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Cancer discovery, ISSN 2159-8290, 2017, Volume 7, Issue 7, pp. 736 - 749
Journal Article
Molecular vision, ISSN 1090-0535, 2018, Volume 24, pp. 789 - 800
Purpose: This study aimed to investigate the effect of nintedanib on the conversion of human Tenon's fibroblasts (HTFs) into myofibroblasts and reveal the... 
OPHTHALMOLOGY | ACTIVATED PROTEIN-KINASE | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TGF-BETA-1 | Transforming Growth Factor beta1 - antagonists & inhibitors | Humans | Actins - metabolism | Smad3 Protein - metabolism | Actins - genetics | Dose-Response Relationship, Drug | Myofibroblasts - metabolism | Smad3 Protein - genetics | Snail Family Transcription Factors - genetics | Cell Transdifferentiation - drug effects | Mitogen-Activated Protein Kinase 1 - genetics | Smad2 Protein - genetics | Snail Family Transcription Factors - antagonists & inhibitors | Tenon Capsule - metabolism | Indoles - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism | Snail Family Transcription Factors - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Smad2 Protein - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Signal Transduction - genetics | Myofibroblasts - drug effects | Gene Expression Regulation - drug effects | Myofibroblasts - cytology | Cell Movement - drug effects | Actins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | Cell Proliferation - drug effects | Fibroblasts - cytology | Primary Cell Culture | Mitogen-Activated Protein Kinase 1 - metabolism | Tenon Capsule - cytology
Journal Article
Biomaterials, ISSN 0142-9612, 2016, Volume 85, pp. 180 - 194
Abstract Access to smooth muscle cells (SMC) would create opportunities for tissue engineering, drug testing, and disease modeling. Herein we report the direct... 
Advanced Basic Science | Dentistry | Direct reprogramming | Smooth muscle cell differentiation | Direct transdifferentiation | Myocardin | Tissue-engineered blood vessel | ENGINEERED BLOOD-VESSELS | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | INTRACELLULAR CALCIUM | DIRECT CONVERSION | PLURIPOTENT STEM-CELLS | TRACTION FORCE | SERUM RESPONSE FACTOR | GENE-EXPRESSION | NEURONAL CELLS | UMBILICAL-CORD BLOOD | Up-Regulation | Endothelial Progenitor Cells - cytology | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Cadherins - metabolism | Humans | Actins - metabolism | Myosin Heavy Chains - genetics | Antigens, CD - genetics | Myosin Heavy Chains - metabolism | Actins - genetics | Antigens, CD - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Muscle Proteins - metabolism | Trans-Activators - genetics | Endoglin - genetics | Cell Transdifferentiation | Microfilament Proteins - metabolism | Cadherins - genetics | Nuclear Proteins - genetics | Microfilament Proteins - genetics | Myocytes, Smooth Muscle - cytology | Tissue Engineering | Gene Transfer Techniques | Down-Regulation | Nuclear Proteins - metabolism | Muscle Proteins - genetics | Trans-Activators - metabolism | Endoglin - metabolism | Biological products | Tissue engineering | Analysis | Stem cells | Smooth muscle | Gene expression | Endothelium | Human | Drugs | Surgical implants | Vasoconstriction | Muscles | Vasodilation | Arteries | smooth muscle cell differentiation | myocardin | tissue-engineered blood vessel | direct transdifferentiation | direct reprogramming
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 04/2014, Volume 18, Issue 4, pp. 698 - 708
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 10/2011, Volume 108, Issue 41, pp. 17016 - 17021
... at very high frequencies. Using this system, we performed a systematic analysis of whether during transdifferentiation the cells transiently reactivate progenitor-restricted genes or even retrodifferentiate... 
T lymphocytes | B lymphocytes | Epithelial cells | Genes | Stromal cells | Stem cells | Cell lines | Macrophages | Progenitor cells | Hematopoietic stem cells | Cell reprogramming | Hematopoietic differentiation lineage commitment | Cell fate decision | PROGENITOR CELLS | STEM-CELLS | DEFINED FACTORS | MULTIDISCIPLINARY SCIENCES | NEUTROPHILS | PLURIPOTENCY | FIBROBLASTS | cell reprogramming | C/EBP-ALPHA | cell fate decision | IN-VIVO | DIFFERENTIATION | hematopoietic differentiation lineage commitment | HEMATOPOIETIC STEM | Precursor Cells, B-Lymphoid - metabolism | RNA, Messenger - genetics | Cells, Cultured | Transcriptome | Cell Transdifferentiation - genetics | Macrophages - cytology | RNA, Messenger - metabolism | fms-Like Tyrosine Kinase 3 - genetics | Macrophages - metabolism | Animals | Cell Transdifferentiation - physiology | T-Lymphocytes - cytology | T-Lymphocytes - metabolism | CCAAT-Enhancer-Binding Protein-alpha - physiology | Precursor Cells, B-Lymphoid - cytology | Erythrocytes - metabolism | CCAAT-Enhancer-Binding Protein-alpha - genetics | Erythrocytes - cytology | Proto-Oncogene Proteins c-kit - genetics | Mice | Megakaryocytes - cytology | Megakaryocytes - metabolism | Cell Lineage - genetics | Genes, cdc | Biological Sciences | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | hematopoietic differentiation | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | lineage commitment | Cell- och molekylärbiologi
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2019, Volume 139, Issue 1, pp. 119 - 133
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 3554 - 18
...ARTICLE ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion Mike R. Wilson1,6, Jake J... 
TRANSCRIPTION FACTORS | READ ALIGNMENT | MUTANT P110-ALPHA | CELL-MIGRATION | MULTIDISCIPLINARY SCIENCES | REMODELING GENE ARID1A | CANCER-ASSOCIATED MUTATIONS | MYOMETRIAL INVASION | EXPRESSION | SOMATIC MUTATIONS | STATISTICAL-MODEL | Chromatin - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Loss of Function Mutation | Class I Phosphatidylinositol 3-Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | DNA-Binding Proteins - metabolism | Endometrial Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Female | Nuclear Proteins - genetics | Disease Models, Animal | Cell Line | Myometrium - pathology | Mice, Transgenic | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Haploinsufficiency | Phosphatidylinositol 3-Kinases - genetics | Transcription Factors - metabolism | Animals | Endometrial Neoplasms - pathology | Mice | Endometrium - pathology | Neoplasm Invasiveness - genetics | Repressing | Phenotypes | Chromatin | Mesenchyme | Epithelial cells | Vagina | Activation | Kinases | Gene expression | Epithelium | Neoplasms | Bleeding | 1-Phosphatidylinositol 3-kinase | Cell activation | Uterus | Transcription activation | Mutation | Endometrium
Journal Article
Nature reviews. Molecular cell biology, ISSN 1471-0080, 2011, Volume 12, Issue 2, pp. 79 - 89
Journal Article