mature blood cells, are regulated within the marrow microenvironment. We... 
Bone marrow | Irradiation | Prostaglandin E2 | Hematopoietic stem cells | Apoptosis | PROGENITOR CELLS | OSTEOBLASTIC MC3T3-E1 CELLS | WHOLE-BODY IRRADIATION | DUODENAL-ULCER | 16,16-DIMETHYL PROSTAGLANDIN-E2 | MACROPHAGES | BONE-MARROW | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CYCLOOXYGENASE-2 EXPRESSION | HEMATOLOGY | EXPOSURE | MEGAKARYOCYTE MATURATION | Whole-Body Irradiation | Gene Expression - drug effects | Apoptosis - drug effects | Apoptosis - radiation effects | Radiation Injuries, Experimental - immunology | Hematopoietic Stem Cells - pathology | Male | Actins - immunology | Actins - genetics | Cellular Microenvironment - radiation effects | Cyclooxygenase 2 - genetics | Radiation Injuries, Experimental - drug therapy | Radiation-Protective Agents - pharmacology | Bone Marrow Cells - drug effects | Macrophages - radiation effects | Cyclooxygenase 2 - immunology | Hematopoietic Stem Cells - radiation effects | Cell Differentiation - radiation effects | Hematopoietic Stem Cells - drug effects | Cell Survival - drug effects | Dinoprostone - pharmacology | Macrophages - pathology | Bone Marrow Cells - pathology | Mice, Transgenic | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Cell Survival - radiation effects | Gene Expression - radiation effects | Animals | Cell Differentiation - drug effects | Dinoprostone - analogs & derivatives | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Cellular Microenvironment - drug effects | Cell Proliferation - radiation effects | Medical colleges | Nuclear radiation | Analysis | Prostaglandins E | Information management | Macrophages | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0139271 - e0139271
Exposure to high-dose radiation results in detrimental effects on survival. The effects of combined trauma, such as radiation in combination with hemorrhage,... 
HYPOXIA-INDUCIBLE FACTOR | IRRADIATION | ERYTHROPOIETIN | ACTIVATION | COMBINED INJURY | MULTIDISCIPLINARY SCIENCES | MICE | MECHANISMS | INOS | INDUCED INCREASES | BLOOD | Body Weight | Kidney - blood supply | Kidney - pathology | Caspase 3 - metabolism | Hemorrhage - mortality | Male | MicroRNAs - metabolism | NF-kappa B - metabolism | Hematopoiesis - radiation effects | Inflammation - metabolism | Kidney - metabolism | Erythropoietin - metabolism | Anemia - etiology | Cytokines - metabolism | Thrombocytopenia - etiology | Bone Marrow Cells - cytology | Hemorrhage - complications | Water - metabolism | Bone Marrow Cells - radiation effects | Lethal Dose 50 | Radiation Injuries - complications | Thrombocytopenia - metabolism | Anemia - metabolism | Disease-Free Survival | Kidney - radiation effects | Animals | Mice | Leukopenia - etiology | Hemorrhage - pathology | Bone Marrow Cells - metabolism | Physiological aspects | Complications and side effects | MicroRNA | Radiotherapy | Hemorrhage | Health sciences | Transcription factors | Erythropoietin | Radiation | Life assessment | Caspase-3 | Blood | Interleukin 6 | Thrombopenia | Nuclear accidents & safety | Blood volume | Hematopoiesis | Bone marrow | Radiation injuries | Anesthesia | Armed forces | Injuries | Euthanasia | Spleen | Radiation effects | γ Radiation | Cell survival | Kidneys | Leukopenia | Mortality | MiRNA | Caspase | Inflammation | Exposure | Tumor necrosis factor-α | Gene expression | Trauma | Survival | Ileum | Radiation dosage | Hemopoiesis | Pathology | Depletion | Tumor necrosis factor | MicroRNAs | Hypoxia | Laboratory animals | α Radiation | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2009, Volume 62, Issue 4, pp. 479 - 493
Understanding the physiopathology of affective disorders and their treatment relies on the availability of experimental models that accurately mimic aspects of... 
STEMCELL | HUMDISEASE | MOLNEURO | SEROTONIN-1A RECEPTOR FUNCTION | MESSENGER-RNA | BETA-ARRESTINS | PROTEIN-COUPLED RECEPTORS | ANTIDEPRESSANT TREATMENT | CELL-PROLIFERATION | ADULT MICE | MAJOR DEPRESSION | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | NEUROSCIENCES | Depression - pathology | Microtubule-Associated Proteins - metabolism | Radiation | Arrestins - genetics | GTP-Binding Protein alpha Subunit, Gi2 - metabolism | Male | Hippocampus - drug effects | Antidepressive Agents, Second-Generation - therapeutic use | RNA, Messenger - metabolism | Arrestins - metabolism | Hypothalamus - radiation effects | Corticosterone - toxicity | Depression - drug therapy | GTP-Binding Protein alpha Subunit, Gi2 - genetics | Anxiety - diet therapy | Depression - chemically induced | Reaction Time - drug effects | Exploratory Behavior - drug effects | Neurogenesis - radiation effects | Neurogenesis - drug effects | Bromodeoxyuridine - metabolism | Fluoxetine - therapeutic use | Hypothalamus - drug effects | Disease Models, Animal | Cell Survival - drug effects | Drug Administration Schedule | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Neuropeptides - metabolism | Hippocampus - pathology | Cell Survival - radiation effects | Anxiety - pathology | Feeding Behavior - drug effects | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Hypothalamus - metabolism | Analysis of Variance | beta-Arrestin 2 | beta-Arrestins | Hippocampus - radiation effects | Gene Expression Regulation - radiation effects | Anxiety - chemically induced | Cell Proliferation - drug effects | Mice | Arrestins - deficiency | Cell Proliferation - radiation effects | Neurosciences | Corticosterone | Neurons | Fluoxetine | Analysis | Depression, Mental | Models | Survival analysis | Genotype & phenotype | Brain research | Antidepressants | Anxieties | Rodents | Behavior | Feeds | Neurogenesis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 12/2015, Volume 528, Issue 7580, pp. 93 - 98
Journal Article